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Current jobs in the Department of Pathology at the University of Cambridge.
Updated: 1 hour 6 min ago

Postdoctoral Research Associate in Immunology (Fixed Term)

Thu, 04/07/2024 - 00:00

Join our team as a Postdoctoral Research Associate in Immunology.

The McGovern lab is seeking a talented and motivated Postdoctoral Research Associate in Immunology. Our research aims to understand how mononuclear phagocytes function within human tissues in health and disease.

The McGovern Lab:

Our team focuses on characterising human mononuclear phagocytes, this includes dendritic cells monocytes and macrophages. These cells perform vital roles in tissue development and function, fight infection and resolve inflammation. To develop our understanding of these cells, we utilise a range of technologies including proteomic, transcriptomic and epigenetic approaches. Recent approaches include work with organoid systems and spatial transcriptomics.

https://www.path.cam.ac.uk/research/immunology-division/mcgovern-group

https://www.mcgovernlab.com/

About the role:

You project will aim to understand how cells communicate at the maternal-fetal interface and act to defend us from infection. You will do this by utilising organoid systems, primary tissue macrophage culture systems and human transcriptomic data sets generated within the McGovern lab.

Main duties:

  • Generate and maintain organoid and macrophage culture systems

  • Design, implementation and application of infection assays

  • Statistical analysis and data visualization

  • To identify, develop and apply a broad range of techniques to pursue the research objectives

  • To present scientific work at seminars within the laboratory and at external meetings

  • To contribute to laboratory-wide discussions on developments within the field

  • To draft scientific papers, and contribute to the overall preparation of research for publication

  • To contribute to public engagement events

  • To assist in the training of PhD students and other members of the team

Key responsibilities:

Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three-year lifespan.

To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your Supervisor.

To identify, develop, modify and apply the necessary techniques to achieve the goals of the project.

To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.

To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.

To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.

To enhance your research and generic skills through a tailored development programme.

Essential:

  • PhD in immunology or cellular biology, or in the final stages of PhD submission

  • Experience with RNA sequencing data sets

  • Proven track record of research (e.g: publication record)

  • Strong written and oral communication skills

Why join us?

  • Contribute to cutting-edge immunology research with real-world implications

  • Collaborate with experts across the fields of immunology, virology, microbiology, and clinicians

  • Work in a supportive and collaborative environment that fosters professional growth.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

How to apply:

Please provide a statement of interest/cover letter. This should explain why you are interested in this position. Please also provide your CV and 2 references.

Please quote reference PK42340 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant (Part Time, Fixed Term)

Mon, 01/07/2024 - 00:00

We wish to recruit a highly motivated Research Assistant to join the laboratory of Prof Rahul Roychoudhuri within the Division of Immunology at the Department of Pathology, University of Cambridge (http://www.roychoudhurilab.org).

Despite the success of CAR T cell therapy in haematological malignancies, its application in solid tumours has faced significant challenges. Solid tumours often exhibit genetic and phenotypic heterogeneity, making it difficult to identify a single target antigen consistently expressed on all tumour cells. Moreover, solid tumours create an immunosuppressive microenvironment that inhibits the function and survival of CAR T cells. The complex extracellular matrix of solid tumours can also act as a physical barrier, preventing efficient homing and penetration of CAR T cells into the tumour mass. Furthermore, CAR T cells can become exhausted and lose their effector function over time, particularly in the context of chronic antigen exposure and the immunosuppressive tumour microenvironment. This research aims to enhance the persistence and long-term functionality of CAR T cells through genetic modifications of transferred cells based on a mechanistic understanding of CD8 T cell biology.

The successful applicant will join a large, friendly and collaborative team of researchers with access to cutting-edge facilities and resources within the centre of Cambridge on the historic Tennis Court Road site. The applicant will gain exposure to cutting-edge experimental approaches in cellular and molecular immunology including conditional mouse genetics, in vivo genetic cell barcoding and fate-tracking, molecular biology and high throughput RNA- and DNA-sequencing. The applicant will also have the opportunity to utilise platforms for high-throughput CRISPR/Cas9-based mutagenesis screens recently developed in the laboratory. The applicant will benefit from the collaborative and collegial environment of the laboratory, the Department and the wider research community present in Cambridge. The project will also benefit from a collaboration with the groups of Prof Adrian Liston and Dr Tim Halim within Cambridge, bringing together leading scientific and technical expertise in cancer immunology/immunotherapy, immune regulation and inflammation biology. The ideal candidate will be motivated, independent and enthusiastic, and have a an undergraduate degree in immunology, cell biology, or a related field. Experience with flow cytometry, cell culture, and molecular biology techniques and a track record of publications in peer-reviewed journals are desirable. Strong analytical and problem-solving skills, written and verbal communication skills, and the ability to work independently as well as part of a team are desirable.

