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The structural biology lab of Professor Marko Hyvonen is seeking a postdoctoral research associate to support ongoing projects at Bicycle Therapeutics employing structural biology and to develop tools to facilitate structure determination of proteins by X-ray crystallography and cryo-EM. The post-holder will generate biophysical and structural data for peptide-bound protein targets using x-ray crystallography, cryo-electron microscopy, surface plasmon resonance and ITC. The postholder will also be developing novel methods, through protein engineering, for empowering structural analysis of target proteins, be it for cryo-EM or crystallography.

You will be responsible for driving this academic-industrial collaboration on the structural and biophysical characterisation of bicyclic peptides in complex with therapeutic protein targets in immune-oncology and other debilitating diseases and for development of methods that enable complex targets to be analysed structurally. You will be in charge of the complete gene-to-structure pipeline. You will be in charge of design and generation of expression constructs of target proteins through protein production in bacterial, insect or mammalian cells. You will be responsible for structure determination of protein:inhibitor complexes by X-ray crystallography and by cryo-electron microscopy and for interaction analyses using various biophysical methods. You will provide analysis of the data you produce and contribute to the iterative design process of the peptides.

You should have a PhD from biochemistry, molecular biology, chemistry of closely related field with significant expertise in structural biology, in particular in protein crystallography, from your PhD and/or postdoctoral positions. You should have high level of analytical and problem-solving capability in protein biochemistry and structural biology and creative problem-solving skills.

The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA), and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualized metrics in their applications. For more information: https://www.biology.cam.ac.uk/files/dora.pdf

Fixed-term: The funds for this post are available for 12 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to: Professor Hyvonen mh256@cam.ac.uk or Gustavo Bezerra gustavo.bezerra@bicycletx.com

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH39738 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

A postdoctoral position is available for 12 months (in the first instance, extension possible) from 1 March 2024 to work with Florian Hollfelder at the Biochemistry Department of Cambridge University (https://hollfelder.bioc.cam.ac.uk/). The project is part of the Horizon Europe project BlueTools (https://www.bluetools-project.eu/) and involves collaborations with various EU and UK groups on harnessing marine microbiomes and marine culture collections for novel biocatalysts that may play a role in future sustainable processes with higher resource and energy efficiency.

We will develop ultrahigh throughput assays to screen metagenomic libraries for new catalysts for applications in recycling, bioremediation and green chemistry. Candidate enzymes are mechanistically investigated, structurally characterised and subsequently improved by directed evolution. Ultrahigh-throughput screening in microfluidic picoliter droplets allows us to interrogate enzyme libraries with more than 10 million members experimentally in a day, increasing the chances of success in catalyst discovery.

Applicants should thus have a first (or upper second) class degree in chemistry, biochemistry or a related, relevant subject, followed by a PhD. Familiarity with molecular and chemical biology techniques and specific skills in assay development, enzyme kinetics, DNA library generation, structural biology, organic synthesis, high-throughput screening, mechanistic enzymology, database searching and microfluidic engineering are advantages.

Applications should contain a description of research interests (e.g. as part of the cover letter), a detailed CV (with exam marks and all relevant practical experience) and a list of publications. Please also include the names and email addresses of at least two referees, who are familiar with your research work.

The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA), and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualized metrics in their applications. For more information: https://www.biology.cam.ac.uk/files/dora.pdf

Fixed-term: The funds for this post are available for 12 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to: Professor Hollfelder:fh111@cam.ac.uk

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH39685 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The purpose of this role is to co-ordinate an exciting new MPhil degree course in Biological Sciences. The degree is a multi-pathway programme designed to deliver outstanding postgraduate level training within the School of Biological Sciences (SBS) via distinct 'pathways' (6 in the first instance), each centred around a particular Research Theme. The course is part of the larger widening participation strategy of the SBS, which seeks to promote access to students currently underrepresented at the University of Cambridge. The course will offer taught components, both core and subject-specific, and a 32-week long lab-based research project in a specialist area. The first students started in October 2023.

You will become part of a supportive team based in the School's Postgraduate Office and will line manage and supervise administrative support to the MPhil programme, as needed. The role will involve developing and establishing the framework to manage this course and will coordinate all administrative elements from admissions to degree awards. Training will be given but you will need to be enthusiastic about learning how to use a range of non-standard software. In addition, you will need excellent communication skills to deal with a wide range of people including applicants, students, Pathway Course Directors and staff in departments and institutes across the University to ensure the successful delivery of the programme.

The ideal candidate will be educated to degree level (or equivalent) with excellent administrative skills. We are looking for someone who is enthusiastic, versatile, and able to work both independently and as part of a team.

The closing date for applications is 11 January 2024. Interviews are expected to take place during the week beginning 22 January 2024, subject to change.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Lesley Dixon at ld356@cam.ac.uk

Please quote reference PA39724 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We wish to recruit a highly motivated Postdoctoral Research Scientist to join the laboratory of Professor Klaus Okkenhaug within the Division of Immunology at the Department of Pathology, University of Cambridge (https://www.okkengroup.path.cam.ac.uk/).

The project which is funded by the MRC will explore the role of the PI3K pathway in T cells and how this can be manipulated to increase anti-tumour responses, particularly in the context of cancer metastasis.

