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Current jobs in the Department of Physiology, Development and Neuroscience at the University of Cambridge.
Updated: 24 min 31 sec ago

Postdoctoral Research Associate (Fixed Term)

Thu, 17/11/2022 - 00:00

We are pleased to advertise a Postdoctoral Research Associate position in Dr Elena Scarpa's group to investigate the role of tissue-scale mechanical stress during in vivo cell migration and cell division.

In vivo, cells migrate through tight spaces and may undergo division in crowded environments, both in physiological and pathological contexts, for example during immune cells diapedesis or cancer cell dissemination. These phenomena are difficult to observe in vivo, especially in mammalian models. Key studies in the field have largely exploited in vitro systems, for example culturing cells in 3D collagen matrices or microfabrication of PDMS microchannels, to mimic interstitial confining environments. From this wealth of work, it has become clear that cells experiencing physical confinement during cell migration suffer mechanical stress. This causes deformation of the largest organelle, the nucleus, and loss of nuclear integrity, thus inducing DNA damage. Physical compression can even promote genetic diversity in cancer cells. In addition, when cells in culture undergo mitosis under mechanical compression, they show extensive cortical blebbing and suffer division defects. Together, these findings show that mechanical stress negatively impacts the integrity of the genome and this has been proposed to underlie cancer initiation and progression. However, the consequences of mechanical compression on cells during in vivo cell migration remain so far unexplored.

Our lab uses Zebrafish trunk neural crest cell migration as a novel, physiological model to understand whether physical confinement threatens the integrity of the genome in vivo, and whether this can promote cancer initiation.

The post-holder will carry out in vivo laser and embryological manipulations, live imaging, and quantitative image analysis. For example, they will be involved in designing and establishing tissue-scale methods to alter in vivo mechanical compression. Besides these tasks, the PDRA may train and supervise students recruited to carry out complementary aspects of the lab's research. In addition, they will meet and discuss the work with collaborators, present at conferences and contribute to write articles describing the outputs of the research.

Candidates should have a PhD in a relevant subject. The multidisciplinary nature of the post requires previous experience in the Zebrafish animal model, live imaging and quantitative image analysis. The ability to plan, execute and record scientific studies; make independent decisions and solve routine problems encountered in research projects is essential, as are excellent verbal and written communication skills.

This position is available from 1 March 2023 for 12 months in the first instance. We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply to this post, submit a CV and a motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference. The application deadline is 8 January 2023, and we will hold interviews for shortlisted candidates in W/C 16 January 2023.

Please quote reference PM34253 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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Reserch Laboratory Trainee Technician (Fixed Term)

Wed, 16/11/2022 - 00:00

Applications are invited for the position of Research Laboratory Technician to join the group of Professor Magda Zernicka-Goetz from 3 July 2023. Professor Zernicka-Goetz's group's long term research goal is to understand the development of cell lineages and patterning in the early mammalian embryo.

The ideal candidate will be educated to A' level or NVQ level 3 in a biological or other related subject and/or relevant laboratory experience in molecular biology, including genetics/genomics. They will have a good understanding of molecular biology and excellent general laboratory skills. The candidate should have meticulous documentation and note-keeping skills and be able to manage their time and work effectively. Good communication skills and the ability to work effectively within a team are essential.

The role will support the research of Professor Magda Zernicka-Goetz's group. There are 10 group members, excluding Professor Zernicka-Goetz, all of whom are research staff. The post will provide basic laboratory support, molecular biology techniques, genotyping of mice, laboratory housekeeping, looking after simple laboratory equipment, passing on knowledge to graduate students. There will also be some administrative tasks including making travel arrangements for the Principal Investigator.

Fixed-term: The funds for this post are available for 12 months.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Closing date: 15 December 2022.