Key responsibilities:

  • Conducting research in the field of immunology and immunotherapy

  • Leading collaborations with other researchers within the group, and in other laboratories

Essential criteria:

  • Independent, motivated and highly organized individual, who is passionate about science and keen to support the day-to-day coordination of a collaborative team of scientists

  • Applicants must have a degree in Immunology, Molecular Biology, Cell Biology or a related discipline

  • Experience of mouse immunology, including working with experimental mice, tissue dissection and flow cytometry. Ability to learn and assimilate new techniques, and to train other researchers

  • Demonstrate core values of enthusiasm, openness and integrity.

Fixed-term: The funds for this post are available for 2 years in the first instance

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For more information about the work of the laboratory, visit: http://roychoudhuri.path.cam.ac.uk Informal enquiries about the position can be made by email to rr257@cam.ac.uk

Please quote reference PK42257 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Property Maintenance Apprentice

Wed, 19/06/2024 - 00:00

People are at the heart of everything we do at Pathology, so why not join our professional services team as a Property Maintenance Apprentice and start supporting excellence in research and education. We can offer a welcoming work environment where you can feel valued, encouraged to develop, and supported to achieve your full potential. You will be working with colleagues who manage the maintenance, facilities and safety across the large Department of Pathology consisting of dry and wet laboratories, classrooms, offices & lecture theatres. You will undertake training & increasingly over the apprenticeship, respond to breakdowns, perform preventive maintenance tasks & installation work.

The successful candidate will work towards completing the Property Maintenance Operative Level 2 Apprenticeship via Cambridge Regional College.

The position is varied, and is required to support the departmental and core team needs, but will include duties such as:

  • Learn basic skills in the area of work (e.g. use of basic workshop tools and machinery)

  • Work independently on elements of a project or task, referring all decisions to the supervisor, applying new skills as appropriate

  • Be involved with the general maintenance of the fabric of the Department, including painting, minor carpentry work, installation of benching and flooring

  • Undertake preventive maintenance tasks such as air filters, water temperature checks and fume hood inspections

  • Understand basic health and safety hazards and risk management within the working environment. Learn and abide by standard operating procedures and risk assessments. (E.g. workshop safety and chemical safety)

  • Respond to breakdowns, perform preventive maintenance tasks & installation work. You will gain an understanding of our operations and what it takes to keep a large, busy department running!

Applicants should have a minimum of 2 GCSEs or equivalent at Grade 3/D or above including English, and Maths

Expected duration: 27 months.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

How To Apply:

To apply for this role, please use this link to access the National Apprenticeship Service site and follow the on-screen instructions on how to submit your application: https://www.findapprenticeship.service.gov.uk/apprenticeship/1000259403.

If you have any queries regarding the application process, please contact the Hannah from CRC on 01223 418778

Informal enquiries about the vacancy are welcomed and should be directed to Jodi Smith, HR Coordinator: hr@path.cam.ac.uk

The closing date for applications is 7th July 2024.

Please quote reference PK41895 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant/Research Associate (Fixed Term)

Tue, 18/06/2024 - 00:00

Applications are invited for a Post-Doctoral Research Associate position in innate immunity to start in September 2024.

The successful candidate will join the laboratories of Dr Brian Ferguson (https://www.fergusonlab.path.cam.ac.uk/) and Professor Clare Bryant in a BBSRC-funded project to investigate the innate immune responses in livestock animals affected by the zoonotic disease, Q fever.

The post will held within the Departments of Pathology and Veterinary Medicine, University of Cambridge and can involve travel to collaborative laboratories in India.

The candidate should have completed a PhD** level degree in immunology, cell biology, biochemistry or a closely related field and have a proven track record of success in biomedical research. In addition, it would be advantageous if the candidate had demonstrable wet-lab research experience and a particular interest in innate immunity. Experience in the following is desirable but non-essential: cell culture, CRISPR editing, western blot, RNA-seq, proteomics, infection biology.

** Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

Successful applicants should have strong written and oral communication skills as well as the ability to supervise students. They will be expected to design and carry out research both independently and as part of a team. The successful applicants will become an integral and valued member of a multi-disciplinary, dynamic and sociable research group.

Fixed-term: The funds for this post are available until 16th June 2027 subject to a satisfactory 6-month probation period.

The closing date for all applications is 30th July and interviews will be held shortly thereafter.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries about the position can be made to Dr Brian Ferguson (bf234@cam.ac.uk).

Please quote reference PK42131 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Flow Cytometry Technician (Fixed Term)

Fri, 07/06/2024 - 00:00

We are seeking a Flow Cytometry Technician for the School of the Biological Sciences Flow Cytometry Facility, housed in the Department of Pathology, University of Cambridge.

https://www.path.cam.ac.uk/research/facilities/flow-cytometry

The Flow Cytometry Facility comprises three rooms within the Department of Pathology on Tennis Court Road in central Cambridge and currently includes five analysers (two Cytek Aurora, Thermo Fisher Attune NxT, Beckman Coulter CytoFLEX LX, and CytoFLEX S) and three cell sorters (BD FACSDiscover S8, BD FACSAria III, and BD FACSAria IIu). The FACSDiscover S8 is the first imaging-enabled spectral cell sorter in the market and the first installed in Cambridgeshire, expanding the power of cell analysis and sorting to new dimensions by combining full spectral flow cytometry with real-time spatial and morphological insights.

