http://www.jobs.cam.ac.uk/job/?unit=u00269&format=rss

Physiology, Development and Neuroscience delivers over half of the teaching requirements for the first two years of the Medicine and Veterinary Medicine courses (Medical Sciences Tripos and Veterinary Sciences Tripos ~390 students/year), as well as three large courses available (as options) to first and second year science students following the Natural Sciences Tripos (NST) at Cambridge (~300 students in all). All of these undergraduate courses involve hands-on practical experimental work by the students in the Department's four teaching classrooms. The practical classes are supported by three distinct but collaborative technical teams (Human Anatomy, Veterinary Anatomy, and Physiology).

We are looking for a Teaching and Research Technician, assigned to the Physiology team, to primarily support the Chief Teaching Technician, University Physiologist and other teaching officers in the running of our busy undergraduate (Part I) teaching classrooms, supporting the delivery of a wide range of practical classes and lectures to first and second-year students.

This is an excellent opportunity to gain further experience in supporting teaching in a higher education environment. Duties will include, but are not limited to, providing technical assistance and guidance to staff and students throughout the planning and delivery of undergraduate practical classes and examination; assist with histological work, ensuring health and safety procedures are adhered to, maintenance of laboratory equipment and general administrative duties, including the support of apprentices in the Department.

Applicants should be educated to at least A level and have experience of working a laboratory environment, preferably in an educational setting. They should have good IT skills and be manually dexterous. Accuracy, flexibility and reliability are essential, as are good communication skills and the ability to work as part of a small team to meet tight deadlines.

Informal enquiries about the role are encouraged, and these can be directed to Lorna Roberts, lar54@cam.ac.uk.

Apply

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two professional referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Closing date: 30 September 2024.

Please quote reference PM43179 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Would you like to join a friendly and busy department? The Department of Physiology, Development and Neuroscience (PDN) is looking for a cleaner to join our team providing an efficient and reliable service to our buildings located in central Cambridge.

Our small team of cleaners make essential contributions to our community. You will work as part of the team providing a high standard of cleaning in all areas. Duties will include washing of scientific glassware, cleaning research and teaching laboratories, lecture theatres, offices, corridors, stairways and toilets.

No formal qualifications are required as training will be provided, however NVQ Level 1 Cleaning and Support Services Skills would be advantageous. Experience of laboratory and/or office cleaning would be beneficial. Good communication skills are essential as is the ability to follow written and verbal instructions from supervisors. A willingness to be flexible in approach and reliability are essential.

For this position, the University Real Living Wage (RLW) supplement applies, which sets the minimum rate of pay at £12 per hour.

The position is offered on a permanent, part-time basis (25 hours per week). The hours of work are flexible, between 7am and 4pm.

For more information about this post, please contact Katie Conran, Facilities and Operations Manager kc662@cam.ac.uk.

Apply:

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two professional referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

If you are unable to use the online system for your application, please contact Tracey Flack, pdnhr@pdn.cam.ac.uk.

The closing date for applications is midnight on 22 September 2024. Interviews will take place shortly after the closing date.

Please quote reference PM43143 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are looking for passionate and skilled researchers with expertise in molecular/cellular biology and a keen interest in cellular decision-making mechanisms to join our collaborative, multidisciplinary team. The positions would suit those with experience in live-cell microscopy and tracking or in molecular approaches for analysing chromatin and transcription factor binding.

The overarching aim of Sarah Bray's research group is to explore mechanisms regulating cell choices in development, health, and disease. To discover how developmental signals are decoded in real time in vivo we are using methods for live-imaging of transcription and of nuclear complexes. We now wish to complement these with molecular and genomics approaches to address global and epigenetic mechanisms that are operating to reprogramme enhancers and their target promoters during cell fate transitions.

We are an inclusive and welcoming group, committed to mentoring and supporting the career development of all members. We are looking to recruit highly motivated scientists with strong investigative skills. Experience with genomic analysis of chromatin and transcription factor binding would be an advantage for one of the posts. Knowledge of developmental biology, Drosophila genetics and/or live imaging approaches would be useful.

We will consider applicants at either Research Assistant or Research Associate level. You should have a degree in a STEM/biological subject (Research Assistant) and preferably a PhD (Research Associate), with relevant expertise in cell and molecular biology techniques.

Salary Ranges: Research Assistant: £29,605 - £33,966, Research Associate: £36,024 - £44,263.

Further information about research in the Bray group can be found at: https://www.pdn.cam.ac.uk/directory/sarah-bray. For informal enquiries, please email Prof Bray at: sjb32@cam.ac.uk.

Fixed-term: The funds for this post are currently available until 30 September 2026 from an MRC Programme Grant.