Please quote reference PM34225 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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Facilities and Operations Manager

Fri, 11/11/2022 - 00:00

This is an opportune time to join a large, welcoming and inclusive Department with an exceptional international record in teaching and research. The Facilities and Operations Manager will be part of the Department's senior management team and is responsible primarily for the management and operations of the physical infrastructure and facilities in the Anatomy and Physiology Buildings, and associated staff. They will be required to work on site and interact effectively with a wide range of professional services staff, academics, students, and contractors.

We are seeking a versatile individual with excellent problem solving skills as well as a collaborative and hands-on approach to their work. The successful candidate will have a strong Building Management and/or Laboratory and Facilities background and significant staff management experience.

Please refer to the Further Particulars for a full list of the essential skills and experience required for the role.

The appointment is offered on a permanent, full-time basis.

For informal enquiries please contact Olivia Speed, Departmental Administrator (pdnadmin@pdn.cam.ac.uk).

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. Please also include in your application a short statement on what Equality, Diversity and Inclusivity means to you. The full contact details for two referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Closing date: 7 December 2022.

Interviews are expected to be held in W/C 12 December 2022.

Please quote reference PM33958 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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Next Generation Research Fellow (Fixed Term), Centre for Trophoblast Research

Wed, 19/10/2022 - 00:00

The Centre for Trophoblast Research (CTR) was founded in 2007 as a Centre of excellence to promote scientific study of the placenta, early development and maternal-fetal interactions during pregnancy. It brings together over 30 Principal Investigators, many of whom are recognized international experts in their fields. The CTR was one of the University of Cambridge's first inter-school initiatives, bridging research in the Departments of Physiology, Development, and Neuroscience, Obstetrics and Gynaecology, Genetics, Pathology and allied institutes, including Metabolic Science, as well as the Gurdon, Sanger, Babraham and Stem Cell Institutes.

The CTR has an opening for a Next Generation Fellow who will complement and synergise with our existing research programmes. Next Generation Fellowships are a springboard to a long and successful career in the field of placental and reproductive biology, and are aimed at promoting the careers of high-calibre individuals pursuing innovative research falling within the remit of the Centre. Next Generation Fellowships are highly flexible to suit individual needs, and to enable the postholder to develop as an independent researcher within a supportive and stimulating environment. Holders are expected, and will be supported, to apply for Research Fellowship/Career Development Awards from research councils or other funders, or a faculty position during their tenure.

Next Generation Fellows will be mentored to develop and establish an independent research program to carry out research that will complement that of other groups within the Centre for Trophoblast Research. Next Generation Fellows will be expected to contribute fully to the activities of the CTR and to their host department. They will supervise MPhil/masters, summer and/or undergraduate students. They may be a co-applicant on research grant applications to recruit, train and co-supervise postdoctoral researchers, research assistants, technical staff and PhD students, depending on the outcome of external funding. They will act proactively to manage their group members.

The post holder will be expected to create a strong track record of publishing high impact papers and disseminate the results of their work in any ways that seem appropriate and effective (e.g. via conferences and seminars). They will be responsible for compliance with all the relevant laws (Home Office, HTA, HFEA).

Candidates should hold a PhD and have a high-quality publication track record in academic journals or equivalent. Please refer to the further particulars document for a full list of essential list of skills and qualifications.

Appointments will be made on a fixed-term, full-time, basis for a period of 3 years, although we would also welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements. The contract further includes research consumables/equipment up to £20,000 per annum & travel support up to £750.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply to this post, candidates should first identify a research Sponsor from the list of Principal Investigators https://www.trophoblast.cam.ac.uk/people/principal-investigators within the Centre for Trophoblast Research, and discuss their research plans with them.

In addition to this, pleasure ensure that you upload the application documentations as follows:

(i) Curriculum Vitae (CV)

(ii) Up to 3 letters of reference

(iii) Letter of support from your chosen CTR sponsor

(iv) CTR Next Generation Fellowship application form (please see Further Information below)

We welcome applications from across a diverse range of research relevant to our Grand Challenges https://www.trophoblast.cam.ac.uk/about-us/objectives.