The postholder will ideally have experience operating both cell sorters and analysers, but training will be provided in-house and externally. The postholder will be attending the 4-day FACSDiscover S8 Cell Sorter operator course in Belgium at BD's European headquarters.

This course is designed for new operators who want to learn about the imaging cell sorter and includes theoretical explanations of the BD CellView Image Technology, BD SpectralFX Technology and sorting with hands-on practical exercises. Additionally, interaction with BD Research Cloud and FlowJo software will be demonstrated.

In addition to the Department of Pathology, users from the Departments of Biochemistry, Genetics, Physiology, Development and Neuroscience, Chemistry, Plant Sciences, and the Gurdon Institute use this central core facility. Benefits include the opportunity to work with world-leading scientists at the University of Cambridge and to help the Facility thrive and grow to meet the demand for its services.

Job description

  • The postholder will operate the cell sorters on behalf of the end users after appropriate training.

  • Equipment maintenance to ensure all machines are available and functioning including running QC procedures.

  • Routine maintenance of the flow facility. The postholder will help in the weekly instrument cleaning rota and maintenance.

  • Be able to troubleshoot instruments. The postholder is expected to help users who encounter any problems while running their experiments.

  • Depending on experience, the postholder may be required to train new users who request access to the analysers.

  • Working with the flow cytometry community within the Research Campus including collaborating with research groups and companies.

Selection Criteria

Essential

  • College or University Degree in Biological science or other relevant experience.
  • Ability to work independently and communicate effectively with end users.
  • Ability to learn on the job and to organise the day-to-day calendar to ensure that experiments run on time.
  • Ability to work in a Biosafety Level 2 lab.

Desirable

  • Previous experience working with flow cytometry (either as a research scientist or as a facility assistant)

The postholder will report to the Head of the Immunology Division (Professor Klaus Okkenhaug).

Fixed-term: The funds for this post are available for 12 months in the first instance.

Interviews are expected to take place on 15th July 2024

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries about the position can be made to Joana Cerveira (jf651@cam.ac.uk, Flow Cytometry Manager).

Please quote reference PK41973 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant (Fixed Term)

Fri, 07/06/2024 - 00:00

A full time Research Assistant position funded by the BBSRC is available in the Division of Cellular and Molecular Pathology working within the laboratory of Dr Paolo D'Avino to contribute to a research project investigating the regulation and function of cell division by phosphorylation.

Candidates should have a B.Sc. or preferably an M.Sc. degree in a relevant discipline (Biology/Biomedicine) and considerable experience in human cell culture, molecular biology, and microscopy. The ability to work both independently and as part of a team, coupled with good communication and organizational skills is required. Other duties/responsibilities will include preparation of reagents, maintenance of stocks, and assisting in the day-to-day running of the laboratory.

For more information about the laboratory please visit: https://www.path.cam.ac.uk/research/cellular-and-molecular-pathology-division/davino-group.

Fixed-term: The post is available until 31st August 2025 starting on the 27th of August 2024 or as soon as possible thereafter and subject to a probationary period.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The deadline for applications is 4th July 2024.

Interviews will take place week commencing 22nd July 2024.

Informal queries should be directed to Dr Paolo D'Avino, ppd21@cam.ac.uk.

General queries should be directed to hr@path.cam.ac.uk.

Please quote reference PK41965 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Flow Cytometry Technician (Fixed Term)

Fri, 07/06/2024 - 00:00

We are seeking a Flow Cytometry Technician for the School of the Biological Sciences Flow Cytometry Facility, housed in the Department of Pathology, University of Cambridge.

https://www.path.cam.ac.uk/research/facilities/flow-cytometry

The Flow Cytometry Facility comprises three rooms within the Department of Pathology on Tennis Court Road in central Cambridge and currently includes five analysers (two Cytek Aurora, Thermo Fisher Attune NxT, Beckman Coulter CytoFLEX LX, and CytoFLEX S) and three cell sorters (BD FACSDiscover S8, BD FACSAria III, and BD FACSAria IIu). The FACSDiscover S8 is the first imaging-enabled spectral cell sorter in the market and the first installed in Cambridgeshire, expanding the power of cell analysis and sorting to new dimensions by combining full spectral flow cytometry with real-time spatial and morphological insights.

The postholder will ideally have experience operating both cell sorters and analysers, but training will be provided in-house and externally. The postholder will be attending the 4-day FACSDiscover S8 Cell Sorter operator course in Belgium at BD's European headquarters.

This course is designed for new operators who want to learn about the imaging cell sorter and includes theoretical explanations of the BD CellView Image Technology, BD SpectralFX Technology and sorting with hands-on practical exercises. Additionally, interaction with BD Research Cloud and FlowJo software will be demonstrated.

In addition to the Department of Pathology, users from the Departments of Biochemistry, Genetics, Physiology, Development and Neuroscience, Chemistry, Plant Sciences, and the Gurdon Institute use this central core facility. Benefits include the opportunity to work with world-leading scientists at the University of Cambridge and to help the Facility thrive and grow to meet the demand for its services.

