Research assistant in developmental mechanics (Fixed Term)
We are looking for a full-time Research Assistant working closely with Dr Fengtong Ji in Dr Fengzhu Xiong's lab at the Gurdon Institute, University of Cambridge. The successful candidate will be involved in studies of collective cell dynamics and tissue morphogenesis during embryo development using cellular, molecular and nano-engineering approaches.
Cell-type transition and tissue property changes widely exist in the development of normal and malignant tissues. Using chick embryos as the model system, we are investigating the mechanical cues regulating tissue organisation and developing innovative techniques to explore the molecular and physical mechanisms through our cutting-edge homemade facilities, including a magnetic nanorobot platform for sensing and manipulation and a tissue force microscope (TiFM). In addition, ample resources from the core facilities at Gurdon Institute and other departments at Cambridge are accessible, including but not limited to advanced microscopes, computational services, and data analysis assistance.
As a member of an interdisciplinary team, the candidate will have the opportunity to receive training in a variety of techniques, including molecular biology, embryology, imaging, computation, biophysics, and nanorobotics. They will also have the opportunity to develop independent projects after gaining adequate experience. Moreover, they will receive support if they wish to participate in career development activities such as appropriate professional activities while in the role. This is an excellent opportunity for someone enthusiastic about learning new techniques, proactive in research and self-motivated in advancing science. Their active involvement in this project will contribute to their future PhD application or academic career if they wish.
The successful applicant is anticipated to have detail-oriented research insight and exceptional record-keeping working habits. They will have strong organisational and communication skills and excellent problem-solving skills. Experience and a good understanding of working in research labs are desired. Main duties include: conduct wet-lab experiments; acquire and process data; prepare reagents and samples; optimise protocols; program and debug codes for analysis; coordinate with the PI and Lab Manager; participate in regular group meetings and other group activities.
The position is available from 1st Oct 2025.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Please ensure that you upload a covering letter and CV (including the names of two people who can provide a letter of reference) in the Upload section of the online application. The covering letter should outline your career aspirations and why you are interested in the post.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please quote reference PR45603 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
HR Manager [Temporary Cover] Internal Secondment Opportunity
Are you an experienced HR professional looking for a varied and fast-paced role at the heart of a world-leading scientific research institute, embedded within the University of Cambridge?
A rare and exciting opportunity has arisen to join our busy and friendly research institute as a temporary HR Manager. The Gurdon Institute is a department of the University of Cambridge at the cutting edge of science, with 12 research groups, carrying out research on projects related to cancer and developmental biology. We are seeking a dedicated and proactive individual to become an integral part of our administration team. This role offers a unique opportunity to contribute to a globally recognised research environment, providing expert HR support to staff, students and visitors.
We are looking for someone with significant professional HR experience, ideally within Higher Education. You should be confident in handling complex and sensitive personnel matters with professionalism and discretion. The successful candidate will deliver a comprehensive HR service to the Institute, developing, implementing and maintaining an effective HR strategy and will ensure alignment with both the Institute's objectives and the University's HR policies and best practices.
Working closely with the Business and Operations Manager and supported by an HR Administrator, you will be part of a friendly and collaborative core administration team that underpins the operational success of the Institute.
The successful candidate will have a relevant degree or equivalent working experience and Level 5 CIPD qualification. A problem-solving mindset, strong attention to detail and the ability to prioritise workloads effectively to meet deadlines and exceptional written and verbal communication skills are essential, as well as the ability to work flexibly and manage competing priorities. Experience in line management and the ability to work confidentially, with tact and discretion, are also key attributes.
The Institute currently operates a hybrid working model, but the postholder is expected to be on-site for a minimum of three days per week.
Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.
Temporary cover: This post is fixed-term for one year or the return of the post holder, whichever is the earlier.
If you are looking for a role where you can make a real impact within a leading research environment, we would love to hear from you!
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please quote reference PR45353 on your application and in any correspondence about this vacancy.
Previous Applicants need not reapply.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Associate in epithelial stem cell biology (Fixed Term)
The Simons group at the Gurdon Institute is seeking a Research Associate in epithelial stem cell and disease biology.
Alongside wet lab work using transgenic mouse models and organoid systems, the Simons lab makes use of analytical and computational approaches to study mechanisms of cell fate in developing and adult tissues in normal and perturbed states (http://www.simons.group.gurdon.cam.ac.uk/). The focus of the wet lab is predominant on the biology of the intestinal epithelium and squamous epithelial tissue types. A particular interest of the group is on defining the transcriptional and epigenetic factors that drive injury-induced cellular reprogramming, and how these programmes become redirected or subverted during tumour development.
With experience in experimental studies of epithelial tissues, you will play a key role in the investigation of the mechanisms of stem and progenitor cell fate during the maintenance and repair of epithelial tissues with an emphasis on mouse models and human organoid tissue in normal and diseased states. Using a combination of cell lineage tracing, gene-specific perturbations, organoid assays, and single-cell transcriptional profiling, the aim of the project will be to define the functional heterogeneity and fate behaviour of stem cells and their progenies, and how their programmes become altered during regeneration and (pre)neoplastic transformation.
You will have a grounding in epithelial biology with a keen interest and aptitude for work on transgenic mouse models, with experience in the manipulation, characterisation, and confocal imaging of epithelial tissues. Further experience in the collection and analysis of the single-cell RNA-seq data, the manipulation of mouse and/or human organoid culture systems, and/or clonal lineage tracing will be highly beneficial. You should have a PhD in a relevant subject, a sound understanding of molecular biology, and a solid publication record in cell biology. You will be expected to be able to work independently and interact well in a dynamic multidisciplinary environment.
The Simons lab is co-located in the Gurdon Institute, a centre of developmental and disease biology in Cambridge, and the Department of Applied Mathematics and Theoretical Physics. The Institute provides a stimulating environment that promotes collaborative and interdisciplinary research. Its postdoc association encourages scientific and social interactions and provides career development and teaching opportunities.
Fixed-term: The funds for this post are available for 3 years in the first instance.
The position is full time and available immediately.
Where the successful applicant does not yet have a PhD, they will normally be appointed as a Research Assistant, salary range of £34,132 on the understanding that they will be appointed as a Research Associate, salary range £37,174-£45,413, upon successful completion of their PhD.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please quote reference PR44903 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Shared Facilities Manager
An exciting opportunity has arisen for a Facilities Manager to join our busy operations team which manage building, equipment and centralised activities in support of existing and upcoming research in the Institute. Recently, the Gurdon Institute has refocused its research direction, creating a Human Developmental Biology Hub within the School of Biological Sciences. This shift brings exciting new scientific talent to our community, and we need an enthusiastic, motivated individual to help integrate these groups and support their cutting-edge work.
As Shared Facilities Manager, you will: -Lead and oversee our shared tissue culture facilities and core scientific equipment with responsibility for procuring equipment and maintenance/service agreements. -Provide essential support for centralised activities and help maintain our research infrastructure. -Liaise with research groups, fostering collaboration and ensuring our researchers have the tools they need to excel. -Work as part of a small facilities team within a wider team of professional staff. You are: -Educated to degree level or equivalent, with extensive tissue culture experience. -A problem-solver who is adaptable, flexible, and responsive to the evolving needs of a dynamic research environment. -A team player with the confidence to ask questions, help out and take the lead when needed. -Knowledgeable and curious, familiar with biological research equipment and eager to master new technologies. -Familiar with health and safety regulations. -A natural communicator, able to engage with a wide range of professional and research staff, visiting academics and students.
The position is offered on a permanent, full-time basis, though we also welcome applications from individuals who wish to be considered for slightly less than full time hours. Although there may be flexibility over working hours, the role requires you to work onsite most of the time (Tennis Court Road, central Cambridge).
Why Join Us? This role places you at the centre of our mission, ensuring that as research directions evolve, we remain agile and equipped to support new scientific needs. This is your chance to play a pivotal role in the shaping of a new chapter in the life of this globally renowned institute.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please quote reference PR44715 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
