Research Assistant (Fixed Term)
Applications are invited from enthusiastic, motivated and experienced Research Assistants to join the Cambridge Stem Cell Institute to work in the Sinha group. This post is funded for 13 months and will be initially 1 month full time, and then 12 months 50% FTE.
The successful candidate will support the smooth running of tissue culture activities and carry out research studies on animals as part of wider research activities. Duties will include: performing experimental procedures, tissue culture of pluripotent stem cell-derived cardiovascular cells such as beating cardiomyocytes, for 2D line generations or production of engineered heart constructs, and other bioengineering techniques.
Molecular techniques such as RNA extraction and qRT-PCR, flow cytometry, immunohistochemistry will be required, along with standard laboratory management practices such as stock maintenance, planning and record keeping. Additional techniques will include protein isolation and quantification from cells and human tissue to perform Western Blot and immunoprecipitation.
There will also be the opportunity to learn a novel technique that involves slicing of ultrathin sections of living human hearts and perform extended culture in vitro, to study the functional response of the tissue to different degrees of mechanical load.
There is also an opportunity to conduct experimentation alone or in collaboration for individual and/or collaborative research projects; including helping with the planning and design of experiments, and collection and analysis of data. They will also assist with housekeeping and safety in the research laboratories and liaise regularly with their line managers, PI and other lab members.
The ideal candidate will have a BSc, or higher, in a biological subject, together with experience in areas of relevance to the research group. Excellent organisational skills and the ability to work as part of a team, as well as independently, are also essential, along with having a high degree of precision and accuracy and communication skills.
The Cambridge Stem Cell Institute is the largest Stem Cell Institute in Europe and a world-leading centre for stem cell research and regenerative medicine. Scientists collaborate to advance our knowledge of stem cell biology and tissue repair and to perform pioneering work in translational research areas, providing the foundation for new medical treatments including those for the damaged heart. The institute boasts a large number of core facilities, including an imaging, flow cytometry and histology facility.
Fixed-term: The funds for this post are available until 30 September 2026 in the first instance.
Informal enquiries should be directed to Professor Sanjay Sinha (SS661@cam.ac.uk).
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date: 2nd July 2025
Interview date: to be confirmed
Please quote reference PS46363 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
NGS & Spatial Omics Assistant (Fixed Term)
We have an exciting opportunity for an NGS and Spatial Omics Assistant to join the NGS Core Facility team in the Cambridge Stem Cell Institute. CSCI is a world-leading centre for stem cell research based in the Jeffrey Cheah Biomedical Centre on the Cambridge Biomedical Campus.
We are seeking a self-motivated, reliable and well-trained Genomics Assistant to join the Stem Cell Institute's Next Generation Sequencing (NGS) core facility. This facility supports the general NGS needs of our researchers and is currently expanding into delivering spatial genomics services.
You will be responsible for performing a wide variety of bulk and single cell NGS protocols, as well as spatial transcriptomics processes on 10X Visium CytAssist..
You will work closely with the Facility Manager to ensure the smooth running of the NGS facility, and collaborate with colleagues in the Imaging and Histology core facilities to help develop and support spatial omics pipelines.
Routine tasks will include coordinating and planning incoming bulk, single cell, and spatial projects, receiving samples from facility users, performing a wide variety of NGS library preparations, implementing and establishing new protocols, managing specialised equipment such as Chromium X and Visium CytAssist, providing expert technical advice to our users, liaising with customers about their results, and general lab maintenance such as safety, sample tracking and ordering.
You will be an experienced molecular biologist with a degree or equivalent in a biological science, superior laboratory skills in molecular biology, extensive practical experience and theoretical knowledge of conventional and single cell NGS technologies, and have a good understanding of the latest spatial transcriptomics developments. Prior experience of cell culture would be advantageous but experience in stem cell biology is not necessary. You should be confident working independently, to research, learn and apply new techniques, and troubleshoot and optimise protocols.
You will have demonstrable organizational, documentation and time management skills, together with experience supporting a variety of research projects in a core environment or support role. The ability to work as part of a team and communicate effectively with all levels of staff is essential.
This is a full-time role for 36.5 hours per week.
Fixed-term: The funds for this post are available for 3 years in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online application form.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date: 25th June 2025
Interview date: Most likely to be 7th or 8th July 2025
Please quote reference PS46269 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Assistant (Bulstrode Lab) (Fixed Term)
The Bulstrode Lab studies the biology of neural stem cells in development, cancer and neurodegeneration. We are also developing new technology for targeted delivery of treatments to patients. Recent grant award from Parkinson's UK will fund a Research Assistant to join the group and work respectively on:
(1) 'Developing an Adaptable Dopamine Cell Therapy for Parkinson's Using the HIF Pathway'
The successful candidate will have a strong basic science research track record. Experience in some or all of mammalian cell culture, routine molecular biology workflows, imaging, cloning, and next generation sequencing analysis is highly desirable.
We benefit from privileged access to human patient tissue resected at operation and to human embryo brain tissue, and you will be applying the above techniques to state-of-the-art human model systems including:
- Primary patient-derived cell lines
- Pluripotent stem-derived neurons and organoids.
- Human brain organotypic slice culture
- Isolated human brain cell fractions
Alongside the aptitude and initiative to pursue personal research objectives, candidates will need to demonstrate the scientific knowledge, expertise and enthusiasm to help guide students day-to-day, contribute scientifically and socially to the lab and wider institute, and contribute some admin and organisational duties. It is essential that the successful candidate can work both independently and as part of a research team, with good communication and organisational skills.
Key responsibilities
- Plan and manage your research project work and coordinate day-to-day research activity within the framework of the agreed programme.
- Already be familiar with or have the capacity to become quickly familiar with standard research techniques detailed ('Relevant Experience' below).
- Analyse and interpret research results including next generation sequencing datasets
- Present research progress and outcomes at lab meetings and conferences
- Keep abreast of developments and publications in the field
- Advise based on your experience and expertise on student research questions, experimental design, interpretation and presentation in the wider group.
- Contribute to lab administrative duties e.g. maintenance of safety and tissue records, laboratory duty rotas and ordering of supplies.
- Liaise with colleagues and students around day-to-day lab business and establishing links to expand knowledge and understanding, and develop collaborations
- Contribute pro-actively to collaborative projects with colleagues in partner institutions, and research groups.
Fixed-term: The funds for this post are available until 3 August 2027 in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date: 19th June 2025
Interview date: to be confirmed
Please quote reference PS46217 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Senior Receptionist
The Jeffrey Cheah Biomedical Centre (JCBC) is a state of the art research facility located on the Cambridge Biomedical Campus. The JCBC houses up to 1000 staff and visitors across three different Department/Institutes.
The JCBC Building Services Team (BST) is looking for a proactive and attentive full-time Senior Receptionist to join their team. The post-holder will be a key member of the BST and will be responsible for the day-to-day running of the front-of-house reception area and have experience in providing professional reception and administrative support to groups and visitors to the building.
Key duties and responsibilities:
- Welcome staff, visitors and contractors and manage access accordingly.
- To manage telephone calls, emails, taxi bookings and room booking requests.
- To supervise one receptionist, give training and guidance as appropriate.
- Carry out administrative and clerical tasks, including cross-charging of invoices.
- Work with all departments in the JCBC to ensure data and security access is accurate.
Key requirements:
- Reception or customer service experience, in a senior capacity.
- Attention to detail and knowledge of Microsoft Office packages.
- Great communication and interpersonal skills with the ability to multi-task and work unsupervised.
This role is permanent, and full time with flexibility around core hours. It is office-based at the JCBC.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment, a security check and a standard Disclosure and Barring Service check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Closing date: 6th June 2025
Interview date: 25th June 2025
Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online application form.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
For information about how your personal data is used as an applicant, please see the section on Applicant Data (https://www.hr.admin.cam.ac.uk/hr-staff/hr-data/applicant-data) on our HR web pages.
Please quote reference PS46076 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Assistant (Fixed Term)
Applications are invited for a Research Assistant position in the group of Dr Maria P. Alcolea within the Cambridge Stem Cell Institute (CSCI) and PDN Department at University of Cambridge. This post will be part of an ERC funded international collaborative effort to understand mutant cell competition.
Our group investigates how cells change their behaviour in response to tissue perturbations such as injury, ageing and the acquisition of cancer-related mutations. We make use of an interdisciplinary approach combining human tissue, mouse transgenic models, lineage tracing and 3D in vitro techniques to understand epithelial stem cell biology in the gastrointestinal tract.
We are looking to recruit a research assistant. The primary role will involve the management of multiple transgenic strains, performing and coordinating in vivo and in vitro experiments, administering varied treatment protocols and interventions as well as tissue collection and processing. The ideal candidate will also be able to oversee animal welfare and regulatory compliance.
The successful candidate will also be expected to provide technical support for other research activities, such as genotyping, staining, imaging, culturing of tissues, as well as to keep detailed records of the data and work undertaken. This role offers the opportunity to work in a multi-disciplinary team building on previously published work on epithelial stem cell biology and early cancer.
Please note that an occasional weekend or evening work may be required.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check. This appointment also requires a Research Passport application.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing Date: 22nd April 2025
Interview Date: To Be Confirmed
Please quote reference PS45659 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Laboratory Manager (Fixed Term)
We have an exciting opportunity for a Research Laboratory Manager to join the Káradóttir lab in the Cambridge Stem Cell Institute. CSCI is a world-leading centre for stem cell research based in the Jeffrey Cheah Biomedical Centre on the Cambridge Biomedical Campus.
The Káradóttir lab has expertise in neuroscience and stem cell biology using both human and rodent models in vivo and in vitro. The team aims to understand (1) how neurons regulate oligodendrocyte progenitor cell differentiation throughout life in both health and disease; (2) to what extent myelin changes once it is formed; (3) the effect myelin changes, and damage, have on neuronal circuit function; and (4) how myelin regeneration can be promoted. The lab uses a combination of molecular, genetic, cellular, imaging, physiological and behavioural methods to address these aims.
We are looking for a proactive and flexible Research Laboratory Manager to work closely with Prof. Káradóttir to coordinate research activities, supervise the day-to-day running of the lab and line manage a Research Assistant. You will support students and postdoctoral researchers with project management and experimental design, helping to ensure that we achieve our research objectives on time and within budget.
As the primary technical expert in the group, you will develop, implement and train others in specialised methods including imaging, in vivo calcium recording, electrophysiology and computational data analysis. Previous experience of electrophysiology and imaging are essential for the role, as well as the use of statistics and image analysis.
You will be a key point of contact for staff, students and collaborators so excellent communication skills are essential. The ideal candidate will have previous experience of scientific writing and contributing to publications. We are looking for someone who enjoys working cooperatively and has good project management and organisational skills.
You will be qualified to degree level or equivalent in neuroscience or a related subject and hold a PhD in a relevant area.
This is a full-time role of 37 hours per week. This post is fixed-term with funding available for 2 years in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date: 7th May 2025
Interview date: 23rd May 2025
Please quote reference PS45572 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Associate x 2 (Fixed Term)
The Tzelepis lab is recruiting two postdoctoral research associates to drive our translational work on novel RNA biology of disease (particular focus on solid tumors and neurodegeneration). Our lab focuses on the epitranscriptome-associated roles of stem cell homeostasis and disease. Our approaches include functional genetics, normal and abnormal stem cell cultures, development and characterisation of novel treatments as well as various mouse models of disease.
The postholders will actively contribute to our research and be responsible for ensuring that the Tzelepis laboratory research is competitive and novel. The ideal candidate will be a team player with excellent communication skills and support a variety of experimental procedures, animal handling, imaging and data collection as well as preparing results for publications and grant submissions. The post also entails training students and visiting researchers in techniques and equipment use, as well as instructing correct research conduct.
Our work is highly collaborative, and we operate at the Cambridge Stem Cell Institute, the Department of Haematology and the wider scientific ecosystem (Babraham campus, Sanger Institute etc.) with access to state-of-the-art equipment and facility support.
Essential requirements are a PhD in a relevant subject and strong expertise in either:
Condensate biology of disease or
Disease-associated tRNA modifications. The ideal candidate will also have experience in either stem-cell/cancer biology, mouse models and/or nucleic acid editing.
For queries regarding this post, please contact Dr Konstantinos Tzelepis, email: kt404@cam.ac.uk
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Applicants must have (or be close to obtaining) a PhD.
Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,132) moving to Research Associate (Grade 7) upon confirmation of your PhD award.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date: 16th April 2025
Interview date: 23rd April 2025
Please quote reference PS45501 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