Job description

  • The postholder will operate the cell sorters on behalf of the end users after appropriate training.

  • Equipment maintenance to ensure all machines are available and functioning including running QC procedures.

  • Routine maintenance of the flow facility. The postholder will help in the weekly instrument cleaning rota and maintenance.

  • Be able to troubleshoot instruments. The postholder is expected to help users who encounter any problems while running their experiments.

  • Depending on experience, the postholder may be required to train new users who request access to the analysers.

  • Working with the flow cytometry community within the Research Campus including collaborating with research groups and companies.

Selection Criteria

Essential

  • College or University Degree in Biological science or other relevant experience.
  • Ability to work independently and communicate effectively with end users.
  • Ability to learn on the job and to organise the day-to-day calendar to ensure that experiments run on time.
  • Ability to work in a Biosafety Level 2 lab.

Desirable

  • Previous experience working with flow cytometry (either as a research scientist or as a facility assistant)

The postholder will report to the Head of the Immunology Division (Professor Klaus Okkenhaug).

Fixed-term: The funds for this post are available for 12 months in the first instance.

Interviews are expected to take place on 15th July 2024

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries about the position can be made to Joana Cerveira (jf651@cam.ac.uk, Flow Cytometry Manager).

Please quote reference PK41973 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant (Fixed Term)

Fri, 07/06/2024 - 00:00

A full time Research Assistant position funded by the BBSRC is available in the Division of Cellular and Molecular Pathology working within the laboratory of Dr Paolo D'Avino to contribute to a research project investigating the regulation and function of cell division by phosphorylation.

Candidates should have a B.Sc. or preferably an M.Sc. degree in a relevant discipline (Biology/Biomedicine) and considerable experience in human cell culture, molecular biology, and microscopy. The ability to work both independently and as part of a team, coupled with good communication and organizational skills is required. Other duties/responsibilities will include preparation of reagents, maintenance of stocks, and assisting in the day-to-day running of the laboratory.

For more information about the laboratory please visit: https://www.path.cam.ac.uk/research/cellular-and-molecular-pathology-division/davino-group.

Fixed-term: The post is available until 31st August 2025 starting on the 27th of August 2024 or as soon as possible thereafter and subject to a probationary period.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The deadline for applications is 4th July 2024.

Interviews will take place week commencing 22nd July 2024.

Informal queries should be directed to Dr Paolo D'Avino, ppd21@cam.ac.uk.

General queries should be directed to hr@path.cam.ac.uk.

Please quote reference PK41965 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

NIHR Clinical Lecturer in Medical Virology

Thu, 30/05/2024 - 00:00

Based on the Cambridge Biomedical Campus, this post offers unrivalled opportunity to undertake high quality research within an outstanding academic and clinical environment. Applicants should be medically qualified, have full GMC registration, and an existing NTN/NTN(A) in Medical Virology.

If a number is not held, candidates will need to be clinically benchmark to be able to take up the post. Clinical benchmarking can be achieved through application for specialty training within the national recruitment window where the minimal appointable score must be achieved. Candidates are responsible for ensuring that their clinical application is submitted within the appropriate recruitment round to ensure that you are benchmarked before the date that the post needs to commence.

Candidates should hold MRCP and have evidence of achievement of Combined Infection Training (CIT) competences from a UK affiliated Programme or equivalent in line with GMC standards/Good Medical Practice. If an applicant is already on a combined ID/Medical Virology training curriculum, it is possible to apply, and if successful, continue/complete the combined training.

You are required to hold or have submitted a PhD/DPhil/MD at the time of your application, and be of the standing required for an appropriate honorary contract of service with the NHS LETB (specialist trainee/LETB). Candidates who have not submitted their PhD/MD at the time of application will not be considered.

This is a fixed term appointment for a maximum of 4 years or until you obtain CCT (subject to any extension that you apply for and be granted by NIHR, which can be for a maximum of 24 months).

Salary Scales

StR £39,260pa - £68,478pa

Nodal £43,923pa - £63,152pa

This appointment requires an Honorary Clinical Contract. This is an integrated appointment between the University and relevant NHS Trust / Body. You will therefore also be issued with an Honorary Clinical Contract by the NHS Trust / Body. You should be aware that if your contract with the NHS Trust / Body is terminated your employment with the University will be terminated, and vice versa.

You will require GMC registration, Licence to Practice and Medical Defence Cover for the duration of your appointment.

Candidates must be available to commence in post by 31 August 2024.

Fixed-term: 4 years.

This appointment requires an Honorary Clinical Contract.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter, CV and the Additional Information Form in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference PK40691 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Post-doctoral Scientist in Cancer Immunology (Fixed Term)

Thu, 16/05/2024 - 00:00

We wish to recruit a highly motivated Postdoctoral Research Scientist to join the laboratory of Professor Rahul Roychoudhuri within the Division of Immunology at the Department of Pathology, University of Cambridge (http://www.roychoudhurilab.org).

