Olivier Giger

Group Leader, Department of Pathology

Olivier Giger is interested in molecular mechanism in tumours and the tumour microenvironment in gastrointestinal tumours. Learn more.

Research Areas

Gastrointestinal stromal tumours

Molecular pathology

Gastrointestinal pathology

Tumour-stroma interaction

Exosomes

Techniques

Next-generation sequencing

Histopathology

Integrated omics profiling

Research Theme

Publications

Journal articles

2021

Wong, NACS., Giger, OT., Ten Hoopen, R., Casey, RT., Russell, K. and Faulkner, C., 2021. Next-generation sequencing demonstrates the rarity of short kinase variants specific to quadruple wild-type gastrointestinal stromal tumours. J Clin Pathol, v. 74
Doi: http://doi.org/10.1136/jclinpath-2020-206613

Whitworth, J., Casey, RT., Smith, PS., Giger, O., Martin, JE., Clark, G., Cook, J., Fernando, MS., Taniere, P., NIHR BioResource, and Maher, ER., 2021. Familial wild-type gastrointestinal stromal tumour in association with germline truncating variants in both SDHA and PALB2. Eur J Hum Genet, v. 29
Doi: http://doi.org/10.1038/s41431-021-00862-5

Aloj, L., Giger, O., Mendichovszky, IA., Challis, BG., Ronel, M., Harper, I., Cheow, H., Hoopen, RT., Pitfield, D., Gallagher, FA., Attili, B., McLean, M., Jones, RL., Dileo, P., Bulusu, VR., Maher, ER. and Casey, RT., 2021. The role of [68 Ga]Ga-DOTATATE PET/CT in wild-type KIT/PDGFRA gastrointestinal stromal tumours (GIST). EJNMMI Res, v. 11
Doi: http://doi.org/10.1186/s13550-021-00747-0

Cheah, SK., Bisambar, CR., Pitfield, D., Giger, O., Hoopen, RT., Martin, J-E., Clark, GR., Park, S-M., Parkinson, C., Challis, BG. and Casey, RT., 2021. Breast cancer in multiple endocrine neoplasia type 1 (MEN1). Endocrinol Diabetes Metab Case Rep, v. 2021
Doi: 10.1530/EDM-20-0196

2020

Staniforth, JUL., Chan, JYH. and Giger, OT., 2020. Molecular deconstruction of a biphasic malignant skin tumour Diagnostic Histopathology, v. 26
Doi: http://doi.org/10.1016/j.mpdhp.2020.06.006

2018

Casey, RT., McLean, MA., Madhu, B., Challis, BG., ten Hoopen, R., Roberts, T., Clark, GR., Pitfield, D., Simpson, HL., Bulusu, VR., Allinson, K., Happerfield, L., Park, S-M., Marker, A., Giger, O., Maher, ER. and Gallagher, FA., 2018. Translating In Vivo Metabolomic Analysis of Succinate Dehydrogenase–Deficient Tumors Into Clinical Utility JCO Precision Oncology,
Doi: http://doi.org/10.1200/PO.17.00191

Casey, R., McLean, M., Basetti, M., Challis, B., ten Hoopen, R., Roberts, T., Clark, G., Bulusu, V., Allinson, K., Happerfield, L., Park, S-M., Pitfield, D., Simpson, H., Marker, A., Giger, O., Gallagher, F. and Maher, E., 2018. Translating In Vivo Metabolomic Analysis of Succinate Dehydrogenase–Deficient Tumors Into Clinical Utility Journal of Clinical Oncology Precision Oncology,
Doi: http://doi.org/10.1200/PO.17.00191

Fewings, E., Larionov, A., Redman, J., Goldgraben, MA., Scarth, J., Richardson, S., Brewer, C., Davidson, R., Ellis, I., Evans, DG., Halliday, D., Izatt, L., Marks, P., McConnell, V., Verbist, L., Mayes, R., Clark, GR., Hadfield, J., Chin, S-F., Teixeira, MR., Giger, OT., Hardwick, R., di Pietro, M., O'Donovan, M., Pharoah, P., Caldas, C., Fitzgerald, RC. and Tischkowitz, M., 2018. Germline pathogenic variants in PALB2 and other cancer-predisposing genes in families with hereditary diffuse gastric cancer without CDH1 mutation: a whole-exome sequencing study. Lancet Gastroenterol Hepatol, v. 3
Doi: http://doi.org/10.1016/S2468-1253(18)30079-7

2017

Casey, RT., Warren, AY., Martin, JE., Challis, BG., Rattenberry, E., Whitworth, J., Andrews, KA., Roberts, T., Clark, GR., West, H., Smith, PS., Docquier, FM., Rodger, F., Murray, V., Simpson, HL., Wallis, Y., Giger, O., Tran, M., Tomkins, S., Stewart, GD., Park, S-M., Woodward, ER. and Maher, ER., 2017. Clinical and Molecular Features of Renal and Pheochromocytoma/Paraganglioma Tumor Association Syndrome (RAPTAS): Case Series and Literature Review The Journal of Clinical Endocrinology & Metabolism, v. 102
Doi: http://doi.org/10.1210/jc.2017-00562

Giger, OT., Glucagon-like petide-2 acts on colon cancer myofibroblasts to stimulate proliferation, migration and invasion of both myofibroblasts and cancer cells via the IGF pathway Peptides,

Casey, RT., Giger, O., Seetho, I., Marker, A., Pitfield, D., Boyle, L., Gurnell, M., Shaw, A., Tischowitz, M., Chatterjee, V., Janowitz, T., Mells, G., Corrie, P. and Challis, B., Rapid disease progression in a patient with mismatch repair-deficient and cortisol secreting adrenocortical carcinoma treated with pembrolizumab Seminars in Oncology,
Doi: 10.1053/j.seminoncol.2018.06.001

Paterson, AL., El-Daly, H., Raso-Barnett, L., Du, M-Q., Giger, O., Soilleux, E., Roberts, T., Huang, Y., Bibawi, H., Matharu, B., Bench, A., Scott, MA. and Liu, H., Contribution of immunoglobulin lambda light chain gene rearrangement analysis in the diagnosis of B-cell neoplasms. British Journal of Haematology,
Doi: http://doi.org/10.1111/bjh.15762

Najgebauer, H., Liloglou, T., Jithesh, PV., Giger, OT., Varro, A. and Sanderson, CM., Integrated Omics Profiling Reveals Novel Patterns of Epigenetic Programming in Cancer-Associated Myofibroblasts Carcinogenesis,
Doi: http://doi.org/10.1093/carcin/bgz001

Casey, R., SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice Scientific Reports,

Casey, R., McLean, M., Bassetti, M., Challis, B., Simpson, H., Gurnell, M., Bulusu, R., Marker, A., Giger, O., Allinson, K., Chatterjee, K., Maher, E. and Gallagher, F., The role of in vivo metabolomics using H-MRS in SDH deficient disease Endocrine Abstracts,
Doi: 10.1530/endoabs.49.gp27

Turner, S., Forde, S., Matthews, J., Jahangiri, L., Lee, L., Prokoph, N., Malcolm, T., Giger, O., Kenner, L. and Burke, A., Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy British Journal of Haematology,

Conference proceedings

2019

Giger, OT., Casey, RT., ten Hopen, R., Bulusu, VR. and Maher, ER., 2019. SDHC Epimutant GIST: Experience from the UK National Paediatric and Adolescent Wild Type and Syndromic (PAWS)-GIST Clinic JOURNAL OF PATHOLOGY, v. 248

2018

Casey, RT., Ten Hoopen, R., Maher, ER., Bulusu, VR. and Giger, OT., 2018. SDH-C Epimutated Gastrointestinal Stromal Tumours: Clinical and Pathological Features and SDH-C Promoter Methylation Analysis JOURNAL OF PATHOLOGY, v. 245

Casey, RT., ten Hoopen, R., Ochoa, E., Challis, BG., Whitworth, J., Smith, PS., Martin, JE., Clark, GR., Rodgers, F., Maranian, M., Allinson, K., Basetti, M., Roberts, T., De Campos, L., Park, S., Marker, A., Watts, C., Bulusu, VR., Giger, OT. and Maher, ER., 2018. Validation of a diagnostic test for SDHC epigenetic silencing and identification of the indications for testing in clinical practice IRISH JOURNAL OF MEDICAL SCIENCE, v. 187

Bulusu, VR., Casey, R., Giger, O., Maher, E., Hardwick, R., Carroll, N., Leahy, MG., Jones, RL., Benson, C., Dileo, P. and Judson, IR., 2018. Paediatric, adolescent, wild type, syndromic gastrointestinal stromal tumours (PAWS-GIST): Report from United Kingdom PAWS-GIST clinic. JOURNAL OF CLINICAL ONCOLOGY, v. 36
Doi: 10.1200/JCO.2018.36.15_suppl.e23519

Olivier Giger

Group Leader, Department of Pathology

Research Areas

Techniques

Research Theme

Publications

2021

2020

2018

2017

2019

2018

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