http://www.jobs.cam.ac.uk/job/?unit=u00269&format=rss

Clare Baker's lab (https://www.pdn.cam.ac.uk/directory/clare-baker) is based in the Department of Physiology, Development and Neuroscience at the University of Cambridge. The lab studies the development of vertebrate electrosensory lateral line organs as a model for understanding how novel cell-types and organs evolve. We are a small group, committed to mentoring and supporting the career development of all members. We share open-plan lab space with two zebrafish groups.

We are looking for a second postdoc to join the lab for a Leverhulme Trust-funded project on the development and evolution of electroreceptors in weakly electric fishes. Electroreception was lost in the ancestors of teleost fishes, but evolved independently at least twice within different teleost groups, most likely via the modification of mechanosensory lateral line neuromasts. The project overall involves knifefishes (gymnotiforms) and freshwater elephantfishes (mormyrids): these lineages independently evolved 'ampullary' organs that detect low-frequency electric fields in water (for example, from other animals), as well as electric organs (modified muscle/nerve) and 'tuberous' organs that respond to high-frequency electric organ discharges (used for communication, electrolocation, etc). You will focus primarily on lateral line organ development in knifefish. The project involves experimental embryology (fate-mapping lateral line placodes with DiI; small-molecule manipulation of different signalling pathways; CRISPR/Cas9-mediated gene targeting in 1-cell embryos), bioinformatic analysis of single-cell transcriptomic datasets and gene-expression studies using in situ hybridisation/HCR. You will undertake all work with live knifefish embryos via extended research visits (each lasting several weeks) to our collaborator Michael Markham's lab at the University of Oklahoma (Norman, OK, USA). Fixed specimens will be shipped to Cambridge for analysis there.

Candidates should hold a PhD in developmental biology and have experience in vertebrate experimental embryology, preferably in teleost fishes. Experience with CRISPR/Cas9 gene targeting in embryos is desirable. Bioinformatics experience with single-cell transcriptomic datasets is desirable.

Fixed-term: The funds for this post are available for 30 months in the first instance.

The position is available immediately but the start date is flexible and would be by negotiation.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, please submit a CV, motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

The closing date for applications is 1st August 2025.

Informal enquiries about the position can be made to Professor Clare Baker (cvhb1@cam.ac.uk)

Please quote reference PM46251 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

An exciting opportunity has arisen to join the Loke Centre for Trophoblast Research (CTR) at the University of Cambridge as Executive Manager, providing maternity cover for the current postholder.

About the Role

This is a senior administrative role supporting the Director of the Centre and providing strategic and operational leadership across a diverse portfolio of activities. This varied role offers the chance to work at the heart of a collaborative, interdisciplinary research centre.

You will coordinate key processes related to governance, recruitment, communications, events, and HR, and act as the main point of contact for internal and external stakeholders.

Key responsibilities include:

• Acting as Secretary to the Loke CTR Board of Managers and Scientific Advisory Board, preparing agendas, drafting papers, producing minutes, and tracking follow-up actions.
• Leading HR processes for Loke CTR-funded PhD studentships and Next Generation Fellowships, including advertising, coordinating interviews, and liaising with supervisors, funders, and HR.
• Managing the day-to-day operations of the Centre, including staff line management, budgeting, team meetings, and supporting efficient internal processes and inductions.
• Overseeing the work of the Loke CTR Events and Communications Administrator, including visitor support and internal communications.
• Supporting academic events and public engagement activities including seminars, conferences, and the Loke CTR Annual Meeting.
• Financial and governance responsibilities, including managing expenses and consumables, and maintaining accurate records in line with University policies.
• Providing support for strategic development of the Loke CTR, including coordinating funding applications and contributing to the Centre's long-term financial sustainability.
• Managing use of office space, coordinating refurbishments, and liaising with departmental administrators.

About You

We are looking for a well-organised, proactive and collaborative individual with experience in academic administration or research management. You will have strong interpersonal and communication skills, excellent attention to detail, and the ability to work independently across a diverse range of responsibilities. Previous experience in a Cambridge department or a similar university environment is desirable.

This role is ideally suited to someone with experience in Cambridge administration who is looking to broaden their operational leadership skills in a supportive environment. The role would also suit a recent PhD graduate looking to gain strategic operations and project management experience in a research environment.

About us

The Loke CTR, based in the Department of Physiology, Development and Neuroscience (PDN), is an internationally recognized centre of excellence committed to advancing the scientific study of the placenta, early development, and maternal-fetal interactions. The Centre is a vibrant, interdisciplinary hub that brings together over 30 research groups across the University.

The core staff team, based in PDN, consists of six people, including the Executive Manager, Events and Communications Administrator, Licensing Coordinator, and Technicians with key support from the departmental Finance, HR and Student Administration teams.

Working Arrangements

The post is offered full-time, though applications from those wishing to work 0.8 FTE or in a job-share will be considered. The role is largely office based but we offer the flexibility of some hybrid working once induction is complete and would be happy to discuss this as part of the interview process. A detailed handover period is planned with overlap with the current postholder.

Temporary cover: This post is fixed-term for 12 months or the return of the post holder, whichever is the earlier.

How to Apply

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply online, click the 'Apply' button on the University jobs portal. Please ensure that you upload a curriculum vitae and cover letter indicating how you would contribute to the responsibilities of the post.

References will be requested from candidates after interviews.

If you are currently employed by the University of Cambridge and would like to apply on the basis of a secondment, please discuss this with your line manager and apply via the University jobs portal. In your application, outline your suitability and what you hope to gain from the secondment.

Find out more

For informal enquiries, please contact Erin Slatery at execmgr.lokectr@pdn.cam.ac.uk.

Please quote reference PM46199 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Postdoctoral Research Associate position in cellular biophysics in the group of Prof. Ewa Paluch. The Paluch lab studies cellular morphogenesis combining cell and molecular biology, quantitative imaging and biophysical approaches to investigate cell shape changes in cultured cells and in vivo. Current projects in the lab include investigating the regulation of the mechanical properties of the cellular actin cortex, the biomechanics of cell division, and the coupling between cell shape and mechanics and cellular state / fate during cellular transitions.

The successful candidate will conduct fundamental research aimed at understanding cell shape dynamics and the cross-talk between cell shape and cell state during epithelial-to-mesenchymal transition (EMT). The aim of the project is to 1) quantitatively characterise cell shape dynamics during EMT and MET in cultured cell lines and in induced pluripotent stem cells, and 2) investigate the regulation and role of cell shape fluctuations during these shape transitions.

You should hold a PhD (or about to be awarded a PhD) in Cell Biophysics, or a related field and have extensive experience with cell culture, cell biophysics, imaging, imaging and image analysis.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

Further information on the lab: https://www.pdn.cam.ac.uk/directory/ewa-paluch and https://paluchlab.uk

Fixed-term: The funds for this post are available for 6 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, please submit a CV and a motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

The closing date for applications is 10th June 2025.

Please quote reference PM46196 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a postdoctoral research associate in the lab of Dr Jasper Poort and based at the Department of Physiology, Development and Neuroscience at the University of Cambridge. The successful candidate will work on a research project that will investigate the neural circuit mechanisms of visual decision-making, learning, and attention.

The project combines electrophysiology and optogenetic manipulation of different cell types and neural projections in visual and decision-making brain areas to understand how mice learn to become experts in different visually-guided decision-making tasks and flexibly switch attention between tasks. The successful applicant will join a supportive and multi-disciplinary research environment.

Applicants should have completed (or are about to submit) a PhD (research associate) or (under)graduate degree (research assistant) in neuroscience, biology, engineering, or other relevant disciplines. We are looking for someone with previous experience in electrophysiology, optogenetics, and behavioural training in mice, and strong data analysis skills (e.g. Matlab or Python). For more information about the lab see https://www.pdn.cam.ac.uk/svl/.

Fixed-term: The funds for this post are available for 1 years in the first instance.

Appointment at Research Associate level is dependent on having a PhD; those without a PhD will be appointed at Research Assistant level. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, please submit a CV, motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

The closing date for applications is 16th June 2025.

Informal enquiries about the position can be made to Dr Jasper Poort (jp816@cam.ac.uk).

Please quote reference PM46068 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Postdoctoral Research Associate position in cellular biophysics in the group of Prof. Ewa Paluch. The Paluch lab studies cellular morphogenesis combining cell and molecular biology, quantitative imaging and biophysical approaches to investigate cell shape changes in cultured cells and in vivo. Current projects in the lab include investigating the regulation of the mechanical properties of the cellular actin cortex, the biomechanics of cell division, and the coupling between cell shape and mechanics and cellular state / fate during cellular transitions.

The successful candidate will conduct fundamental research aimed at understanding cell shape dynamics and the cross -talk between cell shape and cell state during epithelial-to-mesenchymal transition (EMT). The aim of the project is to 1) develop computational pipelines for image analysis and physical analysis of cell shape trajectories, and for combined morpho-molecular analysis of cell shape together with molecular markers, and 2) to develop a physical model of cell shape dynamics during EMT.

You should hold a PhD (or about to be awarded a PhD) in Biophysics or a related field and have extensive experience with cell and developmental biophysics, imaging, image analysis, and modelling of biological processes.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

Further information on the lab: https://www.pdn.cam.ac.uk/directory/ewa-paluch

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, please submit a CV and a motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

The funds for this post are available for 1 years in the first instance.

The closing date for applications is 10th June 2025.

Please quote reference PM46099 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Cardona Lab is a neuroscience research group at the Department of Physiology, Development and Neuroscience at the University of Cambridge. We are looking for a Senior Microscopy Specialist to provide expertise through shared services and usage of the Zeiss Gemini 450 FIB-SEM, installed and operating in the WEMS facility of the University.

Our lab's research focuses on the study of the neural circuit basis of behaviour, starting by mapping the synaptic wiring diagrams, or connectome, of whole brains, formulating computational models of neural circuit function, and testing these models with experiments in the lab, using primarily the fruit fly as a model system, given its outstanding genetic toolkit for monitoring and manipulating neural activity in the stereotyped and individually identifiable neurons of its nervous system. A major technique mastered in the lab is large-scale volume electron microscopy, in both FIBSEM and TEM, plus associated image processing methods for aligning and contrast-correcting volumes followed by machine learning-based approaches to segment neurons and identify synapses to map the connectome.

The role holder's duties will include teaching electron microscopy to graduate students and postdocs; developing novel sample preparation protocols for new samples, particularly of brain tissue; directing multi-week 24/7 imaging sessions to acquire volumes of complete brains; and developing the software for automated imaging. They will also be a reference source of expertise in sample preparation for electron microscopy, embedding in resins, trimming, mounting, and imaging with the lab's FIBSEM instruments.

The successful candidate will have experience working in a research based Electron Microscopy laboratory, which will have included teaching and mentoring in the design and execution of experiments, operating, maintaining and enhancing FIBSEM instruments as well as preparing samples for block face imaging with FIBSEM.

Please refer to the further particulars for a full list of the essential knowledge, skills and experience required for the role.

Informal enquiries about the position can be made to Professor Albert Cardona (ac2040@cam.ac.uk).

Fixed Term: the funds for this post are available for 4 years in the first instance.

Apply:

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, please submit a CV, a motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

The closing date for applications is 10 June 2025.

Please quote reference PM46083 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Department of Physiology, Development & Neuroscience (PDN) is seeking an enthusiastic Business Administration Apprentice from September 2025. This is an exciting opportunity to join our administration team at the University of Cambridge.

The Apprentice will be part of the departmental admin team and will study the Business Administrator Level 3 qualification. The business administration apprentice will, during their apprenticeship, cover many aspects of administration within the department. They will be given the opportunity to work with HR, Receptions, Events and Finance, as well as other teams to develop a wider perspective on the running of an academic department at the University of Cambridge.

You will be a great team player who has good organisation skills and prioritising skills. The apprentice will need to have basic IT skills and be able to follow instructions and learn new tasks. You will have good communication and interpersonal skills to communicate with staff at all levels.

What you'll do in a working day

• Provide reception and clerical services in a welcoming and professional manner
• Assist with the organisation of events and meetings. Coordinate and book meeting rooms, prepare/order refreshments, collate and distribute materials for events, seminars, meetings, take minutes, assist with departmental communications
• Provide administrative support for different operational areas of the Department. Receive calls and take messages, liaise with other departments and organisations. Review emails to identify priorities, process internal and external mail, deal with couriers, produce letters and other correspondence, data entry and maintenance of data records, attend team meetings and take notes/minutes as required
• Perform general administrative tasks. Assist with processing and updating of access to buildings and keys, ordering University cards. Provide administrative support for projects
• Assist with HR administration in accordance with the University policies and procedures.
• Support the administration of visitors

Fixed-term: 21 months

All applications for this vacancy are being handled by the training provider for this apprenticeship, Cambridge Regional College. Please follow this link to the national apprenticeship website to apply: https://www.findapprenticeship.service.gov.uk/apprenticeship/VAC1000319907.

For informal enquiries about working for the Department please contract Tracey Flack, pdnhr@pdn.cam.ac.uk. For queries relating to the apprenticeship please contact Cambridge Regional College.

Closing Date: 8 June 2025. Interviews are expected to take place in late June 2025.

Please quote reference PM45517 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Postdoctoral Research Associate position in cellular biophysics in the group of Prof. Ewa Paluch. The Paluch lab studies cellular morphogenesis combining cell and molecular biology, quantitative imaging and biophysical approaches to investigate cell shape changes in cultured cells and in vivo. Current projects in the lab include investigating the regulation of the mechanical properties of the cellular actin cortex, the biomechanics of cell division, and the coupling between cell shape and mechanics and cellular state / fate during cellular transitions.

The successful candidate will conduct fundamental research aimed at understanding cell shape dynamics and the cross -talk between cell shape and cell state during epithelial-to-mesenchymal transition (EMT). The aim of the project is to 1) develop computational pipelines for image analysis and physical analysis of cell shape trajectories, and for combined morpho-molecular analysis of cell shape together with molecular markers, and 2) to develop a physical model of cell shape dynamics during EMT.

You should hold a PhD (or about to be awarded a PhD) in Biophysics or a related field and have extensive experience with cell and developmental biophysics, imaging, image analysis, and modelling of biological processes.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

Further information on the lab: https://www.pdn.cam.ac.uk/directory/ewa-paluch

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, please submit a CV and a motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

The funds for this post are available for 1 years in the first instance.

The closing date for applications is 26th May 2025.

Please quote reference PM45966 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a postdoctoral position in Dr. Sepiedeh Keshavarzi's laboratory at the University of Cambridge. The lab's Wellcome-Trust-funded research investigates neural circuits for the sense of direction and self-motion by combining in vivo and ex vivo neuronal recording and manipulation with quantitative behavioural assays in mice. For more details, please visit our website: keshavarzilab.com.

This project will dissect the organisation of head-direction circuits in the mouse brain, with a focus on the retrosplenial cortex and its reciprocal cortical and thalamic connections. In the first phase, you'll employ slice electrophysiology (whole-cell patch-clamp), circuit tracing and optogenetic mapping to characterize the synaptic and intrinsic properties of defined pathways. In the second phase, you'll investigate how these circuits remodel during spatial-orientation tasks, probing whether neuronal plasticity is necessary for accurate spatial learning. Collaborative opportunities will allow you to bridge ex vivo and in vivo approaches. Highly driven postdocs who establish efficient slice workflows may broaden their skillset to include complementary in vivo approaches - ranging from extracellular recordings with Neuropixels probes and two-photon calcium imaging to spatial-orientation behavioural assays - either independently or in partnership with colleagues specialising in these techniques.

We seek a motivated, ambitious researcher with a strong background in cellular neurophysiology and clear interest in the lab's research program.

The successful candidate will join a collaborative laboratory committed to rigorous, innovative research and to fostering professional development of its members. We provide funding and logistical support for conferences and workshops, guidance on independent fellowship applications, and ongoing career mentorship. You will work within a multidisciplinary team interacting regularly with other neuroscience groups in the Department and collaborate with both in-house experimentalists and external engineers and computational neuroscientists. The Department's seminars, along with events hosted by the Cambridge Neuroscience Network, will enrich your experience through further scientific exchange and networking.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applications should include a cover letter highlighting your motivation for joining the lab, how your skills align with the project and your research ambitions and career goals. Please also provide a detailed CV and the names and addresses of two academic referees.

The position is available from 15 July 2025 for for an initial three-year term; precise start date is negotiable.

The closing date for applications is 9th June 2025. Applications will be reviewed on a rolling basis and the position may close early once filled.

For informal inquiries, please contact Dr. Sepiedeh Keshavarzi at sk2244@cam.ac.uk.

Please quote reference PM45938 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly encourages women and candidates from a Black, Asian or Minority Ethnic background to apply for this vacancy.

Applicants interested in applying for the role that do not currently hold the right to work in the UK may be eligible to be sponsored by the University in order to apply for a visa and the appropriate right to work status. Visa sponsorship is issued at the discretion of the University.

We are inviting applications for a curious and motivated Postdoctoral Scientist (Research Associate) to join the de Hoz lab at the Department of Physiology, Development and Neuroscience. The de Hoz lab investigates systems neuroscience questions, specifically the role of cortico-subcortical loops in statistical learning. We focus on the auditory system and perform awake/asleep electrophysiology recordings (Neuropixels) and behaviour in mice, while assessing their mental state. We ask questions such as how are noisy sensory inputs recognized and represented in the brain? how are dynamic texture sounds (waterfall, fire) represented? What is the role of corticofugal projections in setting expectations? How does the auditory system integrate information over time? How does representation change with mental state (aroused, asleep, groggy)? We are a small, supportive, and dynamic group (www.dehozlab.org) made of a diversity of people united by a passion for science and the brain. The lab is now transitioning to the University of Cambridge, where this post will be held. We are looking for a person to perform the experiments and help setup the lab at PDN. This vibrant and interactive department spans systems neuroscience and plasticity questions, and is imbedded in the wider Cambridge neuroscience environment.

The key ingredient is to be passionate about the questions of the lab, to be independent, and a background in systems neuroscience. Ideally you would have experience with mouse behaviour and/or Neuropixels recordings and analysis, as well as with opto/chemogenetics. Being a pro with Python/MatLab helps.

Please refer to the further particulars document for a full list of the essential knowledge, skills and experience required for the role.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, please submit a CV, a motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

Informal enquiries about the position can be made to Livia de Hoz (ld749@cam.ac.uk and livia.dehoz@charite.de). If you feel that you don't have all necessary skills but are very interested in the research, please contact me.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

The funds for this post are available for 20 months, starting between October 2025 and March 2026.

The closing date for applications is 31st July 2025.

Please quote reference PM45891 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Department of Physiology, Development and Neuroscience is seeking to appoint a self-motivated, enthusiastic person to join our friendly Human Anatomy Centre team. The facility delivers first and second year anatomy and neuroanatomy courses to an intake of around 320 pre-clinical medical students each year, and supports both research projects and external courses for a wide range of medical professionals. This is an exciting opportunity for someone looking for an interesting and varied role within a busy teaching environment.

Reporting to the Human Anatomy Centre Manager, and working closely with the University Clinical Anatomists and the organisers of preclinical anatomy and neuroanatomy, the role-holder will provide valuable support to help ensure the smooth running of the Centre. Duties will be diverse and will include providing administrative support to the anatomy Course Organisers, as well as the body donation programme in the Centre.

The successful candidate will have excellent communication skills, with the ability to deal professionally and efficiently with enquiries from students, colleagues, bereaved relatives and medical professionals, and will work well in a small and inclusive team. They will also be highly organised and have a flexible approach to work, with an ability to move between tasks at short notice to meet deadlines. Proficiency in Microsoft Office and the ability to manage databases of sensitive and confidential data is also essential. Familiarity with medical terminology would be useful, but training in the work of the Centre will be provided, and a lack of directly related experience is not a bar to applying.

The appointment is offered on a permanent, full-time basis, though we also welcome applications from individuals who wish to be considered for part-time working (minimum 25 hours per week, over five days).

For informal enquiries please contact the Department's HR team at pdnhr@pdn.cam.ac.uk who will be happy to direct your enquiry.

Apply:

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two professional referees should be provided; one of whom should be your current line manager. Please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

Closing date: Wednesday 21 May 2025.

Interviews will be held in person on Wednesday 4 June.

Please quote reference PM45845 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited from an enthusiastic and highly motivated researcher to join the laboratory of Prof Amanda Sferruzzi-Perri. The Sferruzzi-Perri lab (https://www.pdn.cam.ac.uk/directory/amanda-sferruzzi-perri) focuses on understanding the aetiology of pregnancy complications and the regulation of developmental processes in a broader physiological and environmental contexts. The lab employs integrative approaches combining environmental mouse models and human pregnancy samples with cutting edge molecular, cellular and physiological techniques.

The successful candidate will join a collaborative multidisciplinary team investigating how placental development and function contribute to adverse pregnancy outcomes in cases affected by hypoxia or elevated heat exposure.

Candidates should hold a PhD (or be close to completion) or a first degree in a relevant field, with a strong background in pregnancy or developmental physiology research. A proven track record of research productivity and the ability to lead diverse but complementary projects to completion is essential.

Experience in in vivo experimentation with rodents, RNA sequencing (or other high-throughput technologies), bioinformatic analysis, and the handling of large datasets is essential. Proficiency in ex vivo tissue analysis, cell and organoid culture, and gene targeting (e.g., CRISPR/Cas9) is highly desirable. Additional experience in animal husbandry, possession of a Home Office Personal Licence, and handling of human clinical samples would be advantageous.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applications should include a personal statement highlighting suitability to the post, detailed CV and the names and addresses of two academic referees. The position is available from September 2025 for 18 months in the first instance.

The closing date for applications is 30th May 2025.

For further details, please email Prof Sferruzzi-Perri at: ans48@cam.ac.uk.

Please quote reference PM45843 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The GOdogs group is looking to appoint researcher to our group which studies the genetics of obesity, starting with canine genetics but with a strong programme of allied human comparative genetics and functional/molecular studies.

Whilst the focus of this recruitment drive is to find a candidate with genomics expertise, enquiries would also be welcome from molecular biologists interested in using their skills to pursue functional studies of new obesity genes (especially related to endocytosis and cell signalling).

We use GWAS and genetic approaches to identify novel genes responsible for obesity and other common conditions in pet dogs, then use comparative genomics to determine those genes also relevant to humans. Genes and variants responsible are studied in the molecular biology lab and by testing their effect on the physiology and eating behaviour of dogs. All our canine work is done with pet dogs, volunteered by their owners for study (not dedicated lab animals).

This post will be focussed on the genetics of appetite and obesity. Candidates should be of postdoctoral level with relevant experience of canine or/and human genomics, or molecular biology. Candidates without PhD but significant expertise in bioinformatics and genetics would also be considered.

For genetics-focussed candidates, subject knowledge in obesity/metabolism is welcome, but not essential. For molecular biology candidates, background knowledge relevant to understanding the molecular links between genes and obesity is more important.

We are a small group with diversity of background, interest and experience in which wider professional development and pursuit of your interests are encouraged alongside scientific rigour and excellence.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

Informal enquiries can be made to Dr Eleanor Raffan er311@cam.ac.uk. Candidates interested in part time or flexible working are encouraged to discuss this in advance of application.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply for this post, please submit a CV and a covering letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference.

The closing date for applications is 26th May 2025.

Please quote reference PM45840 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Next Generation Fellow, Centre for Trophoblast Research

The Loke Centre for Trophoblast Research (CTR) was founded in 2007 as a Centre of excellence to promote scientific study of the placenta, early development and maternal-fetal interactions during pregnancy. It brings together over 30 Principal Investigators, many of whom are recognized international experts in their fields.

The Loke CTR has an opening for a Next Generation Fellow who will complement and synergise with our existing research programmes. Next Generation Fellowships are a springboard to a long and successful career in the field of placental and reproductive biology and highly flexible to suit individual needs, to enable the postholder to develop as an independent researcher. Holders are expected, and will be supported, to apply for Research Fellowship/Career Development Awards from research councils or other funders, or a faculty position during their tenure. Find out more about the fellowship on our website: https://www.trophoblast.cam.ac.uk/ngf-overview

The Next Generation Fellowships are a springboard to a long and successful career in the field of placental and reproductive biology. Many of our Next Generation Fellows have used the opportunity as a stepping stone to independent group leader positions: https://www.trophoblast.cam.ac.uk/next-generation-fellow-alumni.

What to expect

Next Generation Fellows will be mentored to develop and establish an independent research program that will complement that of other groups within the Centre for Trophoblast Research. Fellows will be expected to contribute fully to the activities of the Loke CTR and to their host department. They will supervise MPhil/masters, summer and/or undergraduate students. They may be a co-applicant on research grant applications to recruit, train and co-supervise postdoctoral researchers, research assistants, technical staff and PhD students.

The post holder will be expected to create a strong track record of publishing high impact papers and disseminate the results of their work in any ways that seem appropriate and effective (e.g. via conferences and seminars). They will be responsible for compliance with all the relevant laws (Home Office, HTA, HFEA).

Candidates should hold a PhD and have a high-quality publication track record in academic journals or equivalent. We welcome applications from across a diverse range of research relevant to our Grand Challenges https://www.trophoblast.cam.ac.uk/about-us/objectives.

Contract details

Appointments will be made on a fixed-term, full-time, basis for a period of 3 years (Grade 7, £37,174- £45,413 for appointments in 2025). There is a possibility of up to 1-year extension. The contract further includes research consumables/equipment of £60,000 per annum & travel support up to £750 over the duration of the fellowship.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To apply to this post, candidates should first identify a research Sponsor from the list of Principal Investigators https://www.trophoblast.cam.ac.uk/people/principal-investigators within the Centre for Trophoblast Research, and discuss their research plans with them.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

In addition to this, please ensure that you upload the application documentations as follows:

• Curriculum Vitae (CV)

• Up to 3 letters of reference

• Letter of support from your chosen Loke CTR sponsor

• Loke CTR Next Generation Fellowship application form

The closing date for applications is 30th January 2026.

Please quote reference PM45775 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Department of Physiology, Development and Neuroscience (PDN) is seeking a Grants Assistant to support the Department's research groups. PDN is a large, welcoming, and inclusive Department with an exceptional international record in teaching and research, with a grant income in the order of £10 million annually.

Reporting to the Research Grants Administrator, the Grants Assistant will provide administrative support to those applying or considering applying for grants and Fellowships. They will also support those who have successfully secured research funding.

You will be educated to at least A Level standard or equivalent or possess a comparable level of practical experience. The successful candidate will be highly organised, computer literate, and have excellent attention to detail. Good communication and people skills are also prerequisites for the role, which involves interacting with a range of stakeholders in the Department, the wider University and externally. For more details, please see the Further Particulars.

The position is offered on a permanent, full-time basis, though we also welcome applications from individuals who wish to be considered for part-time working (minimum 30 hpw) or other flexible working arrangements.

Informal enquiries should be directed to Tracey Flack, pdnhr@pdn.cam.ac.uk.

Apply

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two professional referees should be provided; one of whom should be your current line manager. Please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

The closing date for applications is midnight on 28 April 2024. Interviews will take place shortly after the closing date.

Please quote reference PM45639 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Project Title: Sex-dependent role of dopamine D3 receptors in the individual vulnerability to develop compulsive drug seeking and taking behaviour: preclinical investigations using a novel highly selective antagonist

Supervisor: Professor David Belin

Department/Institute: Physiology, Development & Neuroscience (PDN)

Industrial Partner: Shionogi

Project details:

The opioid epidemic that has been claiming the lives of over half a million people in the US in the past decade is reaching the UK. There are still no effective treatments for addiction to opiate and other drugs such as cocaine and alcohol, thereby limiting our ability to help those who suffer from this debilitating psychiatric disorder, in part due to our lack of understanding of the cellular mechanisms mediating the transition from controlled to compulsive drug seeking and taking behaviour, the hallmark of substance use disorder. Among candidate mechanisms, those downstream of the dopamine D3 receptor, whose expression is profoundly exacerbated by exposure to addictive drugs, have long stood out. However, the role of this receptor in compulsive drug-seeking behaviour has never been determined due to the lack of appropriate procedures in non-human species. Capitalising on a novel animal model of compulsive heroin-seeking habits developed by the Belin lab, a new multi-million-pound partnership with Shionogi has recently been launched to test, among others, the therapeutic potential, and the associated neural signature, of a new highly selective dopamine D3 receptor on drug-seeking habits, compulsive drug seeking and escalation of drug self-administration in male and female rats. This programme of research at the interface of Behavioural neuroscience, neuropharmacology and molecular biology will provide a unique opportunity for a PhD student to acquire a deep knowledge of the psychological and neural basis of substance use disorders while also acquiring a wide range of experimental skills in a very supportive environment.

The industrial partner is one of the few Big Pharma laboratories left investing in fundamental research in neuroscience and pursuing the development of novel treatments for CNS disorders. It has long been interested in expanding their drug discovery strategy to drug addiction. Shionogi has become a primary industrial partner of the Cambridge landscape and is very active in its collaboration with the Cambridge Neuroscience Community. Over the past five years, Shionogi has supported a new line of research into the role of peripheral mu opiate receptors in the behavioural effects of opiates in the context of a BBSRC-ICase studentship with the Belin that has proven very successful, thereby being a testament to the commitment of Shionogi to support research in the field of substance use disorders.

Applicants will be expected to have extensive experience with chronic intravenous self-administration procedures in rats.

Further information on the Cambridge Bioscience DTP PhD programme can be found at this link: https://bbsrcdtp.lifesci.cam.ac.uk/bbsrc-dtp-programme/icase-studentships. Full details of the University's entrance requirements and scholarships are specified in the following link: https://www.postgraduate.study.cam.ac.uk/.

Funding

Full funding covering Maintenance at the UKRI stipend rate (£20,780 for the academic year 2025/26) and the University Composition Fee at the Home UK rate (2025-26 £10,356) is provided for the studentship, with effect from 1 October 2025.

This studentship is only available to students who qualify for UK home fees. Please check your eligibility: https://www.postgraduate.study.cam.ac.uk/finance/fees/what-my-fee-status.

Fixed-term: The funds for this post are available for 4 years.

Application Process

To apply please visit: https://www.postgraduate.study.cam.ac.uk/courses/directory/blpdpdpdn and click 'Apply Now' selecting the following course:

• PhD in Physiology, Development & Neuroscience (Full-time)
• Start Date: 1st October 2025
• Project Supervisor: Professor David Belin
• Project Title: Include title as listed above
• Research Proposal: Include project details as listed above

Applications should include:

• Two academic references
• Transcript
• CV/resume
• Evidence of competence in English (If required - you can check using our tool)
• Statement of Interest outlining your suitability, why you are interested in a PhD in this area, your background and research interests.
• School of Biological Sciences - Widening Participation Questionnaire (applicants are asked to complete an additional form to provide contextual information about their previous study. Find out more about our use of contextual information here: https://www.postgraduate.study.cam.ac.uk/applying/contextual-data.

For queries related to this PhD studentship, please contact Professor David Belin email bdb26@cam.ac.uk.

Closing date

Completed applications (with ALL supporting documentation and references) to be submitted via the portal by 23:59pm (midnight) UK time on the 22nd of April 2025 at the latest. Interviews will be scheduled for the 1st of May.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Would you like to join a friendly and busy department? The Department of Physiology, Development and Neuroscience (PDN) is looking for a cleaner to join our team providing an efficient and reliable service to our buildings located in central Cambridge.

Our small team of cleaners make essential contributions to our community. You will work as part of the team providing a high standard of cleaning in all areas. Duties will include washing of scientific glassware, cleaning research and teaching laboratories, lecture theatres, offices, corridors, stairways and toilets.

No formal qualifications are required as training will be provided, however NVQ Level 1 Cleaning and Support Services Skills would be advantageous. Experience of laboratory and/or office cleaning would be beneficial. Good communication skills are essential as is the ability to follow written and verbal instructions from supervisors. A willingness to be flexible in approach and reliability are essential.

The position is offered on a permanent, part-time basis, 32 hours per week. The hours of work are flexible, between 7am and 4pm

The University is an accredited Real Living Wage (RLW) employer, and will ensure that employees are paid at least the prevailing RLW rate.

For more information about this post, please contact Katie Conran, Facilities and Operations Manager kc662@cam.ac.uk.

Apply:

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two professional referees should be provided; please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

If you are unable to use the online system for your application, please contact Tracey Flack, pdnhr@pdn.cam.ac.uk.

The closing date for applications is midnight on 13 April 2025. Interviews will be held on 24 April 2025.

Please quote reference PM45497 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The Department of Physiology, Development & Neuroscience particularly welcomes applications from candidates from a BME background for this vacancy as they are currently under-represented in our department.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a trainee laboratory technician to support the research work in the Loke Centre for Trophoblast Research (Loke CTR), starting in late July 2025. This is an exciting opportunity for somebody passionate about getting started in scientific research to join a vibrant and friendly team of researchers in the heart of Cambridge and work in a state-of-the-art laboratory.

About the role

The role will support the research activities of the groups operating in the Loke CTR shared laboratory space based in the department of Physiology, Development and Neuroscience (PDN). There are 6 research groups based permanently in the shared lab space, led by Prof Kathy Niakan, Prof Bill Colledge, Prof Erica Watson, Dr Thorsten Boroviak, Dr Courtney Hanna, and Dr Claire Senner. The role will provide direct support for approximately researchers across these groups, including the Loke CTR Next Generation Fellows.

This is an exciting role with varied responsibilities. You will support our tissue culture facilities, a molecular biology lab, histology preparation room, and placental, endometrial and human embryo shared facility. You will provide laboratory housekeeping to ensure a well-functioning laboratory environment, including performing tissue culture and histology techniques, preparing stock solutions, monitoring and replenishing stocks, and contributing to the health and safety culture of the research groups. You will also provide support for the Biology of the Human Uterus in Pregnancy and Disease Tissue Bank, which is used by Loke CTR researchers across the University with an interest in pregnancy and early development.

The Loke Centre for Trophoblast Research (Loke CTR)

The Loke Centre for Trophoblast Research (Loke CTR) is a centre of excellence to promote scientific study of the placenta, early development and maternal-fetal interactions during pregnancy. The Loke CTR unites 28 group leaders across 10 departments and affiliated institutes and provides diverse opportunities for scientific interaction through events, training and shared state-of-the-art facilities to support world leading trophoblast-related research across Cambridge.

What you will need You should be educated to a minimum of A-level or NVQ level 3 in a biological or other related subject and/or relevant laboratory experience in molecular biology. You should have a good understanding of molecular biology and previous research experience would be an advantage.

Good communication skills and the ability to work effectively within a team are essential. You should have meticulous documentation and note-keeping skills and be able to manage your time and work effectively.

The position is flexible to suit individual needs. We will make an appointment for 1 year in the first instances and welcome applications from candidates interested in full-time work or part-time work for a minimum of 3 days per week. Due to the nature of the work, you will be required to work on site.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The closing date for applications is 21st April 2025.

To find out more about the Loke CTR please visit our website at: https://www.trophoblast.cam.ac.uk/

For an informal conversation about the role, please contact Erin Slatery, Loke CTR Executive Manager (execmgr.lokectr@pdn.cam.ac.uk). If you have any queries about the recruitment process, please contact Tracey Flack, Chief HR Administrator (pdnhr@pdn.cam.ac.uk).

Please quote reference PM45421 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

An exciting opportunity has arisen for a versatile custodian to join our friendly team in the Department of Physiology, Development and Neuroscience, providing an efficient, safe, reliable and welcoming service in our buildings located in central Cambridge.

The role holder will provide day to day support in the Department, supporting Reception, dealing with visitors and contractors, assisting with events, portering and supporting the facilities team with minor maintenance across our two buildings which consist of laboratories, classrooms, offices and lecture theatres.

The successful candidate will have good organisational and time management skills, as well as basic DIY and IT skills. You will have a flexible working approach and have good interpersonal, team-working and customer service skills. You will be willing to learn and whilst experience in a caretaking or similar role would be advantageous, it is not essential as training will be given.

For more information about this post, please contact Katie Conran, Facilities and Operations Manager kc662@cam.ac.uk.

This post is offered on a full-time basis, working 36.5 hours per week, Monday-Friday.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Apply:

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain the reasons for your application and how your knowledge, skills and experience match the requirements of the role. The full contact details for two professional referees should be provided, one of who should be your most recent line manager. Please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.

The closing date for applications is 23 March 2025. Interviews will be held on Tuesday 1 April.

If you are unable to use the online system for your application, please contact Tracey Flack, pdnhr@pdn.cam.ac.uk.

Please quote reference PM45242 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.