T cells drive immune activation and promote clearance of infections and cancer. However, their function can provoke autoimmune and allergic inflammation. The immune system therefore employs a variety of suppressive mechanisms, collectively known as immunoregulatory mechanisms, to restrain excessive T cell activation and prevent autoimmune and allergic inflammation. However, such suppressive mechanisms also powerfully inhibit anti-tumour immunity to drive deleterious immunosuppression in cancer.

The laboratory utilises mouse genetics, cellular immunology and molecular biology to understand molecular mechanisms of immunity and immune suppression in cancer and inflammation. This research aims to uncover novel molecular and cellular mechanisms of tumour immunity and cancer immunosuppression. You will contribute to fundamental discoveries in the field of tumour immunology that will pave the way for new therapies aimed at manipulating immune function in patients with cancer.

The successful applicant will join a large, friendly and collaborative team of researchers with access to cutting edge facilities and resources within the centre of Cambridge on the historic Tennis Court Road site.

The applicant will gain exposure to cutting-edge experimental approaches in cellular and molecular immunology including conditional mouse genetics, in vivo genetic cell barcoding and fate-tracking, molecular biology and high throughput RNA- and DNA-sequencing.

The applicant will also have the opportunity to utilise platforms for high-throughput CRISPR/Cas9-based mutagenesis screens recently developed in the laboratory. The applicant will benefit from the collaborative and collegial environment of the laboratory, the Department and the wider research community present in Cambridge. The project will also benefit from a collaboration with the groups of Prof Adrian Liston and Dr Tim Halim within Cambridge, bringing together leading scientific and technical expertise in cancer immunology/immunotherapy, immune regulation and inflammation biology.

The ideal candidate will be motivated, independent and enthusiastic, and have a Ph.D. or MD/PhD* in immunology, cell biology, or a related field.

Experience with flow cytometry, cell culture, and molecular biology techniques and a track record of publications in peer-reviewed journals are desirable.

Strong analytical and problem-solving skills, written and verbal communication skills, and the ability to work independently as well as part of a team are desirable.

Fixed-term: The funds for this post are anticipated to be available until 30th September 2026 in the first instance.

For more information on the work of the Roychoudhuri group, please visit http://www.roychoudhurilab.org.

Where the successful applicant does not yet have a PhD, they will normally be under-appointed as a Research Assistant until they obtain their PhD degree.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquiries, or to find out specific details about available projects in the laboratory, please email rr257@cam.ac.uk.

Please quote reference PK41648 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Junior Laboratory Technician (Part Time)

Tue, 30/04/2024 - 00:00

People are at the heart of everything we do at Pathology, so why not join our professional services team as a Junior Laboratory Technician. We can offer a welcoming work environment where you can feel valued, encouraged to develop, and supported to achieve your full potential.

You will support research work in the Department of Pathology's laboratories at its Addenbrooke's Hospital site, and at its Tennis Court Road site when required. The role holder will provide a glassware-washing, autoclaving and waste removal service. Ideally you will have some relevant experience of working in a laboratory, although an aptitude for this type of work is more important as full training will be provided. Basic awareness of health and safety, the ability to adhere to Standard Operating Procedures reliably, good communication skills, the ability to prioritise your workload and to work both independently and as part of a team are essential. You will also be reliable and have good timekeeping skills.

What we Offer

Our Professional Services staff play a fundamental role in the School's academic vision of the pursuit of education and research at the highest levels of excellence. The University of Cambridge offers excellent benefits, extensive opportunities in a stimulating environment.

*The University salary structure includes automatic service-related pay progression in many of its grades and an annual cost of living increase. In addition to this, employees are rewarded for outstanding contribution through a number of regular pay progression schemes. Staff also benefit from a generous annual leave entitlement.

*The University offers employees a wide range of competitive benefits, from health care cash plans to childcare, a cycle to work scheme, to shopping and insurance discounts.

*University-led initiatives in the areas of equality, diversity and wellbeing include staff and students networks. These include the Women's Staff Network, the Disabled Staff Network, the Black, Asian and Minority Ethnic Staff Network, Parents and Carers and the LGBT+ Network. We also hold a wide range of Equality and Diversity events on a regular basis.

*Wellbeing at Cambridge is a University-wide initiative aiming at supporting and maximising the health and wellbeing of staff. It encompasses a network of Wellbeing Advocates, who provide guidance and general signposting about wellbeing issues, including mental or physical health and Dignity @ Work concerns.

*The University offer a range of family-friendly policies, including maternity, adoption and shared parental leave. In addition, workplace nurseries, childcare vouchers, a childcare salary sacrifice scheme and a high-quality holiday play scheme are available to help support University employees with caring responsibilities

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

We particularly welcome applications from women and /or candidates from a BME background for this vacancy as they are currently under-represented at this level in our department/institution/Faculty/School/University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Contact Samuel Odeyemi for an informal chat on 01223 336912 or swo28@cam.ac.uk and check out our website: https://www.path.cam.ac.uk/

Please quote reference PK41416 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Please note we are unable to offer sponsorship for this role as it does not meet the minimum skill and/or salary requirements for this visa route.

