http://www.jobs.cam.ac.uk/job/?unit=u10044&format=rss

The Rowitch lab is seeking to appoint a research assistant or associate to manage lab imaging and sequencing data for ongoing research projects. The post-holder will have an interest in high through-put image analysis, and practical experience in data and server management. We are based in the Wellcome-MRC Cambridge Stem Cell Institute (CSCI) and the Department of Paediatrics, University of Cambridge. The team uses techniques of stem cell biology, high content imaging, molecular biology, genetics, biochemistry, bioinformatics & bioengineering to study many aspects of brain development.

Responsibilities:

• Assisting the Senior Imaging Officer in maintaining servers and trouble-shooting of equipment problems.
• Developing pipelines for data handling.
• Collecting, organizing and managing imaging/sequencing data from various sources.
• Conducting image analysis using software tools such as ImageJ, Fiji, MATLAB, Python, or other tools as needed.
• Creating visualizations and preparing figures for presentations and publications.
• Collaborating with other team members to support ongoing research projects.
• Assisting with other lab duties as required.

Requirements:

• Bachelor's degree in biological or computer science, ideally a Masters degree in a related field, or appropriate experience or equivalent qualification.
• Excellent IT skills and record keeping.
• Strong attention to detail and organisational skills.
• Excellent communication skills.
• Ability to work independently and in a team environment.
• Proficiency in single-cell RNA-seq analysis would be advantageous.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 16th April 2023

The interview date for the role is: To be confirmed

Please quote reference PS36086 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We have an exciting opportunity for an experienced Imaging Technologist to join our Advanced Microscopy Facility in the Wellcome - MRC Cambridge Stem Cell Institute, based in the Jeffrey Cheah Biomedical Centre.

We are a large, multi-user core facility offering access to a comprehensive range of imaging platforms, including super-resolution confocal microscopy and live cell imaging, and transmission and scanning electron microscopy. We believe in creating a collaborative environment to support cutting-edge research, and serve as a friendly and approachable source of imaging expertise.

This is a rewarding role requiring an enthusiastic individual with in-depth experience of biological light microscopy to provide training and technical support to research staff and students. You will work as part of a small team to operate and maintain specialised imaging systems and troubleshoot issues with equipment, samples and experimental design.

With a keen interest in innovation, you will keep up to date with the latest imaging methodologies, collaborating with researchers to optimise protocols and develop new techniques. You will contribute towards facility management and deputise for the Facility Manager, administering booking and recharge systems and implementing safety and operational procedures.

You will have excellent communication skills and the ability to build effective working relationships in a diverse environment. Strong IT and image analysis skills are essential, together with significant experience in providing a core service and training researchers of all ability levels. You must be able to work independently, prioritising tasks and organising your time accordingly.

You will ideally be qualified to degree level or equivalent. Extensive practical experience and specialist knowledge of confocal and widefield microscopy are essential. Coding skills and experience in electron microscopy are desirable.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 2nd May 2023

The interview date for the role is: 18th May 2023

Please quote reference PS36029 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Philpott group in the Wellcome - MRC Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk/people/pi/philpott), in collaboration with the Simons group at the Wellcome/CRUK Gurdon Institute(https://www.gurdon.cam.ac.uk/people/ben-simons/), are seeking a Research Associate in Computational Biology.

Mechanisms that lead to the establishment and maintenance of cell identity are paramount for organismal health. They also underpin successful cellular reprogramming for disease modelling and cell replacement therapies. Alongside experimental lab work using embryonic stem cells, cancer cells and Xenopus frog embryos, the Philpott lab, in collaboration with the Simons lab, makes use of analytical and computational approaches to study mechanisms of lineage fidelity and transcriptional reprogramming of cell fate during development and in disease. Current interests include the roles played by the epigenome and cofactors in regulating lineage transcription factor-mediated establishment and stabilisation of cell fate.

With experience in the development of statistical and computational methods, the role holder will have a key position in analysing single-cell and bulk genome-wide datasets across a range of projects and experimental model systems. As well as performing computational genomics analyses, the role holder will also make use of functional data to develop mechanistic insights using statistical modelling-based methods and/or computational approaches. The role holder will work closely with experimental colleagues to transform sequencing data into biologically meaningful information. Reflecting this central role in data analysis and integration, the role holder's contributions will be acknowledged accordingly. There will also be the opportunity to carry independent research in close collaboration with experimental scientists in the lab.

Applicants should have a strong background in statistical methods and computational biology, and prior experience in the analysis of high-throughput genomic and transcriptomic data and may have experience in the deployment of machine learning analysis pipelines. Previous experience in the analysis of single-cell data would be an advantage. The applicant should have a PhD in a relevant subject, a sound understanding of molecular biology, and a strong publication track-record in computational biology or computer science. As well as being able to work independently, the role requires strong communication skills and the ability to work in a dynamic multidisciplinary team environment.

The Philpott lab is located in the Cambridge Stem Cell Institute, which provides a stimulating environment that promotes collaborative and interdisciplinary research. Its postdoc association encourages scientific and social interactions and provides career development and teaching opportunities.

Informal enquiries can be directed to Dr Frances Connor fac31@cam.ac.uk

Fixed-term: The funds for this post are available until 31 March 2026 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 4th April 2023

The interview date for the role is: To be confirmed

Please quote reference PS35805 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

A Postdoctoral Research Associate position is currently available for a highly talented and motivated individual to work in the laboratory of Prof. Anna Philpott within the Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk/people/pi/philpott). The Philpott lab has broad interests in understanding the fundamental mechanisms that determine cell fate choice and differentiation during embryonic development and in cancers, as well as how these processes are coordinated with cell cycle progression.

The successful candidate will undertake a project investigating transcriptional regulation of lineage fidelity during fate specification and differentiation, focusing on uncovering epigenetic and co-factor-dependent mechanisms underlying these processes. Within the laboratory, we use several experimental systems including mammalian embryonic stem and cancer cell culture as well as embryos of the frog Xenopus laevis. This project will use single cell transcriptomic and multi-omic analysis to determine the cellular response to transcription factor reprogramming and will focus on the response of cells using the in vivo Xenopus embryo system, while aligning closely with related work on ES cells in the lab. We use many techniques including genome-wide analysis of gene expression in single and multiple cells, chromatin binding and accessibility studies, CRISPR genome editing as well as classical embryology and biochemistry.

The successful candidate will have a PhD, considerable experience in molecular biology and genome-wide, preferably single cell, approaches to probing transcriptional activity. While experience in the use of Xenopus as a model system would be desirable, full training can be provided and an enthusiasm to embrace this model alongside use of cultured cell systems is essential. Evidence of experience in developmental biology, neurobiology, reprogramming or a similar field, and a proven track record in scientific publication are also essential. Experience of genome-wide and /or single cell transcriptional analysis, including computational / bioinformatic analysis would also be highly desirable although additional bioinformatic support as well as training is available. Applicants must display an ability to undertake project management, work within a multi-disciplinary team environment, have excellent presentation and communication skills and the ability to contribute to an environment supporting researchers at all stages of their careers. The Wellcome - MRC Cambridge Stem Cell Institute (CSCI) is a world-leading centre for stem cell research with the mission to transform human health through a deep understanding of stem cell biology. https://www.stemcells.cam.ac.uk/

Informal enquiries should be directed to Dr Frances Connor fac31@cam.ac.uk

Fixed-term: The funds for this post are available until 31 March 2026 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 4th March 2023

The interview date for the role is: To be confirmed

Please quote reference PS35808 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Sampaziotis lab is based at the Welcome-MRC Cambridge Stem Cell Institute which is a world-leading centre for regenerative therapies and stem cell research that hosts more than 28 research groups and cutting-edge facilities.

The Sampaziotis lab focuses on bile duct diseases (cholangiopathies) which are a leading cause for liver transplantation in children and adults. We use bile duct epithelial cell (cholangiocyte) organoids, single cell transcriptomics, animal models and ex-vivo perfused human organs to understand how the biliary epithelium regenerates and gain insights into the pathogenesis of biliary diseases. We apply this knowledge to develop disruptive bioengineering and regenerative medicine therapies to treat these disorders. Importantly, we focus on the bile duct epithelium as a proof-of-principle system to unveil universal mechanisms governing epithelial regeneration and pioneer novel regenerative medicine approaches that can be subsequently translated to multiple other systems beyond the biliary tree. More information can be found on our website https://www.stemcells.cam.ac.uk/people/pi/sampaziotis

We are looking for an enthusiastic and dedicated Lab Manager to join our expanding academic group and contribute to the team's management, organisation and scientific output.

About the lab manager role

You will hold one of the most important roles within the lab ¿ directing the day-to-day lab operations, managing the members of the team, and serving as the main liaison between the lab and various external partners (Cambridge University Hospitals NHS Foundation Trust, industrial partners, and various international collaborators). We seek a highly organized, accountable, and self-motivated individual with excellent follow-through, who will integrate seamlessly in the team, communicate clearly, and earn the respect of his/her peers through their proactive approach and problem-solving skills.

What you will do:

• Manage day-to-day activities within the research laboratory. These include: Maintenance of lab reagents, such as plasmids, antibodies, organoid lines and primary tissue
• Maintaining and updating databases of lab reagents, lines and tissue samples
• Ensuring operation of essential equipment Stocking supplies
• Placing and chasing orders (this can be performed remotely) Space allocation

Act as a primary point of contact for all lab communications, including collaborating closely with vendors, ordering of supplies, maintenance of inventories, service contracts, and repairs of equipment; as well as arranging Material Transfer Agreements and shipment of reagents to collaborators.

Write and develop protocols, and ensure compliance with institutional and national guidelines, including HTA compliance, environmental health and laboratory safety, and animal care regulations.

Review budgets and track expenditures on a daily/weekly/monthly basis.

Contribute to the training and supervision for new lab members, including teaching basic molecular biology techniques.

Help new members of the team integrate and maintain an oversight of all lab members, ensuring their training and compliance with internal and external guidelines. These include mandatory inductions, training courses, obtaining a research passport for access to clinical areas.

Assisting with editing grants, manuscripts, proposals, presentations and other documents.

For inquiries, please contact Dr Fotios Sampaziotis at fs347@cam.ac.uk.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 27th March 2023

The interview date for the role is: To be confirmed

Please quote reference PS35695 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The internship will be conducted through the University of Cambridge Temporary Employment Service and will be based and managed within the Wellcome - MRC Cambridge Stem Cell Institute.

The Wellcome - MRC Cambridge Stem Cell Institute (CSCI) is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

Applications are invited for a skilled and enthusiastic computational biologist/bioinformatician intern to join the CSCI's Core Bioinformatics Group over the Summer 2023 (July - September). The group applies and creates state-of-the-art computational methods for the understanding of the biological properties and biomedical potential of stem cells (https://www.corebioinf.stemcells.cam.ac.uk/publications). We process extensive collections of diverse samples generated by CSCI PIs or through collaboration with local and international groups. We contribute to exciting and challenging international projects to systematically disentangle gene-to-gene interactions in stem cells.

The internship is suitable for individuals with background in a relevant quantitative discipline (Computer Science, Bioinformatics/ Computational Biology, or Applied Statistics/ Mathematics). You will interact daily with other bioinformaticians and periodically with members of other research groups within the CSCI. You are expected to have excellent communication skills and enthusiasm for learning how to excel in a multidisciplinary environment.

You will use existing cutting-edge software and help devise new methods for analysing a variety of NGS datasets including single-cell and bulk RNAseq, ChIP-seq and methylation assays. Candidates with experience in processing imaging data are also encouraged to apply.

Candidates should be familiar with a UNIX/Linux environment. Proficiency with an imperative programming/scripting language (e.g. Perl/Python/Java/C++) and statistical data analysis environments (R, Matlab) would be a strong advantage. Demonstrated expertise in the analysis of very large datasets and in problem solving using data science (machine learning) approaches is desirable.

The intern will be involved in both standardised and customised analyses applied on multilayer genomics, transcriptomics and epigenomics data with the aim of understanding the dynamic changes in the underlying regulatory networks. Training in specialist computational tools will be provided; an important criterion is the interest in using and developing bioinformatics tools and pipelines to advance stem cell research.

Informal enquiries are welcomed and should be directed to: Head of Bioinformatics/Scientific Computing, Dr Irina Mohorianu, iim22@cam.ac.uk.

This internship is for 12 weeks, 20 hours per week paid at £10.42 per hour. You will receive full training and will be mentored by Dr Irina Mohorianu on daily basis.

The closing date is Sunday 2nd April 2023 with interviews taking place the second half of April 2023.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference PS35673 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Duque-Correa Group at the Wellcome - Medical Research Council Cambridge Stem Cell Institute has an opening for a Research Associate to investigate how whipworms (Trichuris spp.) manipulate host intestinal stem cell niche remodelling to establish chronic infections, using single-cell and spatial RNA sequencing and state-of-the-art microscopy.

This project will focus on understanding the effects of whipworm infection on intestinal epithelial stem cell fate and on stromal and immune cell responses that result in changes in mucosal physiology and inflammation, enabling chronic infections. Specifically, this project will characterise the gene expression changes (using bulk, single-cell and spatial transcriptomics) of intestinal epithelial cells and stem cell niche populations across infection and after eradication of the parasite. Stem cell remodelling pathways modulated by the parasite will be further studied using lineage tracing and imaging, and stem and stromal cell function will be assessed using organoid assays. We anticipate this work will lead to fundamental new knowledge on the whipworm mucosal niche, potentially yielding new targets for anti-parasitic therapies and providing novel insights into how intestinal epithelia repair damage with relevant application toward intestinal inflammatory diseases.

Candidates should hold a PhD in a relevant field. In particular, they will have a strong background in intestinal stem cell biology, immunology or parasitology. Demonstrated expertise in performing bulk and single-cell transcriptomic experiments and in the analysis of RNA sequencing data is required. Additional expertise with tissue culture, imaging, flow cytometry techniques, mouse models and/or helminth infection biology would be desirable. Finally, candidates will have demonstrated experience in leading a project and a strong scientific achievement via their publication record.

We are looking for an enthusiastic and ambitious individual to develop, drive, and deliver their research project while collaborating regularly with other members of the Duque-Correa group. You will be detail orientated, analyse data, interpret results in their biological context, and prepare manuscripts for publication. You will be able to work independently, have excellent interpersonal and communication skills, and interact well with collaborators and colleagues and the broader scientific community.

The closing date for applications is 31 March 2023. Interviews are expected to be held in the week commencing 11 April 2023.

Fixed-term: The funds for this post are available until 31 December 2024 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

The Duque-Correa Lab is a new research group funded by a £1.2M Wellcome Sir Henry Dale Fellowship award that broadly aims to understand the "whipworm niche at the host intestinal epithelia". Whipworms infect hundreds of millions of people and cause trichuriasis, a major neglected disease. These large metazoan parasites inhabit a multi-intracellular niche within their host gut lining, where they can remain for years. We investigate the host-whipworm interactions that underpin parasite invasion, colonisation and persistence in its mucosal niche, using a mouse model of infection with the mouse whipworm (Trichuris muris) and the first in vitro model to reproduce whipworm infections based on organoids (Duque-Correa et al 2020 International Journal of Parasitology; Duque-Correa et al 2022 Nature Communications). To study the responses of both the host and whipworm, we employ a range of cellular and molecular biology techniques, including confocal imaging, FACS and transcriptomics. This research is supported by a strong collaborative and training network that the Postdoctoral Research Associate will benefit from both inside and outside of the Stem Cell Institute.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Questions regarding the post can be directed to Dr Maria Duque-Correa who can be contacted at mad75@cam.ac.uk.

Please quote reference PS34710 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Sampaziotis lab is based at the Wellcome-MRC Cambridge Stem Cell Institute which is a world-leading centre for regenerative therapies and stem cell research that hosts more than 28 research groups and cutting-edge facilities.

The Sampaziotis lab focuses on bile duct diseases (cholangiopathies) which are a leading cause for liver transplantation in children and adults. We use bile duct epithelial cell (cholangiocyte) organoids, single cell transcriptomics, animal and ex-vivo human organ models to understand how the biliary epithelium regenerates. We apply this knowledge to gain insights into the pathogenesis of biliary diseases and develop disruptive bioengineering and regenerative medicine therapies to treat these disorders. Importantly we use biliary diseases and cholangiocyte organoids as a proof-of-principle system to unveil universal mechanisms governing epithelial regeneration and pioneer novel regenerative medicine approaches that can be subsequently translated to multiple other systems beyond the biliary tree.

We are looking for an enthusiastic and dedicated research assistant to contribute to these projects. Creativity and personal initiative is highly encouraged. Candidates building on existing data to develop additional/new projects will be strongly supported and it is expected that the successful candidate will also lead a dedicated scientific project in the lab.

Successful applicants should have a MSc in Biotechnology (or any related field). The candidates should have demonstrable experience in designing and experience in 3D cell culture, bioengineering, qPCR, RNA-sequencing, confocal microscopy and Western blot analyses. Expertise in general areas of cell biology including image analysis, molecular biology, basic genome editing skills, histology would be suitable for this position. Previous experience in industry and academic labs is desirable. It is essential that the post-holder is organized, able to work collaboratively as a member of a team and can communicate effectively and clearly.

Start date is flexible but can be as early as March 2023. The post duration is 6 months with an opportunity to extend it further.

For inquiries, please contact Dr Fotios Sampaziotis at fs347@cam.ac.uk.

Fixed-term: The funds for this post are available for 6 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 13th March 2023

The interview date for the role is: To be confirmed

Please quote reference PS35657 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Research Laboratory Floor Technician to join the Scientific Facilities team in the Wellcome - MRC Cambridge Stem Cell Institute.

We are a world-leading centre for stem cell research with a mission to transform the prevention, diagnosis and treatment of disease through a deep understanding of how stem cells work. We are based in the Jeffrey Cheah Biomedical Centre on the Cambridge Biomedical Campus.

As a Floor Technician, you will use your experience to provide support and assistance to researchers and ensure the smooth running of laboratories. You will have responsibility for communal equipment areas and maintenance and repair of core equipment, and will liaise with laboratory groups over any servicing which may impact their work.

You will contribute towards the management of health and safety in the Institute, providing training to researchers, writing COSHH and risk assessments and ensuring safety procedures are observed.

You will work closely with others as part of a small team and will be a key point of contact for staff, students and visitors, so excellent communication and teamworking skills are essential. You must also be able to work independently, prioritising tasks and organising your time accordingly.

You will ideally be qualified to degree level or equivalent in a science subject. Previous experience of working in a research laboratory environment and using a range of laboratory equipment is essential, along with experience of laboratory health and safety.

Fixed-term: The funds for this post are available until 30 June 2024 in the first instance.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 13 March 2023

The interview date for the role is: To be confirmed, but soon after the closing date

Please quote reference PS35588 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Health and Safety Coordinator to support safety management in the Wellcome - Medical Research Council Cambridge Stem Cell Institute. Our mission is to transform the prevention, diagnosis and treatment of disease through a deep understanding of how stem cells work. We are based in the Jeffrey Cheah Biomedical Centre on the Cambridge Biomedical Campus.

You will use your laboratory experience and organizational skills to coordinate health and safety management in areas including biological, chemical and physical safety, under the direction of the Departmental Safety Officer and Biological Safety Officer.
You will also support the Human Tissue Act Person Designate by developing and implementing procedures to ensure HTA regulatory compliance.

This is a varied role requiring a dynamic and organised individual who can engage with scientists and support staff alike. You will provide advice and training to others, write and review risk and COSHH assessments, help manage Containment Level 2 laboratories and take a proactive approach to problem solving. As a key point of contact for researchers, you will respond to queries and develop Institute-wide systems for record keeping.

The ideal candidate will be qualified to degree level or equivalent in a biological science, with previous experience of safety procedures in a research laboratory environment. Excellent communication and teamworking skills are essential, but you must also be able to work on your own initiative.

Part-time: this position is 0.6 FTE with the potential to agree a flexible working pattern.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 20 March 2023 The interview date for the role is: 28 March 2023

Please quote reference PS35555 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are looking for an IT Technician to join an expanding IT team within the Wellcome - MRC Cambridge Stem Cell Institute (CSCI), the Therapeutic Immunology -and Infectious Diseases (CITIID) and the Milner Institute. The CSCI is a world-leading centre for stem cell research with a mission to transform human health through a deep understanding of stem and progenitor cell biology (http://www.stemcells.cam.ac.uk) and is supported by the Wellcome and the Medical Research Council.

The CITIID - Cambridge Immunology is designed to showcase and enhance the University of Cambridge's position as a leading international centre for research and teaching in immunology (https://www.immunology.cam.ac.uk/). The Milner Therapeutics Institute at the University of Cambridge is dedicated to the conversion of ground-breaking science into therapies. (https://www.milner.cam.ac.uk/).

The successful applicant will join an IT team creating a comprehensive IT support service for these multiple departments in a new Capella building on the biomedical campus https://www.stemcells.cam.ac.uk/about-us/newbuilding.

These centres provide outstanding scientists with the opportunity and resources to undertake ground-breaking research. The IT team will support this demanding environment, delivering an effective and efficient service.

Applicants should either be educated to BTEC/HNC standard, hold equivalent industry qualification, or have worked in a computing support role previously. The successful applicant should have good customer service skills and will be expected to have proven hardware and software troubleshooting skills. Experience supporting Active Directory, Windows and Office and experience supporting MacOS is required for this role.

The role holder will provide user support via phone, email and face-to-face contact. You will work closely with the rest of the IT team, managing the data network, audio-visual facilities, and a variety of computer platforms so experience of working as part of team is essential.

Experience using ticketing / documentation systems to manage own work and familiarity with supporting scientific software and equipment is desirable. Managing and/or troubleshooting Linux; scripting and automation - e.g. PowerShell, Unix shell scripting would also be advantageous.

Training will be provided as a mixture of Computing Service courses and knowledge transfer via the senior team members.

Informal enquiries are welcomed and should be directed to Ivan Trahanov on ipt23@cam.ac.uk

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 19th March 2023

The interview date for the role is: To be confirmed

Please quote reference PS35549 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Biomedical Research Technician position in the group of Dr Maria P. Alcolea within the Wellcome MRC Cambridge Stem Cell Institute (CSCI) based at the Cambridge Biomedical Campus. This represents a collaborative effort with Prof. Phil Jones at the Wellcome Trust Sanger Institute. This role offers the opportunity to work in a multi-disciplinary team building on previously published work on epithelial stem cell biology and early cancer.

We are looking to recruit a Biomedical Research Technician to co-ordinate all aspects of the mouse colonies, along with individual researchers and the PPL holder in the team. The successful candidate will perform in vivo mouse work (such as overseeing multiple transgenic strains, administering various treatment protocols and interventions as well as tissue collection and processing) supervised by researchers in our research group. Good communication skills are key as the candidate will liaise with the NACWO's, NVS and HO inspector regarding mouse colonies, animal welfare and regulatory compliance along with individual researchers and the PPL holder. The role holder will also be involved in other research tasks, such as genotyping, staining, imaging, culturing of tissues (mouse and human), as well as keeping detailed records of the data and work undertaken.

As such, the candidate should have good interpersonal and organisational skills, paying close attention to detail. Other responsibilities include a range of tasks to ensure the smooth running of the laboratory, such as ordering and maintaining laboratory supplies, and maintaining and updating protocols and reagent databases. An understanding of the principles of cellular and molecular biology and basic knowledge of computational experience would be desirable.

Informal enquiries are welcomed and should be directed to Dr MP. Alcolea ( mpa28@cam.ac.uk ).

Fixed-term: The funds for this post are available for 12 months in the first instance.

Closing Date: 9th February 2023

Interview Date: To be confirmed

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference PS35079 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.