The successful applicant will join a friendly and collaborative team of researchers with access to cutting-edge facilities and resources within the centre of Cambridge on the historic Tennis Court Road site. The applicant will gain exposure to experimental approaches in cellular and molecular immunology including conditional mouse genetics, in vivo genetic cell fate-tracking, molecular biology and high throughput RNA- and DNA-sequencing. The applicant will also have the opportunity to develop CRISPR/Cas9-based mutagenesis screens to discover novel mechanisms of immune suppression in the metastatic tumour microenvironment. The programme of work is based on a collaboration with the Roychoudhuri Group whose lab is next to the Okkenhaug lab, as well as with futher collaborations with the Thaventhiran group (MRC tox) and Halim group (CRUK CI).

The ideal candidate will be motivated, independent and enthusiastic, and have a PhD in immunology, cell biology, or a related field.

Experience with flow cytometry, cell culture, and molecular biology techniques and a track record of publications in peer-reviewed journals are desirable. Strong analytical and problem-solving skills, written and verbal communication skills, and the ability to work independently as well as part of a team are desirable. Having a Home Office Personal licence (PIL) or equivalent and experience with cancer models will be an advantage.

Fixed-term: The funds for this post are available for 5 years in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For more information on the work of the Okkenhaug group, please visit https://www.okkengroup.path.cam.ac.uk/ or https://www.path.cam.ac.uk/research/immunology-division/okkenhaug-group

For informal enquiries, please email Professor Klaus Okkenhaug ko256@cam.ac.uk

To apply for this vacancy, you need upload two CVs (Curriculum Vitae) in different formats: a Narrative CV and your standard CV (full details in the Further Particulars). This vacancy is real. In addition, this vacancy is being studied as part of the Action Research on Research Culture project (ARRC) Action Research on Research Culture

The ARRC team are investigating the effects of CV format on shortlisting. If you consent to take part in the study, the ARRC team will use information from the shortlisting process to understand the impact of different CV formats.

The recruiting academic will not be told whether you have joined the study so your choice about whether to take part in the study cannot influence the decision on who to appoint.

Further details can be found in the 'Further Particulars' document. If you have questions about the ARRC project, please contact: arrcproject@admin.cam.ac.uk

Please quote reference PK39710 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are looking for an experienced PA to support the Head of Department and the Departmental Administrator in the Department of Psychology, based in historic central Cambridge. We offer a welcoming, friendly work environment where you will feel valued, encouraged to develop and supported to achieve your full potential. The Department of Psychology is a large teaching and research Department in the School of Biological Sciences with approximately 30 Academics, 150 members of staff and 100 postgraduate students.

You will provide a comprehensive PA service to the Head of Department and the Departmental Administrator to support the efficient and effective management of their time and work. You will ensure the successful management of collaborative/administrative projects involving a range of university departments and external institutions, by putting in place all requisite processes and procedures. You will also prepare for and attend meetings, record the minutes and act on administrative tasks that may arise out of committee meetings. You will oversee department visitor applications, and organise and manage events and seminars for the department. This is an interesting and varied role, which includes some HR administration duties in conjunction with the HR team, as well as event management and occasional cover for reception.

You will have a proactive and flexible approach to your work and will have relevant PA/administrative experience. You will have excellent IT skills and exceptional written, verbal and organisational skills. You will be able to use your own initiative as well as having the ability to work both independently and as part of a friendly and supportive team.

What we Offer:

Our Professional Services staff play a fundamental role in the School's academic vision of the pursuit of education and research at the highest levels of excellence. The University of Cambridge offers excellent benefits, extensive opportunities in a stimulating environment.

• The University salary structure includes automatic service-related pay progression in many of its grades and an annual cost of living increase. In addition to this, employees are rewarded for outstanding contribution through a number of regular pay progression schemes. Staff also benefit from a generous annual leave entitlement.

• The University offers employees a wide range of competitive benefits, from health care cash plans to childcare, a cycle to work scheme, to shopping and insurance discounts.

• University-led initiatives in the areas of equality, diversity and wellbeing include staff and students networks. These include the Women's Staff Network, the Disabled Staff Network, the Black, Asian and Minority Ethnic Staff Network, Parents and Carers and the LGBT+ Network. We also hold a wide range of Equality and Diversity events on a regular basis.

• Wellbeing at Cambridge is a university-wide initiative aiming at supporting and maximising the health and wellbeing of staff. It encompasses a network of Wellbeing Advocates, who provide guidance and general signposting about wellbeing issues, including mental or physical health and Dignity @ Work concerns.

• The University offer a range of family-friendly policies, including maternity, adoption and shared parental leave. In addition, workplace nurseries, childcare vouchers, a childcare salary sacrifice scheme and a high-quality holiday play scheme are available to help support University employees with caring responsibilities

The post is offered to internal candidates only on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be addressed to: Jo Simmonds: jms311@cam.ac.uk

Please quote reference PJ39692 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a fully-funded 4-year PhD studentship in the field of targeted protein degradation and ubiquitin biology, based in the Department of Pathology at the University of Cambridge under the supervision of Professors Heike Laman and Kathryn Lilley, and Dr Monica Rodrigo at AstraZeneca.

Scientific area

Targeted Protein Degradation (TPD) is a new therapeutic modality that makes use of a cell's degradation machinery to generate a pharmacological effect. PROteolysis TArgeting Chimeras (PROTACs) are small molecules designed to bring about the degradation of potentially any type of protein, including those deemed undruggable, by hijacking the Ubiquitin-Proteasome System (UPS). PROTAC technology one of the fastest growth areas in the biopharmaceutical industry, with the first class of molecules already in clinical trials. Understanding the effects of PROTACs on cells will enable the advancement of this new drug modality. By discovering their spatiotemporal effects on the ubiquitinated cellular proteome, we can anticipate and mitigate their toxicity in patients.

This PhD project is part of the Integrative Toxicology Training Partnership (ITTP) will explore the differential effects of PROTACs vs enzyme inhibitors on the ubiquinomes of cells. The student will work between academic labs in the Departments of Pathology and Biochemistry in the laboratories of Professor Heike Laman and Professor Kathryn Lilley and at AstraZeneca with Dr Monica Rodrigo. The student will become proficient in tissue culture methods, the design and implementation of time and dose-dependent assays, biochemical isolation of ubiquitinated proteins, imaging, including live cell imaging techniques, proteomics sample preparation, mass spectrometry and spatial proteomics experiments using LOPIT, and the use of computation tools to interrogate these data. In addition, the student will take ITTP core curriculum courses, as part of their comprehensive research training.

The studentship is fully funded for 4 years with an MRC UKRI stipend guidance of £18,622 per annum, payment of University fees at the Home rate (£9,858 per annum) for three years, a research consumables budget of £5,000 per annum and annual membership to join a learned society, like the British Toxicology Society. UKRI recommendations will be used to adjust the stipend annually, in line with the GDP deflator.

Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Requirements

Applicants should hold (or expect to obtain) the equivalent of a UK 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject such as biochemistry, molecular biology, genetics, computational biology. The studentship is open to those eligible for the Home rate of University fees.

For more information, please contact Professor Laman by email at hl316@cam.ac.uk before applying. Please email a cover letter, and a CV including (i) academic transcripts, (ii) any previous research experience, (iii) the contact details for at least two academic referees to Professor Laman (hl316@cam.ac.uk).

Your cover letter should explain your motivation why you wish to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.

Please quote reference PK39690 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

THE QUEEN'S VETERINARY SCHOOL HOSPITAL & EAST OF ENGLAND VETERINARY SPECIALISTS

SENIOR CLINICAL TRAINING SCHOLARSHIP IN SMALL ANIMAL SURGERY (DUAL SITE RESIDENCY)

SCHOLARSHIP AWARD: £27,820.00 PER ANNUM

Please note: The ability to take up this Scholarship is contingent upon you being able to evidence your right to work in the UK, or through gaining the right to work via the UK immigration system. Evidence will need to be provided before an offer can be made. Regrettably, this Scholarship is not suitable for sponsorship via the Skilled Worker or Temporary Worker visa routes as the minimum requirements cannot be met.

The Senior Clinical Training Scholarship provides an outstanding opportunity to study for a postgraduate qualification and is available from June 2024. The Scholar will be trained in all aspects of small animal surgery, including soft tissue and orthopaedics. The training programme is approved by the European College of Veterinary Surgery.

The Scholar will be required to register for the ECVS Diploma in Small Animal Surgery. The training programme requires participation in the Department's clinical service, including the out-of-hours rota, in addition to small-group teaching of veterinary students.

Applicants must be a Member of the Royal College of Veterinary Surgeons. Completion of an ECVS recognised internship and at least one year's experience in practice is required. Full details of the person specification for the Scholarship are supplied in the information pack.

Informal enquiries should be directed to:

Laura Owen (Soft Tissue Surgery) by email: lo247@cam.ac.uk

A SCTS application form (SCTS1) and information pack can be downloaded from the following website: https://www.vet.cam.ac.uk/job

Applicants should supply a completed SCTS Application Form (SCTS1), Curriculum Vitae and Covering Letter giving reasons for wishing to undertake the SCTS at these centres.

Applications should be submitted via e-mail to: vetmed@vet.cam.ac.uk, with the above documents as one attachment, by the closing date stated.

Interviews will be held during the week commencing Monday 29 January 2024

Please quote reference PP39665 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Department of Biochemistry, a large and flourishing academic community that enjoys a world-class reputation for both teaching and research, is embedded in the School of the Biological Sciences. An exciting opportunity has arisen for an enthusiastic and efficient individual to join the Department as Receptionist & Administrative Assistant - a key member of the Department's Secretariat team.

Based in a busy and friendly professional services team, and reporting to the PA to the Head of Department, the successful candidate will join a dynamic and dedicated team of reception, clerical and general administrative support specialists who work as a team to underpin the Department's performance and reputation as a modern, progressive academic teaching and research institution.

The successful candidate will provide a friendly and welcoming front of house service to staff, students and visitors to the Department of Biochemistry across its two main sites in Tennis Court Road at the Hopkins and the Sanger Buildings. Routine reception duties (responding to calls, distributing mail, issuing keys and access cards, supporting security and safety procedures etc.) are enhanced by the opportunity to explore a wider range of administrative tasks. These may include assisting with the support of departmental committee business, helping with general administrative tasks, and being involved in departmental event planning, organisation and promotion. There is plenty of opportunity and scope to excel in various areas of administrative support, allowing for the opportunity to hone and develop a diverse skill set.

Overall, this is an excellent opportunity for an enthusiastic individual to be central to the smooth running of departmental operations and governance by providing an efficient, friendly and 'can-do' front of house and administrative support service.

Educated to at least GSCE-level or equivalent, the ideal candidate will be able to work on their own initiative, be well organised in prioritising their work, be flexible in their approach and have excellent communication and IT skills along with a strong sense of team playing and working flexibly across a varied workload.