Categories: Latest Jobs

Computational Research Associate (Fixed Term)

Fri, 26/04/2024 - 00:00

Join our team as a Computational Research Associate!

The McGovern lab is seeking a talented and motivated Computational Research Associate to join their research group. Our research aims to understand the role of mononuclear phagocytes in autoimmunity and placental development.

This is a grade G7 Research Associate post, dependant on previous skills and experience.

The McGovern Lab:

Our team focuses on characterising human mononuclear phagocytes, crucial immune cells distributed across all tissues in the body. These cells perform vital functions in tissue development and function, fighting infection and resolving inflammation. We utilise a range of technologies to develop our understanding of the ontogeny and function of these cells including proteomic, transcriptomic and epigenetic approaches. We utilise cells isolated from primary human tissue samples and organoid systems. As part of our team, you will contribute to groundbreaking research in understanding the properties of mononuclear phagocytes in both health and disease.

https://www.path.cam.ac.uk/research/immunology-division/mcgovern-group https://www.mcgovernlab.com/

About the role:

You will develop your own projects and support other projects in the lab. This will involve analysis of single cell and spatial transcriptomic data sets generated from human tissues to understand immune cells and their cross-talk with stromal cells in health and disease. You will be working with cell biologists across a range of expertise including immunology, virology, microbiology, and clinicians to adapt, improve, and integrate existing software, to best answer the scientific questions of the research programme. You will also be encouraged to develop novel computational tools to support this.

Your tasks:

  • Design, implementation and application of single-cell and spatial transcriptomic analysis workflows

  • Statistical analysis and data visualization

  • Interaction and collaboration with researchers within the McGovern team

  • Consultation regarding the planning and design of sequencing experiments

  • Presentation and reporting of results

  • Recommendation of publicly available resources and tools

  • Working in a team with bioinformatic and computational colleagues

  • Training and supervision of undergraduate and PhD students

Your profile:

  • PhD in cell biology, bioinformatics or any other related field

  • Expertise in the analysis and visualization of single-cell and other types of high-throughput data (e.g., RNA-seq, ATAC-seq, ChIP-seq); experience with proteomics data is of advantage

  • Knowledge of statistics

  • Proficiency in programming, e.g. with R and Python

  • Experience in machine learning

  • Background in mammalian cell biology and an interest in immunology

  • Passion for unravelling complex biological systems

  • Excellent communication and presentation skills and fluency in written and spoken English

  • Team player capable of adapting to a rapidly evolving and interdisciplinary research environment

Why join us?

  • Contribute to cutting-edge immunology research with real-world implications

  • Collaborate with experts across the fields of immunology, virology, microbiology, and clinicians

  • Work in a supportive and collaborative environment that fosters professional growth

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

How to apply:

Please provide a statement of interest/cover letter, CV and 2 references.

Please quote reference PK41464 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Business Administrator

Tue, 23/04/2024 - 00:00

People are at the heart of everything we do at Pathology, so why not join our professional services team as our Business Administrator and start supporting excellence in research and education. We can offer a welcoming work environment where you can feel valued, encouraged to develop, and supported to achieve your full potential.

You will provide a comprehensive administrative service to the Head of the Division of Virology and the other staff of the division. Ideally you will have some relevant administrative experience with high competency in standard software packages. Good communication skills and the ability to deal with a wide range of people at all levels are key skills to bring to the role. This is a busy and varied role, so the ability to plan and prioritise your own workload is essential. However, you will work within our friendly team, so will have a support network to help you along the way.

What we Offer

*Our Professional Services staff play a fundamental role in the School's academic vision of the pursuit of education and research at the highest levels of excellence.

*The University of Cambridge offers excellent benefits, extensive opportunities in a stimulating environment.

*The University salary structure includes automatic service-related pay progression and an annual cost of living increase. In addition to this, employees are rewarded for outstanding contribution through a number of regular pay progression schemes.

*Staff also benefit from a generous annual leave entitlement.

*The University offers employees a wide range of competitive benefits, from health care cash plans to childcare, a cycle to work scheme, to shopping and travel discounts.

*University-led initiatives in the areas of equality, diversity and wellbeing include staff and students networks. These include the Women's Staff Network, the Disabled Staff Network, the Black, Asian and Minority Ethnic Staff Network, Parents and Carers and the LGBT+ Network. We also hold a wide range of Equality and Diversity events on a regular basis.

*Wellbeing at Cambridge is a University-wide initiative aiming at supporting and maximising the health and wellbeing of staff. It encompasses a network of Wellbeing Advocates, who provide guidance and general signposting about wellbeing issues, including mental or physical health and Dignity@Work concerns.

*The University offer a range of family-friendly policies, including maternity, adoption and shared parental leave. In addition, workplace nurseries, a childcare salary sacrifice scheme and a high-quality holiday play scheme are available to help support University employees with caring responsibilities

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

We particularly welcome applications from women and /or candidates from a BME background for this vacancy as they are currently under-represented at this level in our department/institution/Faculty/School/University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Contact Fiona Craig for an informal chat on 01223 333693 or fcc21@cam.ac.uk and check out our website: https://www.path.cam.ac.uk/

Please quote reference PK41272 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Please note we are unable to offer sponsorship for this role as it does not meet the minimum skill and/or salary requirements for this visa route.

