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School of the Biological Sciences

 
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Current jobs in the Department of Pharmacology at the University of Cambridge.
Updated: 55 min 35 sec ago

Research Associate x 3 (Fixed Term)

Fri, 23/02/2024 - 00:00

Applications are invited for three PDRA positions to be part of an interdisciplinary team spanning the Departments of Pharmacology, Biochemistry and Chemistry, University of Cambridge. The aim is to create Modular Activator and Silencer Therapeutics (MAST) by developing novel platforms of antibodies, E3 ligase-mediated degraders, and proteases, to advance drug discovery. We are looking for motivated scientists with a strong team spirit to work on achieving the goals of MAST, with mentorship support from the labs of Laura Itzhaki (degraders; PMID 33623657), Paul Miller (ion channel antibodies; PMID 35140402), Florian Holfelder (proteases; PMID 36765057), Mark Howarth (antibodies; PMID 36865256), Catherine Wilson (degraders; PMID 32286286), and Pietro Sormanni (antibody design; PMID 37024501). See the document below for more info on groups.

This project provides opportunities for creative protein engineering, including database mining (to build structural antibody/ligase/protease libraries), machine learning (AI) approaches to antibody design and interpretation of directed evolution trajectories of proteases, phage display, structural biology (X-ray/cryo-EM) of ion channels and ligases to understand antibody modulation, cell biology and advanced degrader/protease kinetic analysis, and directed protein evolution.

The applicants will have completed a PhD (or soon to be awarded one) and will have appropriate experience in at least one or more of the approaches described above and/or foundational skills in molecular biology/cloning, biophysics, protein expression and purification, biophysics & synthetic biology.

The funds for this post are available from 14th May 2024 with flexibility in the precise start date and continue for 24 months.

Successful candidates who have not been awarded their PhD by the appointment date will be appointed as a Research Assistant at Grade 5 (£29,605-£33,966). Upon the award of the PhD the individual will be promoted to Research Associate, Grade 7 (£36,024-£44,263).

The University of Cambridge is a signatory to the San-Francisco Declaration on Research Assessment (DORA), and will in recruitment assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualized metrics in their applications. For more information: https://www.biology.cam.ac.uk/files/dora.pdf Appointment will be based on merit alone.

Online or in-person interviews are anticipated to take place in April.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The online application requires you to include your personal details, names and addresses of referees, as well as your CV, research publications list and cover letter to describe you interests and ambitions. Please state in the cover letter the areas of the MAST project that most interest you, i.e. antibodies, ligases or proteases, specific techniques etc.

Informal enquiries about the position can be made to Dr Paul Miller (pm676@cam.ac.uk). For enquiries about the online application process please contact the HR Team, hr@phar.cam.ac.uk

Please quote reference PL40636 on your application and in any correspondence about this vacancy.

The Departments of Pharmacology and Biochemistry are part of the School of Biological Sciences, which holds an Athena SWAN Bronze award, demonstrating a commitment to provide equal opportunities and to advance the representation of women in science subjects. We welcome applications from all qualified candidates irrespective of gender, but we particularly encourage women and individuals from under-represented groups to apply.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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Business Administrator

Thu, 08/02/2024 - 00:00

The Department of Pharmacology, University of Cambridge, is seeking two efficient, organised and dedicated Business Administrators to join our Professional Services team. These are new roles created due to the need of supporting our growing department.

The job holder will provide a reception and administrative support for the Department in order to provide a welcoming and efficient service to visitors and staff, as well as facilitating the smooth operation of the professional services team.

The Business Administrators will provide front-of-house services to anyone visiting the Gleeson building. In addition to the more common front-of-house responsibilities, such as managing meeting rooms and parking space bookings, coordinate post and deliveries, assist with taxi bookings, be first aid trained, etc., the Business Administrator will assist with other general administrative duties. These include dealing with incoming queries, photocopy, print and scan documents, assist with data input when required, minute taking, produce reports and assisting with organising events.

The ideal candidate will have previous administrative experience/following office procedures and be competent in standard software packages (in particular Word, Excel and Outlook). A confident IT user with excellent organisational skills, the candidate should also possess good time management, communication and interpersonal skills. We are looking for someone who is service-oriented and pro-active, able to use their own initiative as well as adhering to the collaborative environment that our department fosters. Candidates must be educated to at least A-level standard or equivalent, including English and Mathematics at GCSE level.

Further details can be found in the Further Particulars document.

If you have any questions about this vacancy or the application process, please contact the HR Team (hr@phar.cam.ac.uk).

Interviews will take place in March 2024.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that in the "upload section" of the online application you upload your Curriculum Vitae (CV), research publications list, 2-page covering letter (on professional experience and how you will fit with the Department, contribute to teaching, and encourage diversity and inclusion), and 2-page research proposal. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

If you have any questions about this vacancy or the application process, please contact Thury Agustsdottir (DA@phar.cam.ac.uk).

Please quote reference PL40449 on your application and in any correspondence about this vacancy.

The School of Biological Sciences holds an Athena SWAN bronze award, demonstrating a commitment to provide equal opportunities, values diversity and is committed to equality of opportunity. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant in G protein-coupled receptor pharmacology (Fixed Term)

Tue, 16/01/2024 - 00:00

Applications are invited for a Research Assistant position in the University of Cambridge, Department of Pharmacology, central Cambridge, working in the laboratory of Prof Graham Ladds.

The lab uses multidisciplinary approaches to investigate G protein-couped receptor (GPCR) signalling and enjoys collaborations with both academia and industry. This project has arisen through a direct collaboration with Takeda Pharmaceuticals. You can find more information about the lab and current projects at: https://www.phar.cam.ac.uk/research/Ladds and on twitter: @GPCR_Ladds.

The successful candidates should have a BSc in Pharmacology, Biochemistry, Medicine, or a related field. The project focusses upon GPCR pharmacology so knowledge of in the use of GPCR research would be an advantage. The appointee will be enthusiastic, methodical, work effectively as part of a team, be able to perform and analyse experiments with appropriate supervision of a Post-doctoral research associate, willing to engage with the research literature, and be able to write regular research reports. Experience of using GraphPad Prism is desired.

Funds are available for a fixed term of 5 months initially, with the possibility to extend if funding secured, after probationary review and is available immediately.

Key duties will be to assist our Post-doctoral research associate team studying how regulatory proteins receptor activity modifying proteins (RAMPs) contribute to the gastric inhibitory polypeptide (GIP) receptor pharmacology. We will be studying GIPR agonist bias and cellular trafficking. We are keen to explore new signalling pathways modulate by GIPR and to determine how RAMPs influence these responses. Training in these techniques will be provided. This work builds upon ongoing projects in the Ladds-GPCR lab. More details are available on request.

For the online application you will need to provide your personal details, names and e-mail addresses of two referees familiar with your academic performance, CV, your availability and a cover letter (including a description of your experience as it relates to the job specifications).

The Department holds an Athena SWAN bronze award and is committed to provide equal opportunities and advance the representation of women in science. We welcome applications from all candidates irrespective of gender. Appointment will be based on merit alone.

Fixed-term: The funds for this post are available for 5 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be made by contacting Prof Graham Ladds (grl30@cam.ac.uk).

If you have any questions about the application process please contact the HR team at hr@phar.cam.ac.uk.

Please quote reference PL40138 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant/Associate in discovery of novel protein regulators of GPCR signalling (Fixed Term)

Tue, 09/01/2024 - 00:00

Applications are invited for a Research Associate position in the University of Cambridge, Department of Pharmacology, central Cambridge, working in the laboratory of Prof Graham Ladds.

About the project: We seek an enthusiastic postdoctoral research associate to join our team studying novel protein modulators of G protein-coupled receptor (GPCR) signalling. This project combines artificial intelligence (AI) models with experimental assays to unveil the roles of the newly discovered non-canonical proteome in the cellular physiology of GPCRs. This interdisciplinary project links AI, bioinformatics, genetics, proteomics, structural biology, pharmacology and cell biology. It aims to use AI to identify and prioritize alternative proteins involved in the regulation of GPCR signalling, and to experimentally validate predictions. This project is a collaboration with Dr Brunet, University of Sherbrooke, Canada, and includes the possibility of working in Dr Brunet's laboratory for a period of up to six months.

The Cell Signalling lab: The Cell Signalling Lab uses multidisciplinary approaches to investigate GPCR signalling, and enjoys collaborations with both academia and industry. The focus of the lab is to establish how different cellular components can control GPCR agonist bias. You can find more information about the lab at: https://www.phar.cam.ac.uk/research/Ladds and on Twitter: @GPCR_Ladds.

The successful candidate should have a PhD in Pharmacology, Biochemistry, or a related field. Experience and expertise in any of the following would be advantageous: cell biology assays, molecular biology, genetics, bioinformatics and computational methods. Knowledge of methods used in GPCR research would be an advantage. The appointee will be enthusiastic, methodical, be able to work effectively as part of a team and independently, be able to perform and analyse experiments with appropriate supervision, be willing to engage with the research literature, and be able to write regular research reports.

The expected starting date is 14th February 2024, although there is some flexibility to start slightly later. Funds are available for a fixed term until 13th August 2025, after probationary review. Successful candidates who have not yet been awarded their PhD by the appointment date will be appointed as a Research Assistant, Grade 5 (£29,605 - £33,966). Upon the award of the PhD the individual will be promoted to Research Associate, Grade 7 (£36,024- £44,263)

Interviews will take place in February.

For the online application you will need to provide your personal details, the names and e-mail addresses of two referees familiar with your academic performance, your CV, your availability and a cover letter (including a description of your experience as it relates to the job specifications).

The Department holds an Athena SWAN Bronze Award and is committed to providing equal opportunities and advancing the representation of women in science. We welcome applications from all candidates irrespective of gender. Appointment will be based on merit alone.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal inquiries can be made by contacting Prof Graham Ladds (grl30@cam.ac.uk).

If you have any questions about the application process, please contact the HR team at hr@phar.cam.ac.uk.

Please quote reference PL40042 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

University Assistant Professor

Wed, 03/01/2024 - 00:00

Applications are invited for Senior Lecturer (Associate Professor) or Lecturer (Assistant Professor) in the Department of Pharmacology, University of Cambridge with effect from 1 September 2024, or as soon as possible thereafter. The Department offers excellent facilities for teaching and research, and has particular interests in cell signalling, cancer, pain, macromolecular structure and molecular therapeutics, neuropharmacology, and vascular pharmacology. We are seeking to recruit within the broad field of pharmacology, and particularly in the field of structural and molecular pharmacology.

The role holder will be based in Central Cambridge. The key duties and responsibilities will include but not be limited to: giving lectures and seminars and supervising undergraduate / post-graduate students, course development and innovation, taking an active part in examinations, carrying out innovative research and writing papers on topics relevant to the specialist subject area (this will include journals, books and other material), and obtaining research grant funding. A full description of the teaching and research activities in the Department can be found at http://www.phar.cam.ac.uk. It is also expected that the successful candidate will take an active role in engaging with the School of Biological Sciences Research Themes (https://www.bio.cam.ac.uk/research/research-themes) where many of our current group leaders act as Theme Leads.

The successful applicant will have a PhD in a relevant specialist subject area, as well as postdoctoral experience, and be developing a bibliography of research publications. They will keep up to date with the latest thinking in their specialist subject area by reading other academic material, attending conferences and active discussions with researchers in the field. The successful candidate will also have a track record in teaching at a higher education institution.

Appointments will be made at Lecturer (Assistant Professor) or Senior Lecturer (Associate Professor) level with a probationary period of five years, with appointment to the retiring age thereafter subject to satisfactory progress. The starting salary, depending upon experience, will be in the region of £45,585 per annum. Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure, a security check, and a health assessment. Whether the outcome is satisfactory will be determined by the University.

Prospective candidates are invited to contact the Head of Department, Professor Laura Itzhaki, for informal enquires (Tel: +44 (0) 1223 334017, email: lsi10@cam.ac.uk).

The School of Biological Sciences holds an Athena SWAN bronze award, demonstrating a commitment to provide equal opportunities and to advance the representation of women in science subjects. We welcome applications from all qualified candidates irrespective of gender but, as women are currently under-represented at this level in our department, we strongly encourage applications from female candidates. The University values diversity and is committed to equality of opportunity. Appointment will be based on merit alone.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that in the "upload section" of the online application you upload your Curriculum Vitae (CV), research publications list, 2-page covering letter (on professional experience and how you will fit with the Department, contribute to teaching, and encourage diversity and inclusion), and 2-page research proposal. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

If you have any questions about this vacancy or the application process, please contact Thury Agustsdottir (DA@phar.cam.ac.uk).

Please quote reference PL39955 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

University Assistant Professor

Wed, 03/01/2024 - 00:00

Applications are invited for Senior Lecturer (Associate Professor) or Lecturer (Assistant Professor) in the Department of Pharmacology, University of Cambridge with effect from 1 September 2024, or as soon as possible thereafter. The Department offers excellent facilities for teaching and research, and has particular interests in cell signalling, cancer, pain, macromolecular structure and molecular therapeutics, neuropharmacology, and vascular pharmacology. We are seeking to recruit within the broad field of pharmacology, and particularly in the field of ageing (including, but not limited to, neurodegeneration).

The role holder will be based in Central Cambridge. The key duties and responsibilities will include but not be limited to: giving lectures and seminars and supervising undergraduate / post-graduate students, course development and innovation, taking an active part in examinations, carrying out innovative research and writing papers on topics relevant to the specialist subject area (this will include journals, books and other material), and obtaining research grant funding. A full description of the teaching and research activities in the Department can be found at http://www.phar.cam.ac.uk.

The successful applicant will have a PhD in a relevant specialist subject area and be developing a bibliography of research publications. They will keep up to date with the latest thinking in their specialist subject area by reading other academic material, attending conferences and active discussions with researchers in the field. The successful candidate will also have a track record in teaching at a higher education institution.

Appointments will be made at Lecturer (Assistant Professor) or Senior Lecturer (Associate Professor) level with a probationary period of five years, with appointment to the retiring age thereafter subject to satisfactory progress. The starting salary, depending upon experience, will be in the region of £45,585 per annum. Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure, a security check, and a health assessment. Whether the outcome is satisfactory will be determined by the University.

Prospective candidates are invited to contact the Head of Department, Professor Laura Itzhaki, for informal enquires (Tel: +44 (0) 1223 334017, email: lsi10@cam.ac.uk).

The Department holds an Athena SWAN bronze award, demonstrating a commitment to provide equal opportunities and to advance the representation of women in science subjects. We welcome applications from all qualified candidates irrespective of gender but, as women are currently under-represented at this level in our department, we strongly encourage applications from female candidates. The University values diversity and is committed to equality of opportunity. Appointment will be based on merit alone.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that in the "upload section" of the online application you upload your Curriculum Vitae (CV), research publications list, 2-page covering letter (on professional experience and how you will fit with the Department, contribute to teaching, and encourage diversity and inclusion), and 2-page research proposal. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

If you have any questions about this vacancy or the application process, please contact Thury Agustsdottir (DA@phar.cam.ac.uk).

Please quote reference PL39953 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs