http://www.jobs.cam.ac.uk/job/?unit=u10044&format=rss

Senior Research Associate (£45,585-£57,696) or Principal Research Associate (£66,857-£77,476) depending on skills and experience.

The Cambridge Stem Cell Institute is a world-leading centre for stem cell research with a mission to transform human health through a deep understanding of stem and progenitor cell biology (http://www.stemcells.cam.ac.uk). The Institute is located in the Jeffrey Cheah Biomedical Centre, a state-of-the-art building adjacent to Addenbrooke's and Royal Papworth Hospitals and multiple research institutes (http://cambridge-biomedical.com). This has nucleated a fully integrated, vibrant and cohesive stem cell community ideally placed to capitalise on the surrounding unique intellectual and clinical environment. The Institute currently has 28 research groups with approximately 300 biological, computational, clinical and physical scientists operating across a wide range of tissues and at multiple scales. CSCI benefits from long-term investment by Wellcome, most recently via a new Discovery Research Platform for Tissue Scale Biology (https://www.stemcells.cam.ac.uk/news/launch-discovery-research-platform-tissue-scale-biology) . The Institute also serves as a hub for the wider stem cell community across Cambridge and has more than 30 affiliated researchers across 13 University departments and the neighbouring Babraham and Sanger Institutes.

The Institute has openings for a new Group Leader who will complement and synergise with our existing programmes. We welcome applications from across the entire range of basic and translational stem/progenitor cell biology, including experimental and/or computational research relevant to:

• Cardiovascular, glial/neural or epithelial tissues.
• Cell and Gene therapy.
• Organ regeneration and repair.

This would be ideal for a candidate with a minimum of 3 years post-doctoral experience, distinctive research achievements and a cutting-edge research plan for the next 5 years. Interdisciplinary and collaborative research is strongly encouraged across the University and its associated institutes. The Institute offers a collegiate environment with excellent core facilities, extensive opportunities to pursue basic and disease focussed studies. Successful candidates will be supported to obtain external personal fellowship and grant support, prior to contracts commencing. Interim start-up packages may be available depending on individual circumstances.

Applicants should upload a cover letter, curriculum vitae (max 3 pages, to include date of PhD and details of any career gaps if applicable) with contact details of 3 referees, and a 3-page outline of your research proposal, by 21st October 2024.

Informal enquiries about the post are welcome via email to Anthea Stanley (ajs333@cam.ac.uk).

Benefits include generous maternity / paternity leave, flexible working, funds for returning carers and other family-friendly schemes.

Fixed Term: The offer of any position will be conditional on the candidate securing a fellowship which includes their salary. Candidates may already have secured a fellowship in which case the end date of the post would be the same as the end date of fellowship. If candidates have not already secured a fellowship they will only be able to take up appointment when they have done so - the tenure of the appointment will be the length of the fellowship term.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Research Associate (SRA) level; appointment as an SRA will require evidence of an independent research reputation. Due to the levels of skills and experience required we anticipate making an appointment either on the RA scale or towards the bottom of the SRA scale.

Approval to Senior Research Associate is subject to Faculty Board approval.

Closing date: 21st October 2024

Date of interview: Interviews will be held over a 2-day period likely to be in Late October/Early November.

Please quote reference PS43203 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

A Senior Research Associate position is available for a highly talented and motivated individual to work with considerable responsibility in the laboratory of Prof. Anna Philpott within the Cambridge Stem Cell Institute, a world-leading centre for stem cell research. The Philpott lab has broad interests in understanding the fundamental mechanisms that determine cell fate choice and differentiation, and their coordination with the cell cycle, during embryonic development and cellular reprogramming. Understanding how cells maintain a correct identity may help to advance regenerative therapies and provide new strategies to treat cancers.

The successful candidate will take a lead with Prof Anna Philpott in driving forward the scientific programmes in the lab. A major focus of research for this role-holder will be to use iPSC-derived truck-like structures to investigate transcriptional regulation of lineage fidelity during fate specification and differentiation, focusing on uncovering epigenetic and co-factor-dependent mechanisms underlying this control. This work will be complemented by ongoing studies of similar developmental mechanisms in embryos of the frog Xenopus laevis and by studies of conflicting cues of lineage formation using embryonic stem cells. Within the laboratory, we use a number of experimental systems and many techniques including genome-wide analysis of gene expression in single and multiple cells, chromatin binding and accessibility studies and CRISPR genome editing, alongside classical embryology and biochemical approaches. Our overall goal is to exploit an understanding of normal transcriptional and developmental control to enhance cellular reprogramming and develop new treatments for cancer.