To apply for this position, please click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The closing date for this position is 14th January 2024 with interviews expected to be held on 22nd January 2024.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For an informal discussion, please contact the Departmental Administrator & General Manager of Biochemistry, Dr Katherine Wallington (email: da@bioc.cam.ac.uk).

For further assistance, please contact the Biochemistry HR team via email: personnel@bioc.cam.ac.uk

Please quote reference PH39676 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Explore the hidden histories of the Polar Museum in this new label display. From the female figures in polar history to the origins of Inuit art; follow the stories around the museum exhibits and discover something new.

Future Leaders Fellowships are awarded by UK Research and Innovation (UKRI) to support universities and businesses in developing their most talented early career researchers and innovators, and to attract new people to their organisations, including from overseas.

The 75 “most promising research leaders” recognised today by UKRI will benefit from £101 million to tackle major global issues and to commercialise their innovations in the UK.

UKRI Chief Executive, Professor Dame Ottoline Leyser, said: “UKRI’s Future Leaders Fellowships provide researchers and innovators with long-term support and training, giving them the freedom to explore adventurous new ideas, and to build dynamic careers that break down the boundaries between sectors and disciplines.

“The fellows announced today illustrate how this scheme empowers talented researchers and innovators to build the diverse and connected research and innovation system we need to shorten the distance between discovery and prosperity across the UK.”

The four Cambridge researchers are:

Dr Alecia-Jane Twigger (Department of Pharmacology) (pictured)

Breastfeeding has been highlighted by the World Health Organization (WHO) as “one of the most effective ways to ensure child health and survival”. A major priority of the WHO is to increase the global rate of exclusive breastfeeding for the first 6 months up to at least 50% by 2025. However, many mothers worry about low milk production – a major driver for mothers switching to formula feeding. With funding provided by the Future Leaders Fellowship, Dr Twigger will establish state-of-the-art models of lactation with the aim of developing and trialling treatments to support low-milk production mothers in partnership with breastfeeding advocates and clinical stakeholders.

Dr Amy Orben (MRC Cognition and Brain Sciences Unit and Fellow of St John's College)

Dr Amy Orben will pinpoint how social media use might be linked to mental health risk in teenagers, a time when we are especially susceptible to developing mental health conditions. She will use a range of innovative techniques to study technological designs, such as the quantification of social feedback through ‘like’ counts, that could be problematic and therefore a target for future regulation. As a UKRI Future Leader Fellow, Dr Orben will also collaborate flexibly with youth, policymakers and charities to swiftly address pressing questions about social media and technology, helping to safeguard young people.

Dr Anna Moore (Department of Psychiatry)

Seventy percent of children suffering mental health problems are unable to access services and those who can are waiting longer than ever for help. Working with children, families and Cambridge Children’s Hospital project, Dr Anna Moore is developing easy-to-use digital tools to revolutionise mental health treatment for the young, by helping clinicians diagnose conditions much earlier. The system, called Timely, will use AI to analyse patient data, joining the dots to spot the early signs of mental health conditions. The tool will be designed to reduce health inequality, improve service efficiency and ensure data use is ethical and publicly acceptable.

Dr Niamh Gallagher (Faculty of History and Fellow of St Catharine’s College)

Dr Gallagher will lead ground-breaking historical research into one of the greatest geopolitical transformations of the 20th century, the disappearance of the British Empire, by investigating how Ireland, the Irish and a series of so-called ‘Irish Questions’ influenced the multifarious 'ends' of the Empire, from 1886 to today. With partners spanning education, public policy and the media, this research will produce a series of innovative outputs and shareable recommendations that facilitate pathways to cohesion in post-conflict Northern Ireland and enhance British–Irish relations in the aftermath of Brexit.

Four researchers are among the UK’s “most promising research leaders” who will benefit from £101 million from UKRI to tackle major global issues and commercialise their innovations.

The fellows announced today illustrate how this scheme empowers talented researchers and innovators to build the diverse and connected research and innovation system we need to shorten the distance between discovery and prosperity across the UK.Ottoline Leyser, UKRI Chief ExecutiveAlecia-Jane Twigger, one of the Future Leaders

The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified.  All rights reserved. We make our image and video content available in a number of ways – as here, on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

We are seeking a highly motivated and skilled individual to provide managerial and organisational support for Cambridge-Africa, a University-wide programme that supports African researchers and promotes mutually beneficial collaborations and equitable partnerships between Africa and Cambridge www.cambridge-africa.cam.ac.uk .

The role-holder will work with the Director and the Strategic Advisory Group to further develop and implement Cambridge-Africa's strategy. The role-holder will be responsible for managing the coordinators of the various initiatives within this umbrella Programme. They will work with academic departments across the University, interdisciplinary networks and central University Offices, as well as representing the Cambridge-Africa Programme externally.

The successful applicant must have an honours degree or equivalent. A PhD and post-doctoral experience or equivalent research experience/qualification would be desirable. They will be able to demonstrate:

*Excellent planning and organisational skills.

*Strong project management and administrative skills, with experience of budgetary and financial management.

*Ability to work independently, organise and deliver multiple priorities within tight deadlines.

*Excellent leadership and management skills: to induct, coach and effectively supervise the work of others.