The application deadline is 30th January 2023, and we aim to hold Zoom interviews for shortlisted candidates within 2-3 months after the closing date .

Please quote reference PM33698 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK, please see https://www.jobs.cam.ac.uk/right/have/.

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Electron Microscopy Specialist (Maternity Cover), Cambridge Advanced Imaging Centre (CAIC)

Wed, 19/10/2022 - 00:00

This role is to provide specialist technical support within the electron microscopy team at the Cambridge Advanced Imaging Centre (CAIC). At present CAIC has an FEI Verios 460 SEM, Tecnai G2 TEM and ATUMtome with associated sample preparation equipment. The Electron Microscopy team is in high demand across the School of Biological Sciences. This team consists of the lead Electron Microscopist, a Technical Specialist (this role) and a technician. The advanced EM services provided by this team serves over 100 research groups across the University and is openly accessible to external users from HEIs or industry.

The role holder will be responsible for assisting the lead electron microscopist in the delivery of a professional and comprehensive EM service with an emphasis on maximising use of our 3D EM and block face imaging services. The role holder will develop EM sample preparation and imaging methodology in collaboration with our users alongside providing routine training and equipment maintenance. The Electron Microscopy Specialist will assist in achieving a well-maintained and efficient facility that provides state-of-the-art electron microscopy to the School of Biological Sciences.

You should have experience working in an electron microscopy facility or in an electron microscopy based research laboratory. You should also have a proven track record of laboratory/resources management and have excellent interpersonal skills.

Temporary cover: This post is fixed-term until 31 December 2023 or the return of the post holder, whichever is the earlier.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please upload your CV and a covering letter highlighting your suitability to the post. Please also include in your application a short statement on what Equality, Diversity and Inclusivity means to you. The full contact details for two referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Closing date: 13 November 2022.

Please quote reference PM33723 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Centre for Trophoblast Research PhD Studentship

Mon, 17/10/2022 - 00:00

The Centre for Trophoblast Research (CTR) (https://www.trophoblast.cam.ac.uk/phd-studentships) provides a dynamic environment for PhD training in placental biology and reproductive science. Founded in 2007, it brings together over 30 Principal Investigators with a shared interest in the scientific study of the placenta, early development and maternal-fetal interactions during pregnancy. Our PIs are recognized international experts in their fields based across Cambridge in the Departments of Physiology, Development, and Neuroscience, Obstetrics and Gynaecology, Pathology and Genetics, and allied institutes, including Metabolic Science, the Babraham, Gurdon Institutes, Cambridge Stem Cell Institute, and MRC Toxicology Unit and Epidemiology Unit. A CTR Studentship will be held within the relevant Department or Institute, where an internal Departmental Postgraduate Educational Committee is responsible for administering your degree.

Our PhD students have access to unique training opportunities to prepare them for successful careers in research. Students will present their research by giving seminars at our annual CTR Away Days and Annual Meetings and attend a variety of seminars given by distinguished scientists with the CTR and affiliated Department or Institute. There are also opportunities to participate and present in interdisciplinary seminars hosted by Cambridge Reproduction Strategic Research Initiative of which the CTR is a founding member. Students will gain training in our Placental Biology Course and receive support from the to attend international meetings. CTR PhD students will also become members of the Postgraduate School of the Life Sciences, which organises and promotes many further training opportunities.

We are pleased to consider applications for fully funded, full-time study over four years or part-time over five years. Studentships are open for applications in September of the year prior to the start of your studies. Candidates are expected to begin studies in October (Michaelmas term).

Please investigate research projects (https://www.trophoblast.cam.ac.uk/opportunities/projects) on offer for the 2022/2023 application cycle and contact potential supervisors in advance of applying. Once you have identified a potential supervisor(s) and project(s), please make a formal application following the instructions and requirements detailed on our website.

The application deadline is 7th November 2022. We will hold an initial round of Zoom interviews with potential PhD supervisors in mid/late November (2022). Shortlisted candidates will be invited to a second round of interviews in early January (2023).

CTR PhD Studentships will cover all University and College fees for home and international students, along with a stipend rate as follows:

Year 1: £19,919 Year 2: £21,542 Year 3: £23,298 Year 4: £23,298

Awarded studentships also include a justified research consumables/equipment of £5,000 per annum for years 1-3 and up to £750 funds for conference travel.

We welcome applications from highly qualified students of all nationalities. Applicants for this course should have achieved a UK Good II.i Honours Degree. If your degree is not from the UK, please check International Qualifications (https://www.postgraduate.study.cam.ac.uk/international/international-qualifications) to find the equivalent in your country.

We are looking for strong candidates that will contribute to the science in the CTR and have potential as researchers. During the admissions process, we will consider the academic record and the comments from referees as well as the research experience and achievements of the applicants. We are mindful that the extent of research opportunity and publications can vary substantially depending on background and undergraduate training, for example some countries have longer undergraduate courses, different master requirements, offer short courses and practical research, etc, and all these are put into context when evaluating potential.

Please refer to the University Entry requirements (https://www.postgraduate.study.cam.ac.uk/application-process/entry-requirements) for further detail.

If you have any questions regarding the selection process, please refer to our website or email ctrphd@pdn.cam.ac.uk.

Please quote reference PM33705 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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Communications Co-ordinator

Wed, 12/10/2022 - 00:00

The Department of Physiology, Development and Neuroscience (PDN) are seeking to appoint an enthusiastic and creative Communications Co-ordinator in this friendly and busy department.

Working proactively with a wide range of people, you will produce and coordinate written, visual and digital content for our range of communication channels, including social media. You will be working and learning across all areas of departmental communications both internally and externally. This opportunity would suit someone looking to develop skills in this area, including social media skills, with ideas of how we can continue to enhance our communications in an effective and efficient way.

Excellent oral and written communication skills and experience of using web software is essential. You should have experience of writing and editing copy and drafting documents for a varied audience. Excellent interpersonal skills, and the ability to foster relationships and partnerships with a variety of key stakeholders, are also prerequisites for this role.

Experience of using design software and basic photography would be useful, though the post holder will be able to work with other staff in the wider University where more specialist skills are required.

There is an opportunity for some hybrid working in this role although the successful candidate will be expected to be in the Department for the majority of time.

The successful candidate will be educated to at least A level qualification or equivalent level of practical experience, and have some previous experience in an administrative or communications-related role.

For informal enquiries please contact Olivia Speed, Departmental Administrator (pdnadmin@pdn.cam.ac.uk).

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. Please also include in your application a short statement on what Equality, Diversity and Inclusivity means to you. The full contact details for two referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Closing date: 6 November 2022.

Interviews are expected to be held on 16 November 2022.

Please quote reference PM33482 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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Research Associate (Fixed Term)

Mon, 03/10/2022 - 00:00

We are looking for an enthusiastic Post-Doctoral Research Associate to join Dr Courtney Hanna's group, a developmental epigenetics lab based in the Centre for Trophoblast Research and Department of Physiology, Development and Neuroscience. The successful candidate will join a Wellcome Trust/Royal Society-funded project investigating the mechanisms of epigenetic programming during early placental development and the importance of these epigenetic marks in placental function throughout pregnancy. We are an inclusive and welcoming group, committed to supporting the career development of all members.

In this position, you will investigate embryo and placental phenotypes in established transgenic mouse models, perform molecular and next generation sequencing experiments, analyse sequencing data for histone modifications, DNA methylation, transcription factor binding and gene expression, and contribute to manuscripts arising from this work. This position will include formal training in bioinformatics and the opportunity to attend international conferences.

Candidates must hold a PhD in biological sciences or have their thesis submitted when commencing the post. Candidates should have excellent organisational, collaboration and communication skills. Experience in molecular techniques and basic bioinformatics analyses is essential for this position. Experience in placental cell biology, mouse embryology and method optimisation is desirable, but not essential.

Fixed-term: The funds for this post are available for three years in the first instance.

Informal inquiries are invited and can be directed to Dr Courtney Hanna (cwh36@cam.ac.uk).

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please submit a CV and motivation letter detailing why you want to be part of this project and how this post will be good stepping-stone for your career. Please provide contact details for two people who can provide a professional reference.

Closing date for applications is 4 November 2022. We aim to hold Zoom interviews for shortlisted candidates in late November.

Please quote reference PM33451 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Associate (Fixed Term)

Thu, 29/09/2022 - 00:00

Applications are invited from an enthusiastic and highly motivated researcher at Research Associate level. The work is funded by a Medical Research Council grant held Prof Amanda Sferruzzi-Perri. The main focus of the Sferruzzi-Perri lab is to understand the aetiology of pregnancy complications and the regulation of developmental processes in a wider context (https://www.pdn.cam.ac.uk/directory/amanda-sferruzzi-perri). The lab combines unique gene targeting strategies and established environmental models with cutting edge molecular, cellular and physiological approaches in the mouse. You will work in a collaborative multidisciplinary team that is investigating specifically the role of placental endocrine function in promoting changes in maternal metabolism and insulin resistance in obese pregnancies and its importance for the health of the offspring in later life.

The successful candidate should have a PhD in a relevant field, have a background in developmental physiology and/or metabolic regulation and have a good track record of research achievements. You will have experience of performing in vivo experiments or ex vivo assessments of tissues from rodents and handling large datasets. Experience in conducting fluorescence activated cell sorting, cell culture, gene targeting methods, RNA-sequencing (and/or other high-throughput technologies), bioinformatic analysis is desirable. Animal husbandry experience and a Home Office Personal Licence would be an advantage.

The position is available from November 2022.

For further details, please email Prof Sferruzzi-Perri at: ans48@cam.ac.uk.

Fixed-term: The funds for this post are available until 30 June 2023 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applications should include a personal statement highlighting suitability to the post and a detailed CV. The full contact details for two referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Please quote reference PM33408 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Chief Secretary

Fri, 23/09/2022 - 00:00

The Department of Physiology, Development and Neuroscience are seeking to appoint an experienced, self-motivated and proactive administrator to join our administration team in this friendly and busy department. This is an exciting opportunity for someone looking for an interesting and varied role within administration, as this post has a wide range of responsibilities including PA to the Heads of Department and the support of HR administration.

The role holder will provide valuable administrative support to help ensure the smooth running of the Department. Duties will include administrative support for senior staff, supporting communications, minute taking for various committees, visitor administration, including being the first point of contact for prospective visitors to the Department, organising events, co-ordinating recruitment and appointments as well as other HR-related tasks. The post holder will also supervise a Grade 3 administrator.

The successful candidate will have excellent customer service and communication skills, and the ability to deal professionally and efficiently with enquiries. They will be approachable and flexible with excellent communication skills and have the ability to organise their own workload meeting multiple conflicting deadlines with a high level of professionalism.

The appointment is offered on a permanent, full-time basis, though we also welcome applications from individuals who wish to be considered for part-time working. There is an opportunity for some hybrid working in this role although the successful candidate will be expected to be in the office for the majority of time.

The successful candidate will be educated to HND, HNC, level 4/5 vocational qualification or equivalent level of practical experience, and have previous PA/Secretarial or Administrative experience.

For informal enquiries please contact Tracey Flack at tf315@cam.ac.uk.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Closing date: 13 October 2022.

Interviews are expected to be held in w/c 17 October 2022.

Please quote reference PM33313 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

PDN SBS DTP PhD Studentship (Fixed Term)

Tue, 20/09/2022 - 00:00

In collaboration with the School of Biological Sciences, the Department of PDN will offer a 4-year "PDN SBS DTP PhD Studentship" to a successful applicant for the PhD in Physiology, Development and Neuroscience. This award is aimed at students from low-income households with experience of educational disadvantage and students from under-represented groups, including Black, British Bangladeshi or British Pakistani, backgrounds who will be charged University fees at the Home or UK rate.

The award will provide a stipend for 4 years at the UKRI level; university fees at the home rate; and research consumables for 4 years (£18,000 in total). You will also undertake a 3-month long Professional Internship for PhD students (PIPS) at some stage during your study, and will participate in training and cohort-building events alongside other funded students.

The Funding Application Form will be made available to all applicants who receive an offer of a place to study on the PhD in Physiology, Development and Neuroscience who will be charged University fees at the Home or UK rate and who applied by the funding deadline of: Thursday 5 January (23:59 UK time).

Please see this link for further information about the eligibility criteria and the Funding Application form https://www.pdn.cam.ac.uk/postgraduate/pdn-sbs-dtp-phd-studentship-eligibility-criteria.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

PhD Studentship - Avian iPSCs and Cerebral Organoids (Fixed Term)

Tue, 20/09/2022 - 00:00

Supervisors: Prof. David Keays (LMU Munich/Cambridge) and Dr. Madeline Lancaster (LMB, Cambridge)

The Project - An opportunity exists for a driven and passionate student to undertake a Phd under the supervision of Prof. David Keays and Dr Madeline Lancaster on avian stem cells and cerebral organoids. This joint project will exploit the Keays lab's expertise in Avian biology and the Lancaster Lab's experience in self organising neural tissue. The project will aim to generate a library of avian iPSCs and ES cells for the generation of three dimensional neuronal cultures. The latter will then be employed to interrogate Avian specific aspects of neurodevelopment and sensory biology exploiting CRISP-Cas9 genome editing, single cell sequencing, and histological methods.

The ideal candidate - This ambitious project requires a candidate with an existing interest in stem cell biology and/or developmental neuroscience. They should be patient, be impervious to scientific failure, value quantitative approaches and have a strong academic record. Prior experience in cell culture methods and molecular biology will be advantageous. The student will be based in the Physiology, Development and Neuroscience department (PDN) in Cambridge, but should be prepared to spend time at the Laboratory of Molecular Biology (LMB) in Cambridge and at LMU in Munich. We actively encourage applications from prospective postgraduate students from underrepresented groups. The position is funded for three years and will cover home fees, as well as costs associated with travel, training and consumables.

Website: www.Keayslab.org and www2.mrc-lmb.cam.ac.uk/groups/lancaster/

Application: Please send applications to dak55@cam.ac.uk and mlancast@mrc-lmb.cam.ac.uk. Please include a CV, letter of motivation and the contact details of two referees. The deadline for applications is December 1st 2022, but interested applicants are encourage to contact us beforehand. It is anticipated that the student would begin in the Easter Term in 2023 (April 17th).

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Human Anatomy Technician [Temporary Cover]

Fri, 26/08/2022 - 00:00

The Department of Physiology, Development and Neuroscience is seeking to appoint a self-motivated, enthusiastic person to join our friendly Human Anatomy Centre team. The facility delivers first and second year anatomy and neuroanatomy courses to an intake of around 320 pre-clinical medical students each year, and supports both research projects and external courses for a wide range of medical professionals. This is an exciting opportunity for someone looking for an interesting and varied technical role within a busy teaching environment.

Reporting to the Human Anatomy Centre Manager, and joining a team of four other professional services staff, the role holder will provide valuable technical support to help ensure the smooth running of the Centre. Duties will be diverse and will primarily include Human Dissection Room tasks related to the teaching and research activities of the Centre, all involving the use of human anatomical material. We are flexible in who we are looking to recruit, depending on prior experience. Ideally, we are looking for someone with the ability to undertake unsupervised anatomical embalming, although training can be provided for a role holder without this experience. Equally, we would also be keen keen to recruit someone with expertise in the preparation of anatomical prosections, and for such a person the daily responsibilities can be adjusted to accommodate a greater prosecting role.

The successful candidate will have excellent communication skills, with the ability to deal professionally and efficiently with enquiries from students, colleagues and associated professionals, and will work well in a small and inclusive team. They will also be highly organised and have a flexible approach to work, with an ability to move between tasks at short notice to meet deadlines. Proficiency in the use of basic software packages (Microsoft Outlook, Word and Excel) and the ability to deal appropriately with sensitive and confidential information is also essential.

Temporary Cover: this appointment is offered on a fixed-term, 6-month contract. We are ideally seeking to appoint a full-time colleague, but will be happy to consider applicants interested in a part-time and/or flexible roll, depending on their other commitments.

For informal enquiries please contact Dr Richard Lloyd, Human Anatomy Centre Manager rl643@cam.ac.uk

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please refer to the Further Particulars for this role, and use this as a guideline for your application.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Please quote reference PM32887 on your application and in any correspondence about this vacancy.

Interviews will be held in person on Tuesday 27th September.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Associate (Fixed Term)

Fri, 12/08/2022 - 00:00

We are looking for a highly motivated, proactive and enthusiastic postdoc to work on a BBSRC funded project within the recently founded Galliano Laboratory (https://gallianolab.org) in the Department of Physiology, Development and Neuroscience. This project aims to elucidate the role of morphologically and developmentally diverse dopaminergic neurons in olfactory processing.

This project will combine timed stereotaxic injections of opto- and chemogenetic effectors and automated olfactory behavioural testing with whole-cell electrophysiology. By integrating these approaches, you will provide a multi-level synthesis of how developmentally-defined neurons of the same class differentially contribute to sensory processing.

Your key role will be to optimise, validate and employ our newly-built and fully-automated apparatus inspired by the Schaefer's laboratory's "AutonoMouse". This cage enables high-throughput, self-initiated training of large cohorts of mice, while providing detailed quantitative data on how individual animals learn to interact with a range of sensory stimuli. You will perform stereotaxic injections of chemogenetic tools to manipulate developmentally distinct populations and DA neurons, design and supervise behavioural experiments in the AutonoMouse, and develop analysis pipelines for the large datasets generated by the automated testing. In parallel, you will be trained to perform whole-cell patch-clamp experiments in olfactory bulb acute slices carrying opsins and fluorescent indicators. Working closely with one of the lab's PhD students on this aspect of the project, you will combine electrophysiology and optogenetics to probe the connectivity of the developmentally distinct DA populations.

The successful candidate will have, or be about to receive, a PhD in Neuroscience or a related discipline. They will have technical expertise with behavioural neuroscience, ideally including test and apparatus design, animal handling, stereotaxic surgery for opto- or chemo-genetic manipulations; be experienced in data analysis; and able to demonstrate that they have led a complex project to completion. Please refer to the further particulars for a full list of skills.

Appointments will be made on a fixed-term, full-time basis for 3 years in the first instance. We are open to discuss different patterns of part-time work that could better suit individual circumstances and/or caring responsibilities. The start date is flexible, but ideally January 2023.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Candidates should upload a CV (max 3 pages) and a motivation letter detailing (a) why you want to be part of our lab and lead this project, (b) how this post will be a good stepping stone for your career, (c) and which are, in your opinion, the most interesting and yet unanswered question in the fields of olfaction/adult neurogenesis/neuronal heterogeneity. Please include the contact details of two professional referees. The application deadline is 16 October, and we aim to hold interviews between 22 October and 2 November 2022.

Please quote reference PM32700 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs