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New approach to monitoring freshwater quality can identify sources of pollution, and predict their effects

News from the Department of Biochemistry - Thu, 28/03/2024 - 18:00

The source of pollutants in rivers and freshwater lakes can now be identified using a comprehensive new water quality analysis, according to scientists at the University of Cambridge and Trent University, Canada.

Microparticles from car tyres, pesticides from farmers’ fields, and toxins from harmful algal blooms are just some of the organic chemicals that can be detected using the new approach, which also indicates the impact these chemicals are likely to have in a particular river or lake.

Importantly, the approach can also point to the origin of specific organic matter dissolved in the water, because it has a distinct composition depending on its source.

The approach uses a technique called high-resolution mass spectrometry to analyse water samples: within an hour this provides a comprehensive overview of all the organic molecules present.

Water quality is strongly determined by the diversity of organic matter dissolved in it – termed ‘chemodiversity.’ The scientists say that the thousands of different dissolved organic compounds can keep freshwater ecosystems healthy, or contribute to their decline, depending on the mixture present.

The paper is published today in the journal Science.

“Traditional approaches to monitoring water quality involve taking lots of different measurements with many devices, which takes a lot of time. Our technique is a very simple way to get a comprehensive overview of what’s going on in a particular river or lake,” said Jérémy Fonvielle, a researcher in the University of Cambridge’s Departments of Plant Sciences and Biochemistry, and co-author of the paper.

To understand what drives this chemodiversity, the team reviewed studies of dissolved organic matter in freshwater samples from rivers and lakes across Europe and northern Canada.

For example, water analysis of Lake Erie in Canada revealed high levels of phosphorus pollution. By looking at the composition of individual molecules in the water sample, researchers identified agricultural activities as the source of this pollution, rather than wastewater effluent. 

“Whereas before, we could measure the amount of organic nitrogen or phosphorus pollution in a river, we couldn't really identify where pollution was coming from. With our new approach we can use the unique molecular fingerprint of different sources of pollution in freshwater to identify their source,” said Dr Andrew Tanentzap at Trent University School of the Environment, co-author of the report.

Traditional approaches involve separately measuring many indicators of ecosystem health, such as the level of organic nutrients or particular pollutants like nitrogen. These can indicate the condition of the water, but not why this state has arisen.

Dissolved organic matter is one of the most complex mixtures on Earth. It consists of thousands of individual molecules, each with their own unique properties. This matter influences many processes in rivers and lakes, including nutrient cycling, carbon storage, light absorption, and food web interactions - which together determine ecosystem function.

Sources of dissolved organic matter in freshwater include urban runoff, agricultural runoff, aerosols and wildfires.

“It's possible to monitor the health of freshwater through the diversity of compounds that are present. Our approach can, and is, being rolled out across the UK,” said Tanentzap.

Fonvielle will now apply this technique to analysing water samples from farmland drainage ditches in the Fens, as part of a project run by the University of Cambridge’s Centre for Landscape Regeneration to understand freshwater health in this agricultural landscape.

The research was funded primarily by the Natural Sciences and Engineering Research Council and the European Research Council.

Reference: Tanentzap, A.J. and Fonvielle, J.A: ‘Chemodiversity in freshwater health.’ Science, March 2024. DOI: 10.1126/science.adg8658

Analysing the diversity of organic compounds dissolved in freshwater provides a reliable measure of ecosystem health, say scientists.

Our technique is a very simple way to get a comprehensive overview of what’s going on in a particular river or lake.Jérémy FonvielleSam WoodmanStudy lake in Norway


The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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New approach to monitoring freshwater quality can identify sources of pollution, and predict their effects

News - Thu, 28/03/2024 - 18:00

The source of pollutants in rivers and freshwater lakes can now be identified using a comprehensive new water quality analysis, according to scientists at the University of Cambridge and Trent University, Canada.

Microparticles from car tyres, pesticides from farmers’ fields, and toxins from harmful algal blooms are just some of the organic chemicals that can be detected using the new approach, which also indicates the impact these chemicals are likely to have in a particular river or lake.

Importantly, the approach can also point to the origin of specific organic matter dissolved in the water, because it has a distinct composition depending on its source.

The approach uses a technique called high-resolution mass spectrometry to analyse water samples: within an hour this provides a comprehensive overview of all the organic molecules present.

Water quality is strongly determined by the diversity of organic matter dissolved in it – termed ‘chemodiversity.’ The scientists say that the thousands of different dissolved organic compounds can keep freshwater ecosystems healthy, or contribute to their decline, depending on the mixture present.

The paper is published today in the journal Science.

“Traditional approaches to monitoring water quality involve taking lots of different measurements with many devices, which takes a lot of time. Our technique is a very simple way to get a comprehensive overview of what’s going on in a particular river or lake,” said Jérémy Fonvielle, a researcher in the University of Cambridge’s Departments of Plant Sciences and Biochemistry, and co-author of the paper.

To understand what drives this chemodiversity, the team reviewed studies of dissolved organic matter in freshwater samples from rivers and lakes across Europe and northern Canada.

For example, water analysis of Lake Erie in Canada revealed high levels of phosphorus pollution. By looking at the composition of individual molecules in the water sample, researchers identified agricultural activities as the source of this pollution, rather than wastewater effluent. 

“Whereas before, we could measure the amount of organic nitrogen or phosphorus pollution in a river, we couldn't really identify where pollution was coming from. With our new approach we can use the unique molecular fingerprint of different sources of pollution in freshwater to identify their source,” said Dr Andrew Tanentzap at Trent University School of the Environment, co-author of the report.

Traditional approaches involve separately measuring many indicators of ecosystem health, such as the level of organic nutrients or particular pollutants like nitrogen. These can indicate the condition of the water, but not why this state has arisen.

Dissolved organic matter is one of the most complex mixtures on Earth. It consists of thousands of individual molecules, each with their own unique properties. This matter influences many processes in rivers and lakes, including nutrient cycling, carbon storage, light absorption, and food web interactions - which together determine ecosystem function.

Sources of dissolved organic matter in freshwater include urban runoff, agricultural runoff, aerosols and wildfires.

“It's possible to monitor the health of freshwater through the diversity of compounds that are present. Our approach can, and is, being rolled out across the UK,” said Tanentzap.

Fonvielle will now apply this technique to analysing water samples from farmland drainage ditches in the Fens, as part of a project run by the University of Cambridge’s Centre for Landscape Regeneration to understand freshwater health in this agricultural landscape.

The research was funded primarily by the Natural Sciences and Engineering Research Council and the European Research Council.

Reference: Tanentzap, A.J. and Fonvielle, J.A: ‘Chemodiversity in freshwater health.’ Science, March 2024. DOI: 10.1126/science.adg8658

Analysing the diversity of organic compounds dissolved in freshwater provides a reliable measure of ecosystem health, say scientists.

Our technique is a very simple way to get a comprehensive overview of what’s going on in a particular river or lake.Jérémy FonvielleSam WoodmanStudy lake in Norway


The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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TB vaccine may enable elimination of the disease in cattle by reducing its spread

News - Thu, 28/03/2024 - 18:00

The research, led by the University of Cambridge and Penn State University, improves prospects for the elimination and control of bovine tuberculosis (TB), an infectious disease of cattle that results in large economic costs and health impacts across the world.  

This is the first study to show that BCG-vaccinated cattle infected with TB are substantially less infectious to other cattle. This remarkable indirect effect of the vaccine beyond its direct protective effect has not been measured before.

The spillover of infection from livestock has been estimated to account for about 10% of human tuberculosis cases. While such zoonotic TB (zTB) infections are most commonly associated with gastro-intestinal infections related to drinking contaminated milk, zTB can also cause chronic lung infections in humans. Lung disease caused by zTB can be indistinguishable from regular tuberculosis, but is more difficult to treat due to natural antibiotic resistance in the cattle bacteria.

TB remains endemic in many countries around the world, including in Europe and the Americas, where its control costs farmers and taxpayers hundreds of millions of dollars each year.

The study is published today in the journal Science.

In the study, carried out in Ethiopia, researchers examined the ability of the vaccine, Bacillus Calmette-Guérin (BCG), to directly protect cattle that receive it, as well as to indirectly protect both vaccinated and unvaccinated cattle by reducing TB transmission. Vaccinated and unvaccinated animals were put into enclosures with naturally infected animals, in a novel crossover design performed over two years.

“Our study found that BCG vaccination reduces TB transmission in cattle by almost 90%. Vaccinated cows also developed significantly fewer visible signs of TB than unvaccinated ones. This suggests that the vaccination not only reduces the progression of the disease, but that if vaccinated animals become infected, they are substantially less infectious to others,” said Andrew Conlan, Associate Professor of Epidemiology at the University of Cambridge’s Department of Veterinary Medicine and a corresponding author of the study.

Using livestock census and movement data from Ethiopia, the team developed a transmission model to explore the potential for routine vaccination to control bovine tuberculosis.

“Results of the model suggest that vaccinating calves within the dairy sector of Ethiopia could reduce the reproduction number of the bacterium — the R0 — to below 1, arresting the projected increase in the burden of disease and putting herds on a pathway towards elimination of TB,” Conlan said.

The team focused their studies in Ethiopia, a country with the largest cattle herd in Africa and a rapidly growing dairy sector that has a growing burden of bovine tuberculosis and no current control program, as a representative of similarly situated transitional economies.

“Bovine tuberculosis is largely uncontrolled in low- and middle-income countries, including Ethiopia,” said Abebe Fromsa, associate professor of agriculture and veterinary medicine at Addis Ababa University in Ethiopia and the study’s co-lead author. “Vaccination of cattle has the potential to provide significant benefits in these regions.”

“For over a hundred years, programs to eliminate bovine tuberculosis have relied on intensive testing and slaughtering of infected animals,” said Vivek Kapur, professor of microbiology and infectious diseases and Huck Distinguished Chair in Global Health at Penn State and a corresponding author of the study.

He added: “This approach is unimplementable in many parts of the world for economic and social reasons, resulting in considerable animal suffering and economic losses from lost productivity, alongside an increased risk of spillover of infection to humans. By vaccinating cattle, we hope to be able to protect both cattle and humans from the consequences of this devastating disease.”

Professor James Wood, Alborada Professor of Equine and Farm Animal Science in the University of Cambridge’s Department of Veterinary Medicine, noted that despite TB being more prevalent in lower-income countries, the United Kingdom, Ireland and New Zealand also experience considerable economic pressures from the disease which continues to persist despite intensive and costly control programs.

Wood said: “For over twenty-years the UK government has pinned hopes on cattle vaccination for bovine tuberculosis as a solution to reduce the disease and the consequent costs of the controls. These results provide important support for the epidemiological benefit that cattle vaccination could have to reduce rates of transmission to and within herds.”

This research was supported by The Bill & Melinda Gates Foundation, as well as the Biotechnology and Biological Sciences Research Council; Foreign, Commonwealth and Development Office; Economic & Social Research Council; Medical Research Council; Natural Environment Research Council; and Defence Science & Technology.

Reference: Fromsa, A. et al: ‘BCG vaccination of cattle reduces transmission of bovine tuberculosis, improving the prospects for elimination.’ Science, March 2024. DOI: 10.1126/science.adl3962

Vaccination not only reduces the severity of TB in infected cattle, but reduces its spread in dairy herds by 89%, research finds.

Our study suggests that vaccination not only reduces the progression of the disease, but that if vaccinated animals become infected, they are substantially less infectious to others.Andrew ConlanGetty/ kamisokaHerd of cows in a grassy field


The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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‘Exhausted’ immune cells in healthy women could be target for breast cancer prevention

News - Thu, 28/03/2024 - 10:03

Everyone has BRCA1 and BRCA2 genes, but mutations in these genes - which can be inherited - increase the risk of breast and ovarian cancer.

The study found that the immune cells in breast tissue of healthy women carrying BRCA1 or BRCA2 gene mutations show signs of malfunction known as ‘exhaustion’. This suggests that the immune cells can’t clear out damaged breast cells, which can eventually develop into breast cancer.

This is the first time that ‘exhausted’ immune cells have been reported in non-cancerous breast tissues at such scale - normally these cells are only found in late-stage tumours.

The results raise the possibility of using existing immunotherapy drugs as early intervention to prevent breast cancer developing, in carriers of BRCA1 and BRCA2 gene mutations.

The researchers have received a ‘Biology to Prevention Award’ from Cancer Research UK to trial this preventative approach in mice. If effective, this will pave the way to a pilot clinical trial in women carrying BRCA gene mutations.

“Our results suggest that in carriers of BRCA mutations, the immune system is failing to kill off damaged breast cells - which in turn seem to be working to keep these immune cells at bay,” said Professor Walid Khaled in the University of Cambridge’s Department of Pharmacology and Wellcome-MRC Cambridge Stem Cell Institute, senior author of the report.

He added: “We’re very excited about this discovery, because it opens up potential for a preventative treatment other than surgery for carriers of BRCA breast cancer gene mutations.

“Drugs already exist that can overcome this block in immune cell function, but so far, they’ve only been approved for late-stage disease. No-one has really considered using them in a preventative way before.”

The results are published today in the journal Nature Genetics.

Risk-reducing surgery, in which the breasts are removed, is offered to those at increased risk of breast cancer. This can be a difficult decision for young women to make and can have a significant effect on body image and sexual relationships.

“The best way to prevent breast cancer is to really understand how it develops in the first place. Then we can identify these early changes and intervene,” said Khaled.

He added: “Late-stage breast cancer tends to be very unpredictable and hard to manage. As we make better and better drugs, the tumours just seem to find a way around it.”

Using samples of healthy breast tissue collected from 55 women across a range of ages, the researchers catalogued over 800,000 cells - including all the different types of breast cell.

The resulting Human Breast Cell Atlas is now available as a resource for other researchers to use and add to. It contains huge amounts of information on other risk factors for breast cancer including Body Mass Index (BMI), menopausal status, contraceptive use and alcohol consumption.

“We've found that there are multiple breast cell types that change with pregnancy, and with age, and it’s the combination of these effects - and others - that drives the overall risk of breast cancer,” said Austin Reed, a PhD student in the University of Cambridge’s Department of Pharmacology and joint first author of the report.

He added: “As we collect more of this type of information from samples around the world, we can learn more about how breast cancer develops and the impact of different risk factors - with the aim of improving treatment.”

One of the biggest challenges in treating breast cancer is that it is not just one disease, but many. Many different genetic variations can lead to breast cancer, and genetic risk interacts with other risk factors in complicated ways.

For example, it is known that the likelihood of breast cancer increases with age, but this risk is greatly reduced by pregnancy early in life. And age-associated risk is greatly increased in carriers of the breast cancer genes BRCA1 and BRCA2.

The new study aimed to understand how some of these risk factors interact, by characterising the different cell types in the human breast under many different physiological states.

The researchers used a technique called ‘single cell RNA-sequencing’ to characterise the many different breast cell types and states. Almost all cells in the body have the same set of genes, but only a subset of these are switched on in each cell – and these determine the cell’s identity and function. Single cell RNA-sequencing reveals which genes are switched on in individual cells.

“Breast cancer occurs around the world, but social inequalities mean not everyone has access to treatment. Prevention is the most cost-effective approach. It not only tackles inequality, which mostly affects low-income countries, but also improves disease outcome in high-income countries,” said Dr Sara Pensa, Senior Research Associate in the University of Cambridge’s Department of Pharmacology and joint first author of the study.

Breast tissue samples were provided by the Breast Cancer Now tissue bank.

The research was primarily funded by the Medical Research Council and Cancer Research UK.

Reference: Reed, A.D. et al: ‘A human breast cell atlas enables mapping of homeostatic cellular shifts in the adult breast.’ Nature Genetics, March 2024. DOI: 10.1038/s41588-024-01688-9

Researchers at the University of Cambridge have created the world’s largest catalogue of human breast cells, which has revealed early cell changes in healthy carriers of BRCA1 and BRCA2 gene mutations.

We’re very excited about this discovery, because it opens up potential for a preventative treatment other than surgery for carriers of BRCA breast cancer gene mutations.Walid KhaledAngiola Harry on UnsplashWoman holds pink breast cancer awareness ribbon. Credit angiola-harry-unsplash


The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

YesLicence type: Attribution-Noncommerical

Teaching Manager

We are looking for a motivated, enthusiastic and positive individual to lead our Teaching Team and to ensure the effective administration and delivery of undergraduate and postgraduate education in the Department of Zoology. We are one of the larger research and teaching departments in the University, with a final-year undergraduate class of about 90. The Department teaches on 10 courses within the undergraduate Natural Sciences Tripos and currently trains approximately 90 postgraduate students.

Located in the heart of Cambridge, the Zoology Department is a thriving, friendly and dynamic community of researchers, students, professional services staff and visitors who are passionate about exploring the wonders of the natural world. Our buildings include teaching areas, labs and offices as well as the Museum of Zoology. We offer a welcoming work environment where you can feel valued, are encouraged to develop, and supported to achieve your full potential.

We are looking for someone with great organisational skills, experience in planning and delivering programs and projects, excellent written and verbal communication abilities, and a demonstrable capacity to engage with students, academics, and professional services staff. You will be a great team player with a genuine interest in this fulfilling field and preferably have some existing knowledge of higher education teaching and administration.

Experience in successfully managing staff is desirable as the role holder will manage the Postgraduate Administrator and the Teaching Office Assistant who support the administration of all undergraduate and postgraduate programs within the Department.

Excellent IT skills, including knowledge of word processing, spreadsheets, databases, webpages and email packages, are essential together with a knowledge of, or willingness to learn, Moodle (Virtual Learning Environment), Panopto (online video recording and hosting system) and other University computing systems such as CamSIS (the University's student records system).

The position is full time and is available on a permanent basis.

Full information about the role can be accessed via the link below.

Interviews will be held in the week commencing Monday 13 May 2024.

If you have any questions about this vacancy or about the application process, please contact Louise Balshaw, Departmental Administrator on da@zoo.cam.ac.uk

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Flexible working requests will be considered.

We particularly welcome applications from candidates from a BME background for this vacancy as they are currently under-represented at this level in our University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process please contact Anastasia Nezhentseva. Email: an286@cam.ac.uk Telephone: (0)1223 330117

Please quote reference PF41113 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Associate - Genome regulation

The Ahringer lab in the Gurdon Institute is looking for an experienced laboratory research scientist with expertise in molecular biology and genomics to support its research programmes. We decipher how chromatin and gene expression are regulated to direct the step-by-step development of the single-celled totipotent zygote to the differentiated state. We use the C. elegans model, where the invariant lineage makes it the only organism where it is feasible to determine cell-to-cell genomic regulatory transitions across development. We apply single cell profiling, bulk genomic assays, microscopy, and mutant analyses to determine how the genome is regulated to drive developmental decisions and their expression.

This is a key role that will offer collaborative support and technical expertise across the scientific programmes in the laboratory. The role covers a wide range of activities, allowing for continuity of lab operations. Activities include:

  • Collaborating with lab members on research projects.
  • Providing experimental or technical support to other lab members.
  • Providing technical expertise and input to develop, optimise and troubleshoot relevant and novel methodologies.
  • Independently undertaking own research projects, designing, and executing experiments in consultation with the group leader.
  • Participating in academic activities, including group meetings and journal clubs, seminars, and scientific meetings.
  • Writing up findings and completing revisions.
  • Maintaining laboratory organisation, supplies, and safety procedures
  • Training new and existing lab members in standard operating procedures

This is a highly collaborative position, so excellent communication and interpersonal skills are essential. You should be a motivated and organised individual with expertise in a broad range of molecular biology techniques and have the ability to work both independently and as part of a team. Experience in genomic profiling techniques (e.g. ChIP-seq, ATAC-seq, RNA-seq, single cell analyses) is highly desirable. Candidates should have a PhD in a relevant discipline and have a capacity to apply initiative and creativity to solve technical and biological problems.

The Gurdon Institute is a world-renowned centre of Developmental biology and Cancer research embedded in the University of Cambridge. It provides an exceptional and stimulating environment that promotes collaborative and interdisciplinary research in a supportive and modern setting, with access to state-of-the-art technologies such as super-resolution imaging, single-cell analyses, genome engineering, and genomics and computer modelling.

Informal enquiries can be made to Julie Ahringer via ja219@cam.ac.uk

If you have any questions about this vacancy or the application process, please contact hr@gurdon.cam.ac.uk.

Fixed-term: The funds for this post are available until 31 December 2025 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please quote reference PR41123 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant (Fixed Term)

Department of Physiology, Development and Neuroscience (https://www.pdn.cam.ac.uk/), University of Cambridge.

The position involves investigating the organisation and function of neural circuits underlying spatial orientation and self-motion perception, funded by the Wellcome Trust. The project provides the opportunity to integrate behaviour, electrophysiology, calcium imaging, and circuit manipulation across thalamic and cortical networks involved in navigation, using the mouse model. For more information about the lab's research questions and approaches, please visit https://www.keshavarzilab.com/.

Key Experience and Competencies:

We are seeking a highly motivated individual with prior experience in cellular or systems neuroscience research.

Essential criteria include:

  • A first-class degree (or equivalent) in neuroscience, engineering, biology, or other relevant disciplines.
  • Proficient programming skills (Matlab, Python) for the control and analysis of behavioral and neurophysiological experiments.
  • A solid knowledge of neurobiology with critical thinking abilities.
  • Excellent communication skills in English, both verbal and written.
  • A clear interest in the lab's research program.

Preference will be given to candidates who additionally demonstrate:

  • Experimental expertise in any of the following techniques: electrophysiology, calcium imaging, quantitative animal behavior, stereotactic surgery.
  • Willingness to pursue a PhD in our lab and apply to the department's PhD program in 2024.

Role summary:

The role involves developing and conducting novel behavioural experiments to study spatial orientation abilities in mice, recording neural activity using electrophysiology and/or calcium imaging techniques, manipulating specific circuits and cell types with opto- and chemogenetics, as well as designing and performing data analysis.

The research assistant will join a multidisciplinary research environment, closely interacting with other circuit/systems neuroscience groups. Regular seminars held at the department and various scientific and networking events organised by the Cambridge Neuroscience Network will further provide excellent opportunities for scientific discussion and networking with fellow researchers and the wider neuroscience community.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please submit a CV, including your overall grade for each higher education degree, and a cover letter addressing the following:

  • Your motivation for joining the lab.
  • How your research skills align with the job description.
  • Your research ambitions and career goals.

Please provide the contact details of two individuals who can serve as references.

The closing date for applications is 30th April 2024. Please note that we will be reviewing applications on a regular basis. We reserve the right to close the position early once the available position is filled.

The post is available from September 2024 onwards for one year in the first instance.

Informal enquiries about the position can be made to Dr Sepiedeh Keshavarzi (sk2244@cam.ac.uk).

Please quote reference PM41068 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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Student Liaison Administrator

This is an excellent opportunity for a friendly and well organised full-time administrator to join a small team working in the office of the School of the Biological Sciences in central Cambridge.

You will be able to use your technical and communication skills to support staff who deliver our teaching to around 2,500 students. The role's primary purpose is to be responsible for maintaining and running services provided by the School for the smooth administration of student matters. This includes designing and updating documents, coordinating teaching input from the departments and technical responsibility for maintaining websites, timetables and class lists. The role holder also has direct responsibility for administration of aspects of interdepartmental courses.

Our ideal candidate will be able to communicate clearly and effectively both in written work and orally with staff and students throughout the University and be able to work with colleagues in wide range of professional roles. Excellent customer service skills are required and previous experience in a customer focused office environment is desirable. You will be educated to at least A-level standard, and will be highly competent in standard software packages, ideally with web-authoring experience, as well as being enthusiastic about learning how to use a range of non-standard software. You will need to be able to prioritise your own workload and be able to work effectively on your own as well as within a small group.

For full details of the post please see the Further Particulars.

The deadline for applications is midnight on Monday 15 April. We hope to hold interviews for the post during the week commencing 22 April 2024.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

We particularly welcome applications from women and /or candidates from a BME background for this vacancy as they are currently under-represented at this level in our School.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be made by contacting the Administrative Officer (Teaching and Examinations), Chad Pillinger, on cp316@cam.ac.uk.

Please quote reference PA41050 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Departmental Administrator

The School of Biological Sciences, a flourishing academic community that enjoys a world-class reputation for both teaching and research, has an exciting opportunity for a highly motivated and experienced administrator to join the team as Departmental Administrator at the Department of Pharmacology, University of Cambridge. The Departmental Administrator is responsible for effective and efficient delivery of all operational and administrative functions within the Department and supports the Head of the Department in achieving the Department's strategic aims and objectives in relation to governance, policy and business operations in support of teaching and research.

As an experienced manager, you will advise, manage, and motivate the Department's professional services staff, who deliver key support services in HR, finance, grants administration, teaching, buildings and facilities, health and safety, IT, internal and external communications, compliance, and other operational areas. You will also interact with both undergraduate and postgraduate students undertaking taught and research-based courses with the Department.

You will utilise your communication and interpersonal skills, not only to build effective working relationships within your team, but also to develop and maintain effective working networks within the School of the Biological Sciences and the University's central administration. Experience of strategic planning and risk management, compliance, committee management, mentoring/coaching, project management, change management, problem solving, and conflict resolution is highly desirable.

The ideal candidate will have good time management, communication, and interpersonal skills, with a strong ability to build relationships at all levels of the organisation. A proactive approach, persuasive tactfulness, and an enthusiastic attitude towards their work are qualities we deem essential for the appointed candidate.

Educated to at least degree level, the ideal applicant will be able to engage with the values and aspirations of a research-intensive Department, School and University. You will join us with the ability to handle a diverse and varied workload, with the ability to manage both projects and operational tasks concurrently. Experience in a senior administrative role within a Higher Education environment would be beneficial.

Further details can be found in the Further Particulars document.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any questions about this vacancy, please contact Ms Thury Agustsdottir (ta421@cam.ac.uk).

Any queries regarding the application process can be directed at the HR Team (hr@phar.cam.ac.uk).

Please quote reference PL41064 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Laboratory Technician (Fixed Term)

The Crop Science Centre is seeking to recruit a Laboratory Technician. This is an exciting opportunity for somebody passionate about supporting scientific research to join a new team of vibrant and friendly group of researchers and technicians and work in a state-of-the-art laboratory.

The Crop Science Centre opened in October 2020 and is part of the Department of Plant Sciences. It benefits from the diverse skills and expertise of the University of Cambridge and NIAB, providing an environment for research excellence in crops, with the drive and expertise for scientific translation to address real-world problems. Over 80 staff and students are located at the Centre, distributed in between six research groups.

The role holder will report to the Research Service Manager. The successful candidate will work alongside the Lab Manager Assistant to ensure the smooth running of CSC labs including procurement of lab consumables and equipment, and correct use and maintenance of research equipment. The role holder will also assist with Health and Safety at CSC, including updating risk assessments and standard operating procedures. The role holder will provide assistance in support of research activity, like maintaining stocks of competent cells or running a N. benthamiana transient transformation service.

The ideal candidate should have prior experience in working in a research laboratory and understanding of laboratory technician work. Experience with media preparation or horticultural practices will be advantageous. The role holder will work as part of a wider dynamic and friendly Professional Services technical team and willingness to help when demands are high, and being a strong team player is essential. Good communication, attention to details and interpersonal skills are essential.

CSC is committed to technician development, supporting the Technician Commitment initiative to ensure recognition, visibility, career development and sustainability of the Professional Services-technical group.

Fixed-term: The funds for this post are available for 21 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcome and should be directed to Dr Susana Sauret Gueto, Research Service Manager, ss2359@cam.ac.uk.

Please quote reference PD40958 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

2024-04-08 19:30 - Cambridge International Piano Festival&Academy Opening Concert - MinJung Baek Piano Recital

What's on in the University - Mon, 25/03/2024 - 10:13
Come enjoy a mesmerizing piano recital by MinJung Baek with special guest artists, promising a night of unforgettable musical brilliance!

Clinical Veterinarian in Oncology

Do you have a passion for clinical oncology, teaching and research?

Do you want to work as part of an internationally recognised team in a state of the art Hospital?

The Department has an exciting opportunity for a Clinical Veterinarian in Oncology with effect from 1 May 2024 or as soon as possible thereafter.

Along with other academic staff you will be responsible for providing small animal referral oncology services to the Queen's Veterinary School Hospital; practical teaching of small animal oncology to undergraduates; and for training Junior and Senior Clinical Training Scholars. Whilst this is primarily a clinical service post, the role holder would be expected and encouraged to contribute to current and future clinical research projects. Participation in an on call rota will be required.

Applicants should be a member of the Royal College of Veterinary Surgeons and hold a Diploma of the European or American College of Veterinary Internal Medicine (sub-specialty Oncology). However, candidates who have completed an approved Residency training programme in Medical Oncology and who are eligible to sit the ECVIM-Onc certifying examination will also be considered. Documented undergraduate teaching experience is desirable.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Alison Hayes, Associate Principal Oncologist, by email: amh243@cam.ac.uk

Applicants should complete the online application process in addition to submitting a Curriculum Vitae (CV), covering letter outlining suitability for the role and contact details for two referees.

Please ensure that you upload your CV and a covering letter in the Upload section of the online application. If you upload any additional documents that have not been requested we will not be able to consider these as part of your application.

For further particulars for the role and information about the Department, please visit: https://www.hospital.vet.cam.ac.uk/

Closing date for applications: Monday 1st April 2024

We reserve the right to close this vacancy early if we receive sufficient applications for the role. Therefore, if you are interested, please submit your application as early as possible.

Please quote reference PP40907 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Scientific Support Coordinator

The Department of Zoology is internationally renowned for its exceptional record in teaching and research. It is home to a thriving community of around 260 staff, graduate students and visitors. Research in the Department ranges from cell and developmental biology through conservation science or evolutionary genetics.

We are looking to recruit a keen and enthusiastic individual to join our scientific support team who provide a highest standard of support to our research and teaching labs. This is a great opportunity to become part of Zoology's vibrant, friendly and welcoming community and contribute towards its success.

You will be part of a team responsible for ensuring that scientific departmental needs are supported. This is an exciting role with diverse responsibilities: you will be involved with the management of the media and glass washing facility, you will work closely with the Senior Animal Care Technician, and you will manage the tissue culture facility, including hands-on bench and tissue culture work. You will also manage departmental service contracts for communal scientific equipment and you will provide assistance to the Teaching Lab when required.

You will be a proactive, enthusiastic and versatile individual to undertake this exciting role in the Department. You should have experience working within a biological lab environment, be an excellent communicator with good organisation skills, keen attention to detail, and the ability to make decisions on your own whilst also working effectively as part as a wider team.

We have a proactive approach to personal and team development and we will provide training where necessary for this role. As a department within the University of Cambridge, the successful applicant will benefit from the stability that comes from such a world-renowned Institution. They will also have access to a broad selection of staff benefits and personal development opportunities including discounts at a wide range of local and national businesses and educational opportunities available exclusively to University of Cambridge employees.

This role is required to work on site and the appointment is offered on a permanent, full-time basis. A requirement of the role is to be part of the additional cover team at weekends, Bank Holidays and on occasion, out of hours. The candidate will therefore be required to work outside of normal working hours at certain periods of time.

Informal enquiries should be directed to Sylviane Moss, Lab and Facilities Manager: smmc2@cam.ac.uk

Please refer to the Further Particulars for this role, and use this as a guideline for your application.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Flexible working requests will be considered.

We particularly welcome applications from women and candidates from a BME background for this vacancy as they are currently under-represented at this level in our University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process please contact Anastasia Nezhentseva.

Email: an286@cam.ac.uk Telephone: (0)1223 330117

Please quote reference PF41035 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Laboratory Support Technician

Based in the heart of Cambridge, the Department of Pharmacology prides itself in being a thriving, dynamic and friendly department within the School of Biological Sciences, dedicated to the pursuit of world-class research, teaching and learning.

With the number of research and academic staff growing, so are our Professional Services teams and we are now looking to appoint a knowledgeable and dedicated Research Laboratory Support Technician to join our department.

Reporting to the Facilities and Safety Manager, the Research Laboratory Support Technician will be essential to our research and teaching staff by providing specialist technical support and ensuring the smooth running of a workshop facility.

The role is varied and dynamic, with duties ranging from manufacturing and preparing specialist equipment in support of research project and setting up equipment for teaching or research, to providing technical advice to research students and researchers. The post holder will discuss work requests to ascertain the aims and technical requirements of the request/project; construct, test and modify specialist equipment and provide technical specifications based on rough drawings and sketches or verbal instructions. The Research Laboratory Support Technician will carry out research into new technologies and manufacture methods, whilst monitoring laboratory resources within a set budget.

Therefore, excellent communication and problem-solving skills are required in order to work in this active and interesting role. We would expect the post holder to be pro-active and have a high degree of precision and accuracy. IT skills are essential to this role.

Applicants should hold a qualification equitable to HND/HNC, level 4/5 vocational qualifications or an equivalent level of practical experience. It is also essential that applicants demonstrate factual and theoretical knowledge relevant to the post, as well as being up to date with current regulations and practices.

It is expected that this role will be based in the Department in order to be able to provide in-person support.

In return, we are offering: - Competitive rates of pay with automatic service-related pay progression and annual cost of living increases; - Generous annual leave allowance of 36 days paid leave (including bank holidays); - Generous maternity, adoption and shared parental leave entitlement and other family friendly schemes; - An auto-enrolment pension scheme , with a generous employer contribution; - A clear training and induction plan to ensure you are equipped with the skills and knowledge necessary to achieve success; - Access to University personal development training courses to support your ongoing learning and development; - A supportive and inclusive working environment that encourages collaboration and supports wellbeing.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

All applications must submitted via the University Recruitment System - please note that we cannot accept applications that are submitted via post or email.

If you have any questions about this vacancy or the application process, please contact our HR team at hr@phar.cam.ac.uk.

Please quote reference PL41029 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Senior Clinical Training Scholarship (SCTS) in Diagnostic Imaging

Scholarship award: £27,820.00

This Senior Clinical Training Scholarship (SCTS) provides an outstanding opportunity to study for a postgraduate qualification, and is available to start on 1 July 2024 or as soon as possible thereafter. You will be trained in all aspects of veterinary diagnostic imaging, including radiology, ultrasonography, magnetic resonance imaging and computed tomography. The training programme is approved by the European College of Veterinary Diagnostic Imaging.

The Scholarship is for one year in the first instance, renewable for periods of one year up to a total of three years. It is subject to an initial monitoring period of six months and review on an annual basis.

You will be required to register with the ECVDI for the Diploma in Diagnostic Imaging. The training programme requires participation in the Department's clinical service, including the out-of-hours rota and first opinion clinic, in addition to small-group teaching of veterinary students. You will also be expected to participate in research projects as part of your training.

You must be a Member of the Royal College of Veterinary Surgeons, or hold a veterinary degree qualifying you for membership. Completion of a recognised internship or a minimum of two years' experience in small animal practice is essential.

We welcome candidates wishing to apply for the scholarship to come and visit the hospital and to meet the team. Please contact Marie-Aude Genain, Principal Clinical Radiologist, on mag72@cam.ac.uk to arrange a convenient date.

A SCTS application form (SCTS1) and information pack can be downloaded from the following website: https://www.vet.cam.ac.uk/job

Applicants should supply a completed SCTS Application Form (SCTS1), Curriculum Vitae and Covering Letter giving reasons for wishing to undertake the SCTS in the Department of Veterinary Medicine, University of Cambridge.

Applications should be submitted via e-mail to vetmed@vet.cam.ac.uk with the above documents as one attachment, by the closing date stated.

Closing date for applications: Wednesday 17 April 2024

Interviews will be held on the week commencing 22 April 2024.

Please quote reference PP41012 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Associate in Developmental Genetics (Fixed Term)

Applications are invited for a Postdoctoral Research Associate to join the group of Dr Erik Clark at the Department of Genetics in central Cambridge.

We are looking for a talented and enthusiastic individual to join a small interdisciplinary team investigating the robust patterning of the early Drosophila embryo. Duties will include developing and applying cutting-edge imaging approaches, Drosophila genetics, and general lab management.

The primary focus of the role is to lead imaging experiments in the lab, using techniques such as smFISH, HCR, immunofluorescence, MS2, and llamatags and acquiring data on fluorescence confocal miscroscopes. Significant imaging experience is therefore essential with multiplexed and single molecule imaging experience preferred. Quantitative image analysis experience would also be beneficial.

The successful applicant will be conducting this research using early Drosophila embryos, therefore a thorough understanding of early Drosophila development and proficiency in Drosophila genetics and Drosophila husbandry is essential. A track record of research into gene regulation in the Drosophila blastoderm is particularly desirable with previous experience of non-Drosophila arthropods also very welcome.

Suitable applicants should hold a PhD in a relevant scientific discipline and be able to demonstrate a thorough working knowledge of general lab management principles. They should have experience of supervising junior lab members and students and be confident at delivering training in wet-lab techniques.

Strong communication skills and the ability to discuss research with different audiences is essential. This includes presenting at conferences, contributing to publications, supporting teaching activities and helping to lead group discussions.

Fixed-term: The funds for this post are available for 4 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries about the role are welcome and should be directed to Dr Erik Clark (ec491@cam.ac.uk).

The role is available for an immediate start and we will be looking to interview shortly after the closing date.

Please quote reference PC41022 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant / Associate (Fixed Term)

We are seeking an enthusiastic and well-organised Research Assistant/Associate to join the group of Dr Valeria Lulla (https://www.path.cam.ac.uk/research/virology-division/lulla-group) at the Department of Pathology (Addenbrooke's campus). Our research is focused on investigating human intestinal pathogens that progress to infections of the central nervous system. We are a strong and diverse team of researchers spanning multiple scientific disciplines, including molecular virology, imaging, omics and organoid infection models.

This position, funded by the Wellcome Trust, offers an exciting opportunity to integrate organoid infection models and molecular virology methods with high-throughput imaging, sequencing and RNA/protein interactions methods, to obtain novel insights into intestinal virus biology.

Candidates should have a PhD, or expect to obtain one shortly, and have a strong track record in RNA/protein molecular biology. Where the successful applicant does not yet have a PhD, he/she will normally be appointed as a Research Assistant on the understanding that he/she will be appointed as a Research Associate upon successful completion of his/her PhD.

Relevant experience in RNA/protein molecular biology is essential. Knowledge of virology, biochemistry and handling biosafety level 2 material would be advantageous.

The successful candidate will use a wide range of techniques, including cloning and mutagenesis, construction of recombinant viruses and replicons, human intestinal organoid culture and infection assays, RNA/protein/organelle extraction and analysis, protein-protein and protein-RNA interaction assays, microscopy, high-throughput RNA-seq and ribosome profiling.

The duties/responsibilities of this post include developing and driving research objectives, preparing research results for presentation/publication, mentoring undergraduate and graduate students, delivering occasional seminars, acquiring new skills, keeping up with the scientific literature, using established procedures and developing new approaches, and maintaining accurate records of experiments and reagents.

Successful applicants will become an integral and valued member of a multidisciplinary group. The ability to work both independently and as part of a team, together with excellent communication and critical thinking skills are also essential. There are many professional development and training activities available via the university, and the successful applicant is encouraged to engage with such opportunities.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Specific queries may be directed to Dr Valeria Lulla (vl284@cam.ac.uk)

Please quote reference PK41010 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Teaching Office Assistant (Part Time, Fixed Term)

We are looking for an enthusiastic and positive individual to join the teaching team in the Department of Zoology as a Temporary Teaching Office Assistant. You will make an important contribution to the effective administration and delivery of undergraduate education in the Department.

The Department of Zoology is one of the largest research and teaching departments in the University, with a final-year undergraduate class of about 90. The Department teaches on 10 courses within the undergraduate Natural Sciences Tripos and currently trains approximately 90 graduate students.

The role will include various tasks associated with providing day-to-day delivery of all administrative processes and functions related to undergraduate and graduate teaching. You will organise the four residential undergraduate field courses, be a point of contact for student and academic staff queries within the Department and assist the Teaching Manager. You may also be required to provide additional support to the Postgraduate Administrator, particularly during the postgraduate admissions period. You will be a great team player with excellent communication, organisational and great time management skills. You should have an excellent working knowledge of Microsoft Office (Word, Excel, Outlook). Previous experience in a responsible administrative role would be desirable.

What can we offer you:

  • Competitive rates of pay with automatic service-related pay progression and annual cost-of-living increases;
  • Generous annual leave allowance;
  • Generous maternity, adoption, and shared parental leave entitlements, and other family-friendly schemes (e.g., workplace nurseries);
  • An auto-enrolment pension scheme, with a generous employer contribution;
  • Travel benefits and retail discounts at over 2,000 local and national stores;
  • Schemes to support relocation/provision of accommodation.

If you have the skills, experience, and personality to succeed in this role, we would be delighted to hear from you.

Informal conversations are welcomed. Please email Francesca Anthony fa377@cam.ac.uk to learn more about this role.

For more details, please refer to the Further Information below.

Fixed-term: The funds for this post are available for twelve months.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Flexible working requests will be considered.

We particularly welcome applications from candidates from a BME background for this vacancy as they are currently under-represented at this level in our University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process please contact Anastasia Nezhentseva.

Email: an286@cam.ac.uk Telephone: (0)1223 330117

Please quote reference PF40995 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

2024-03-27 12:30 - God After Harm

What's on in the University - Wed, 20/03/2024 - 10:37
Join Dean of Chapel Rev Dr Stephen Cherry in conversation with leading representatives of Jewish, Christian, and Islamic perspectives to consider together what God expects of victims and survivors of harm.

2024-03-21 09:00 - Migration, Identity and Memory Exhibition

What's on in the University - Wed, 20/03/2024 - 10:37
This exhibition is part of Pembroke's 'Migration, Identity and Memory' Symposium This exhibition will be in the Foyer on 21+22 March. It will then be moved to the Ferguson Nazareth Room in Milstein House and remain there until Thursday 28 March 2024.