We are looking for a scientist with significant post-doctoral experience in research and a proven track record in supporting more junior scientists. Providing scientific leadership within the laboratory, the successful candidate will work closely with Prof. Anna Philpott to ensure delivery of strategic scientific goals, while having considerable scope to set day-to-day research objectives. The successful candidate is expected to develop research projects independently, in consultation with Prof Philpott, and use their initiative and creativity to solve problems as well as provide support to more junior scientists in the laboratory. They will have significant responsibility for scientific outputs of the lab including grant preparation and management, writing and editing publications, as well as undertaking scientific talks and outreach. The successful candidate will have a PhD, considerable post-doctoral experience in stem cell biology, epigenetics, molecular biology, developmental biology, or a similar field, and a proven track record in scientific publication. Prior experience in mammalian cell culture is essential. Experience of transcriptional regulation and/or epigenetics, as well as experience of genome-wide transcriptional analysis and analysis at the single cell level, are also essential. Applicants will be able to assess, interpret and evaluate outcomes of research and translate knowledge of advances in the field into research activity. They must display an ability to undertake project management, have good presentation and communication skills and the ability to support researchers at all stages of their careers.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Please contact Prof. Anna Philpott (ap113@cam.ac.uk) with any informal enquiries.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV and research proposal of no more than 3 pages in length in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Research Associate (SRA) level; appointment as an SRA will require evidence of an independent research reputation. Due to the levels of skills and experience required we anticipate making an appointment either on the RA scale or towards the bottom of the SRA scale.

The closing date for applications is: 2nd September 2024

The interview date for the role is: To be confirmed

Please quote reference PS42963 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

Applications are invited for a Biomedical Research Technician position in the group of Dr Mekayla Storer within the Cambridge Stem Cell Institute (CSCI) based at the Cambridge Biomedical Campus. Our group is focused on understanding why mammals do not regenerate their limbs following amputation. Surprising, it has been shown that some mammalian digit tips (including mice and humans) can regenerate following removal of the tip, demonstrating that mammals are capable of innate tissue regeneration.

The successful candidate will provide support for researchers that investigate digit tip regeneration in mice to gain a broad understanding of which cells and molecular pathways are necessary for this process.

We are seeking a developmental biologist with prior experience of laboratory-based research and expertise in handling mice. The successful candidate will be expected to support the research team by providing technical assistance in the research projects and recording data from experiments. As such, the candidate should have good interpersonal skills, be organized and pay attention to detail. Other responsibilities include a wide range of tasks to ensure the smooth running of the laboratory, including ordering and maintaining laboratory supplies, as well as maintaining and updating protocols and reagent databases.

An understanding of the principles of cellular and molecular biology (histology, DNA & RNA extraction, cell culture) or computational experience would be desirable.

Fixed-term: The funds for this post are available until 31st October 2026 in the first instance with prospect of renewal.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

Informal enquiries should be directed to Dr Mekayla Storer on ms2786@cam.ac.uk.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 6th September 2024

The interview date for the role is: Tuesday 10th or Wednesday 11th September

Please quote reference PS42940 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited to join a dynamic team led by Prof Sanjay Sinha (https://www.sinha-lab.org/ and https://www.stemcells.cam.ac.uk/people/pi/sinha), to investigate human heart development using single cell technologies and in vitro modelling.

Cardiovascular diseases are the leading cause of mortality worldwide, necessitating the development of more effective treatments. The heart is composed of various cell types, each with distinct roles in health and disease, and single cell technologies can dissect this cellular heterogeneity. Our research focuses on leveraging stem cells to model and study cardiovascular diseases in a human-specific manner, aiming to bridge the gap between existing models and the true physiology and pathophysiology observed in humans.

Recently, we have generated a high-resolution map of the developing human heart and the great vessels. The developmental information obtained through single cell genomics can enhance the fidelity of stem cell-derived cardiac models. This project will focus on mimicking the natural developmental processes, to generate more physiologically relevant cardiac cells in vitro, improving their utility for disease modeling and drug testing.

Knight-Schrijver, Nature Cardiovascular Research (2022) Bayraktar, BioRXiv (2024) Cranley, BioRXiv (2024)

We are seeking highly motivated postdoctoral scientists to join our team and advance our understanding of cardiovascular diseases through innovative approaches. This position will be based at the Sinha lab within the Cambridge Stem Cell Institute at the University of Cambridge. The Sinha lab focuses on using pluripotent stem cell-based systems to generate cardiovascular cells including 3D engineered heart tissues.

The successful candidate will be highly motivated, collaborative and have expertise in pluripotent stem cell biology and cardiac biology. Prior experience in single cell genomics, stem cell culture and gene editing is highly desirable. Key Responsibilities:

Develop and optimize stem cell-based models for disease modeling Analyze single-cell data to uncover insights into cardiac cell development and disease mechanisms Use bioinformatics tools to interpret large-scale genomic data and identify key regulatory pathways involved in heart development Generate new cell lines through genetic editing

A Ph.D. in cardiovascular biology, stem cell biology, molecular biology, genomics, or a related field Strong background in stem cell culture and differentiation techniques Experience with single-cell RNA sequencing and related computational analysis Proficiency in bioinformatics and statistical analysis software (e.g., R, Python) Ability to work independently and as part of a collaborative research team

Fixed-term: The funds for this post are available until 30 September 2024 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference PS42768 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Finance Assistant to work in the joint administration team supporting the Department of Haematology and the Cambridge Stem Cell Institute (CSCI). The Department of Haematology is one of 11 departments and 7 Institutes within the School of Clinical Medicine (SCM) http://www.haem.cam.ac.uk/. The Institute is a world-leading centre for stem cell research with a mission to transform human health through a deep understanding of stem and progenitor cell biology (http://www.stemcells.cam.ac.uk).

This role is based in the Jeffrey Cheah Biomedical Centre located on the Cambridge Biomedical Campus.

The Finance Assistant under the supervision of the Finance Coordinator will provide Finance Service to all Department of Haematology and Institute staff. We are looking for someone who has the ability to communicate at all levels and who can maintain a high level of accuracy whilst working to deadlines. The ability to work within a small team is essential.

A suitable candidate will be educated to A level standard /NVQ level 3 or an equivalent level of practical experience. They should have finance experience, ideally in a university setting. Candidates should be an experienced user of Microsoft Office and have a working knowledge of financial management software/systems. They should be flexible, with the ability to communicate at all levels and be well-organised so as to manage conflicting deadlines.

Though this is envisioned as a full-time role with the possibility of hybrid working, we will consider requests for arrangements such as part-time work, flexible hours or job shares.

If you feel you have the qualities that we are looking for and would like to work in this friendly team, we look forward to receiving your application.

Informal enquiries about the post are also welcome via email David Hughes, Finance Coordinator on dch43@cam.ac.uk.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 1st September 2024

The interview date for the role is: week commencing 09 September 2024

Please quote reference PS42734 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The purpose of this role is to support and maintain the University's national and international reputation for excellence in research. Contribution to excellence in research will be as a member of a research team carrying out research at a similar level to that undertaken by lecturing staff and will provide substantial scope for academic judgement, originality, interpretation and presentation of results. The role holder might assist with grant administration and the writing of reports for funding bodies. The role holder will participate in the overall contribution of the Institute, as appropriate.

Key responsibilities

Research and Scholarship

• Develop research objectives and proposals for own or joint research.
• Conduct individual and collaborative research projects.
• Write up research work for presentation and publication.
• Continually update knowledge and understanding in field or specialism.
• Translate knowledge of advances in the subject areas into research activity.
• Manage own research and administrative activities, with guidance if required.
• Assist in the preparation of proposals and applications to external bodies, e.g. for funding and contractual purposes.
• Communicate material of a specialist or highly technical nature.

Liaison and Networking

• Liaise with colleagues and students. -Build internal and external contacts and participate in networks for the exchange of information and to form relationships for future collaboration.

Planning and Organising

• Plan the use of research resources, laboratories and workshops as appropriate.
• Plan and manage own research activity in collaboration with others.
• Contribute to planning of joint research projects led by principal investigator.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 5th September 2024

The interview date for the role is: End of w/c 9th September 2024

Please quote reference PS42659 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Bulstrode Lab studies the biology of neural stem cells in development, cancer and neurodegeneration. We are also developing new technology for targeted delivery of treatments to patients. Recent grant awards from Parkinson's UK and Brain Research UK will each fund a Postdoctoral Research Associate to join the group and work respectively on:

(1) 'Developing an Adaptable Dopamine Cell Therapy for Parkinson's Using the HIF Pathway'

(2) 'Gene and mRNA therapy approaches to Tumour Associated Macrophages in Glioblastoma'.

The successful candidates will have a strong basic science research track record at doctoral level. Experience in some or all of mammalian cell culture, routine molecular biology workflows, imaging, cloning, and next generation sequencing analysis is highly desirable.

We benefit from privileged access to human patient tissue resected at operation and to human embryo brain tissue, and you will be applying the above techniques to state-of-the-art human model systems including:

• Primary patient-derived cell lines
• Pluripotent stem-derived neurons and organoids.
• Human brain organotypic slice culture
• Isolated human brain cell fractions

Alongside the aptitude and initiative to pursue personal research objectives, candidates will need to demonstrate the scientific knowledge, expertise and enthusiasm to help guide students day-to-day, contribute scientifically and socially to the lab and wider institute, and contribute some admin and organisational duties. It is essential that the successful candidate can work both independently and as part of a research team, with good communication and organisational skills.

Key responsibilities

• Plan and manage your research project work and coordinate day-to-day research activity within the framework of the agreed programme.
• Already be familiar with or have the capacity to become quickly familiar with standard research techniques detailed ('Relevant Experience' below).
• Analyse and interpret research results including next generation sequencing datasets
• Present research progress and outcomes at lab meetings and conferences
• Keep abreast of developments and publications in the field
• Advise based on your experience and expertise on student research questions, experimental design, interpretation and presentation in the wider group.
• Contribute to lab administrative duties e.g. maintenance of safety and tissue records, laboratory duty rotas and ordering of supplies.
• Liaise with colleagues and students around day-to-day lab business and establishing links to expand knowledge and understanding, and develop collaborations
• Contribute pro-actively to collaborative projects with colleagues in partner institutions, and research groups.

Fixed-term: The funds for this post are available for 30 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 8th September 2024

The interview date for the role is: Soon after the post closes

Please quote reference PS42651 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Tzelepis lab is recruiting a dedicated lab technician to support our translational work on novel RNA biology of disease.

Our lab focuses on the epitranscriptomic roles of stem cell homeostasis and disease. Our approaches include functional genetics, normal and cancer stem cell cultures, development and characterisation of novel treatments as well as various mouse models of disease.

Key responsibilities

The postholder will actively contribute to our research and be responsible for ensuring that the Tzelepis laboratory runs smoothly and safely. The ideal candidate will be a team player with excellent communication skills and support a variety of experimental procedures, animal handling, imaging and data collection as well as preparing results for publications. The post also entails maintaining the infrastructure of the laboratory areas, ordering of equipment and reagents, as well as instructing correct safety procedures.

Our work is highly collaborative and we operate at the Cambridge Stem Cell Institute and the wider scientific ecosystem (Babraham campus, Sanger Institute etc.) with access to state-of-the-art equipment and facility support.

Essential requirements are a first degree in a relevant subject or equivalent experience. The ideal candidate will have experience in either stem-cell/cancer biology, mouse models and/or nucleic acid editing.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 18th August 2024

The interview date for the role is: Likely to be 29th or 30th of August

Please quote reference PS42609 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Research Technician position in the group of Dr Richard Tyser within the Cambridge Stem Cell Institute (CSCI) based at the Cambridge Biomedical Campus. The Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

The Tyser Lab studies how the mammalian heart forms during embryonic development, exploring how the initiation of function occurs and to what extent this defines and influences the progression of subsequent cardiac morphogenesis. We use a combination of different models including primary mouse and human samples as well as in vitro human Pluripotent Stem Cell differentiation (Tyser, Ibarra-Soria et al. Science 2021; Tyser, Mahammadov et al. Nature 20201; Tyser, Miranda et al. Elife 2016). This research will answer questions of fundamental biological importance with clear clinical relevance such as providing new insight into the origins of Congenital Heart Defects (CHD) as well as augmenting cell-based approaches to treat disease. We are seeking an enthusiastic and dedicated Research Technician to join our research group with prior experience of laboratory-based biological research, and ideally with expertise in handling mice. The successful candidate will support the research team by providing technical assistance, such as aiding in the management of genetic mouse models. As such, the candidate should have good interpersonal and organisational skills, paying close attention to detail. Other responsibilities include a range of tasks to ensure the smooth running of the laboratory, such as ordering and maintaining laboratory supplies, and maintaining and updating protocols and reagent databases. An understanding of the principles of cellular and molecular biology (DNA & RNA extraction, quantitative PCR, molecular cloning) or computational experience would be desirable.

For this position we would welcome applications for part-time/flexible working patterns, including shorter working days.

Responsibilities/duties

• Provide support and technical assistance for research projects. Conduct experimental protocols and techniques from general verbal instructions, prepare and analyse samples, collating results for interpretation by self and others.
• Aid in the management of genetic mouse model colonies and in vivo experiments.
• Maintenance and running of the research laboratory. Instruct research students and staff in the correct application, use and maintenance of equipment, established laboratory procedures and routine experimental techniques. Advise on solutions, sample preparation and analysis methods that could be used, considering time and financial constraints
• Ensure the laboratory has adequate stocks of sterile media, disposables, and equipment. Place orders for consumables, and equipment when required and process delivery notes.
• Liaise with the departmental safety officer to ensure codes of practice and relevant safety regulations are implemented and observed within the research laboratory, carry out risk assessments as well as introduce new staff and researchers to the health and safety procedures within the laboratory.

Fixed-term: The funds for this post are available until 30 October 2029 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 9th September 2024

The interview date for the role is: 16th September 2024

Please quote reference PS42605 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking an enthusiastic person to join our Building Services Team in the new Jeffrey Cheah Biomedical Centre (JCBC). The JCBC is a new state of the art research facility on the Cambridge Biomedical Campus, which became operational in 2019. The new building contains laboratories, office space and on the ground floor a Imaging Research Facility (CRF) besides seminar and conference rooms.

You will be part of a building services team and will provide a stores service for the building, to ensure timely ordering and delivery of equipment and consumables.
The role holder will be part of the Building Services Team and will provide a full Goods In/Out and Stores services for the building to ensure timely ordering and delivery of equipment and consumables. They will assist with carrying out stock checks and all services running through the Goods In department.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 13th August 2024

The interview date for the role is: Shortly after closing date

Please quote reference PS42586 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

The laboratory of Dr Mekayla Storer (https://www.stemcells.cam.ac.uk/people/pi/dr-mekayla-storer) uses multidisciplinary approaches to understand why the distal portion of the digit tip is the only part of the limb that can regenerate in mammals. The key step in this process is the formation of a blastema, a transiently proliferating mass of cells that the regenerates the different cell types of the digit to replicate the original structure. Therefore the broad goal of our research is to understand which cells and molecular pathways are necessary for this process. A portion of our present research builds on our previous work (Storer et al., Dev. Cell 2020) that used high-throughput single-cell mRNA sequencing and Cre-recombinase based lineage tracing to define the transcriptional identity of the mesenchymal cells comprising the blastema and the major transitions during mammalian digit tip regeneration. We are looking for a dedicated post-doctoral researcher to determine which of these factors present during digit tip amputation are necessary for successful regeneration and the mechanisms that underly this process. The post holder will use high-resolution imaging analysis, single cell transcriptomics/multi-omics approaches, in vitro culture with CRISPR-mediated gene regulation and in vivo transplantation assays.

Requirements:

Successful applicants should have a PhD in the field of regenerative biology, genomics, epigenetics or cell/developmental biology or be close to the completion of their degree. Expertise in general areas of stem cell biology including image analysis, CRISPR genome editing, in vivo mouse models and histology would be suitable for this position. It is essential that the post-holder is organized, able to work collaboratively as a member of a team and can communicate effectively and clearly.

Start date is flexible but can be as early as October 2024.

Fixed-term: The funds for this post are available for 24 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 18th August 2024

The interview date for the role is: Soon after the closing date

Please quote reference PS42568 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

A Research Assistant position is available in the laboratory of Dr. Walid Khaled. The group uses multidisciplinary approaches to understand epithelial cell fate decisions during normal development and early stages of tumourigenesis. The lab is now focusing on how the whole tissue responds to tumour initiation. In particular, what is the role of the cell of origin and the stroma/immune microenvironment in shaping the developmental trajectory of nascent cancer cells. To achieve this the lab is recruiting a research assistant scientist to join the team.

Requirements:

We are looking for candidates who hold a BSc and OR MPhil in Biological science with demonstrable experience in analysing scRNAseq data. The candidates should have experience in using R, Python and other sequencing analysis pipelines. It preferable if the candidate has experience in integrating large scRNAseq datasets. It's essential that the post-holders are organised, responsible, able to work collaboratively as a member of a team and can communicate effectively and clearly both orally and in writing. Proven capacity to design, execute, and interpret your own experiments is essential.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 15th August 2024

The interview date for the role is: 20th August 2024

Please quote reference PS42411 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Wellcome - MRC Cambridge Stem Cell Institute (CSCI) is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and their developmental origins, and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

The Tissue Culture Facility enhances the quality and efficiency of cell culture research within the CSCI. We provide support and resources to a large number of busy stem cell culture laboratories, catering to a wide range of specialities from ES cell derivation to virus production.

We are seeking a Cell Culture Laboratory Technician to join the Tissue Culture Facility team. The role holder will have daily supervision from the Tissue Culture Research Laboratory Technician and will be expected to produce high volumes of sterile aliquots, cell culture and culture media, run routine assays, contribute towards the smooth running of the facility and provide fully detailed, traceable records for all reagents produced.

The ideal candidate will be qualified to A level or NVQ level 3, with previous practical experience of working in a tissue culture laboratory. Experience of culturing cells lines and stem cells is desirable, but training can be provided. This role will require a high degree of precision and accuracy, so organisational skills and attention to detail are essential. We are seeking someone with good communication skills who will work well as part of a team.

Candidates with minimal laboratory experience, but with high levels of manual dexterity, precision, accuracy and attention to detail are encouraged to apply, but would be appointed at a lower grade until fully competent at aliquot and cell culture production.

This position is for 20 hours per week spread over 4-5 days (Monday ¿ Friday).

Fixed-term: The funds for this post are available until 30 June 2026 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 4th August 2024

The interview date for the role is: W/C 2nd of September

Please quote reference PS42193 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited from enthusiastic, motivated and experienced Research Associates to join the Cambridge Stem Cell Institute to work with Dr Johannes Bargehr in the Sinha group. This post is funded by a BHF Intermediate Clinical Research Fellowship and will run for 4 years. Dr Bargehr uses human pluripotent stem cells to generate cardiovascular cells to treat damaged hearts (Bargehr et al. Nature Biotech 2019;37:895-906). This project will make use of immunomodulatory strategies to make stem cell therapy more efficacious and prepare it for clinical translation.

The successful candidate will support the smooth running of tissue culture activities and carry out research studies on animals as part of wider research activities. Duties will include performing experimental procedures, tissue culture of pluripotent stem cell-derived cardiovascular cells such as beating cardiomyocytes, QRT-PCR, flowcytometry, immunohistochemistry, stock maintenance, planning and record keeping. There is also an opportunity to conduct experimentation alone or in collaboration for individual and/or collaborative research projects; including helping with the planning and design of experiments, and collection and analysis of data. They will also assist with housekeeping and safety in the research laboratories and liaise regularly with their line managers, PI and other lab members.

The ideal candidate will have a BSc, or higher, in a biological subject, together with experience in areas of relevance to the research group. Excellent organisational skills and the ability to work as part of a team, as well as independently, are also essential, along with having a high degree of precision and accuracy and communication skills. The Cambridge Stem Cell Institute is the largest Stem Cell Institute in Europe and a world-leading centre for stem cell research and regenerative medicine. Scientists collaborate to advance our knowledge of stem cell biology and tissue repair and to perform pioneering work in translational research areas, providing the foundation for new medical treatments including those for the damaged heart. The institute boasts a large number of core facilities, including an imaging, flow cytometry and histology facility.

Fixed-term: The funds for this post are available for 4 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 1st September 2024

The interview date for the role is: 9th September 2024

Please quote reference PS42147 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

This is an exciting opportunity to join the Building Services Team in the Jeffrey Cheah Biomedical Centre (JCBC). You will be expected to undertake a part-time level 3 Maintenance and Operations Engineering Technical apprenticeship at Cambridge Regional College. You will be an integral part of the JCBC Building Services Team, aiming to support Institute groups to work together in a single location to create a fully-integrated, vibrant and cohesive scientific research community.

This role provides a chance to work alongside experienced staff to gain practical experience and a qualification. Being part of the team ensuring the smooth running of the building, core equipment and facilities means the role is varied and you need to be able to adapt to changing priorities and work well under pressure. It is important that you are someone who understands and applies problem solving skills and is keen to learn and apply the practices and procedures for planning to maintain systems and equipment. The role will provide support across building and equipment maintenance, safety management, laboratory support, trouble-shooting and working at the customer service coal-face.

This is a great opportunity to join a busy and successful team whilst working towards your NVQ Level 3 in Maintenance and Operations Engineering and building your professional skills. This standard will meet the professional standards of the Engineering Council for registration as Engineering Technician (Eng Tech) by an appropriate Professional Engineering Institution.

You will have strong organisation and communication skills and be able to pay attention to detail whilst keeping on top of a number of tasks at once. You will have some experience of basic computer programmes such as word processing, spreadsheets and email and have the ability to build strong working relationships whilst having the motivation to learn new skills. You must be educated to GCSE level or equivalent with a minimum of a grade c/4 in Maths and English. An interest in machinery, engineering and building operations management would be an advantage.

You will be supported by having weekly meetings with your line manager and regular assessments and reviews by your Assessor to ensure you are on track to successfully achieve your qualification.

The role will sit in the Building Services Team in the JCBC which houses three world-leading institutes including the Cambridge Stem Cell Institute https://www.stemcells.cam.ac.uk/.

Fixed-term: The funds for this post are available for 42 months in the first instance.

How To Apply:

To apply for this role, please use this link to access the National Apprenticeship Service site and follow the on-screen instructions on how to submit your application:

https://www.findapprenticeship.service.gov.uk/apprenticeship/1000254002

Please quote reference PS41894 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

This is an exciting opportunity to join the Building Services Team in the Jeffrey Cheah Biomedical Centre (JCBC). You will be expected to undertake a part-time level 3 Maintenance and Operations Engineering Technical apprenticeship at Cambridge Regional College. You will be an integral part of the JCBC Building Services Team, aiming to support Institute groups to work together in a single location to create a fully-integrated, vibrant and cohesive scientific research community.

This role provides a chance to work alongside experienced staff to gain practical experience and a qualification. Being part of the team ensuring the smooth running of the building, core equipment and facilities means the role is varied and you need to be able to adapt to changing priorities and work well under pressure. It is important that you are someone who understands and applies problem solving skills and is keen to learn and apply the practices and procedures for planning to maintain systems and equipment. The role will provide support across building and equipment maintenance, safety management, laboratory support, trouble-shooting and working at the customer service coal-face.

This is a great opportunity to join a busy and successful team whilst working towards your NVQ Level 3 in Maintenance and Operations Engineering and building your professional skills. This standard will meet the professional standards of the Engineering Council for registration as Engineering Technician (Eng Tech) by an appropriate Professional Engineering Institution.

You will have strong organisation and communication skills and be able to pay attention to detail whilst keeping on top of a number of tasks at once. You will have some experience of basic computer programmes such as word processing, spreadsheets and email and have the ability to build strong working relationships whilst having the motivation to learn new skills. You must be educated to GCSE level or equivalent with a minimum of a grade c/4 in Maths and English. An interest in machinery, engineering and building operations management would be an advantage.

You will be supported by having weekly meetings with your line manager and regular assessments and reviews by your Assessor to ensure you are on track to successfully achieve your qualification.

The role will sit in the Building Services Team in the JCBC which houses three world-leading institutes including the Cambridge Stem Cell Institute https://www.stemcells.cam.ac.uk/.

Fixed-term: The funds for this post are available for 42 months in the first instance.

How To Apply:

To apply for this role, please use this link to access the National Apprenticeship Service site and follow the on-screen instructions on how to submit your application:

https://www.findapprenticeship.service.gov.uk/apprenticeship/1000254002

Please quote reference PS41894 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.