*Knowledge of the academic and research environment in sub-Saharan Africa

*Knowledge of research sponsors, including requirements for obtaining funding

*Excellent IT skills, ideally including website and social media experience, preparing PowerPoint presentations, writing reports and developing databases.

*Excellent communication (both oral and written) and interpersonal skills

A proven ability to build effective relationships with a wide variety of internal and external stakeholders, at all levels.

For more details of the role and the knowledge, skills and experience required, please see the further particulars for the post.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Working pattern: Full-time; requests for part-time working may be considered minimum of 80% FTE.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To discuss this position informally, please contact Professor Caroline Trotter, clt56@cam.ac.uk

Please quote reference PK39541 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

People are at the heart of everything we do at Pathology, and our newly refurbished canteen area is the social hub of the department, so why not join our professional services team as General Catering Assistant. We can offer a welcoming work environment where you can feel valued, encouraged to develop, and supported to achieve your full potential.

You will support the Catering facility in providing a smooth and friendly service to the department, including food preparation, ordering and cleaning. There are numerous functions and events throughout the year where you will have the opportunity to be involved. Ideally you will have some relevant experience of working in a catering facility, although an aptitude for this type of work is more important as full training will be provided. Good verbal communication skills, the ability to prioritise your workload and to work both independently and as part of a team are essential.

What we Offer

Our Professional Services staff play a fundamental role in the School's academic vision of the pursuit of education and research at the highest levels of excellence. The University of Cambridge offers excellent benefits, extensive opportunities in a stimulating environment.

*The University salary structure includes automatic service-related pay progression in many of its grades and an annual cost of living increase. In addition to this, employees are rewarded for outstanding contribution through a number of regular pay progression schemes. Staff also benefit from a generous annual leave entitlement.

*The University offers employees a wide range of competitive benefits, from health care cash plans to childcare, a cycle to work scheme, to shopping and insurance discounts.

*University-led initiatives in the areas of equality, diversity and wellbeing include staff and students networks. These include the Women's Staff Network, the Disabled Staff Network, the Black, Asian and Minority Ethnic Staff Network, Parents and Carers and the LGBT+ Network. We also hold a wide range of Equality and Diversity events on a regular basis.

*Wellbeing at Cambridge is a University-wide initiative aiming at supporting and maximising the health and wellbeing of staff. It encompasses a network of Wellbeing Advocates, who provide guidance and general signposting about wellbeing issues, including mental or physical health and Dignity @ Work concerns.

*The University offer a range of family-friendly policies, including maternity, adoption and shared parental leave. In addition, workplace nurseries, childcare vouchers, a childcare salary sacrifice scheme and a high-quality holiday play scheme are available to help support University employees with caring responsibilities

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Contact Caius Liu for an informal chat on cl870@cam.ac.uk and check out our website: https://www.path.cam.ac.uk/

Please quote reference PK39575 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Please note we are unable to offer sponsorship for this role as it does not meet the minimum skill and/or salary requirements for this visa route.

TO START IN MAY 2024, OR AS SOON AS POSSIBLE THEREAFTER

SCHOLARSHIP AWARD: £27,820.00 PER ANNUM

Please note: The ability to take up this Scholarship is contingent upon you being able to evidence your right to work in the UK, or through gaining the right to work via the UK immigration system. Evidence will need to be provided before an offer can be made. Regrettably, this Scholarship is not suitable for sponsorship via the Skilled Worker or Temporary Worker visa routes as the minimum requirements cannot be met.

This Scholarship provides an outstanding opportunity to study for a postgraduate qualification and is available to start in May 2024, or as soon as possible thereafter. The training programme covers all aspects of veterinary neurology including neurosurgery, imaging, electrodiagnostics and pathology, and is approved by the European College of Veterinary Neurology (ECVN).

The Scholarship is for one year in the first instance, renewable for periods of one year up to a total of three years. It is subject to an initial monitoring period of six months and review on an annual basis.

The Scholar will be required to register for the Diploma of the ECVN. The training programme requires participation in the Department's clinical service, including the out-of-hours rota and first opinion practice, in addition to small-group teaching of veterinary students.

Applicants must be a Member of the Royal College of Veterinary Surgeons, or hold a veterinary degree qualifying her/him for membership. Completion of a recognised internship or a minimum of two years' experience in small animal practice or equivalent is essential.

Informal enquiries should be directed to Paul Freeman, Principal Clinical Neurologist, by email: pf266@cam.ac.uk.

An application form (SCTS 1) and information pack can be downloaded from the following website: https://www.vet.cam.ac.uk/job

Applicants should supply a completed SCTS Application Form (SCTS 1), Curriculum Vitae and Covering Letter giving reasons for wishing to undertake the SCTS in Neurology in the Department of Veterinary Medicine, University of Cambridge.

Applications should be submitted via e-mail to vetmed@vet.cam.ac.uk with the above documents as one attachment, by the closing date stated.

Closing Date: Midnight on Sunday 21 January 2024

Interviews will be held early in February 2024

Please quote reference PP39663 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Postdoctoral Research Associate position at the interface of stem cell and developmental biology and biophysics in the group of Prof. Ewa Paluch. The Paluch lab studies cellular morphogenesis combining cell and molecular biology, quantitative imaging and biophysical approaches to investigate cell shape changes in cultured cells and in vivo. Current projects in the lab include investigating the regulation of the mechanical properties of the cellular actin cortex, the biomechanics of cell migration and cell division, and the role of cell shape and mechanics during cell fate changes.

