Research Assistant (Fixed Term)
Applications are invited for a Research Assistant position in the group of Dr Maria P. Alcolea within the Cambridge Stem Cell Institute (CSCI) and PDN Department at University of Cambridge. This post will be part of an ERC funded international collaborative effort to understand mutant cell competition.
Our group investigates how cells change their behaviour in response to tissue perturbations such as injury, ageing and the acquisition of cancer-related mutations. We make use of an interdisciplinary approach combining human tissue, mouse transgenic models, lineage tracing and 3D in vitro techniques to understand epithelial stem cell biology in the gastrointestinal tract.
We are looking to recruit a research assistant. The primary role will involve the management of multiple transgenic strains, performing and coordinating in vivo and in vitro experiments, administering varied treatment protocols and interventions as well as tissue collection and processing. The ideal candidate will also be able to oversee animal welfare and regulatory compliance.
The successful candidate will also be expected to provide technical support for other research activities, such as genotyping, staining, imaging, culturing of tissues, as well as to keep detailed records of the data and work undertaken. This role offers the opportunity to work in a multi-disciplinary team building on previously published work on epithelial stem cell biology and early cancer.
Please note that an occasional weekend or evening work may be required.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check. This appointment also requires a Research Passport application.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing Date: 22nd April 2025
Interview Date: To Be Confirmed
Please quote reference PS45659 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Laboratory Manager (Fixed Term)
We have an exciting opportunity for a Research Laboratory Manager to join the Káradóttir lab in the Cambridge Stem Cell Institute. CSCI is a world-leading centre for stem cell research based in the Jeffrey Cheah Biomedical Centre on the Cambridge Biomedical Campus.
The Káradóttir lab has expertise in neuroscience and stem cell biology using both human and rodent models in vivo and in vitro. The team aims to understand (1) how neurons regulate oligodendrocyte progenitor cell differentiation throughout life in both health and disease; (2) to what extent myelin changes once it is formed; (3) the effect myelin changes, and damage, have on neuronal circuit function; and (4) how myelin regeneration can be promoted. The lab uses a combination of molecular, genetic, cellular, imaging, physiological and behavioural methods to address these aims.
We are looking for a proactive and flexible Research Laboratory Manager to work closely with Prof. Káradóttir to coordinate research activities, supervise the day-to-day running of the lab and line manage a Research Assistant. You will support students and postdoctoral researchers with project management and experimental design, helping to ensure that we achieve our research objectives on time and within budget.
As the primary technical expert in the group, you will develop, implement and train others in specialised methods including imaging, in vivo calcium recording, electrophysiology and computational data analysis. Previous experience of electrophysiology and imaging are essential for the role, as well as the use of statistics and image analysis.
You will be a key point of contact for staff, students and collaborators so excellent communication skills are essential. The ideal candidate will have previous experience of scientific writing and contributing to publications. We are looking for someone who enjoys working cooperatively and has good project management and organisational skills.
You will be qualified to degree level or equivalent in neuroscience or a related subject and hold a PhD in a relevant area.
This is a full-time role of 37 hours per week. This post is fixed-term with funding available for 2 years in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date: 7th May 2025
Interview date: 23rd May 2025
Please quote reference PS45572 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Associate x 2 (Fixed Term)
The Tzelepis lab is recruiting two postdoctoral research associates to drive our translational work on novel RNA biology of disease (particular focus on solid tumors and neurodegeneration). Our lab focuses on the epitranscriptome-associated roles of stem cell homeostasis and disease. Our approaches include functional genetics, normal and abnormal stem cell cultures, development and characterisation of novel treatments as well as various mouse models of disease.
The postholders will actively contribute to our research and be responsible for ensuring that the Tzelepis laboratory research is competitive and novel. The ideal candidate will be a team player with excellent communication skills and support a variety of experimental procedures, animal handling, imaging and data collection as well as preparing results for publications and grant submissions. The post also entails training students and visiting researchers in techniques and equipment use, as well as instructing correct research conduct.
Our work is highly collaborative, and we operate at the Cambridge Stem Cell Institute, the Department of Haematology and the wider scientific ecosystem (Babraham campus, Sanger Institute etc.) with access to state-of-the-art equipment and facility support.
Essential requirements are a PhD in a relevant subject and strong expertise in either:
Condensate biology of disease or
Disease-associated tRNA modifications. The ideal candidate will also have experience in either stem-cell/cancer biology, mouse models and/or nucleic acid editing.
For queries regarding this post, please contact Dr Konstantinos Tzelepis, email: kt404@cam.ac.uk
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Applicants must have (or be close to obtaining) a PhD.
Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,132) moving to Research Associate (Grade 7) upon confirmation of your PhD award.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date: 16th April 2025
Interview date: 23rd April 2025
Please quote reference PS45501 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Associate (Fixed Term)
Applications are invited to join a dynamic team led by Prof Sanjay Sinha (https://www.sinha-lab.org/ and https://www.stemcells.cam.ac.uk/people/pi/sinha), to investigate coronary artery smooth muscle cell (SMC) development and its role in atherosclerosis using human stem cell-based models and state-of-the-art bioinformatics.
In the proposed project, we will explore the hypothesis that the metaplastic SMC response in atherosclerosis is a re-enactment of embryonic processes. That some SMCs in human coronary atherosclerosis de-differentiate to immature cells akin to embryonic precursor cells in the developing heart, which subsequently proliferate and re-differentiate to produce the mesenchymal cell types that build the atherosclerotic plaque. To test this idea, we have partnered with Prof Jacob Bentzon's group (Univ of Aarhus, Denmark) who specialises in atherosclerosis and the PDRA will work closely with the Bentzon group towards the project aims.
The Sinha lab has extensive expertise on using pluripotent stem cell-based systems to generate cardiovascular cells (Cheung et al Nature Biotech 2012, Iyer et al Development 2015, Bargehr et al Nature Biotech 2019) and have recently generated a high resolution multi-omic atlas of the developing human heart (Bayraktar et al BioRxiv 2024 Cranley et al BioRxiv 2024). These approaches will be used to generate coronary SMCs in vitro and to understand how metaplastic differentiation may impact atherosclerosis development.
Please reach out to Prof S Sinha (Sinha@stemcells.cam.ac.uk) if you have further questions about this position.
About You
The successful candidate will be highly motivated, collaborative and have expertise in cell biology and bioinformatics. Prior experience with human pluripotent stem cells and/or vascular biology is highly desirable but not essential.
Appointment at Research Associate is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level (grade 5), which will be amended to Research Associate (grade 7) once PhD has been awarded.
Fixed-term: The funds for this post are available until 31/08/2027 in the first instance. Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Applicants must have (or be close to obtaining) a PhD.
Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,132) moving to Research Associate (Grade 7) upon confirmation of your PhD award.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date: 31st March 2025
Interview date: 16th April 2025
Please quote reference PS45315 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
PhD and Training Administrator (Part Time, Fixed Term)
Do you have experience of working in a busy office environment in role assisting various stakeholders? Are you an energetic highly motivated individual with excellent administrative and organisational skills? Can you make a positive contribution to our team?
The role holder will work as part of the Cambridge Stem Cell Institute Administrative team, as the main day-to-day admin contact for all Graduate matters. The role holder will be the first point of contact for general queries from current students and will provide assistance to the Institute Director and PhD Programme Director in all Graduate student matters, to ensure that all Graduate students at the Cambridge Stem Cell Institute have a positive experience. The role holder will co-ordinate the admissions processes and course(s) support systems within the Cambridge Stem Cell Institute (CSCI) in order to provide an efficient admissions experience for prospective students, be a point of contact for current students and organise the course schedule and two annual student events.
This role will be based on the Cambridge Biomedical Campus. We are open to discussing flexible working arrangements. This is a part time role of 21.9 hours per week or 0.6 FTE.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a standard Disclosure and Barring Service check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
The closing date for applications is 6th March with interview date to be confirmed.
Informal enquiries about the post are also welcome via email to Danielle Daft, Research Manager, dmj34@cam.ac.uk
Please quote reference PS45171 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
