Post-doctoral Research Associate (Storer Lab) (Fixed Term)
Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).
The laboratory of Dr Mekayla Storer (https://www.stemcells.cam.ac.uk/people/pi/dr-mekayla-storer) uses multidisciplinary approaches to understand why the distal portion of the digit tip is the only part of the limb that can regenerate in mammals. The key step in this process is the formation of a blastema, a transiently proliferating mass of cells that the regenerates the different cell types of the digit to replicate the original structure. Therefore the broad goal of our research is to understand which cells and molecular pathways are necessary for this process. A portion of our present research builds on our previous work (Storer et al., Dev. Cell 2020) that used high-throughput single-cell mRNA sequencing and Cre-recombinase based lineage tracing to define the transcriptional identity of the mesenchymal cells comprising the blastema and the major transitions during mammalian digit tip regeneration. We are looking for a dedicated post-doctoral researcher with computational expertise to determine which of these factors present during digit tip amputation are necessary for successful regeneration and the mechanisms that underly this process. The post holder will use single cell transcriptomics/multi-omics approaches, spatial transcriptomics, computational modelling and receive additional supervision from the Teichmann group.
Requirements:
Successful applicants should have a PhD in the field of regenerative biology, bioinformatics, genomics, or cell/developmental biology or be close to the completion of their degree. Expertise in general areas of stem cell biology would be suitable for this position. A strong background in epigenetics and computational biology would be an advantage. It is essential that the post-holder is organized, able to work collaboratively as a member of a team and can communicate effectively and clearly.
Informal enquiries about the post are also welcome via email on Mekayla Storer ms2786@cam.ac.uk.
Fixed-term: The funds for this post are available for 12 months in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 27th August 2023
The interview date for the role is: To be confirmed
Please quote reference PS38130 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Senior Research Associate (Transcriptional Control of Cell Fate)
- The appointment will be at Senior Research Associate (Grade 9) and is subject to approval by the Faculty Board of Clinical Medicine.*
A Senior Research Associate position is currently available for an individual to work with considerable responsibility in the laboratory of Dr. Brian Hendrich within the Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk). The Hendrich Lab studies how chromatin remodelling proteins are used by cells to alter gene expression patterns during cell fate decisions. We focus on how chromatin remodellers and extracellular signalling pathways coordinate to alter enhancer chromatin as mouse and human pluripotent stem cells undergo lineage commitment.
The successful candidate will take a lead in driving forward our scientific programme investigating how extracellular signalling pathways interact with chromatin remodellers to direct lineage commitment in human pluripotent stem cells. Providing scientific leadership within the laboratory of Dr. Hendrich, the successful candidate will have considerable scope to set day-to-day research objectives, will work closely with Dr. Hendrich to ensure delivery on strategic scientific goals and will also develop and optimise research projects independently.
The successful candidate will have significant responsibility for scientific outputs of the lab including writing and editing publications, undertaking scientific talks and outreach, and grant preparation and monitoring. They will be expected to use their initiative and creativity to solve routine and non-routine problems related to research projects and technical development projects and will also undertake day-to-day management of lab finances and operations, interactions with the core facilities and wider collaborators and provide training, supervision and mentorship for students, postdocs and support staff in the lab.
The successful candidate will have a PhD, considerable post-doctoral experience in mammalian developmental biology, chromatin, transcription, molecular biology and biochemical techniques and method development. A proven track record in scientific publication is essential. Experience with human naïve pluripotent cell culture and manipulation is highly desirable. Experience of biochemical dissection of transcriptional regulation is essential, and experience of genome-wide transcriptional analysis would also be an advantage. Applicants must display an ability to undertake project management, work within a multi-disciplinary team environment, and have good presentation and
communication skills. The successful candidate will have experience maintaining a safe working environment, including a good working knowledge of UK health and safety regulations and preparation of detailed risk assessments.
Informal enquiries should be directed to Dr. Brian Hendrich, bdh24@cam.ac.uk.