Categories: Latest Jobs

Finance Administrator (Part Time)

Mon, 22/04/2024 - 00:00

The Department of Pathology is seeking a highly motivated and professional individual to undertake financial duties, providing proactive support to academic and research staff.
We are a department that truly values teamwork and has strong and inclusive programme of wellbeing.

Candidates will ideally be educated to AAT level four (or equivalent level of practical experience). You will be highly numerate, analytical and proficient in standard software packages, particularly Excel. You will be well-organised and able to prioritise effectively and work to tight deadlines. The role requires a good understanding of finance and strong problem solving skills. Excellent communication skills are also essential, including the ability to explain financial regulations and procedures effectively to non-finance staff. You will need to have strong interpersonal skills and be able to work effectively as a member of a team and to build positive working relationships with a wide variety of colleagues. Previous experience of working in an accounts environment within a University would be an advantage.

Working closely with the Department's Finance Coordinator this role has a wide range of responsibilities, including:

  • Acting as a Departmental key contact working proactively with academics, researchers, and departmental budget holders as well as other University departments and external suppliers/customers to resolve queries

  • Carry out the Department's month end and year end procedures

  • Ensuring accuracy of financial information on University financial system (CUFS), identifying and resolving any problems

  • Working with the Shared Financial Services team to ensure that accounts payable and receivable transactions are accurate and timely

  • Carry out accounts administration relating to the general ledger and research grants

  • Carry out financial management and reporting activities as required

It is vital that you possess excellent inter-personal skills to be able to work well with the team and manage good working relationships with a wide variety of people from all over the world, in order to gain an understanding of the needs of academics and research staff and deliver a responsive financial service to them.

You will be involved in contributing to continuous improvements in the Department's financial administration through close cooperation with the central Finance team. The Department is committed to supporting training and development opportunities for colleagues.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For an informal chat, please contact Fiona Craig on (01223) 333693 or fcc21@cam.ac.uk

Please quote reference PK41083 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Paediatric Cancer Programme Research Assistant (Fixed Term)

Thu, 11/04/2024 - 00:00

We are seeking an enthusiastic and well-organised Research Assistant to join the group of Professor Matthew Murray (https://www.path.cam.ac.uk/directory/matthew-murray) at the Department of Pathology, University of Cambridge to work under the CRUK Cambridge Centre Paediatric Programme (https://crukcambridgecentre.org.uk/research/programmes/paediatric-cancer).

This position, funded by the CRUK Cambridge Centre, will help support sample processing for a range of paediatric cancer clinical trials. The successful candidate will work with existing staff to optimise individual standard operating procedures (SOPs) and help strengthen links between clinical trials and research groups in the programme. This research has fundamental translational potential for patients with cancer to improve diagnosis, disease-monitoring and ultimately transform patient outcomes.

Candidates are expected to hold a BSc or MSc degree in Molecular or Cell Biology or a related discipline. Candidates should have experience with sample handling and processing, database curation, tissue culture, and molecular biology techniques including PCR. Prior experience with working at biosafety level 2 is advantageous, but we will be delighted to consider highly-motivated individuals who can demonstrate excellent relevant laboratory skills and a minimum of six months hands-on laboratory experience.

Successful applicants will become an integral and valued member of the group. Responsibilities of the role include basic laboratory maintenance, sample handling and processing, especially linked to paediatric cancer clinic trials, SOP development, PCR, cell culture, appropriate data documentation & analysis. The candidate should have good interpersonal and communication skills, and the ability to work well independently and as part of a team. The successful candidate will have the opportunity to work under their own initiative and present regularly at lab meetings. There are many professional development and training activities available via the university, and the successful applicant is encouraged to engage with such opportunities.

Fixed-term: The funds for this post are available until 31 March 2026 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries about the position can be made by email to Professor Matthew Murray (mjm16@cam.ac.uk) or Dr Cinzia Scarpini (cgs1001@cam.ac.uk)

Please quote reference PK40973 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

HR Administrator

Wed, 03/04/2024 - 00:00

People are at the heart of everything we do at Pathology, so why not join our professional services team as our HR Administrator and start supporting excellence in research and education. We can offer a welcoming work environment where you can feel valued, encouraged to develop, and supported to achieve your full potential.
You will work closely with our HR Coordinator to provide a comprehensive HR service supporting staff recruitment, induction, probation, contract changes, end of contract procedures and leave requests.

You will also respond to a range of HR queries, advising on HR policy, procedure and best practice. This is a busy and varied role, so good communication skills and the ability to handle a varied workload are key skills to bring to the role. There will be competing demands and deadlines to meet, as well as maintaining a high level of attention to detail. Ideally you will have some relevant administrative experience, be able to deliver a high level of customer service, maintain complete confidentiality and have the ability to plan and prioritise your own workload. However, we really value teamwork at Pathology so you will work within a friendly team and will have a support network to help you along the way.