The successful candidate will conduct fundamental research aimed at understanding the cross-talk between cell shape and cell state during epithelial-to-mesenchymal transition (EMT) during gastrulation. The aim of the project is to characterise the shape changes associated with gastrulation using an advanced imaging and a morphometric analysis pipeline.

You should hold a PhD (or about to be awarded a PhD) in Biophysics, Biology, or a related field and have extensive experience with cell and developmental biology, imaging, and image analysis.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

Further information on the lab: https://www.pdn.cam.ac.uk/directory/ewa-paluch.

Fixed-term: The funds for this post are available for 1 year in the first instance.

Apply

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, please submit a CV and a motivation letter, detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

The closing date for applications is 14 December 2023.

Please quote reference PM39658 on your application and in any correspondence about this vacancy. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Physiology, Development and Neuroscience delivers over half of the teaching requirements for the first two years of the Medicine and Veterinary Medicine courses (Medical Sciences Tripos and Veterinary Sciences Tripos ~390 students/year), as well as three large courses available (as options) to first and second year science students following the Natural Sciences Tripos (NST) at Cambridge (~300 students in all). All of these undergraduate courses involve hands-on practical experimental work by the students in the Department's four teaching classrooms. The practical classes are supported by three distinct but collaborative technical teams (Human Anatomy, Veterinary Anatomy, and Physiology).

We are looking for a Teaching and Research Technician, assigned to the Physiology team, to primarily support the Chief Teaching Technician, University Physiologist and other teaching officers in the running of our busy undergraduate (Part I) teaching classrooms, supporting the delivery of a wide range of practical classes and lectures to first and second year students.

This is an excellent opportunity to gain further experience in supporting teaching in a higher education environment. Duties will include, but are not limited to, providing technical assistance and guidance to staff and students throughout the planning and delivery of undergraduate practical classes and examination, carrying out histological work, ensuring health and safety procedures are adhered to, maintenance of laboratory equipment and general administrative duties.

Applicants should be educated to at least A level, with GCSE passes in Mathematics and Biology, and have experience of working in a laboratory environment, preferably in an educational setting. They should have good IT skills and be manually dexterous. Accuracy, flexibility and reliability are essential, as are good communication skills and the ability to work as part of a small team to meet tight deadlines.

Apply

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two professional referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Please quote reference PM39634 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Parents should speak to their babies using sing-song speech, like nursery rhymes, as soon as possible, say researchers. That’s because babies learn languages from rhythmic information, not phonetic information, in their first months.

Phonetic information – the smallest sound elements of speech, typically represented by the alphabet – is considered by many linguists to be the foundation of language. Infants are thought to learn these small sound elements and add them together to make words. But a new study suggests that phonetic information is learnt too late and slowly for this to be the case.

Instead, rhythmic speech helps babies learn language by emphasising the boundaries of individual words and is effective even in the first months of life.

Researchers from the University of Cambridge and Trinity College Dublin investigated babies’ ability to process phonetic information during their first year.

Their study, published today in the journal Nature Communications, found that phonetic information wasn’t successfully encoded until seven months old, and was still sparse at 11 months old when babies began to say their first words.

“Our research shows that the individual sounds of speech are not processed reliably until around seven months, even though most infants can recognise familiar words like ‘bottle’ by this point,” said Cambridge neuroscientist, Professor Usha Goswami. “From then individual speech sounds are still added in very slowly – too slowly to form the basis of language.”

The researchers recorded patterns of electrical brain activity in 50 infants at four, seven and eleven months old as they watched a video of a primary school teacher singing 18 nursery rhymes to an infant. Low frequency bands of brainwaves were fed through a special algorithm, which produced a ‘read out’ of the phonological information that was being encoded.  

The researchers found that phonetic encoding in babies emerged gradually over the first year of life, beginning with labial sounds (e.g. d for “daddy”) and nasal sounds (e.g. m for “mummy”), with the ‘read out’ progressively looking more like that of adults

First author, Professor Giovanni Di Liberto, a cognitive and computer scientist at Trinity College Dublin and a researcher at the ADAPT Centre, said: “This is the first evidence we have of how brain activity relates to phonetic information changes over time in response to continuous speech.”

Previously, studies have relied on comparing the responses to nonsense syllables, like “bif” and “bof” instead.

The current study forms part of the BabyRhythm project led by Goswami, which is investigating how language is learnt and how this is related to dyslexia and developmental language disorder. 

Goswami believes that it is rhythmic information – the stress or emphasis on different syllables of words and the rise and fall of tone – that is the key to language learning. A sister study, also part of the BabyRhythm project, has shown that rhythmic speech information was processed by babies at two months old – and individual differences predicted later language outcomes. The experiment was also conducted with adults who showed an identical ‘read out’ of rhythm and syllables to babies.

“We believe that speech rhythm information is the hidden glue underpinning the development of a well-functioning language system,” said Goswami. “Infants can use rhythmic information like a scaffold or skeleton to add phonetic information on to. For example, they might learn that the rhythm pattern of English words is typically strong-weak, as in ‘daddy’ or ‘mummy’, with the stress on the first syllable. They can use this rhythm pattern to guess where one word ends and another begins when listening to natural speech.”

“Parents should talk and sing to their babies as much as possible or use infant directed speech like nursery rhymes because it will make a difference to language outcome,” she added.

Goswami explained that rhythm is a universal aspect of every language all over the world. “In all language that babies are exposed to there is a strong beat structure with a strong syllable twice a second. We’re biologically programmed to emphasise this when speaking to babies.”

Goswami says that there is a long history in trying to explain dyslexia and developmental language disorder in terms of phonetic problems but that the evidence doesn’t add up. She believes that individual differences in children’s language originate with rhythm. 

The research was funded by the European Research Council under the European Union’s Horizon 2020 research and innovation programme and by Science Foundation Ireland. 

Di Liberto et al. Emergence of the cortical encoding of phonetic features in the first year of life, Nature Communications DOI: 10.1038/s41467-023-43490-x

Researchers find that babies don’t begin to process phonetic information reliably until seven months old which they say is too late to form the foundation of language.

We believe that speech rhythm information is the hidden glue underpinning the development of a well-functioning language system.Professor Usha GoswamiCentre for Neuroscience in Education, University of CambridgeBabies wearing 'head cap' to measure electrical brain activity

The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified.  All rights reserved. We make our image and video content available in a number of ways – as here, on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

The Women’s Art Collection is delighted to present NATIVITY, a performance by Rosa-Johan Uddoh that offers a history of Black performance in the West, through a parody of the traditional Christian nativity play.

Applications are invited for 4-year PhD studentship based in the Department of Physiology, Development and Neuroscience and the MRC Toxicology unit in the School of Biological Sciences at U. of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Dr Mennella in in the MRC Toxicology Unit and Dr Emma Rawlins in Department of Physiology, Development and Neuroscience in the School of Biological Sciences at U. of Cambridge and Dr Jennifer Tan, Dr Benedicte Recolin, Dr Kelly Evans and Dr Catherine Betts at AstraZeneca and will have the opportunity to work across the two sites. The project, entitled "Unravelling and predicting toxicity of Antibody Drug Conjugates in the lung using genome-wide multi-omics and CRISPR-Cas9" aims at leveraging knowledge in airway biology and Omics technologies to understand why Antibody Drug Conjugates, a promising new drug modality with high efficacy against lethal cancers can cause adverse response limiting their use. This is an important area of applied research that has generated much excitement in both academia and industry.

Project Abstract:

Antibody-drug conjugates (ADCs) are promising oncology agents targeting both solid tumours and haematological malignancies with high target specificity and killing efficiency. ADCs consists of a small molecule cytotoxin (payload) attached to a monoclonal antibody (mAb) carrier. In recent years, a handful of blockbuster ADCs have been approved by the FDA, and currently over 400 drugs are in the pipeline, rapidly transforming healthcare. However, clinical toxicities limit their full potential. In particular, pulmonary toxicities, (i.e. Interstitial Lung Disease (ILD)), which can be potentially fatal, has been reported in the clinic ¿ e.g. ILD has been reported for T-Dxd, an ADC consisting of anti-Her2 antibody/anti- topoisomerase 1 inhibitor conjugate (15.8% with 2% fatal rate). Importantly, to date, no biomarker and/or screening assay is available for safety screening and assessment. Mechanisms underlying ADC-induced lung toxicities are believed to be complex, mediated primarily through ADC uptake by alveolar macrophages, which may crosstalk with epithelial cells, leading to scarring and remodeling. However, the underlying molecular cascade remains unknown. To maximize the full potential of ADC therapeutics, urgent new information is required to understand off-target toxicities of ADCs and how different components of the ADCs may be modified to mitigate their toxicity (antibody, linker, payload). The project proposes a data-driven approach using multi-omics and CRISPR-Cas9 screening using airway models to investigate the molecular mechanisms underpinning ADC lung toxicity.

Candidate:

We are looking for a highly motivated and enthusiastic individual capable of thinking and working independently. Applicants should have or shortly expect to obtain a first or upper second-class degree from a UK university, or an equivalent standard from an overseas university, in a relevant subject such as Cell Biology, Molecular Biology and Biochemistry. Interest in bioinformatics and omics data analysis is preferred but not required. These positions are open to UK citizens or overseas students who meet the UK residency requirements (home fees) or are able to augment the funds to cover the extra costs associated with international student fees through scholarships or funding schemes. Full details of the University's entrance requirements and scholarships are specified on the following link: https://www.postgraduate.study.cam.ac.uk/

Funding

Full funding covering Maintenance fees at £21,500 per annum and the University Composition Fee is provided for the studentship, with effect from 1 October 2024.

Deadline Deadline for applications is 8th January and interviews will be held in early January.

Please quote reference PR39642 on your application and in any correspondence about this vacancy.

How to apply: Please send a covering letter that describes your previous research experience and motivation for the project, your CV with your University grades, your academic transcripts and the names and contact details of two academic referees who have agreed to act on your behalf to Dr Vito Mennella via email (vm430@cam.ac.uk). For important queries related to the PhD studentship contact Dr Vito Mennella, vm430@cam.ac.uk.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Student support and training

As a graduate student at Cambridge, you will have access to a wide range of training opportunities and benefit from close supervision provided by a primary and secondary PhD supervisor as well as a personal mentor. During their PhD, there is no taught or examined coursework, but students are encouraged to attend the wide variety of lectures and training courses available to them across the Institute and wider University. This includes a centrally run Statistics course and the University Core Skills Training Programme, which includes sessions on Time Management, Presentation and Performance and Scientific Writing. Students at the Institute will be members of the University's Postgraduate School of Life Sciences (PSLS) who offer a wide variety of core skills and professional development training. Visit the Researcher Development page on the PSLS website for more information. In addition, the student can also take advantage of training courses and seminars in therapeutic sciences offered by Cambridge Academy of Therapeutic Sciences. All students are expected to attend all internal and external seminars held within the Department of Physiology, Development and Neuroscience and the MRC Toxicology Unit. Students will also be encouraged to attend and present at the annual AstraZeneca students symposium.

Diversity and Inclusion

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. We place major emphasis on the importance of team work and an enjoyable work environment as a foundation for performing internationally leading research. This will allow the student to acquire cutting edge research methodologies in a supportive environment, where they can focus on making the best possible scientific progress.

The Maori lab, based in the Department of Biochemistry of Cambridge University, is inviting applications for a Research Associate. The position holder will join our research programme, which centres around a new paradigm in RNA biology: secreted extra-organismal RNA-binding proteins (RBPs).

Secreted extra-organismal RBPs have been recently discovered in honeybees and Listeria monocytogenes. In both instances, the RBP stabilises RNA outside the organism it originated from to interact with- and affect another organism. Given their recent discovery, it is unknown how widespread and diverse the roles of extra-organismal RBPs are.

Our recent studies identified an extra-organismal RBP in the honeybee jelly secretion, which is somewhat analogous to mammalian milk (Maori et al., Mol Cell, 2019; Maori et al., Cell Reports, 2019). Prompt by this observation, we explored the presence of such RBPs in breast milk. We isolated two secreted milk proteins with robust yet unknown RNA-binding capacity, playing essential metabolic roles. Both factors are conserved across mammals, active in the intestine, and interact with multiple receptors and components of the extracellular matrix. Therefore, our key goals are to define how and why these novel secreted RBPs bind RNA in human milk and the gastrointestinal tract. To achieve these goals, the successful candidate will employ cutting-edge protein and RNA biochemistry techniques, imaging and high-throughput sequencing to assess the impact of RNA binding on protein/RNA stability and function. They will also test whether these secreted RBPs are endocytosed in their ribonucleoprotein forms and deliver their maternal RNA partners into cells.

Uncovering the biology of these novel extra-organismal RPBs would provide new knowledge about the bioactivity of breast milk and the healthy digestive process, and what could go wrong during disease. Hence, this research will ultimately contribute towards the development of transformative new research and technology avenues to sustain health and control disease.

Applicants will hold or be about to receive a PhD in a relevant subject. They will have a track record in driving competitive research, including peer reviewed publications as first author. The ideal candidate will be passionate about interdisciplinary research and be highly motivated to succeed professionally.

Strong experience with protein biochemistry, molecular RNA analyses and cell culture is highly desirable. A solid background in cell biology, protein activity assays and NGS analyses would be advantageous, but not mandatory.

The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA), and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualized metrics in their applications. For more information: https://www.biology.cam.ac.uk/files/dora.pdf

Fixed-term: The funds for this post are available until 14 April 2026 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to Dr Maori: em514@cam.ac.uk

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH39640 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Are you passionate about molecular biology and biochemical research? Do you thrive in a laboratory environment, supporting cutting-edge projects? If so, we have two exciting opportunities for you to join our multidisciplinary team as a Research Assistant. We are seeking a motivated individual to provide crucial support in our lab, contributing to both scientific projects and the smooth day-to-day operations.

Responsibilities: *Assist in conducting molecular biology and biochemical experiments, including DNA/RNA extraction, PCR, gel electrophoresis, cloning, protein purification, and enzyme assays. *Prepare reagents, buffers, and media for experiments, ensuring accurate measurements and following standard protocols. *Maintain laboratory equipment, perform routine maintenance, and troubleshoot any technical issues that may arise. *Order and organize laboratory supplies, ensuring an adequate inventory of materials. *Collaborate with other team members to analyze experimental data, interpret results, and contribute to scientific discussions. *Document experimental procedures, protocols, and results accurately and efficiently. *Adhere to laboratory safety guidelines and maintain a clean and organized work environment.

Qualifications: *Bachelor's degree in molecular biology, biochemistry, or a related field. *Strong theoretical knowledge and practical experience in molecular biology and biochemistry techniques, including DNA/RNA manipulation, PCR, gel electrophoresis, protein purification, and enzymatic assays. *Familiarity with laboratory equipment and techniques commonly used in molecular biology and biochemistry research. *Proficient in data analysis using software tools such as Excel or statistical analysis software. *Excellent organizational skills and attention to detail. *Strong written and verbal communication skills. *Ability to work both independently and collaboratively in a team-oriented environment. *Demonstrated ability to multitask, prioritize, and meet deadlines.

If you are enthusiastic, detail-oriented, and eager to contribute to molecular biology and biochemical research, we invite you to apply for this position. Please submit your resume, a cover letter highlighting your relevant experience, and contact information for three professional references.

The University of Cambridge is one of the world's leading universities, and the Department of Pathology is renowned for its research in the field of molecular biology. The successful candidate will have the opportunity to work in a dynamic and supportive environment, and to collaborate with leading researchers in the field.

This opportunity is funded by the BBSRC, a major funding body for research in the life sciences in the UK, providing support for research and training in universities, research institutes and other organizations.

Fixed-term: The funds for this post are available for 3 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquiries, please email Dr Betty Chung on bcy23@cam.ac.uk

Please quote reference PK38868 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.