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A Research Assistant or Research Associate (post-doc) position in AI and Neuroinformatics is available to work with Prof Zoe Kourtzi (Adaptive Brain Lab, Univ of Cambridge; https://www.abg.psychol.cam.ac.uk) and Prof Eleni Vasilaki (School of Computer Science, Univ of Sheffield).

The position will focus on developing AI-guided tools for understanding brain functions (e.g. learning and adaptive behaviour) and improving early detection of brain disorders. This position is well-suited for candidates eager to develop and translate theoretical AI models into tools that can: a) help understand brain mechanisms in health and disease, b) be deployed in clinical settings.

Successful candidates will engage in developing AI models to synthesise and analyse diverse data sets, including brain imaging, genetic, cognitive, and epidemiological data. The research activity is at the core of a funded programme that brings together multidisciplinary experts in neuroscience, machine learning, clinical practice, clinical informatics with healthcare innovation and pharmaceutical industry partners.

You will receive multi-disciplinary research training at the interface of machine learning, neuroscience, and clinical translation. You will be integrated in a diverse collaborative team and will have the opportunity to participate in workshops as well as exchange visits across labs to facilitate cross-disciplinary training and collaborative working. You will be member of the AI-deas Hub for brain and mental health (https://www.cam.ac.uk/stories/AI-deas-launch). The Hub fosters collaborations between mathematics, statistics, computer science, medicine and industry aiming to develop analytics tools for brain research and healthcare.

Desired Skills and Experience:

• Applicants should have a MRes or PhD (or have submitted by the time of appointment) together with a strong academic track record, in a relevant area: Mathematics, Engineering, Physics, Computer Science, Data Science, Biostatistics, Neuroscience, or Medicine.

  • A strong academic track record and programming skills are essential.

• Experience with machine learning, data science, computational neuroscience, biostatistics, cognitive or clinical neuroscience are highly desirable

• Strong mathematical skills, knowledge of recurrent neural networks, foundation models and a focus on explainable machine learning models, would bring added value to the position.

• The successful applicant should demonstrate enthusiasm for generating new knowledge, openness to learning new approaches, and ability to contribute to a multidisciplinary team across sectors (academia, healthcare, industry).

Fixed-term: The funds for this post are available for 18 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

For informal inquiries, please contact Zoe Kourtzi at zk240@cam.ac.uk

Closing Date: Sunday 6th April at 12 Midnight

Interview dates: TBC

Please quote reference PJ45385 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Department of Genetics, University of Cambridge, is a thriving, friendly and dynamic community of staff and students, dedicated to the pursuit of world-class research, teaching and learning, and driven by curiosity, quality, collaboration and innovation. It is a wonderfully rich and rewarding environment in which to grow, both personally and professionally.

We wish to recruit an enthusiastic and self-motivated IT Technician who can assist with the provision of IT support for all teaching, research and administration activities within the department. The role will be split 50/50 between the main Department of Genetics and the Bioinformatics Training Facility (BTF), which sits within the Department of Genetics. This will be a hands-on role providing the first line of support and therefore requires good communication and relationship-building skills.

The role will be well supported by the IT Managers in the department and BTF, by the School of Biological Sciences Head of IT, and by colleagues in similar roles in other university departments. A wide range of training and professional career development opportunities are also available. If you have the technical skills to help with the delivery of a resilient IT service for the department, and the personality and drive to contribute to an outstanding support culture, please do apply - we'll be delighted to hear from you.

This role is based within the Department of Genetics, and full-time, on-site presence is expected.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Gareth Porteous gsp35@cam.ac.uk and Paul Judge pj237@cam.ac.uk

Please quote reference PC45379 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Innovation Pathway Coordinator at the Milner Therapeutics Insitute (MTI) is a new and exciting opportunity for an individual to play a key role in advancing neurotechnology innovation within the Cambridge NeuroWorks ARIA Activation Partnership.

The partnership comprises a consortium of organisations:Cambridge University Health Partners, several departments of the University of Cambridge, Babraham Research Campus, Cambridge & Peterborough NHS Foundation Trust, Cambridge Network, and Vellos. The partners will provide creative talent with access to the expertise and resources needed to progress a new generation of neuro-technologies designed to treat conditions such as depression, dementia, chronic pain, epilepsy and injuries to the nervous system.

The role coordinates the delivery of the ideation ("What If") programme within the broader Cambridge NeuroWorks activity. This involves supporting the Innovation Pathway Manager to develop and implement the ideation ("What If") programme and support the "Blue Sky" fellows during their experimental exploration (Blue Sky) phase. The role also supports the transitions into the commercial translation ("Activation") phase, (led by the Babraham Research Campus. Collaborating with other programme coordinators and managers the role holder ensures the "What If" programme aligns with the goals of the Cambridge NeuroWorks Activation Partnership.

The role holder will produce programme content, analyse programme feedback, communicate/ promote events, coordinate/ manage communications with Blue Sky fellows and "What If" part-time participants, and foster community engagement with both internal and external stakeholders in the Cambridge NeuroWorks Community space on Connect: Health Tech.

The ideal candidate will have previous experience in working in an entrepreneurial environment and initiating, developing, and maintaining stakeholder relationships. Will also be able to demonstrate knowledge of project coordination, ability to plan, execute and keep to deadlines.