Fixed-term: The funds for this post are available for 5 years in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 20th August 2023
The interview date for the role is: To be confirmed
Please quote reference PS38015 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Associate (Philpott lab) - Lineage Fidelity during Development and Reprogramming (Fixed Term)
A Postdoctoral Research Associate position is currently available for a highly talented and motivated individual to work in the laboratory of Prof. Anna Philpott within the Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk/people/pi/philpott). The Philpott lab has broad interests in understanding the fundamental mechanisms that determine cell fate choice and differentiation during embryonic development and in cancers, as well as how these processes are coordinated with cell cycle progression.
We are looking for a post-doctoral scientist to join our collaborative research team investigating transcriptional regulation of lineage fidelity during fate specification and differentiation. Within the laboratory, we use several experimental systems including embryos of the frog Xenopus laevis, as well as mammalian embryonic stem and cancer cell culture. Ongoing projects use Xenopus embryos as a highly versatile model system to uncover epigenetic and co-factor-dependent mechanisms underlying the cellular response to transcription factor reprogramming. We use many techniques including genome-wide analysis of gene expression in single and multiple cells, chromatin binding and accessibility studies, CRISPR genome editing as well as classical embryology and biochemistry. The role holder may take part in our collaboration with Prof. Allon Klein (Harvard Medical School).
The successful candidate will have a PhD and be experienced in using molecular biology and genome-wide approaches to probe transcriptional activity. While experience in the use of Xenopus as a model system would be desirable, full training can be provided and an enthusiasm to embrace this model alongside use of cultured cell systems is essential. Evidence of experience in developmental biology, neurobiology, reprogramming or a similar field, and a proven track record in scientific publication are also essential. Experience of bioinformatic analysis of genome-wide, and ideally single cell, data would be highly desirable although we will provide excellent infrastructure and bioinformatic support. Applicants must display an ability to undertake project management, work within a multi-disciplinary team environment, have excellent presentation and communication skills and the ability to contribute to an environment supporting researchers at all stages of their careers.
Our group is housed in the Wellcome-MRC Cambridge Stem Cell Institute, a world-leading centre for stem cell research with the mission to transform human health through a deep understanding of stem cell biology (https://www.stemcells.cam.ac.uk/).
Please contact Prof. Anna Philpott (ap113@cam.ac.uk) with any informal enquiries.
Fixed-term: The funds for this post are available until 31 March 2026 in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 4th September 2023
The interview date for the role is: To be confirmed
Please quote reference PS37941 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Assistant (Lee Lab) (Fixed Term)
The Wellcome - Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).
We are looking for a self-motivated, reliable and well-trained research assistant to join the research team of Dr Joo-Hyeon Lee (https://www.stemcells.cam.ac.uk/people/pi/lee). Lee lab studies how stem cells sense environmental changes and determine their cell fate in lung homeostasis and during lung regeneration after injury repair utilising sophisticated genetic mouse models with lineage tracing techniques, high-resolution imaging analysis, single cell transcriptomics, ex vivo mouse and patient-derived human organoid culture with CRISPR-mediated gene regulation. Successful applicants will learn diverse state-of-art techniques and be actively involved in research projects mainly using genetic mouse models, as well as play a role as a lab manger in the Lee Lab.
Requirement:
Successful applicants should have a Bachelor degree in a Bioscience related subject, at 2:1 minimum. A strong experience of murine genetic models and primary cell cultures is required for this post. Experience in confocal image analysis, CRISPR genome editing, and flow cytometry analysis will be highly advantageous. Good knowledge in development and stem cell biology, and molecular cloning would be preferable. Highly organised, independent, and collaborative persons should apply for this position.
Fixed-term: The funds for this post are available for 24 months in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 3rd September 2023
The interview date for the role is: To be confirmed
Please quote reference PS37936 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Associate (Philpott lab) - Oncogenic Transcriptional Regulation in the Paediatric Cancer Neuroblastoma
Neuroblastoma is a devastating paediatric cancer of the peripheral nervous system that causes 15% of all children's cancer deaths in the UK each year. Neuroblastoma arises from neuroblasts that fail to complete their normal developmental programme but are instead locked in a state of enhanced proliferation and inhibited differentiation. The goal of the Philpott lab is to exploit an understanding of normal neuroblast developmental control to restart differentiation in neuroblastoma cells by targeting a key transcriptional network both genetically and with drugs.
We are looking for a highly motivated post-doctoral scientist to join our collaborative research team to probe the molecular regulation of transcriptional networks that control proliferation versus differentiation of neuroblastoma cells. Ongoing projects are interrogating the transcriptional mechanism of action of inhibitors and drugs that can drive neuroblastoma tumour differentiation, with the aim of developing new therapeutic approaches for this terrible disease. The role may include genome-wide analysis of transcription factor binding and activation using ChIPseq, RNAseq and ATACseq techniques, CRISPR screening in neuroblastoma cell lines, as well as other molecular and cellular analyses to dissect neuroblastoma cell behaviour. The role holder will collaborate with Dr Jason Carroll (CRUK Cambridge Institute) who has extensive experience in genome wide analyses and CRISPR screening, and we will provide excellent infrastructure and bioinformatics support. The role holder may also take an active part in our collaboration with Dr Louis Chesler (The Institute of Cancer Research, London) and Prof Suzanne Turner (Pathology Dept, Cambridge) who use mouse models of neuroblastoma to test drugs to drive neuroblastoma differentiation.
Our group is housed in the Wellcome-MRC Cambridge Stem Cell Institute, a world-leading centre for stem cell research with the mission to transform human health through a deep understanding of stem cell biology (https://www.stemcells.cam.ac.uk/).
Please contact Prof. Anna Philpott (ap113@cam.ac.uk) with any informal enquiries.
Fixed-term: The funds for this post are available until 30 September 2024 in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 30th August 2023
The interview date for the role is: To be confirmed
Please quote reference PS37882 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Tissue Culture Cleaner (Part Time, Fixed Term)
The Stem Cell Institute Tissue Culture Facility provides services to research scientists to enhance their research. These services include maintaining and cleaning specialised pieces of equipment. The facility is looking to recruit a cleaner to support this service.
Successful candidates will undertake cleaning duties in the laboratory environment. Experience in a similar role is not essential as full training will be provided. It is important is that you are reliable, conscientious and able to interact with people. The role is physical and is likely to involve lifting and carrying large items.
The contract would be for 11 hours a week in core working time (Monday to Friday), but hours can be flexible on agreement.
Additional benefits, which include:
- Contributory workplace pension with generous employer contributions
- Five weeks annual leave (plus public holidays) and long service holiday accrual
- Cycle to work scheme
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 17th August 2023
The interview date for the role is: To be confirmed
Please quote reference PS37879 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Associate (Laurenti Lab) (Fixed Term)
Applications are invited for the position of Research Associate to join the group of Dr Elisa Laurenti within The Wellcome Trust Medical Research Council Cambridge Stem Cell Institute and Department of Haematology on the Cambridge Biomedical Campus. This project will be run jointly by Dr Laurenti and Prof Göttgens, with funding provided by the Aging Biology Foundation. It will characterise how blood ages, by generating a functionally annotated single cell map of the ageing blood stem and progenitor compartment in humans. This will be achieved studying primary human samples in depth by combining many single cell technologies (scRNA-seq/scATACseq, CITE-Seq, WGS and functional assay of blood production coupled with barcoding technologies). A key biological question we aim to address is why the population of blood stem and progenitor cells functionally declines as we age. This will involve defining the cellular and molecular heterogeneity of blood stem and progenitor cells, linking this to functional changes in the production of mature blood cells, and understanding how somatic mutations inevitably acquired with age contribute to the processes above.
Candidates should hold a PhD in a relevant field. They will have a strong background either in haematopoiesis, malignant haematology or ageing. Experience working with primary haematopoietic samples and flow cytometry is required. The candidate should also possess some experience with single cell -omics technologies and/or genomics. Additional expertise of high-throughput sequencing data analysis or of working closely with bioinformaticians would be desirable. Finally, they will have demonstrated a strong scientific achievement via their publication record.
The post holder is expected to creatively and independently carry out their own research project, while collaborating on a regular basis with a team of experimentalists and computational biologists. They will also effectively communicate their work in writing and oral presentations at internal meetings and international conferences.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is 14th of September 2023.
Interviews are likely to be held on 21th, 22nd and/or 25th of September 2023.
Please quote reference RB37867 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Post-doctoral Research Associate (Lee Lab) (Fixed Term)
The lab of Dr Joo-Hyeon Lee (https://www.stemcells.cam.ac.uk/people/pi/lee) at the Wellcome Medical Research Council Cambridge Stem Cell Institute is looking for a Postdoctoral Fellow/Research Associate to work on an innovative, multi-disciplinary, and collaborative project that investigates the mechanism conferring cell fate competency during tissue regeneration and its significance in disease development
The successful candidates will benefit from multi-disciplinary collaborations and highly innovative experimental model systems (e.g. in vivo novel lineage tracing mouse models, ex vivo mouse and patient-derived human lung organoids, single cell multi-omics, high-resolution imaging platforms, biophysical clonal modelling, etc.) enabling functional interrogation of cell fates and states during regeneration and disease initiation (Lee Lab Publications: Lee et al. Cell 2017; Ombrato et al. Nature 2019; Choi et al. Cell Stem Cell 2020; Youk et al. Cell Stem Cell 2020; Yum et al. Nature 2021; Choi et al. Nature Cell Biol. 2021; Jeon et al. EMBO J. 2022).
Candidates should be enthusiastic about collaborative and interdisciplinary research, the use of innovative technologies, productive, and highly motivated to develop as independent scientists. A strong background in development and stem cell biology, as well as expertise in animal models (preferably genetic mouse models) and multi-omics computational analysis, are required for this post. Experience in primary cell cultures, flow cytometry, and CRISPR genome editing would be advantageous. Candidates will work closely with lab members and collaborators to ensure the quality of our work.
The Wellcome - Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).
Appointment at Research Associate level is dependent on having a PhD, an equivalent research doctorate. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once PhD has been awarded.
Fixed-term: The funds for this post are available for 24 months in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 27th August 2023
The interview date for the role is: To be confirmed
Please quote reference PS37813 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Postdoctoral Computational Biologist/ Research Associate (Alcolea lab)
We are seeking a Postdoctoral Computational Biologist to work in a multi-disciplinary team focused on studying epithelial cell fate reprogramming and plasticity during ageing. The ultimate aim of this research programme is to identify potential targets to partially reduce/reverse age-related complications. This Postdoctoral Computational Biologist/Research Associate position will be based in the group of Dr Maria P. Alcolea (Wellcome ¿ MRC Cambridge Stem Cell Institute; CSCI). This represents a collaborative effort with Prof. Steffen Rulands at Faculty of Physics, Ludwig-Maximilians, University of Munich.
We welcome applications from candidates with experience in the application of computational methods, advanced methods in the field of data science and statistical physics. The role holder will have a key position in analysing existing as well as newly generated multi-omics datasets, including single-cell RNA sequencing. There will be opportunity to develop other quantitative skills, as well as establish collaborative projects with experimental scientists in the lab.
Applicants should have completed, or be close to completion of, a PhD in a relevant subject for example applied mathematics, computer science, genetics, or molecular biology. The ideal candidate will have a strong background in, and exceptional enthusiasm for computational biology, as well as a strong interest in the underlying biological/disease processes and a passion for data driven science. We are looking for a highly motivated and enthusiastic individual capable of thinking and working independently, and as part of a multi-disciplinary team.
Informal enquiries can be directed to Dr Maria Alcolea (mpa28@cam.ac.uk)
Fixed-term: The funds for this post are available until 31 December 2025 in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 13th August 2023
The interview date for the role is: To be confirmed
Please quote reference PS37646 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Laboratory Technician (Stem Cell Biology) (Boroviak lab)
The Boroviak lab is recruiting a dedicated lab manager to support our work on stem cell-based embryo models.
Our lab focuses on how embryonic cells organise themselves to form the most complex lifeforms, such as human and non-human primates. We follow primate embryonic cells through parts of their journey to provide insights into human development. Our approaches include spatial transcriptomics, embryonic stem cell culture and bioengineering of stem cell-based embryo models.
The postholder will actively contribute to our research and be responsible for ensuring that the Boroviak laboratory runs smoothly and safely. Experience with CRISPR/Cas9 based genomic engineering and/or human pluripotent stem cell culture are essential. The ideal candidate will be a team player with excellent communication skills and support a variety of experimental procedures, imaging and data collection as well as preparing results for publications. The post also entails maintaining the infrastructure of the laboratory areas, ordering of equipment and reagents, training students and visiting researchers in techniques and equipment use, as well as instructing correct safety procedures.
Our work is highly collaborative and we operate over two lab sites, the Centre for Trophoblast Research and the Cambridge Stem Cell Institute. Both sites provide access to state-of-the-art equipment and facility support.
Essential requirements are a first degree in a relevant subject or equivalent experience. The ideal candidate will have experience in either stem cell biology, organoid culture, and/or genomic engineering.
Informal enquiries can be directed to Dr. Thorsten Edwin Boroviak (teb45@cam.ac.uk) and further information can be found on our lab website (https://boroviaklab.pdn.cam.ac.uk/).
Fixed-term: The funds for this post are available for 2 years in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload (i) a covering letter, clearly stating why you would like to join our lab and your future career aspirations, (ii) a one-page research proposal on how to model human development with bioprinting (illustrations welcome, min. font size 10) and (iii) an academic CV with three references.
The closing date for applications is: 17th September 2023
The interview date for the role is: 28th and 29th September 2023
Please quote reference PS37637 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Associate (Stem Cell Biology-Bioengineering) (Boroviak lab) (Fixed Term)
The Boroviak lab is recruiting a highly enthusiastic individual to carry out ground-breaking research on bioprinting human embryo models.
We will tackle the origin of human body axis formation, which occurs during the second week of gestation. Deeply embedded within extraembryonic tissues, gastrulation transforms the embryonic disc into three germ layers and organizes the future body plan. All of these events are essential for healthy embryo development, but in human they have been notoriously hard to study for ethical and technical reasons.
Building on our insights from spatial profiling of primate gastrulation in utero (Bergmann et al., Nature 2022), the postholder will pioneer next-generation human embryo models to functionally dissect germ layer formation. The research associate will be responsible for driving various bioprinting approaches to emulate embryogenesis in vitro. Validation includes single-cell transcriptomics and spatial-identity-mapping to our existing embryo datasets. Ultimately, the goal is to interrogate the molecular cross-talk between embryonic and extraembryonic lineages with human and marmoset reporter and knock-out pluripotent stem cell lines in bioprinted embryo models.
Located in the heart of Cambridge, our laboratories are based within a multidisciplinary hub for technology and innovation. We operate from two sites, the Centre for Trophoblast Research and the Cambridge Stem Cell Institute with access to state-of-the-art equipment and facility support. This research project is highly collaborative; we are looking for a team player with excellent communication skills. Essential requirements are a PhD or equivalent experience in bioengineering, stem cell biology, bioinformatics or genomics. Most importantly, the ideal candidate will have a can-do attitude with a genuine drive to push boundaries.
Informal enquiries can be directed to Dr. Thorsten Edwin Boroviak (teb45@cam.ac.uk) and further information can be found on our lab website https://boroviaklab.pdn.cam.ac.uk/.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter, a one-page Research proposal and a CV in the Upload section of the online application. The covering letter should highlight why you would like to join our lab and your future career aspirations. A one-page research proposal on how to model human development with bioprinting (illustrations welcome, min. font size 10)
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 17th September 2023
The interview date for the role is: 28th September and 29th September
Please quote reference PS37605 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Postdoc Computational Biologist/Research Associate (Fixed Term)
We are seeking a Post-doctoral Computational Biologist to apply novel machine learning and artificial intelligence approaches to existing as well as newly generated multi-omics datasets.
PROJECT: Inflammatory Bowel Diseases (IBD) such as Crohn's Disease (CD) and Ulcerative Colitis (UC) cause chronic, relapsing inflammation of the intestine. In the absence of a cure, patients suffer a lifetime of debilitating symptoms. This project aims to develop and apply novel computational methods to existing and newly generated molecular multimodal datasets derived from primary human tissue samples as well as patient-derived intestinal organoids. As part of a large multi-disciplinary team the candidate will develop molecular disease classifiers and clinical biomarkers as well as identify novel treatment targets. The latter will then be tested on our patient-derived organoid models to identify the most promising candidates for further development into novel treatments.
CANDIDATE: Applicants should have completed a PhD in a relevant subject for example applied mathematics, computer science, genetics, or molecular biology. The ideal candidate will have a strong background in, and exceptional enthusiasm for, computational biology and machine learning, as well as a strong interest in the underlying biological/disease processes and a passion for data driven science. We are looking for a highly motivated and enthusiastic individual capable of thinking and working independently, and as part of a multi-disciplinary team.
ENVIRONMENT: The post-holder will join a diverse, supportive, and friendly team of scientists, clinicians, and other professionals based at the Wellcome-MRC Cambridge Stem Cell Institute (CSCI) and the Department of Paediatrics, University of Cambridge. This project is a close collaboration between the groups of Dr Matthias Zilbauer (CSCI) and Dr Namshik Han (Milner Therapeutics Institute (MTI)). The post-holder will therefore be part of the MTI computational research group led by Dr Namshik Han. The CSCI and the MTI are both located in the Jeffrey Cheah Biomedical Centre, based at the heart of the Cambridge Biomedical Research Campus providing access to state-of-the-art research facilities.
Personal development: Our aim is to provide a supportive and inspiring work environment that enables each individual team member to thrive and reach their maximum potential. In addition to a wide range of professional development opportunities offered by CSCI and University of Cambridge, the post-holder will be encouraged (and financially supported) to present their work at national and international meetings. The development of a collaborative network and participation in relevant trainings courses is highly encouraged. Further information on opportunities for post-doctoral researchers including college the Postoc Careers Service and the CSCI Postdoc Mentoring Scheme can be found here: https://www.stemcells.cam.ac.uk/join-us/postdocs
FUNDING: Funding is available for 3 years in the first instance. The successful candidate will be encouraged and supported to obtain external personal fellowship and grant support.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 2nd August 2023
The interview date for the role is: TBC
Please quote reference PS36282 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Computational Biology Research Associate (Philpott lab) (Fixed Term)
The Philpott group in the Wellcome - MRC Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk/people/pi/philpott), in collaboration with the Simons group at the Wellcome/CRUK Gurdon Institute (https://www.gurdon.cam.ac.uk/people/ben-simons/), are seeking a Research Associate in Computational Biology.
Mechanisms that lead to the establishment and maintenance of cell identity are paramount for organismal health. They also underpin successful cellular reprogramming for disease modelling and cell replacement therapies. Alongside experimental lab work using embryonic stem cells, cancer cells and Xenopus frog embryos, the Philpott lab, in collaboration with the Simons lab, makes use of computational approaches to study mechanisms of lineage fidelity and transcriptional reprogramming of cell fate during development and in disease. Current interests include the roles played by the epigenome and cofactors in regulating lineage transcription factor-mediated establishment and stabilisation of cell fate.
With experience in the application of computational methods, the role holder will have a key position in analysing single-cell and bulk genome-wide datasets across a range of projects and experimental model systems. This is a vital position in the Philpott group and the role holder will work closely with experimental colleagues to transform sequencing data into biologically meaningful information. Reflecting this central role in data analysis and integration, the role holder's contributions will be acknowledged accordingly. There will also be the opportunity to carry independent research in close collaboration with experimental scientists in the lab.
Applicants should have a strong background in computational biology, and prior experience in the analysis of high-throughput genomic and transcriptomic data. Previous experience in the analysis of single-cell data would be an advantage. The applicant should have a PhD in a relevant subject, a sound understanding of molecular biology, and a strong publication track-record. As well as being able to work independently, the role requires strong communication skills and the ability to work in a dynamic multidisciplinary team environment.
The Philpott lab is located in the Cambridge Stem Cell Institute, which provides a stimulating environment that promotes collaborative and interdisciplinary research. Its postdoc association encourages scientific and social interactions and provides career development and teaching opportunities.
Informal enquiries can be directed to Dr Frances Connor (fac31@cam.ac.uk)
Fixed-term: The funds for this post are available until 31 March 2026 in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 19th July 2023
The interview date for the role is: To be confirmed
Please quote reference PS35805 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Assistant (Hendrich Lab) (Fixed Term)
A Research Assistant position is currently available for an individual to work in the laboratory of Dr. Brian Hendrich within the Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk/people/pi/hendrich).
The Hendrich Lab studies how chromatin remodelling proteins are used by cells to control gene expression patterns during cell fate decisions. We focus on how chromatin remodellers and extracellular signalling pathways coordinate to alter enhancer chromatin as mouse and human pluripotent stem cells undergo lineage commitment.
The successful candidate will join a project focused on determining how a chromatin remodelling complex controls expression of short interspersed nuclear elements (SINEs) in human pluripotent cells and orchestrates their use as enhancers during neural crest development. We are looking for an enthusiastic and dedicated research assistant who will contribute to this project and be an integral member of our team. Creativity and personal initiative are highly encouraged. Candidates will be encouraged to help form the research direction and it is expected that the successful candidate will lead dedicated sub-projects within the lab. The role requires fastidious human stem cell culture work, so a good working knowledge of mammalian cell culture experience is essential. Experience with chromatin and/or repetitive elements would be advantageous.
The successful applicant will have a BSc degree (or equivalent), a strong grasp of molecular and biochemical lab techniques and several years' basic laboratory experience. Good interpersonal/communication skills are essential, as is the ability to work independently as well as within a laboratory team, as required. You should be self-motivated and able to organise, perform and analyse experiments with minimal instruction and supervision. The post will require frequent weekend work and a flexible approach to working hours. Careful observation and accurate record keeping are essential. You will be required to give oral presentations of your research work to other lab members and prepare figures and text for publications.
The Wellcome - MRC Cambridge Stem Cell Institute (CSCI) is a world-leading centre for stem cell research with the mission to transform human health through a deep understanding of stem cell biology. https://www.stemcells.cam.ac.uk/.
Informal enquiries should be directed to Dr Brian Hendrich (bdh24@cam.ac.uk).
Fixed-term: The funds for this post are available until 30 April 2026 in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 6th July 2023
The interview date for the role is: To be confirmed
Please quote reference PS37155 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Histology Technician (Part Time, Fixed Term)
The Wellcome - MRC Cambridge Stem Cell Institute is seeking a motivated and detail-oriented Histology Technician to join our Scientific Facilities team. You will be responsible for preparing and processing samples for microscopic examination, providing a core service to support innovative research projects. This is an excellent opportunity for someone with a strong background in histology and an efficient, professional, and friendly approach.
You should be comfortable working independently or as part of a team and be able to prioritise and manage your time effectively. You will be familiar with a range of histological preparation techniques, with extensive experience in preparing and handling paraffin and cryopreserved specimens, cutting sections, staining, and mounting sections both by hand and using automated equipment.
You will have excellent communication skills and the ability to build good working relationships with others in a diverse and collaborative environment. An A level/NVQ3 educational level, or equivalent, is also required, along with knowledge of mouse and human anatomy
This is a part-time role for 0.5 FTE (18.25 hours per week).
Fixed-term: The funds for this post are available for 3 years in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 17th July 2023
The interview date for the role is: To be confirmed
Please quote reference PS37136 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