What we Offer

*Our Professional Services staff play a fundamental role in the School's academic vision of the pursuit of education and research at the highest levels of excellence.

*The University of Cambridge offers excellent benefits, extensive opportunities in a stimulating environment.

*The University salary structure includes automatic service-related pay progression and an annual cost of living increase.

*In addition to this, employees are rewarded for outstanding contribution through a number of regular pay progression schemes.

*Staff also benefit from a generous annual leave entitlement.

*The University offers employees a wide range of competitive benefits, from health care cash plans to childcare, a cycle to work scheme, to shopping and travel discounts.

*University-led initiatives in the areas of equality, diversity and wellbeing include staff and students networks. These include the Women's Staff Network, the Disabled Staff Network, the Black, Asian and Minority Ethnic Staff Network, Parents and Carers and the LGBT+ Network.

We also hold a wide range of Equality and Diversity events on a regular basis.

*Wellbeing at Cambridge is a University-wide initiative aiming at supporting and maximising the health and wellbeing of staff. It encompasses a network of Wellbeing Advocates, who provide guidance and general signposting about wellbeing issues, including mental or physical health and Dignity@Work concerns.

*The University offer a range of family-friendly policies, including maternity, adoption and shared parental leave. In addition, workplace nurseries, a childcare salary sacrifice scheme and a high-quality holiday play scheme are available to help support University employees with caring responsibilities

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Contact Jodi Smith for an informal chat on 01223 333 940 or email hr@path.cam.ac.uk

Please quote reference PK41085 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Cell Biologist (Fixed Term)

Tue, 02/04/2024 - 00:00

THE GROUP

We are seeking a highly motivated cell biologist to join Dr. Naomi McGovern's laboratory. The lab works on human mononuclear phagocytes and how their properties are regulated by the local microenvironment. We study these cells in a range of settings including the maternal-fetal interface, inflamed joints and cancer. Details of research projects currently being undertaken in the McGovern lab can be seen at: https://www.mcgovernlab.com/ https://www.path.cam.ac.uk/research/immunology-division/mcgovern-group

We seek a talented, productive and motivated postdoc with a desire to work in a congenial, dynamic and collaborative research team.

PROJECT SUMMARY

The group is interested in studying mononuclear phagocyte biology in diverse settings. The project is funded by the UKRI and will investigate how the properties of macrophages are regulated by their local microenvironment at the maternal-fetal interface. You will work on primary tissues macrophages, iPSCs and organoid systems. Techniques you will use include multiparameter FACS, scRNAseq and confocal microscopy.

PERSON SPECIFICATION

The post holder should embody and demonstrate our core values: Bold, Open, and Collegial, in addition to the following:

Essential:

  • PhD in immunology, molecular or cellular biology or in the final stages of PhD submission

  • Experience with organoids and/or iPSCs

  • Experience with bioinformatics

  • Experience in molecular biology

  • Proven track record of research (e.g: publication record)

  • Strong written and oral communication skills

  • Ability to prioritise and manage own time

  • Ability to multi-task and integrate the demands of different activities in parallel

  • Ability to work independently and also capable of interacting and working within a group

Desirable:

  • Experience in flow cytometry, microscopy, single cell RNA sequencing data analysis using R or Python

Postdoctors are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.

Why join us? - Contribute to cutting-edge immunology research with real-world implications. - Collaborate with experts across the fields of immunology, virology, microbiology, and clinicians. - Work in a supportive and collaborative environment that fosters professional growth. Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please provide a statement of interest/cover letter, CV and 2 references.

Please quote reference PK41109 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant/Research Associate (Fixed Term)

Tue, 02/04/2024 - 00:00

Applications are invited for a BBSRC-funded postdoctoral vacancy in molecular biology to join a multi-disciplinary team based at the Department of Pathology in Central Cambridge. The successful candidate will study RNA-structure dependent translational regulation in response to environmental changes.

Candidates should have a PhD, or expect to obtain one shortly, and have a strong track record in RNA-based molecular biology and/ research. Where the successful applicant does not yet have a PhD, he/she will normally be appointed as a Research Assistant on the understanding that he/she will be appointed as a Research Associate upon successful completion of his/her PhD.

Relevant experience in RNA molecular biology is essential. Knowledge of biochemistry, bioinformatics and handling biosafety level 2 material would be advantageous. The successful candidate will use a range of next-generation sequencing techniques including ribosome profiling as well as molecular biology techniques such as in vitro transcription/translation, recombinant protein expression and protein-protein or protein-RNA interaction assays.

Other possible duties include developing research objectives and proposals for own or joint research; conduct individual and collaborative research projects; write up research work for presentation and publication; assist in the preparation of proposals and applications to external bodies; plan the use of research resources, laboratories and workshops as appropriate; may be required to assist in the supervision of student projects, provide instructions to students and deliver seminars relating to own research area.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries may be directed to Dr Betty Chung (bcy23@cam.ac.uk)

Please quote reference PK41122 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs