Research Assistant in Drosophila Cell Biology (Fixed Term)
Applications are invited for a Research Assistant position in the group of Prof Daniel St Johnston at the Gurdon Institute, University of Cambridge. The post is available for up to 3 years, starting from October 1st, 2025.
The BBSRC-funded project aims to determine how modulation of the key polarity kinase, aPKC, induces apical constriction in epithelial cells and to investigate the role that this mechanism plays in morphogenesis during Drosophila development. Responsibilities will include the generation of transgenic and mutant flies using CRISPR/Cas9, performing crosses to produce the appropriate genotypes, clone generation using the Flp/FRT system and live imaging of Drosophila embryos and egg chambers.
Homepage: http://www.gurdon.cam.ac.uk/research/stjohnston
Applicants must have a Bachelors or Masters level degree in a relevant area of Biology. Expertise in cell biology and Drosophila genetics would be an advantage, although training can be provided where necessary.
The post does not require a PhD qualification.
Fixed-term: The funds for this post are available for 3 years in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Applications should include a CV, a cover letter and the names of two referees.
Please quote reference PR45603 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Assistant in Developmental Mechanics and Morphogenesis (Fixed Term)
We are looking for a full-time Research Assistant in Dr Fengzhu Xiong's lab at the Gurdon Institute, University of Cambridge. The successful candidate will be involved in studies of collective cell dynamics and tissue morphogenesis during embryo development using cellular, molecular and mechanical approaches.
Cell movements underlie tissue patterns and shapes. Using chick embryos as the model system, we are investigating the mechanical cues regulating the partition and migration of body axis progenitors. We have developed innovative techniques such as tissue force microscope (TiFM) enabling in vivo, in situ mimicking of tissue forces, allowing us to map tissue and cell responses to mechanical inputs. This role provides an opportunity to contribute and integrate in ongoing projects as well as to initiate new queries.
As a member of an interdisciplinary team, the candidate will have the opportunity to receive training in a variety of techniques, including molecular biology, embryology, imaging, computation, and biophysics. They will also have the opportunity to develop independent projects after gaining adequate experience. Moreover, they will receive support if they wish to participate in career development activities such as appropriate professional activities while in the role. This is an excellent opportunity for someone enthusiastic about learning new techniques, proactive in research and self-motivated in advancing science. Their active involvement in this project will contribute to their career development, such as increasing their competitiveness in PhD scholarship applications.
The successful applicant is anticipated to have detail-oriented research insight and exceptional record-keeping working habits. They will have strong organisational and communication skills and excellent problem-solving skills.
Main duties will include: conduct tissue-mechanical and imaging experiments using early avian embryos; acquire and process data; prepare reagents and samples; optimise protocols; program and debug codes for analysis; coordinate with the PI and Lab Manager; participate in regular group meetings and other group activities.
Fixed term: The position is available with a flexible starting date. The funds for this post are available for 1 year in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please quote reference PR46629 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
