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Current jobs in the Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute at the University of Cambridge.
Updated: 37 min 16 sec ago

Business Administration Advanced Apprentice

Wed, 17/04/2024 - 00:00

Applications are invited for a Business Administration Advanced Apprentice to work in the Cambridge Stem Cell Institute (CSCI) and Department of Haematology.

This role is based in the Jeffrey Cheah Biomedical Centre located on the Cambridge Biomedical Campus.

This is an exciting opportunity to join the Wellcome MRC Cambridge Stem Cell Institute and Department of Haematology professional services team. The role provides an efficient administrative service to the Finance, Postgraduate Education, HR and Operations (communications, events and public engagement) management in the Institute and Department. The role will provide support across multiple and diverse research groups and will play a key part in the Office, PhD, Finance and HR administration processes in the University. The role will rotate through the sub-teams to earn a broad range of experiences and will provide support to a wide range of different areas and projects.

If you have any queries regarding this position, please contact Rebecca Coull, Senior HR Coordinator rc980@cam.ac.uk

We welcome applications from individuals who wish to be considered for flexible working arrangements.

Fixed-term: 20 months.

How To Apply:

To apply for this role, please use this link to access the National Apprenticeship Service site and follow the on-screen instructions on how to submit your application:

link https://www.findapprenticeship.service.gov.uk/apprenticeships?ApprenticeshipLevel=All&Hash=0&Location=cb20ab&LocationType=NonNational&PageNumber=1&ResultsPerPage=5&SearchAction=Search&SearchField=All&SearchMode=Keyword&SortType=Relevancy&WithinDistance=5&DisabilityConfidentOnly=False

Please quote reference PS41299 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Finance Assistant

Fri, 15/03/2024 - 00:00

Applications are invited for a Finance Assistant to work in the joint administration team supporting the Department of Haematology and the Cambridge Stem Cell Institute (CSCI). The Department of Haematology is one of 11 departments and 7 Institutes within the School of Clinical Medicine (SCM) http://www.haem.cam.ac.uk/. The Institute is a world-leading centre for stem cell research with a mission to transform human health through a deep understanding of stem and progenitor cell biology (http://www.stemcells.cam.ac.uk).

This role is based in the Jeffrey Cheah Biomedical Centre located on the Cambridge Biomedical Campus.

The Finance Assistant under the supervision of the Finance Coordinator will provide Finance Service to all Department of Haematology and Institute staff. We are looking for someone who has the ability to communicate at all levels and who can maintain a high level of accuracy whilst working to deadlines. The ability to work within a small team is essential.

A suitable candidate will be educated to A level standard /NVQ level 3 or an equivalent level of practical experience. They should have finance experience, ideally in a university setting. Candidates should be an experienced user of Microsoft Office and have a working knowledge of financial management software/systems. They should be flexible, with the ability to communicate at all levels and be well-organised so as to manage conflicting deadlines.

Though this is envisioned as a full-time role with the possibility of hybrid working, we will consider requests for arrangements such as part-time work, flexible hours or job shares.

If you feel you have the qualities that we are looking for and would like to work in this friendly team, we look forward to receiving your application.

Informal enquiries about the post are also welcome via email David Hughes, Finance Coordinator on dch43@cam.ac.uk.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 1st April 2024

The interview date for the role is: 15th April 2024

Please quote reference PS40914 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant (Fixed Term)

Thu, 07/03/2024 - 00:00

Applications are invited for a Research Assistant to work in the Cambridge Stem Cell Institute (CSCI). The Institute is a world-leading centre for stem cell research with a mission to transform human health through a deep understanding of stem and progenitor cell biology (http://www.stemcells.cam.ac.uk).

This role is based in the Jeffrey Cheah Biomedical Centre located on the Cambridge Biomedical Campus.

The post holder will be responsible for providing high-level technical support in studies that aims to understand the whipworm (Trichuris trichiura and T. muris) niche at the intestinal epithelia. This research uses both in vivo (mouse) and in vitro (human and mouse organoids) models of whipworm infection. Thus, this role will require a person with in-depth knowledge and experience on work with organoids and tissue culture, mouse models of infection, flow cytometry, molecular biology techniques and, ideally, bioinformatic analysis. This would have been gained through obtaining a degree in Biomedical Sciences and significant experience in those areas.