How to Apply:

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

In your application please upload your Curriculum Vitae (CV) and a motivation letter detailing why you want to be part of this project, explaining how your training and experience are relevant for the position and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

Please quote reference PM43115 on your application and in any correspondence about this vacancy.

Closing date: 27 September 2024.

Interviews are expected to be held in October.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Postdoctoral Research Associate position in Dr. Sepiedeh Keshavarzi's lab at the University of Cambridge, Department of Physiology, Development and Neuroscience (https://www.pdn.cam.ac.uk/). The lab's research, funded by the Wellcome Trust, focuses on the organization and function of neural circuits underlying spatial orientation and self-motion perception.

Project Overview

This project aims to explore how interactions between the thalamus and retrosplenial cortex influence orientation computations and to determine the role of distinct thalamocortical circuits in behaviour. The successful candidate will develop novel behavioural tasks to assess spatial orientation in mice, record neural activity using electrophysiology (Neuropixels) and/or calcium imaging (two-photon imaging and miniscope), manipulate specific circuits and cell types with optogenetics and chemogenetics, and perform comprehensive data analysis.

For more information about the lab's research, please visit Keshavarzi Lab.

Key Experience and Competencies

We seek a researcher with a strong background in circuit/systems neuroscience. Applicants should hold (or be near completion of) a Ph.D. in Neuroscience or a related field.

Essential Qualifications:

• Experimental expertise in either in vivo electrophysiology (single-unit recording/patch clamp) or in vivo calcium imaging (two-photon/miniscope imaging).
• Proficiency in programming, particularly in Python or Matlab, and in data analysis.

Desirable Skills:

• Expertise in developing quantitative behavioral tasks for rodents.
• Expertise in building and controlling custom experimental setups.
• A solid track record of research achievements and publications.

Research Environment and Training

We are a welcoming and inclusive group, committed to providing mentorship and support for the career development of our lab members. The postdoctoral fellow will join a multidisciplinary research environment, with regular interactions with other neuroscience groups within the department. The Department's seminars, along with events hosted by the Cambridge Neuroscience Network, will offer excellent opportunities for networking and scientific discourse.

Training opportunities will be provided in experimental and computational techniques new to the applicant, including support for attending international workshops and courses. Additionally, the position offers opportunities for collaboration with engineers and computational neuroscientists.

How to Apply

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please submit your CV and a cover letter addressing the following points:

• Your motivation for joining the lab.
• How your research skills align with the job description.
• Your research ambitions and career goals.

Please also provide the contact details of two referees.

The position is available from January 2025 onwards for an initial term of three years, with the possibility of extension.

For informal inquiries, please contact Dr. Sepiedeh Keshavarzi at sk2244@cam.ac.uk.

Closing Date: 18 October 2024. Applications will be reviewed on a rolling basis, and the position may close early once filled.

To learn more about this position and what the University offers please see the Further Particulars.

Please quote reference PM36807 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are pleased to advertise a Research Associate position in Dr Elena Scarpa's group to investigate the role of tissue-scale confinement during in vivo and in vitro Zebrafish neural crest cell migration.

In vivo, cells migrate through tight spaces and may undergo division in crowded environments, both in physiological and pathological contexts, for example during immune cells diapedesis or cancer cell dissemination. These phenomena are difficult to observe in vivo, especially in mammalian models. Key studies in the field have largely exploited in vitro systems, for example culturing cells in 3D collagen matrices or microfabrication of PDMS microchannels, to mimic interstitial confining environments. From this wealth of work, it has become clear that cells experiencing physical confinement during cell migration suffer mechanical stress. This causes deformation of the largest organelle, the nucleus, and loss of nuclear integrity, thus inducing DNA damage. Physical compression can even promote genetic diversity in cancer cells. In addition, when cells in culture undergo mitosis under mechanical compression, they show extensive cortical blebbing and suffer division defects. Together, these findings show that mechanical stress negatively impacts the integrity of the genome and this has been proposed to underlie cancer initiation and progression. However, the consequences of mechanical compression on cells during in vivo cell migration remain so far unexplored.

The post-holder will carry out general lab management roles: they will oversee the maintenance of fish stocks (crossing and genotyping), day to day running of the laboratory (ordering, organization, maintaining reagents stocks, health and safety) and will contribute to the training of students.

In addition, they will be responsible for molecular biology and zebrafish transgenesis. They will characterise the novel Zebrafish lines they generate by live imaging of embryos, quantitative image analysis and immunostaining.

The successful candidate will have, or be about to receive, a PhD in a biological subject, with knowledge of Zebrafish trunk neural crest embryology, cell biology, genetics. They should have experience in Zebrafish embryology and microinjection techniques and/or live imaging of Zebrafish. Please refer to the Further Particulars for a full list of the essential skills and experience required for the role.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

Informal enquiries about the position can be made to Elena Scarpa (es697@cam.ac.uk).

Fixed-term: The funds for this post are available for 12 months.

Apply:

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, please submit a CV, and a motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

The closing date for applications is 20 September 2024.

Please quote reference PM43060 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Department of Physiology, Development and Neuroscience (PDN) is seeking a team player to join us as a Stores and Purchasing Administrator in our friendly accounts team. PDN is a large, welcoming, and inclusive Department with an exceptional international record in teaching and research.

You will undertake a wide range of duties following University policy, procedures and best practice in order to deliver a first class Stores and Purchasing service to the Departments scientists, teaching and administration staff.

You will be educated to at least A Level standard or equivalent or possess a comparable level of practical experience. The successful candidate will be highly organised, computer literate, and have excellent attention to detail. Good communication and people skills are also prerequisites for the role, which involves interacting with a range of stakeholders in the Department, the wider University and externally.

For more details, please see the Further Particulars.

The position is offered on a permanent, full-time basis. Informal enquiries should be directed to Lorna Goffee-Palser, Chief Accounts Clerk, lg369@cam.ac.uk.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two professional referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

The closing date for applications is midnight on 25 August 2024. Interviews will take place shortly after the closing date.

Please quote reference PM42820 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The CTR has an established highly-successful programme to fund and mentor Next Generation Fellowships. Next Generation Fellowships are aimed at promoting the careers of high-calibre individuals pursuing innovative research falling within the remit of the Centre. The Fellowships are highly flexible to suit individual needs, and to enable the postholder to develop as an independent researcher within a supportive and stimulating environment. Holders are expected, and will be supported, to apply for Research Fellowship/Career Development Awards from research councils or other funders, or a faculty position during their tenure. The Next Generation Fellowships are a springboard to a long and successful career in the field of placental and reproductive biology. Many of our Next Generation Fellows have used the opportunity as a stepping stone to independent group leader positions: https://www.trophoblast.cam.ac.uk/next-generation-fellow-alumni. The CTR has an opening for a Next Generation Fellow who will complement and synergise with our existing research programmes. We welcome applications from across a diverse range of research relevant to our Grand Challenges: https://www.trophoblast.cam.ac.uk/about-us/objectives.

What to expect Next Generation Fellows will be mentored to develop and establish an independent research programme to carry out research that will complement that of other groups within the Centre for Trophoblast Research. Next Generation Fellows will be expected to contribute fully to the activities of the CTR and to their host department. They will supervise MPhil/masters, summer and/or undergraduate students. They may be a co-applicant on research grant applications to recruit, train and co-supervise postdoctoral researchers, research assistants, technical staff and PhD students, depending on the outcome of external funding. The post holder will be expected to create a strong track record of publishing high impact papers and disseminate the results of their work in any ways that seem appropriate and effective (e.g. via conferences and seminars). They will be responsible for compliance with all the relevant laws (Home Office, HTA, HFEA).

Qualifications Candidates should hold a PhD and have a high-quality publication track record in academic journals or equivalent.

Eligibility Our ambition with this fellowship is to launch the careers of the next generation of faculty in trophoblast biology. The criteria for success in this position is that at the end of the Next Generation Fellowship, the fellow is able to secure a career development fellowship to establish their own independent research group, for example a:

• MRC Career Development Fellowship,
• Wellcome Career Development Award,
• Dorothy Hodgkin Fellowship,
• ERC starting grant,
• or any internationally equivalent awards.

Normally, this would mean that at the point of application you hold a PhD and have undertaken no more than one substantial period of research (e.g. postdoctoral placement/fellowship), with exceptions for career breaks due to sickness or family leave. To be considered suitable for the scheme, applicants should be able to provide a clear rationale of how the Next Generation Fellowship will support their long term career goals.

We welcome applications from candidates of all nationalities for the Next Generation Fellowship and sponsor international visas. Next Generation Fellows requiring a visa to work in the UK are eligible to apply for a Global Talent Visa under the fast-track process of endorsement. Other visa categories are available.

Contract details

Appointments will be made on a fixed-term, full-time, basis for a period of 3 years. There is a possibility of up to 1-year extension. The contract further includes research consumables/equipment up to £20,000 per annum & travel support up to £750.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply to this post, candidates should first identify a research Sponsor from the list of Principal Investigators https://www.trophoblast.cam.ac.uk/people/principal-investigators within the Centre for Trophoblast Research, and discuss their research plans with them.

Applications open annually in October with a closing date in January the following year. We strongly encourage applicants to reach out to potential sponsors far in advance of applications opening with expressions of interest.

The application must include the following:

• Curriculum Vitae (CV)
• Up to 3 letters of reference
• Letter of support from your chosen CTR sponsor
• CTR Next Generation Fellowship application form (please see further particulars below).

Please quote reference PM42798 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are looking for a highly motivated, proactive and enthusiastic postdoc to work on a Wellcome Trust funded project within the Galliano laboratory the University of Cambridge. Our research focuses on investigating how brain cells change in response to altered sensory inputs, and how such changes in brain cells underpin adaptation, learning and memory at the behavioural level. We use mice as model systems, and we probe the brain networks that encode their sense of smell. We are an inclusive, diverse and welcoming group, invested in open-science and outreach, and committed to mentoring and supporting the career development of all members.

You will lead a project investigating how changes in sensory input (such as olfactory deprivation, enrichment, and learning) prompt adaptive and associative plasticity in neurons within the olfactory bulb. This project will employ advanced optical techniques, including 2-photon microscopy and holographic light shaping, to monitor and manipulate neural activity in vivo. The aim is to elucidate how sensory inputs drive different mechanisms of neuronal plasticity in different cell types, and how interactions among different types of neurons enhance circuit output and information transfer to the cortex.

The successful candidate will have:

• PhD in Neuroscience or a related field (or be about to receive one)
• Substantial expertise in either in vivo recording techniques (imaging or physiology) in vertebrates, or a strong background in optics, holographic light shaping, and advanced imaging techniques, particularly 2-photon microscopy
• Strong analytical skills and proficiency in quantitative analysis or large datasets.
• Proven track record of research leadership, as demonstrated by preprints or published article(s).
• Specific examples of excellent communication skills and the ability to work collaboratively within a research team.
• Specific examples of strong problem-solving abilities and instances demonstrating the capability to work independently as well as withing a team.
• Desirably have a background in sensory systems and plasticity research, experience in mouse behavioural testing, familiarity with tool development (e.g., olfactometers), and cranial window surgeries.

Appointments will be made on a fixed-term, full-time basis for 4 years in the first instance. We are open to discussing various patterns of part-time work to accommodate individual circumstances and/or caring responsibilities. The start date is flexible, but ideally, we would like the position to commence in January 2025.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To ensure your application is as strong as possible, please follow the instructions carefully. Candidates should upload a CV (maximum 3 pages) and a cover letter addressing the following points:

• Why you want to join our lab and lead this project.
• How you align with the lab's values and philosophy, found here https://gallianolab.org/how-we-operate/
• How this position will serve as a valuable stepping stone for your career.
• How your previous experience has prepared you for the technical demands of this role. If you lack direct experience, please explain how you plan to acquire the necessary skills, noting that the PI is the only team member with relevant in vivo imaging experience to assist you.
• Your (brief) thoughts on the most interesting and yet unanswered questions in the fields of plasticity and olfaction.

Ensure that your CV and cover letter together address all these criteria. Please also include the contact details of two professional referees. While informal inquiries via email to Elisa Galliano are welcome, we will only consider applications submitted through the online application form and not those sent by email.

The application deadline is 10 September 2024. We plan to conduct a first round of virtual interviews in the last two weeks of September, with final in-person interviews scheduled with top candidates at a mutually convenient time.

Please quote reference PM42789 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for an Assistant/Associate Professorship (University Lecturer/Senior Lecturer) in the field of Vertebrate Systems Neuroscience to be held in the Department of Physiology Development and Neuroscience. We are searching for a talented individual with an excellent track record in research and a commitment to teaching across a range of subjects. The post is available from 1st January 2025 or as soon as possible thereafter. The department offers a world class research and teaching environment with research groups focussed on Cellular and Systems Physiology, Developmental Biology and Reproduction and Neuroscience. (https://www.pdn.cam.ac.uk/research) We welcome applicants who will synergise and enhance the existing neuroscience research in the department as well as develop their own independent research area. We particularly encourage applicants who are using animal models to study aspects of systems neuroscience.

The successful applicants will have a PhD in a relevant subject area and show evidence of leading a successful research programme. Applicants will also have an aptitude and enthusiasm for teaching at undergraduate and postgraduate levels and will be expected to contribute to teaching and other academic activities in the Department and more widely in the School of Biological Sciences, including the design and delivery of undergraduate and graduate lecture courses, examinations and other forms of assessment.

The starting salary is dependent on the level of appointment being made, as determined by the Selection Committee. Assistant Professorships will start in the range of £45,585 - £57,696 per annum; Associate Professorships will start in the range of £61,1987 - £64,914 per annum.

The Department is committed to the Athena SWAN scheme to provide equal opportunities and to advance the representation of women and other under-represented groups in science. We particularly encourage women and/or candidates from a Black, Asian and Minority Ethnic background to apply for this vacancy as they are currently under-represented at this level within our University. Appointment will be based on merit alone. As a signatory of DORA (https://sfdora.org) the University is committed to assessing research on its own merits rather than on the basis of the journal in which it is published.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that in the Upload section of the online application you provide:

• A document containing your Curriculum Vitae (CV), research publications list, and a brief narrative (300 words maximum per output) on each of the three outputs you consider most significant. The Department is committed to the responsible use of bibliometric

• Data and applicants are asked not to include raw citation count, Journal Impact Factor or H-index metrics in their applications.

• A statement of research of no more than two pages, outlining your current and future research plans, with an emphasis on how these fit within the remit of the position and synergies within Department and across the University.

• A one page statement focusing on (i) your teaching experience and interests, (ii) your contributions to and/or vision for open research and improving research culture (see this link) (iii) what Equality Diversity & Inclusion means to you.

• Prospective candidates may contact the joint Heads of Department, Professor Bill Colledge and Professor Sarah Bray (hod@pdn.cam.ac.uk) to informally discuss the position.

The deadline for applications is 1st October 2024

Interviews will be held at the beginning of November 2024

The Department of Physiology, Development and Neuroscience (PDN) is seeking a Grants Assistant to support the Department's research groups. PDN is a large, welcoming, and inclusive Department with an exceptional international record in teaching and research, with a grant income in the order of £10 million annually.

Reporting to the Research Grants Administrator, the Grants Assistant will provide administrative support to those applying or considering applying for grants and Fellowships. They will also support those who have successfully secured research funding.

You will be educated to at least A Level standard or equivalent or possess a comparable level of practical experience. The successful candidate will be highly organised, computer literate, and have excellent attention to detail. Good communication and people skills are also prerequisites for the role, which involves interacting with a range of stakeholders in the Department, the wider University and externally. For more details, please see the Further Particulars.

The position is offered on a permanent, full-time basis, though we also welcome applications from individuals who wish to be considered for part-time working (minimum 30 hpw) or other flexible working arrangements.

Informal enquiries should be directed to Mandy Sherman, Research Grants Administrator mls44@cam.ac.uk.

Apply

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two professional referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

The closing date for applications is midnight on 25 August 2024. Interviews will take place shortly after the closing date.

Please quote reference PM42481 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

An opportunity has arisen for a Building Services Technician to join our friendly, busy, facilities team in the Department of Physiology, Development and Neuroscience, providing an efficient and reliable service to our buildings located in central Cambridge.

The role holder will provide day to day maintenance across our two buildings which consist of laboratories, classrooms, offices and lecture theatres. The role holder will support the team with planned and reactive maintenance of our buildings to ensure the provision of a safe, legal and compliant working environment. This will include the maintenance and monitoring of heating, plumbing, and ventilation systems, dealing with gas canisters, general building infrastructure repairs, assisting with the installation of equipment, electrical testing and portering. The role will also include work which could be part of a refurbishment and would include painting and carpentry.

The successful candidate will have good organisational, problem solving and fault finding skills. You should be flexible, have good communication skills and be able to work in a team. You will have experience in a maintenance role, and whilst experience in a University or laboratory environment would be advantageous, it is not essential and training will be given.

Informal enquiries about the role and working at the University are encouraged, and these can be directed to Katie Conran, kcc62@cam.ac.uk.

If you are unable to use the online system for your application, please contact Tracey Flack, pdnhr@pdn.cam.ac.uk.

Fixed-term: The funds for this post are available for 12 months in the first instance.

The position is offered on a full-time basis, although we welcome applications from individuals who wish to be considered for part-time working (minimum 30 hpw).

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Apply:

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two professional referees should be provided, one of who should be your most recent line manager. Please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

The closing date for applications is 1 August 2024.

Please quote reference PM41726 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Galliano laboratory is a recently funded neuroscience group based at the Department of Physiology, Development and Neuroscience at the University of Cambridge. Our research focuses on investigating how brain cells change in response to altered sensory inputs, and how such changes in brain cells underpin adaptation, learning and memory at the behavioural level. We use mice as model systems, and we probe the brain networks that encode their sense of smell. We are an inclusive, diverse and welcoming group, committed to mentoring and supporting the career development of all members. We believe in open-science, and all members are encouraged to participate in science

Project summary We are seeking a highly motivated, proactive, and enthusiastic research assistant to assist in our research operations. Responsibilities will include performing immunohistochemical and behavioural experiments, presenting progress in written and oral form, managing transgenic mouse lines, procurement of equipment and consumables (including forecasting use). You will assist in training undergraduate project students, and you will contribute to the operational strategy for the lab and in scientific discussions. Attention to detail is essential, along with collaborative teamwork skills, and outstanding multitasking and time management abilities.

We have funding available for a 4-year contract at 80% FTE. The role holder will work solely within the lab, and the post is available from October 2024.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please provide:

• A cover letter where you explain how you meet the job requirements, what you would bring to the group, how your work philosophy aligns to our lab's values.

• A CV.

• The contact details of two individuals who can serve as references.

The application deadline is 29th July 2024.

Please quote reference PM42476 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for the position of Research Assistant to join the group of Professor Magda Zernicka-Goetz. Professor Zernicka-Goetz's group whose long-term goal of our work is to understand the development of cell lineages and patterning in the early mammalian embryo and stem cell models.

The ideal candidate will possess a MSc level of education with relevant laboratory experience in culture of different cells lines in vitro, including stem cell culture experience, molecular biology, including genetics/genomics. He/She will have a good extensive experience of molecular, cell and developmental biology and excellent general laboratory skills. Good communication skills and the ability to work effectively within a team are essential.

The role of the post will be to provide research support and assistance to Professor Zernicka-Goetz and her research group. The role-holder will prepare and conduct experiments supervised by senior group members. He/She will work to defined protocols, and prepare and collate experimental data and results for subsequent interpretation. This will involve embryonic stem cell culture and various molecular biology techniques.

Fixed Term: the funds for this post are available until 29 December 2024.

Apply:

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, submit a CV and a motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Closing Date: 21 July 2024.

Please quote reference PM42393 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Department of Physiology, Development & Neuroscience (PDN) at the University of Cambridge is seeking an enthusiastic Higher Education Technician Apprentice from September 2024. If you would like to develop a career providing technical support for teaching in a supportive environment, we would love to hear from you.

The Department of Physiology, Development and Neuroscience delivers much of the teaching for the first two years of the Medicine and Veterinary Medicine courses, as well as three large courses available to students working towards a BA (Hons) in 'Natural Sciences'. All of these undergraduate courses involve hands-on practical experimental work by the students, which takes place in the Department's four teaching classrooms. The Apprentice will be an essential part of the Departmental Teaching team, who provide technical and administrative support for teaching and learning. You will study for the Education Technician Level 3 qualification.

Most of all, you will be a great team player and demonstrate your commitment to the apprenticeship. You will have good communication and interpersonal skills, and you will be well-organised and able to manage your own time. Due to the nature of this role, you will be able to follow procedures and protocols, and have a good level of physical fitness.

What you'll do in a working day

• Assist in the preparation of classrooms, including setting up equipment and teaching materials, clearing up, documenting student activities.
• Safely demonstrate to students how to operate simple and more complex equipment or techniques.
• Collect data, documentation and resources.
• Maintain learning spaces, to ensure health & safety protocols are followed.
• Undertake and maintain stock control including the management of stock records, purchasing/procurement, equipment inventory, safe receipt, delivery, handling and storage of goods and consumables.
• Generate and maintain risk assessments, standard operating procedures and COSHH forms.
• Monitor air quality.
• Care of preserved 'prosected' tissue used for teaching.
• Organise and catalogue dry learning materials, radiographs, museum pots, bones, plastinated specimens and online resources.
• Museum curation, with a focus on student accessibility.
• Learn about the general workings of a University.

The training you will be getting

Through the training provider, CSR Scientific Training, you will undertake a Level 3 Education Technician Apprenticeship which will include:

• Fully recognised apprenticeship qualification - Level 3 Education Technician.
• On-the-job competency training.
• IOSH Working Safely qualification.

Applicants should have a minimum of 5 GCSEs at Grade C/4 or above (including Mathematics and English).

Fixed-term: 27 months.

The University is committed to the development of technicians and is a signatory to the national, sector-wide Technician Commitment https://sciencecouncil.org/employers/technician-commitment/?doingwpcron=1578673968.3250739574432373046875. The Department is part of the School of Biological Sciences where there are very many opportunities and different tracks for career growth and development. Although the apprenticeship will be based within PDN, there will be opportunities to visit some of the other academic departments in the School of Biological Sciences, and to observe the work of other technicians as they go about their daily business of supporting the delivery of world-class teaching (subject to agreement with the relevant department).

Informal enquiries are encouraged and should be directed to Tracey Flack, Chief HR Administrator: pdnhr@pdn.cam.ac.uk.

Apply:

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form you should explain:

• The reasons for your application.
• What attracts you to the apprenticeship route.
• How your knowledge and skills match the requirements of the role.

The full contact details of two referees should be included; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Closing Date: 16 July 2024. Interviews are expected to take place soon after the closing date.

Please quote reference PM42319 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Department of Physiology, Development & Neuroscience (PDN) is seeking an enthusiastic Higher Education Technician Apprentice from September 2024. This is an exciting opportunity to join our team at the University of Cambridge.

The Department of Physiology, Development and Neuroscience delivers over half of the teaching requirements for the first two years of the Medicine and Veterinary Medicine courses, as well as three large courses available to first and second year science students following the Natural Sciences Tripos at Cambridge. All of these undergraduate courses involve hands-on practical experimental work by the students in the Department's four teaching classrooms. The Apprentice will be part of the Departmental Teaching team, who provide technical support for teaching and research, and will study the Education Technician Level 3 qualification.

You will be a great team player who has good organisation and time management skills. The successful candidate will have good communication and interpersonal skills, as well as good attention to detail. Due to the nature of this role, the role holder should have a good level of physical fitness.

What you'll do in a working day

• Assist in the preparation of classrooms, including setting up equipment and teaching materials, clearing up, documenting student activities.
• Safely demonstrate to students how to operate simple and more complex equipment or a techniques.
• Collection of data, documentation and resources.
• Maintenance of learning spaces, to ensure health & safety protocols are followed.
• Undertake and maintain stock control including the management of stock records, procurement, equipment inventory, safe receipt, delivery, handling and storage of goods and consumables.
• Generation and maintenance of risk assessments, standard operating procedures and COSHH forms.
• Monitor air quality.
• Care of preserved 'prosected' tissue used for teaching.
• Organise and catalogue dry learning materials, radiographs, museum pots, bones, plastinated specimens and online resources.
• Museum curation, with a focus on student accessibility.
• Learn about the general workings of a University.

The training you will be getting

Through the training provider, CSR Scientific Training, you will undertake a Level 3 Education Technician Apprenticeship which will include:

• Fully recognised apprenticeship qualification - Level 3 Education Technician
• On-the-job competency training
• IOSH Working Safely qualification

Fixed-term: 27 months.

All applications for this vacancy are being handled by the training provider for this apprenticeship, CSR Scientific Training. Please follow this link to the national apprenticeship website to apply: https://www.findapprenticeship.service.gov.uk/apprenticeship/1000255325.

Closing Date: 30 June 2024. Interviews are expected to take place in July 2024.

Please quote reference PM41748 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Department of Physiology, Development & Neuroscience (PDN) is seeking an enthusiastic Higher Education Technician Apprentice from September 2024. This is an exciting opportunity to join our team at the University of Cambridge.

The Department of Physiology, Development and Neuroscience delivers over half of the teaching requirements for the first two years of the Medicine and Veterinary Medicine courses, as well as three large courses available to first and second year science students following the Natural Sciences Tripos at Cambridge. All of these undergraduate courses involve hands-on practical experimental work by the students in the Department's four teaching classrooms. The Apprentice will be part of the Departmental Teaching team, who provide technical support for teaching and research, and will study the Education Technician Level 3 qualification.

You will be a great team player who has good organisation and time management skills. The successful candidate will have good communication and interpersonal skills, as well as good attention to detail. Due to the nature of this role, the role holder should have a good level of physical fitness.

What you'll do in a working day

• Assist in the preparation of classrooms, including setting up equipment and teaching materials, clearing up, documenting student activities.
• Safely demonstrate to students how to operate simple and more complex equipment or a techniques.
• Collection of data, documentation and resources.
• Maintenance of learning spaces, to ensure health & safety protocols are followed.
• Undertake and maintain stock control including the management of stock records, procurement, equipment inventory, safe receipt, delivery, handling and storage of goods and consumables.
• Generation and maintenance of risk assessments, standard operating procedures and COSHH forms.
• Monitor air quality.
• Care of preserved 'prosected' tissue used for teaching.
• Organise and catalogue dry learning materials, radiographs, museum pots, bones, plastinated specimens and online resources.
• Museum curation, with a focus on student accessibility.
• Learn about the general workings of a University.

The training you will be getting

Through the training provider, CSR Scientific Training, you will undertake a Level 3 Education Technician Apprenticeship which will include:

• Fully recognised apprenticeship qualification - Level 3 Education Technician
• On-the-job competency training
• IOSH Working Safely qualification

Fixed-term: 27 months.

All applications for this vacancy are being handled by the training provider for this apprenticeship, CSR Scientific Training. Please follow this link to the national apprenticeship website to apply: https://www.findapprenticeship.service.gov.uk/apprenticeship/1000255325.

Closing Date: 30 June 2024. Interviews are expected to take place in July 2024.

Please quote reference PM41748 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Scarpa lab is a cell and developmental biology research team based in the Department of Physiology, Development and Neuroscience at the University of Cambridge. We are passionate about understanding how cells move and divide within complex in vivo tissue environments, and we use Zebrafish embryology, live imaging and mechanical perturbations to address these exciting scientific questions. We are a recently established lab, and our team has included people from 4 continents so far. We are enthusiastic, inclusive and we think diversity is key to drive and develop new ideas in science.

We are looking for a Research Associate to investigate the role of tissue-scale confinement during in vivo and in vitro Zebrafish neural crest cell migration. The role holder will develop new techniques to culture and confine Zebrafish neural crest cells in vitro, and carry out live imaging and quantitative analysis of neural crest cell migration in vivo.

In vivo, cells migrate through tight spaces and may undergo division in crowded environments, both in physiological and pathological contexts, for example during immune cells diapedesis or cancer cell dissemination. These phenomena are difficult to observe in vivo, especially in mammalian models. Key studies in the field have largely exploited in vitro systems, for example culturing cells in 3D collagen matrices or microfabrication of PDMS microchannels, to mimic interstitial confining environments. From this wealth of work, it has become clear that cells experiencing physical confinement during cell migration suffer mechanical stress. This causes deformation of the largest organelle, the nucleus, and loss of nuclear integrity, thus inducing DNA damage. Physical compression can even promote genetic diversity in cancer cells. In addition, when cells in culture undergo mitosis under mechanical compression, they show extensive cortical blebbing and suffer division defects. Together, these findings show that mechanical stress negatively impacts the integrity of the genome and this has been proposed to underlie cancer initiation and progression. However, the consequences of mechanical compression on cells during in vivo cell migration remain so far unexplored.

The successful candidate will have a PhD in a biological subject, with knowledge of Zebrafish trunk neural crest embryology, cell biology, genetics. They will have experience with Zebrafish embryology and microinjection techniques, live imaging of Zebrafish embryos and embryo dissociation and FACS sorting. Please refer to the Further Particulars for a full list of the essential skills and experience required for the role.

Informal enquiries about the position can be made to Dr Elena Scarpa (es697@cam.ac.uk).

Fixed-term: The funds for this post are available for 12 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Apply

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, please submit a CV, and a motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

The closing date for applications is 7 June 2024.

Please quote reference PM41833 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The post is offered to internal candidates only on the basis of a secondment from their current role in the University.

We are looking for a senior manager to provide additional, temporary support and leadership for our facilities team as we embark on an ambitious programme of refurbishment. You will be an integral member of the senior management team with shared responsibility for the management of the physical infrastructure and facilities in the Anatomy and Physiology Buildings, and associated staff. There is also the opportunity to take forward specific projects to further cross-department collaboration in the School of Biological Sciences, including projects to strengthen business continuity planning and management. The role requires onsite working most of the time, including daily interactions with a wide range of professional services staff, academics, students, and contractors.

We are seeking a versatile individual with excellent organisational, communication, and problem solving skills as well as a collaborative and hands-on approach to their work. The role requires experience of building management and/or operations management, and significant staff management experience.

Please refer to the Further Particulars for a full list of the essential skills and experience required for the role.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Our preference is for full-time working (37 hpw) however we would welcome inquiries from applicants seeking to work less than full-time.

Olivia Speed, Departmental Administrator, would be pleased to discuss the role informally with prospective applicants (pdnadmin@pdn.cam.ac.uk).

Apply

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. Please also include in your application a short statement on what Equality, Diversity and Inclusivity means to you. The full contact details for two referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Closing date: 16 June 2024.

Interviews are expected to be held at the end of June.

Please quote reference PM41779 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The post is offered to internal candidates only on the basis of a secondment from their current role in the University.

We are looking for a senior manager to provide additional, temporary support and leadership for our facilities team as we embark on an ambitious programme of refurbishment. You will be an integral member of the senior management team with shared responsibility for the management of the physical infrastructure and facilities in the Anatomy and Physiology Buildings, and associated staff. There is also the opportunity to take forward specific projects to further cross-department collaboration in the School of Biological Sciences, including projects to strengthen business continuity planning and management. The role requires onsite working most of the time, including daily interactions with a wide range of professional services staff, academics, students, and contractors.

We are seeking a versatile individual with excellent organisational, communication, and problem solving skills as well as a collaborative and hands-on approach to their work. The role requires experience of building management and/or operations management, and significant staff management experience.

Please refer to the Further Particulars for a full list of the essential skills and experience required for the role.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Our preference is for full-time working (37 hpw) however we would welcome inquiries from applicants seeking to work less than full-time.

Olivia Speed, Departmental Administrator, would be pleased to discuss the role informally with prospective applicants (pdnadmin@pdn.cam.ac.uk).

Apply

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. Please also include in your application a short statement on what Equality, Diversity and Inclusivity means to you. The full contact details for two referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Closing date: 16 June 2024.

Interviews are expected to be held at the end of June.

Please quote reference PM41779 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.