For the full person specification, click below to view the further particulars.

About the Milner Therapeutics Institute (MTI)

The MTI is a purpose-built research institute at the University of Cambridge, with an overarching vision to convert pioneering science into therapies by driving academic-industry partnerships. The MTI is breaking new ground in academic/industry interactions and demonstrates a world-leading model of start-up companies, academics and pharma working side by side at the bench. The MTI environment offers a unique opportunity to work at the interface of academia and industry, applying ground-breaking technologies to drug discovery and patient treatment.

Fixed-term: The funds for this post are available until 30 September 2027 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For an informal discussion in confidence please contact Alexandra Huener, Head of Entrepreneurship ah930@cam.ac.uk.

Please quote reference PR45366 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Are you an experienced HR professional looking for a varied and fast-paced role at the heart of a world-leading scientific research institute, embedded within the University of Cambridge?

A rare and exciting opportunity has arisen to join our busy and friendly research institute as a temporary HR Manager. The Gurdon Institute is a department of the University of Cambridge at the cutting edge of science, with 12 research groups, carrying out research on projects related to cancer and developmental biology. We are seeking a dedicated and proactive individual to become an integral part of our administration team. This role offers a unique opportunity to contribute to a globally recognised research environment, providing expert HR support to staff, students and visitors.

We are looking for someone with significant professional HR experience, ideally within Higher Education. You should be confident in handling complex and sensitive personnel matters with professionalism and discretion. The successful candidate will deliver a comprehensive HR service to the Institute, developing, implementing and maintaining an effective HR strategy and will ensure alignment with both the Institute's objectives and the University's HR policies and best practices.

Working closely with the Business and Operations Manager and supported by an HR Administrator, you will be part of a friendly and collaborative core administration team that underpins the operational success of the Institute.

The successful candidate will have a relevant degree or equivalent working experience and Level 5 CIPD qualification. A problem-solving mindset, strong attention to detail and the ability to prioritise workloads effectively to meet deadlines and exceptional written and verbal communication skills are essential, as well as the ability to work flexibly and manage competing priorities. Experience in line management and the ability to work confidentially, with tact and discretion, are also key attributes.

The Institute currently operates a hybrid working model, but the postholder is expected to be on-site for a minimum of three days per week.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Temporary cover: This post is fixed-term for one year or the return of the post holder, whichever is the earlier.

If you are looking for a role where you can make a real impact within a leading research environment, we would love to hear from you!

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please quote reference PR45353 on your application and in any correspondence about this vacancy.

Previous Applicants need not reapply.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The degradation of natural habitats and farmland undermines efforts to keep global warming below 2°C, and to meeting the United Nations Sustainable Development Goals. International commitments under the Bonn Challenge seek to 'restore' 350 million hectares by 2030, a goal set in response to a scientific report indicating that 300-400 million hectares of forest needed to be restored to avoid dangerous climate change. While restoration promises to slow climate change, reverse biodiversity loss, and recover soils, 21st century restoration science lacks a joined-up understanding of the effectiveness of different tree planting options.

There is a pressing need to move beyond traditional individual project-level assessments of restoration that may fail to detect complex and larger-scale impacts. This project will conduct novel fieldwork and analysis that explicitly investigates biodiversity and carbon outcomes of the most commonly applied restoration techniques (natural regeneration, tree plantations, and on-farm agroforestry approaches) at large spatial scales. This near-continent-scale integrated programme of research uniquely focuses on wooded savanna and montane ecosystems in sub-Saharan Africa, where ~90 million hectares of restoration are planned.

This Postdoctoral Research Associate post reports directly to Professor David Edwards (University of Cambridge), with direct input from co-investigator Professor Casey Ryan (University of Edinburgh). It will tackle two main Objectives: (1) Quantify how restoration has impacted biodiversity and carbon storage across space and time; and (2) Identify the environmental and socio-economic drivers of restoration outcomes and effectiveness. In tackling these two objectives, this project will deliver a step change in our understanding of the likely consequences of continental-scale restoration, increasing the prospect of achieving its ecological and societal potential and meeting global climate and development goals.

The Postdoctoral Research Associate will conduct rigorous field sampling of birds across restoration types and spanning several countries including but not limited to Sierra Leone, Ghana, Rwanda, and Zambia. They will concurrently collect microclimate data. They will deliver high-quality analyses, including biogeographic multispecies occupancy models developed by Professor Edwards' team to project the biodiversity outcomes of different restoration forms across large spatial scales, and publish their findings in leading scientific journals. They will work with a high degree of independence, as appropriate seeking input from Profs Edwards and Ryan, and the wider network of restoration actors and academic collaborators engaged in this research. They will also become a member of the Centre for Global Wood Security and actively engage in this dynamic, international community.

This is a fixed term position for 2 years with potential for a 2-year extension.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please notice that if you have not received any news from us 1 month after the closing date you should consider that on this occasion your application has not been successful.

Please quote reference PD45365 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The post Highlights from another great year for Cambridge Enterprise appeared first on Cambridge Enterprise.

The Medical Research Council Toxicology Unit is an internationally renowned institution focused on the delivery of field-changing mechanistic insights into toxicology and disease.

We are currently looking to appoint a Laboratory Technician to provide tissue culture, laboratory and media kitchen support to our research groups. The successful candidate will be required to ensure adequate supplies of glassware, general lab consumables and disposal of laboratory waste. You will also provide tissue culture laboratory maintenance including consumables ordering, media preparation, inspection and cleaning of tissue culture rooms and equipment.

You will have excellent communication and interpersonal skills, be well organised and a reliable team player. You should be educated to A level, NVQ level 3 or have equivalent level of practical experience. Some experience of laboratory/biological scientific research work is essential; experience of tissue culture, laboratory and aseptic techniques would be an advantage.

This post is fixed-term with funding available until 31 March 2027 in the first instance.

The University offers a range of staff benefits which include:

Competitive rates of pay with automatic service-related pay progression and annual cost of living increases.

An annual leave allowance of 36 days paid leave (including bank holidays)

Generous maternity, adoption and shared parental leave entitlement and other family friendly schemes (e.g. workplace nurseries and salary exchange schemes for childcare)

An auto-enrolment pension scheme, with a generous employer contribution

Travel benefits and retail discounts at over 2,000 local and national stores

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk

Further information can be found on our website: https://www.mrc-tox.cam.ac.uk

Please quote reference PU45339 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

An exciting opportunity has arisen in the Department of Psychology for a Human Resources Administrator. The Department of Psychology is a friendly and welcoming teaching and research Department in the School of Biological Sciences with approximately 30 University Teaching Officers, around 150 members of staff, 90 visitors and 100 postgraduate students.

This position is as interesting as it is varied, no two days are the same. A key function of the role is undertaking generalist HR administration for both employees and department visitors through the entire lifecycle of the process. The post-holder will need to be confident and able to liaise with people at different levels across the Department. The position requires a high level of accuracy when checking or producing documentation, and as such the post holder should approach their work in an organized and methodical way.

You will enjoy communicating with individuals across the University and be the type of person who strives for a high level of quality in everything that you do.

You will feel comfortable being able to work to deadlines and be happy to be a team player within a supportive environment.

We offer a hybrid working model and the successful candidate will be expected to be in the office for a minimum of two days a week.

Ideally the successful candidate will be able to start at the beginning of June 2025.

Some of our many benefits include: - Competitive rates of pay with automatic service-related pay progression and annual cost of living increases; - Generous annual leave provision - Family & Work-life balance policies including hybrid working and generous carer leave (maternity, paternity, shared parental leave, adoption leave), amongst others - An auto-enrolment pension scheme, with a generous employer contribution; - Exclusive employee discounts via our CamBens scheme - Personal Development: The Department actively encourages and supports personal development and our staff have access to a wide range of courses and training provided by the University of Cambridge Learning and Development team.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal inquiries, please contact Fiona Lyall Grant: fjl25@cam.ac.uk

Closing Date: Sunday 6th April 2025 at midnight

Planned interview date: 23rd April 2025

Please quote reference PJ45322 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Ready to nurture and transform stunning plant collections in one of the most captivating gardens in the region?

Join our Horticultural Team as a Horticulturist, focusing on the vibrant and diverse eastern display areas of the Botanic Garden. Working alongside our Senior Horticulturist, you will be at the heart of maintaining and enhancing iconic garden spaces such as the Dry Garden, Cory Lawn, Scented Garden, Chronological Beds, and the Winter Garden¿vital resources for research, education, and inspiration within the Garden, University, and beyond.

We are seeking a qualified horticulturist with a solid foundation of practical horticultural experience. If you're enthusiastic, hands-on, and have the knowledge to help us maintain and elevate our Garden's eastern displays, we want to hear from you! Your expertise will directly contribute to the ongoing success and beauty of our collections and landscapes, ensuring they continue to thrive and inspire future generations.

For full details, including the essential requirements and person specification, please refer to the Further Particulars.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For any questions relating to this recruitment please contact admin@botanic.cam.ac.uk

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Salary £25,834.00 to £29,539.00 (pro rata for 0.96 FTE) + 15% Shift Allowance = £29,709.00 to £33,969.00 per annum, working an average of 35 hours a week.

This equates to approximately an hourly rate of £14.12 - £16.15 (£16.24-£18.57 with 15% uplift).

We have an exciting opportunity for a Registered Veterinary Nurse to join our nursing team at the Queens Veterinary School Hospital.

The referral hospital is a very fast-paced environment which requires you to be adaptable with the ability to work well under pressure. The role will be to provide nursing to an excellent standard in the Small Animal Wing. The small animal wing consists of four dog, two cat, critical care and isolation wards housing an average of 15-25 patients during the overnight period.

We are looking for nurses who can cover 24/7 working on a 7 week, generous and attractive rotating shift pattern, covering core, early, late, night shifts and time off (includes 10 day off shift period after weeks of nights). Weekend working (2 in 7). Rotas are planned well in advance to help employees maintain a healthy work-life balance.

The role in Small Animal inpatients will include surgical, medical and critical care nursing (training can be given in critical care procedures). Cleaning, hygiene and administration duties linked to inpatient care will form a reasonable percentage of the time. This is a varied role where no two days are the same, so we are seeking individuals with a passion for nursing, with the ability to communicate with all levels of staff, students and clients. The ability to work on your own initiative with minimal supervision is essential. Shifts have student nurse and Veterinary Care Assistant support.

In return, we offer an encouraging and nurturing environment and have a dedicated team of clinicians and nurses who are committed to providing the best care for our patients.

Benefits:

• Generous paid annual leave including bank holidays
• Defined benefit pension scheme
• Enhanced family friendly policies
• Access to a dedicated Personal and Professional Development team
• Wellness programme including Occupational Health team and Staff counselling
• Staff discount scheme including shopping vouchers
• Cycle to work scheme
• Travel to work loans
• Eye care voucher scheme
• Discounted gym membership
• CPD allowance

If you have any questions about this role, please contact the Clinical HR Team on qvsh.hr@vet.cam.ac.uk. Please quote reference PP45293 on your application and in any correspondence about this vacancy.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applications will be monitored regularly, and we may contact candidates prior to the closing date. We reserve the right to close this vacancy early if we receive sufficient applications or extend the closing date if necessary. Therefore, if you are interested, please submit your application as early as possible.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Milner Therapeutics Institute (MTI) at the University of Cambridge aims to accelerate translation of pioneering science into therapies. The newly established Functional Genomics Screening Laboratory (FGSL) at the MTI applies arrayed CRISPR screening in human cellular models to advance mechanistic understanding underlying tissue homeostasis and disease biology. Formed as a joint venture with the Medical Research Council and AstraZeneca, this new laboratory aligns with the MTI's vision of breaking the mould of how academia and industry interact. The FGSL is part of the UK Research and Innovation's Human Functional Genomics Initiative to facilitate innovative and collaborative research to drive new scientific discoveries.

We are seeking to recruit a biologist with a strong background in complex cellular modelling to join the FGSL team. You will be applying your expertise in characterising physiological-relevant models such as organoids, primary cells, co-cultures or stem cells to design and implement arrayed CRISPR screens. The ideal candidate is proficient in developing a range of functional assays such as imaging and flow cytometry to identify key phenotypes suitable for high-throughput screening. Previous experience in utilising automated or semi-automated liquid handlers for microplate-based assays is highly desirable.

This is a highly collaborative role where you will work closely with scientists and bioinformaticians from the MTI, AstraZeneca, small/medium enterprises and academic institutions. You will have the opportunity to develop new skills in areas including multi-modality screens, automation platform and bioinformatics analysis.

The MTI is a buoyant, vibrant and fast-paced environment and is ideal for those who thrive in the face of change. We welcome applications from recent PhD graduates or experienced postdocs that are enthusiastic to work as part of a dynamic team at the interface between academia and industry. We offer an engaging and supportive environment that fosters professional growth and career development.

Interviews will be held at the Milner Therapeutics Institute w/c 14th April. We are aiming for candidates to start as soon as possible once all relevant processes are completed.

To find out the full duties of the role and person specification, click below to view the further particulars.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be directed to Chun Hao Wong, FGSL lead, wc389@cam.ac.uk

Please quote reference PR43930 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

An exciting opportunity has arisen for a versatile custodian to join our friendly team in the Department of Physiology, Development and Neuroscience, providing an efficient, safe, reliable and welcoming service in our buildings located in central Cambridge.

The role holder will provide day to day support in the Department, supporting Reception, dealing with visitors and contractors, assisting with events, portering and supporting the facilities team with minor maintenance across our two buildings which consist of laboratories, classrooms, offices and lecture theatres.

The successful candidate will have good organisational and time management skills, as well as basic DIY and IT skills. You will have a flexible working approach and have good interpersonal, team-working and customer service skills. You will be willing to learn and whilst experience in a caretaking or similar role would be advantageous, it is not essential as training will be given.

For more information about this post, please contact Katie Conran, Facilities and Operations Manager kc662@cam.ac.uk.

This post is offered on a full-time basis, working 36.5 hours per week, Monday-Friday.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Apply:

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two professional referees should be provided, one of who should be your most recent line manager. Please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

The closing date for applications is 23 March 2025. Interviews will be held on Tuesday 1 April.

If you are unable to use the online system for your application, please contact Tracey Flack, pdnhr@pdn.cam.ac.uk.

Please quote reference PM45242 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are looking for an enthusiastic postdoctoral Research Assistant / Research Associate to join the Kromdijk lab to study chilling responses in maize.   Maize is an important global food, feedstock and bioenergy crop. Maize was domesticated by ancient farmers in Mexico approximately 9000 years ago and is one of the most susceptible crops to chilling stress amongst those grown in temperate regions. As a result, maize yields at higher latitudes are limited by a relatively short growing season and maize is sensitive to yield losses due to early and late season cold snaps. Chilling stress in maize is most common at the start of the growing season, where it leads to poor establishment, which decreases maize ability to efficiently capture light, compete with weeds and take up nitrogen fertilizer. In addition, chilling stress decreases general plant health and enhances susceptibility to plant pathogens. While later planting dates would decrease the prevalence of chilling stress, sustainable farm management increasingly focuses on early harvest (which necessitates early sowing) to allow sufficient growing time for cover crops at the season's end to minimize nitrogen leaching.   Altogether, understanding maize chilling stress is clearly important for improving yield security and sustainability of maize cultivation. However, despite decades of research efforts, a full mechanistic understanding of chilling sensitivity in maize is still lacking. Recent work in the Kromdijk group found that root-specific chilling already creates significant damage and downregulation of photosynthesis at mild chilling temperatures at which plants can safely tolerate whole-plant chilling. These results suggest that chilling stress symptoms under field conditions could reflect both maize' poor capacity to cope with low temperature per se, but also with cool temperature of roots relative to shoots.   The advertised role will perform experiments to deconvolute the impact and underlying mechanisms of whole plant chilling and root-specific chilling in maize by focusing on the following objectives: 1. Define damage and plant survival under root-chilling and whole-plant chilling treatments. 2. Combine maize grafting with a reverse genetic approach to determine: a) the role of abscisic acid (ABA) synthesis and perception. b) the role of photoinhibition in chilling stress.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please notice that if you have not received any news from us 1 month after the closing date you should consider that on this occasion your application has not been successful.

Please quote reference PD45325 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Researchers studying British Labrador retrievers have identified multiple genes associated with canine obesity and shown that these genes are also associated with obesity in humans.  

The dog gene found to be most strongly associated with obesity in Labradors is called DENND1B. Humans also carry the DENND1B gene, and the researchers found that this gene is also linked with obesity in people.  

DENND1B was found to directly affect a brain pathway responsible for regulating the energy balance in the body, called the leptin melanocortin pathway.  

An additional four genes associated with canine obesity, but which exert a smaller effect than DENND1B, were also mapped directly onto human genes. 

“These genes are not immediately obvious targets for weight-loss drugs, because they control other key biological processes in the body that should not be interfered with.

But the results emphasise the importance of fundamental brain pathways in controlling appetite and body weight,” said Alyce McClellan in the University of Cambridge’s Department of Physiology, Development and Neuroscience, and joint first author of the report.  

“We found that dogs at high genetic risk of obesity were more interested in food,” said Natalie Wallis in the University of Cambridge’s Department of Physiology, Development and Neuroscience, and joint first author of the report.  

She added: “We measured how much dogs pestered their owners for food and whether they were fussy eaters. Dogs at high genetic risk of obesity showed signs of having higher appetite, as has also been shown for people at high genetic risk of obesity.”  

The study found that owners who strictly controlled their dogs’ diet and exercise managed to prevent even those with high genetic risk from becoming obese - but much more attention and effort was required.  

Similarly, people at high genetic risk of developing obesity will not necessarily become obese, if they follow a strict diet and exercise regime - but they are more prone to weight gain. 

As with human obesity, no single gene determined whether the dogs were prone to obesity; the net effect of multiple genetic variants determined whether dogs were at high or low risk. 

The results are published today in the journal 'Science'. 

“Studying the dogs showed us something really powerful: owners of slim dogs are not morally superior. The same is true of slim people. If you have a high genetic risk of obesity, then when there’s lots of food available you’re prone to overeating and gaining weight unless you put a huge effort into not doing so,” said Dr Eleanor Raffan, a researcher in the University of Cambridge’s Department of Physiology, Development and Neuroscience who led the study. 

She added: “By studying dogs we could measure their desire for food separately to the control owners exerted over their dog’s diet and exercise. In human studies, it’s harder to study how genetically driven appetite requires greater willpower to remain slim, as both are affecting the one person.” 

The current human obesity epidemic is mirrored by an obesity epidemic in dogs. About 40-60% of pet dogs are overweight or obese, which can lead to a range of health problems. 

Dogs are a good model for studying human obesity: they develop obesity through similar environmental influences as humans, and because dogs within any given breed have a high degree of genetic similarity, their genes can be more easily linked to disease. 

To get their results, the researchers recruited owners with pet dogs in which they measured body fat, scored ‘greediness’, and took a saliva sample for DNA. Then they analysed the genetics of each dog. By comparing the obesity status of the dog to its DNA, they could identify the genes linked to canine obesity. 
Dogs carrying the genetic variant most associated with obesity, DENND1B, had around 8% more body fat than those without it.  

The researchers then examined whether the genes they identified were relevant to human obesity. They looked at both large population-based studies, and at cohorts of patients with severe, early onset obesity where single genetic changes are suspected to cause the weight gain.  

The researchers say owners can keep their dogs distracted from constant hunger by spreading out each daily food ration, for example by using puzzle feeders or scattering the food around the garden so it takes longer to eat, or by choosing a more satisfying nutrient composition for their pets. 

Raffan said: “This work shows how similar dogs are to humans genetically. Studying the dogs meant we had reason to focus on this particular gene, which has led to a big advance in understanding how our own brain controls our eating behaviour and energy use.”  

The research was funded by Wellcome, the BBSRC, Dogs Trust, Morris Animal Foundation, MRC, France Genomique consortium, European Genomic Institute for Diabetes, French National Center for Precision Diabetic Medicine, Royal Society, NIHR, Botnar Foundation, Bernard Wolfe Health Neuroscience Endowment, Leducq Fondation, Kennel Club Charitable Trust. 

Reference 
Wallis, N.J. et al: ‘Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans.’ Science, March 2025. DOI: 10.1126/science.ads2145  
 

Researchers at the University of Cambridge have discovered genes linked to obesity in both Labradors and humans. They say the effects can be over-ridden with a strict diet and exercise regime.

Dogs at high genetic risk of obesity showed signs of having higher appetite, as has also been shown for people at high genetic risk of obesity.Natalie WallisJames Barker on UnsplashLabrador licking nose

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The pledge, made in February 2020 by the UK’s nine leading game shooting and rural organisations, aimed to benefit wildlife and the environment and ensure a market for the healthiest game meat food products. 

But a Cambridge team, working with the University of the Highlands and Islands, has consistently shown that lead shot was not being phased out quickly enough to achieve a complete voluntary transition to non-toxic ammunition by 2025. In a final study, published today in the journal Conservation Evidence, the team concludes that the intended transition has failed.

The team has closely monitored the impact of the pledge every year since its introduction, recruiting expert volunteers to buy whole pheasants from butchers, game dealers and supermarkets across Britain and recover embedded shotgun pellets for analysis. 

In 2025, the study - called SHOT-SWITCH - found that of 171 pheasants found to contain shot, 99% had been killed with lead ammunition. 

This year, for the first time, the team also analysed shotgun pellets found in red grouse carcasses shot in the 2024/25 shooting season and on sale through butchers’ shops and online retailers. In all 78 grouse carcasses from which any shot was recovered, the shot was lead. 

“Many members of the shooting community had hoped that the voluntary pledge away from lead ammunition would avert the need for regulation. But the voluntary route has now been tested - with efforts made by many people - and it has not been successful,” said Professor Rhys Green in the University of Cambridge’s Department of Zoology and lead author of the report.

Eating game meat killed using lead shot will expose people unnecessarily to additional dietary lead. Lead is toxic to humans even in very small concentrations; the development of the nervous system in young and unborn children is especially sensitive to its effects. As a result, many food safety agencies now advise that young children and pregnant women should avoid, or minimise, eating game meat from animals killed using lead ammunition.

Discarded shot from hunting also poisons and kills many tens of thousands of the UK’s wild birds each year.

Despite proposing the voluntary change, many shooting organisations and some individual shooters do not support proposed regulatory restrictions on lead ammunition.

Green said: “Private individuals pay a lot of money to shoot pheasants on some private estates - and people don’t like to change their habits. It’s a bit like wearing car seatbelts, or not smoking in pubs. Despite the good reasons for doing these things, some people were strongly against using regulation to achieve those changes, which are now widely accepted as beneficial. The parallel with shooting game with lead shotgun ammunition is striking.” 

Danish shooters now say that the legal ban on lead introduced in Denmark around 30 years ago was justified. They say it has not reduced the practicality or popularity of their sport, and has increased its acceptability to wider society.

“Although a few large UK estates have managed to enforce non-lead ammunition on pheasant shoots, some have had to be quite draconian in order to do it, with the estate gamekeepers insisting on loading the guns for the shooters,” added Green.

In the 2020/21 and 2021/22 shooting seasons, over 99% of the pheasants studied were shot using lead ammunition. This figure dropped slightly to 94% in 2022/23 and 93% in 2023/24, with the remaining pheasants killed by ammunition made of steel or a metal called bismuth, before rising to 99% again in 2024/25.

Retail pressure

The researchers also checked up on a pledge made by Waitrose in 2019 to stop selling game killed with lead ammunition. 

They found that the retailer had been largely let down by suppliers, and that some of their shooters continued to shoot using lead despite making assurances to the contrary. As a result, Waitrose did not sell oven-ready pheasants at all between 2021 and 2023. It sold pheasants again in January 2024 and the 2024/25 season, but the researchers showed that the majority had been killed using lead shot.

In 2022 the National Game Dealers Association (NGDA), which buys game and sells it to the public and food retailers, also announced it would no longer sell game of any kind that had been shot using lead ammunition. But this pledge has since been withdrawn. The researchers bought 2024/25 season pheasants from three NGDA member businesses and found that all had been shot with lead ammunition.

Inside influence 

The researchers also analysed all articles relating to the voluntary transition published in the magazine of the UK’s largest shooting organisation, the British Association for Shooting and Conservation. They found that articles near the beginning of the five-year pledge communicated clear, frequent and positive messages about the effectiveness and practicality of non-lead shotgun ammunition.

But by 2023, mentions of the transition and encouragement to follow it had dropped dramatically. 

The upshot

At the request of the Defra Secretary of State, the UK Health & Safety Executive (HSE) has assessed the risks to the environment and human health posed by lead in shot and bullets. Its report, published in December 2024, proposes that the UK Government bans the use of lead shot and large calibre bullets for game shooting because of the risks they pose to the environment and health. This recommendation is currently under review by Defra ministers, with a response due in March 2025.

Steel shotgun pellets are a practical alternative to lead and can be used in the vast majority of shotguns, as can other safe lead-free alternatives. But the results of this study indicate UK hunters remain unwilling to make the switch voluntarily.

Since 2010, UK governments have preferred voluntary controls over regulation in many areas of environment and food policy and have suggested that regulation be used only as a last resort.

“Shooting organisations did a lot of questionnaire surveys when the pledge was introduced in 2020, and the results suggested many shooters thought the time had come to switch away from lead ammunition. Those responses stand in contrast to what we’ve actually measured for both pheasant and grouse,” said study co-author Dr Mark Taggart at the University of the Highlands and Islands.

Toxic lead

A previous study led by Green and colleagues found that pheasants killed by lead shot contained many fragments of lead too small to detect by eye or touch, and too distant from the shot to be removed without throwing away a large proportion of otherwise useable meat. This means that eating pheasant killed using lead shot is likely to expose consumers to raised levels of lead in their diet, even if the meat is carefully prepared to remove whole shotgun pellets and the most damaged tissue.

Lead has been banned from use in paint and petrol for decades. It is toxic to humans when absorbed by the body and there is no known safe level of exposure. Lead accumulates in the body over time and can cause long-term harm, including increased risk of cardiovascular disease and kidney disease in adults. Lead is known to lower IQ in young children and affect the neurological development of unborn babies.

The studies were part-funded by the RSPB, Waitrose & Partners, and an anonymous donor. They were supported by a group of unpaid volunteers, who are co-authors of the reports.
 

References

Green, R.E. et al: ‘The proportion of common pheasants shot using lead shotgun ammunition in Britain has barely changed despite five years of voluntary efforts to switch from lead to non-lead ammunition.’ March 2025, Conservation Evidence. DOI: 10.52201/CEJ22/EXYS6184

Green, R.E. et al.: ‘Sampling of red grouse carcasses in Britain indicates no progress during an intended five-year voluntary transition from lead to non-lead shotgun ammunition.’ February 2025, Conservation Evidence. DOI: 10.52201/CEJ22/YYWM1722
 

A voluntary pledge made by UK shooting organisations in 2020 to replace lead shot with non-toxic alternatives by 2025 has failed, analysis by Cambridge researchers finds.

The voluntary route has now been tested - with efforts made by many people - and it has not been successful.Rhys GreenAndy Hay, RSPBAdult pheasant

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There is an exciting opportunity to join the Conservation Evidence Research Group as a Research Software Engineer, working alongside conservation and computer scientists. The appointment will be for an initial period of up to 12 months part-time, with the possibility of extension subject to project status and funding , starting as soon as possible. Conservation Evidence collaborates globally across disciplines and sectors to deliver the evidence needs of the conservation community. The group's aim is to ensure that evidence for the effectiveness of conservation actions is easily accessible and embedded within decision making, and we maintain the world's most comprehensive database on what works in conservation: www.conservationevidence.com.

The Research Software Engineer will join an interdisciplinary project and see their technical expertise have real world impacts on nature and biodiversity conservation. The project aims to develop an innovative infrastructure that combines artificial intelligence, namely large language models, and human expertise to transform evidence synthesis, while maintaining academic rigour. The Research Software Engineer will work closely with both conservation science and evidence synthesis experts, as well as computer scientists and be responsible for designing, developing and testing well documented software, maintaining databases, and deploying software in a production environment.

The successful applicant will be a highly skilled software engineer, with demonstrable experience in software development tools (e.g. Git/GitHub), rapid prototyping, basic database administration in a Linux environment, competence in designing, building and maintaining Django applications, familiarity building front ends in HTML, and good knowledge of programming languages such as JavaScript, HTML, SQL, Python (or similar). They will also demonstrate good problem-solving skills and enjoy working collaboratively to find innovative solutions that deliver on the needs of the project and wider team.

The role will be based on site in the departments of Zoology and Computer Science, with hybrid working arrangements possible.

Informal enquiries or requests to arrange a visit to Zoology to discuss this position are welcomed and should be directed to Dr Sam Reynolds (sar87@cam.ac.uk).

Please upload a copy of your CV (maximum 2 sides of A4) and a covering letter (maximum 1 side of A4).

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The Receptionist/Administrator serves as the first point of contact for visitors and callers while providing essential administrative support to ensure smooth office operations. This role involves managing front desk activities, handling correspondence, scheduling appointments, maintaining records, and assisting with general office tasks. The ideal candidate will possess strong communication, organisational, and multitasking skills, with the ability to handle confidential information professionally.

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The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

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Applications are invited to join a dynamic team led by Prof Sanjay Sinha (https://www.sinha-lab.org/ and https://www.stemcells.cam.ac.uk/people/pi/sinha), to investigate coronary artery smooth muscle cell (SMC) development and its role in atherosclerosis using human stem cell-based models and state-of-the-art bioinformatics.

In the proposed project, we will explore the hypothesis that the metaplastic SMC response in atherosclerosis is a re-enactment of embryonic processes. That some SMCs in human coronary atherosclerosis de-differentiate to immature cells akin to embryonic precursor cells in the developing heart, which subsequently proliferate and re-differentiate to produce the mesenchymal cell types that build the atherosclerotic plaque. To test this idea, we have partnered with Prof Jacob Bentzon's group (Univ of Aarhus, Denmark) who specialises in atherosclerosis and the PDRA will work closely with the Bentzon group towards the project aims.

The Sinha lab has extensive expertise on using pluripotent stem cell-based systems to generate cardiovascular cells (Cheung et al Nature Biotech 2012, Iyer et al Development 2015, Bargehr et al Nature Biotech 2019) and have recently generated a high resolution multi-omic atlas of the developing human heart (Bayraktar et al BioRxiv 2024 Cranley et al BioRxiv 2024). These approaches will be used to generate coronary SMCs in vitro and to understand how metaplastic differentiation may impact atherosclerosis development.

Please reach out to Prof S Sinha (Sinha@stemcells.cam.ac.uk) if you have further questions about this position.

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The successful candidate will be highly motivated, collaborative and have expertise in cell biology and bioinformatics. Prior experience with human pluripotent stem cells and/or vascular biology is highly desirable but not essential.

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They say that discovering the mechanism will support ongoing clinical trials, and could lead to the targeted use of aspirin to prevent the spread of susceptible types of cancer, and to the development of more effective drugs to prevent cancer metastasis. 

The scientists caution that, in some people, aspirin can have serious side-effects and clinical trials are underway to determine how to use it safely and effectively to prevent cancer spread, so people should consult their doctor before starting to take it.

Studies of people with cancer have previously observed that those taking daily low-dose aspirin have a reduction in the spread of some cancers, such as breast, bowel, and prostate cancers, leading to ongoing clinical trials. However, until now it wasn’t known exactly how aspirin could prevent metastases.

Professor Rahul Roychoudhuri in the Department of Pathology at the University of Cambridge, who led the work, said: “Despite advances in cancer treatment, many patients with early stage cancers receive treatments, such as surgical removal of the tumour, which have the potential to be curative, but later relapse due to the eventual growth of micrometastases – cancer cells that have seeded other parts of the body but remain in a latent state. 

“Most immunotherapies are developed to treat patients with established metastatic cancer, but when cancer first spreads there’s a unique therapeutic window of opportunity when cancer cells are particularly vulnerable to immune attack. We hope that therapies that target this window of vulnerability will have tremendous scope in preventing recurrence in patients with early cancer at risk of recurrence.”

The study is published today in the journal 'Nature'.  

The scientists say their discovery of how aspirin reduces cancer metastasis was serendipitous. They were investigating the process of metastasis, because, while cancer starts out in one location, 90% of cancer deaths occur when cancer spreads to other parts of the body.

The scientists wanted to better understand how the immune system responds to metastasis, because when individual cancer cells break away from their originating tumour and spread to another part of the body they are particularly vulnerable to immune attack. The immune system can recognise and kill these lone cancer cells more effectively than cancer cells within larger originating tumours, which have often developed an environment that suppresses the immune system. 

The researchers previously screened 810 genes in mice and found 15 that had an effect on cancer metastasis. In particular, they found that mice lacking a gene which produces a protein called ARHGEF1 had less metastasis of various primary cancers to the lungs and liver. 

The researchers determined that ARHGEF1 suppresses a type of immune cell called a T cell, which can recognise and kill metastatic cancer cells. 

To develop treatments to take advantage of this discovery, they needed to find a way for drugs to target it. The scientists traced signals in the cell to determine that ARHGEF1 is switched on when T cells are exposed to a clotting factor called thromboxane A2 (TXA2).

This was an unexpected revelation for the scientists, because TXA2 is already well-known and linked to how aspirin works. 

TXA2 is produced by platelets - a cell in the blood stream that helps blood clot, preventing wounds from bleeding, but occasionally causing heart attacks and strokes. Aspirin reduces the production of TXA2, leading to the anti-clotting effects, which underlies its ability to prevent heart attacks and strokes. 

This new research found that aspirin prevents cancers from spreading by decreasing TXA2 and releasing T cells from suppression. They used a mouse model of melanoma to show that in mice given aspirin, the frequency of metastases was reduced compared to control mice, and this was dependent on releasing T cells from suppression by TXA2.

Dr Jie Yang in the Department of Pathology at the University of Cambridge, first author of the report, said: “It was a Eureka moment when we found TXA2 was the molecular signal that activates this suppressive effect on T cells. Before this, we had not been aware of the implication of our findings in understanding the anti-metastatic activity of aspirin. It was an entirely unexpected finding which sent us down quite a different path of enquiry than we had anticipated.” 

“Aspirin, or other drugs that could target this pathway, have the potential to be less expensive than antibody-based therapies, and therefore more accessible globally.”

In the future, the researchers plan to help the translation of their work into potential clinical practice by collaborating with Professor Ruth Langley, of the MRC Clinical Trials Unit at University College London, who is leading the Add-Aspirin clinical trial, to find out if aspirin can stop or delay early stage cancers from coming back. 

Professor Langley, who was not involved in this study, commented: “This is an important discovery. It will enable us to interpret the results of ongoing clinical trials and work out who is most likely to benefit from aspirin after a cancer diagnosis.” 

“In a small proportion of people, aspirin can cause serious side-effects, including bleeding or stomach ulcers. Therefore, it is important to understand which people with cancer are likely to benefit.”

The research was principally funded by the Medical Research Council, with additional funding from the Wellcome Trust and European Research Council. 

The Add-Aspirin clinical trial is funded by Cancer Research UK, the National Institute for Health and Care Research, the Medical Research Council and the Tata Memorial Foundation of India. 

Reference: J. Yang, et al: “Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity.” Nature, March 2025. DOI: 10.1038/s41586-025-08626-7

Adapted from a press release by the Medical Research Council.

Scientists have uncovered the mechanism behind how aspirin could reduce the metastasis of some cancers by stimulating the immune system.

Aspirin has the potential to be less expensive than antibody-based therapies, and therefore more accessible globally.Jie YangTetra Images on Getty

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In 1885, Pembroke students, shocked by growing poverty and inequality, founded a mission in Walworth, SE London, Pembroke House. They sought a new approach: taking up residence to live, work and solve problems alongside local communities. This talk will explore the ideas that shaped Pembroke House’s beginnings, its role in Walworth today, and the questions being asked about its future.