The project will be wholly undertaken in the laboratory of Dr Maria A. Duque-Correa at the Wellcome-MRC Cambridge Stem Cell Institute. We are looking for an independent and engaged individual with a track record of delivering complex scientific projects, who will work in range of projects by developing and optimising protocols, reviewing literature, designing experiments and analysing data.

If you have any queries regarding this position, please contact Maria Duque Correa, mad75@cam.ac.uk .

We welcome applications from individuals who wish to be considered for flexible working arrangements.

Fixed-term: The funds for this post are available for 42 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 14th March 2024

The interview date for the role is: Shortly after the advert closes

Please quote reference PS40826 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Genomics Technologist in Next Generation Sequencing Facility

Mon, 04/03/2024 - 00:00

Internal applicants only.

The Cambridge Stem Cell Institute is a world-leading centre for stem cell research, with a mission: to transform human health through a deep understanding of stem cell biology. The Institute is located in the Jeffrey Cheah Biomedical Centre on the Biomedical Campus and has around 30 research groups, with over 300 scientists.

This is an exciting opportunity for a self-motivated, reliable and experienced Genomics Technologist to join our Next Generation Sequencing (NGS) facility. This facility supports the general NGS needs of our researchers and is currently expanding into delivering spatial genomics services.

You will deputise for and work closely together with the Facility Manager to ensure the smooth running of the NGS facility, and assist in delivering new innovative methods for our Discovery Research Platform. You will also work collaboratively with bioinformaticians and researchers engaged in various NGS projects.

Routine tasks will include coordinating and planning incoming projects, receiving samples from facility users, performing a variety of single cell and bulk NGS library preparations, QC of RNA and DNA samples and libraries, implementing new protocols, managing specialised equipment, providing expert technical advice and purchasing consumables.

You will be an experienced molecular biologist with a Degree or equivalent in a biological science, proven skills in RNA/DNA manipulation and considerable practical experience and theoretical knowledge of conventional and single cell NGS technologies. Prior experience of cell culture would be advantageous but experience in stem cell biology is not necessary. You should be confident working independently to research, learn and apply new techniques, and troubleshoot and optimise protocols.

You will have demonstrable organizational, documentation and time management skills, together with experience supporting a variety of research projects in a core environment or support role. The ability to work as part of a team and communicate effectively at all levels is essential.

This is a full-time role for 37 hours per week and will start on 1st July 2024.

Fixed-term: The funds for this post are available until 30 June 2031 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 18th March 2024

The interview date for the role is: To be confirmed

Please quote reference PS40756 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant (Bulstrode Lab) (Fixed Term)

Wed, 14/02/2024 - 00:00

Applications are invited for a Research Assistant position in the group of Dr Harry Bulstrode within the Wellcome ¿ MRC Cambridge Stem Cell Institute (CSCI) based at the Cambridge Biomedical Campus. The Wellcome - Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

The Bulstrode Lab studies neural stem cells and their microenvironment in brain development, regeneration and cancer (Bulstrode et al., Genes & Development 2017). We are seeking an enthusiastic and dedicated Research Assistant to join our research group. The successful candidate will be working with state-of-the-art experimental model systems including assay in primary patient brain tissue organotypic slice culture, magnetic antibody-sorted primary patient brain cell fractions, and primary patient-derived cell lines. The project will be focusing on genetic manipulation and gene therapy targeting of the brain myeloid microenvironment. An overarching long term aim is to translate our basic science towards novel treatments for targeted stereotactic brain delivery in patients with malignant brain tumours, Parkinson's and more. You will be responsible for pursuing your personal research objectives, alongside limited day-to-day lab administrative/ organisational duties as below. Experience or understanding of mammalian cell culture, mouse genetic models or computational analysis would be an advantage. It is essential that the successful candidate can work both independently and as part of a research team, having good communication and organisational skills.

Responsibilities/duties

  • Undertake basic research projects and plan day-to-day research activity within the framework of the agreed research programme.
  • Must be familiar with or have the capacity to become quickly familiar with standard research techniques and methods such as PCR and cell culture.
  • Analyse and interpret the results of own research and prepare data for presentations.
  • Present information on research progress and outcomes.
  • Contribute to the planning of research projects.
  • Represent the research group at meetings/seminars, either with other members of the group or alone.
  • Maintenance of human tissue storage and record-keeping arrangements in liaison with Dr. Bulstrode.
  • Maintenance of safety records.
  • Coordinate and maintain ordering for the lab.
  • Coordination and oversight of laboratory duty rotas and ordering of supplies.
  • Liaise with colleagues and students on routine matters as well as make internal and external contacts to develop knowledge and understanding.
  • Act as a source of information and advice to other members of the group on specific techniques and may assist in the supervision of student projects.
  • Carry out collaborative projects with colleagues in partner institutions, and research groups.

The earliest start date of this post is 15th April 2024

Informal enquiries are welcomed and should be directed to Dr. Harry Bulstrode, hb252@cam.ac.uk

Fixed-term: The funds for this post are available until 1 February 2025 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 28th February 2024

The interview date for the role is: To be confirmed

Please quote reference PS40533 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Biomedical Research Technician (Fixed Term)

Fri, 09/02/2024 - 00:00

Applications are invited for a Biomedical Research Technician position in the group of Dr Maria P. Alcolea within the Wellcome ¿ MRC Cambridge Stem Cell Institute (CSCI) based at the Cambridge Biomedical Campus. This represents a collaborative effort with Prof. Phil Jones at the Wellcome Trust Sanger Institute. This role offers the opportunity to work in a multi-disciplinary team building on previously published work on epithelial stem cell biology and early cancer.

We are looking to recruit a Biomedical Research Technician to co-ordinate all aspects of the mouse colonies, along with individual researchers and the PPL holder in the team. The successful candidate will perform in vivo mouse work (such as overseeing multiple transgenic strains, administering various treatment protocols and interventions as well as tissue collection and processing) supervised by researchers in our research group. Good communication skills are key as the candidate will liaise with the NACWO's, NVS and HO inspector regarding mouse colonies, animal welfare and regulatory compliance along with individual researchers and the PPL holder. The role holder will also be involved in other research tasks, such as genotyping, staining, imaging, culturing of tissues (mouse and human), as well as keeping detailed records of the data and work undertaken.

As such, the candidate should have good interpersonal and organisational skills, paying close attention to detail. Other responsibilities include a range of tasks to ensure the smooth running of the laboratory, such as ordering and maintaining laboratory supplies, and maintaining and updating protocols and reagent databases. An understanding of the principles of cellular and molecular biology and basic knowledge of computational experience would be desirable.

Informal enquiries are welcomed and should be directed to Dr MP. Alcolea ( mpa28@cam.ac.uk ).

Start date is flexible but can be as early as end of March 2024.

Fixed-term: The funds for this post are available for 24 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 10th March 2024

The interview date for the role is: To be confirmed

Please quote reference PS40467 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Laboratory Technician Degree Apprentice

Thu, 01/02/2024 - 00:00

This is an exciting opportunity to join the world-leading Wellcome-MRC Cambridge Stem Cell Institute as a Laboratory Technician. As an apprentice you'll study for a Laboratory Scientist degree alongside gaining valuable work experience, learning on the job with no tuition fees to pay.

What you will do in your working day

In your first year you will work as part of the Scientific Facilities team who provide researchers with support, services, and equipment. You'll rotate through our core facilities to learn different skills and techniques: Laboratory Management, Advanced Microscopy, Histology and Next Generation Sequencing. You will then progress to working as a laboratory technician in a research group, carrying out experimental work and contributing to biomedical research projects. You will first join the Storer lab who investigate how stem cells regenerate mammalian digit tips.

Your daily responsibilities will be to:

  • Contribute to the daily operational tasks of a busy and collaborative research institute.
  • Work safely in a laboratory environment and follow Standard Operating Procedures to perform laboratory tasks and use/maintain scientific instrumentation.
  • Produce reliable data and keep accurate records of your laboratory work and results.
  • Analyse, interpret and evaluate data and use appropriate methods to resolve problems.
  • Communicate information appropriately to others in your team and the wider Institute.

The training you will be given:

  • You will receive on-the-job training from experienced technical and research staff, gaining experience in a broad range of laboratory skills.
  • You'll join a supportive team and have regular meetings with your line manager.
  • 20% of your working hours will be dedicated to 'off-the-job' learning. You will attend Anglia Ruskin University for lectures and workshops one day each week during term time.
  • You will achieve a BSc (Hons) Laboratory Scientist Degree upon successful completion of your Apprenticeship.

Skills and personal qualities

You will have a strong interest in biological science and be motivated to learn new skills. The ability to communicate well with others and work as part of a team is essential. You must be organised and responsible, with good attention to detail. You will have some experience of basic computer programmes such as word processing, spreadsheets and email.

Qualifications

You must be educated to A Level or equivalent in 3 subjects including Biology with a minimum of 112 UCAS points. GCSE Maths and English at grade C/4 or above are essential.

This Apprenticeship is for a fixed term of 4 years and 6 months, and will start on 2nd September 2024. The role is full-time for 36.5 hours per week (Monday - Friday).

Informal enquiries are welcomed and should be directed to: Dr Stephanie Hall; Email: slh60@cam.ac.uk.

The closing date for applications is Sunday 17 March 2024, with interviews TBC soon after.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference PS40367 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Senior Computational Scientists (Gottgens Lab) (Fixed Term)

Wed, 17/01/2024 - 00:00

Applications are invited for Senior Computational Scientists to work in the Cambridge Stem Cell Institute (CSCI). The Institute is a world-leading centre for stem cell research with a mission to transform human health through a deep understanding of stem and progenitor cell biology (http://www.stemcells.cam.ac.uk). The CSCI has secured prestigious funding from Wellcome for a Discovery Research Tissue Scale Biology Platform, which will commence in July 2024.

https://www.stemcells.cam.ac.uk/news/wellcome-funding-cambridge-stem-cell-institute-discovery-research-platform-tissue-scale-biology.

The Platform will create a new Senior Technologist Team which includes openings for 3 new Senior Computational Scientists. We welcome applications from individuals with specialist experience in the following areas:

i. Computational Tissue Modelling ii. Bioinformatics iii. Computational Image Analysis

Roles are based in the Jeffrey Cheah Biomedical Centre located on the Cambridge Biomedical Campus.

Post holders will carry out independent research that will complement that of other senior researchers within the Platform to support delivery of Platform research objectives. This will include leading, planning and developing own research ideas, to inform and support Platform projects and aims; conducting collaborative research projects, contributing to the design of new research grant applications, and co- supervising PhD and other students as required. The post holder will assess, evaluate and interpret outcomes of research, routinely communicating conceptual and complex ideas, both to peers and colleagues, and also to those with a limited knowledge and understanding of the topic area. They will collaborate actively within and outside of the CSCI to complete research projects requiring advanced thinking, developing links with relevant colleagues and networks as required.

These posts would be ideal for candidates with a minimum of 3 years relevant post-doctoral experience and distinctive research achievements. Individuals should possess sufficient breadth and depth of specialist knowledge in their discipline and of research methods and techniques to develop research objectives, projects and proposals. Interdisciplinary and collaborative research is strongly encouraged across the University and its associated institutes. The Platform will capitalise on existing and new interdisciplinary collaborations within its multi-disciplinary team.

Fixed-term: The funds for this post are available until 30 June 2031 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference PS40157 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Senior Research and Ethics Governance Coordinator

Mon, 08/01/2024 - 00:00

Applications are invited for a Senior Research and Ethics Governance Coordinator to work in the Cambridge Stem Cell Institute (CSCI). The Institute is a world-leading centre for stem cell research with a mission to transform human health through a deep understanding of stem and progenitor cell biology (http://www.stemcells.cam.ac.uk).

This role is based in the Jeffrey Cheah Biomedical Centre located on the Cambridge Biomedical Campus.

The post holder will be responsible for managing and coordinating aspects of the Cambridge Stem Cell Institute (CSCI) tissue collection/storage for the newly awarded Discovery Research Platform (DRP), funded by the Wellcome Trust. They will also undertake the role of Deputy Biosafety Officer in the CSCI. The role of the Governance Coordinator is to assist with a wide range of tasks to ensure that governance and ethics standards are maintained across the CSCI. The post-holder will manage the Human Tissue Authority audits and Standard Operating Procedures and Policies, as well as all relevant Biosafety documents. The role holder will provide advice to researchers and/or other staff from the CSCI with regards to any Ethical queries and Biological safety matters.

A suitable candidate will be educated to at least degree level/Level 7 vocational qualification or equivalent experience. They should have knowledge and experience of the Human Tissue Act and experience of managing complex projects. Candidates should be experienced users of Microsoft Office. They should be flexible, with the ability to communicate at all levels and be well-organised so as to manage conflicting deadlines.

If you have any queries regarding this position, please contact Danielle Daft, Research Manager: dmj34@cam.ac.uk.

We welcome applications from individuals who wish to be considered for flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 4th February 2024

The interview date for the role is: To be confirmed

Please quote reference PS40025 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Grants Administrator

Thu, 04/01/2024 - 00:00

Applications are invited for a Research Grants Administrator to work in the joint administration team supporting the Cambridge Stem Cell Institute (CSCI) and the Department of Haematology. The Institute is a world-leading centre for stem cell research with a mission to transform human health through a deep understanding of stem and progenitor cell biology (http://www.stemcells.cam.ac.uk). The Department of Haematology http://www.haem.cam.ac.uk/ has an international reputation in biomedical research, with a particular focus on blood cell formation, blood cancers and thrombosis. Approximately 60% of haematology research groups are part of CSCI.

This role is based in the Jeffrey Cheah Biomedical Centre located on the Cambridge Biomedical Campus.

The post holder will be responsible for managing research grants for the CSCI and Haematology. CSCI and Haematology jointly has a total grant income of more than £150M and has approximately 450 staff and students. This role will support researchers in the grant application process, providing advice on funding schemes and procedures. This includes costing and submitting applications using X5, in collaboration with the Principal Investigator. The post holder will also support the management of research grants during the entire project lifecycle, including project accounting reporting and audits.

A suitable candidate will be educated to at least HND, HNC, level 4/5 vocational qualification or an equivalent level of practical experience. They should have grant administrative or finance experience, ideally in a university setting. Candidates should be an experienced user of Microsoft Office and have a working knowledge of grant or financial management software/systems (e.g. X5 & CUFS). They should be flexible, with the ability to communicate at all levels and be well-organised so as to manage conflicting deadlines.

If you have any queries regarding this position, please contact Danielle Daft: dmj34@cam.ac.uk.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 14th January 2024

The interview date for the role is: To be confirmed

Please quote reference PS40010 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant/Post-doctoral Research Associate (Storer Lab)

Thu, 04/01/2024 - 00:00

The Wellcome - Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

The laboratory of Dr Mekayla Storer (https://www.stemcells.cam.ac.uk/people/pi/dr-mekayla-storer) uses multidisciplinary approaches to understand why the distal portion of the digit tip is the only part of the limb that can regenerate in mammals. The key step in this process is the formation of a blastema, a transiently proliferating mass of cells that the regenerates the different cell types of the digit to replicate the original structure. Therefore the broad goal of our research is to understand which cells and molecular pathways are necessary for this process. A portion of our present research builds on our previous work (Storer et al., Dev. Cell 2020) that used high-throughput single-cell mRNA sequencing and Cre-recombinase based lineage tracing to define the transcriptional identity of the mesenchymal cells comprising the blastema and the major transitions during mammalian digit tip regeneration. We are looking for a dedicated post-doctoral researcher to determine which of these factors present during digit tip amputation are necessary for successful regeneration and the mechanisms that underly this process. The post holder will use high-resolution imaging analysis, single cell transcriptomics/multi-omics approaches, in vitro culture with CRISPR-mediated gene regulation and in vivo transplantation assays.

Requirements:

Successful applicants should have a PhD in the field of regenerative biology, genomics, epigenetics or cell/developmental biology or be close to the completion of their degree. Expertise in general areas of stem cell biology including image analysis, CRISPR genome editing, in vivo mouse models and histology would be suitable for this position. A strong background in epigenetics, single cell transcriptomics and computational biology would be an advantage. It is essential that the post-holder is organized, able to work collaboratively as a member of a team and can communicate effectively and clearly.

Start date is flexible but can be as early as March 2024.

Fixed-term: The funds for this post are available for 24 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 29th February 2024

The interview date for the role is: To be confirmed

Please quote reference PS40007 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs