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School of the Biological Sciences

 

 

1866 Professor of Zoology (Emeritus), Department of Zoology 

Michael Akam is interested in the evolution of developmental mechanisms, and how changes in development lead to changes in the form and function of organisms. Learn more. 

 

Research Areas


Evolution of developmental mechanisms
Form and function
Hox regulatory genes
 
 
 

Techniques


Comparative genomics 
Molecular embryology
4D live imaging
RNA interference
 
 
   

 

Research Theme


   Reproduction, Development and Lifelong Health

 

Publications

Journal articles

2017

  • Qu, Z., Bendena, WG., Nong, W., Siggens, KW., Noriega, FG., Kai, Z-P., Zang, Y-Y., Koon, AC., Chan, HYE., Chan, TF., Chu, KH., Lam, HM., Akam, M., Tobe, SS. and Lam Hui, JH., 2017. MicroRNAs regulate the sesquiterpenoid hormonal pathway in Drosophila and other arthropods. Proc Biol Sci, v. 284
    Doi: http://doi.org/10.1098/rspb.2017.1827
  • 2016

  • Green, JE., Dalíková, M., Sahara, K., Marec, F. and Akam, M., 2016. XX/XY System of Sex Determination in the Geophilomorph Centipede Strigamia maritima. PLoS One, v. 11
    Doi: 10.1371/journal.pone.0150292
  • Clark, E. and Akam, M., 2016. Odd-paired controls frequency doubling in Drosophila segmentation by altering the pair-rule gene regulatory network eLife, v. 5
    Doi: http://doi.org/10.7554/eLife.18215
  • 2015

  • Akam, M., 2015. Foreseeing fates: a commentary on Manton (1928) 'On the embryology of a mysid crustacean, Hemimysis lamornae'. Philos Trans R Soc Lond B Biol Sci, v. 370
    Doi: http://doi.org/10.1098/rstb.2014.0381
  • 2014

  • Konopova, B. and Akam, M., 2014. The Hox genes Ultrabithorax and abdominal-A specify three different types of abdominal appendage in the springtail Orchesella cincta (Collembola). Evodevo, v. 5
    Doi: http://doi.org/10.1186/2041-9139-5-2
  • Janssens, H., Siggens, K., Cicin-Sain, D., Jiménez-Guri, E., Musy, M., Akam, M. and Jaeger, J., 2014. A quantitative atlas of Even-skipped and Hunchback expression in Clogmia albipunctata (Diptera: Psychodidae) blastoderm embryos. Evodevo, v. 5
    Doi: http://doi.org/10.1186/2041-9139-5-1
  • Green, JE. and Akam, M., 2014. Germ cells of the centipede Strigamia maritima are specified early in embryonic development. Dev Biol, v. 392
    Doi: 10.1016/j.ydbio.2014.06.003
  • Hunnekuhl, VS. and Akam, M., 2014. An anterior medial cell population with an apical-organ-like transcriptional profile that pioneers the central nervous system in the centipede Strigamia maritima. Dev Biol, v. 396
    Doi: 10.1016/j.ydbio.2014.09.020
  • Chipman, AD., Ferrier, DEK., Brena, C., Qu, J., Hughes, DST., Schröder, R., Torres-Oliva, M., Znassi, N., Jiang, H., Almeida, FC., Alonso, CR., Apostolou, Z., Aqrawi, P., Arthur, W., Barna, JCJ., Blankenburg, KP., Brites, D., Capella-Gutiérrez, S., Coyle, M., Dearden, PK., Du Pasquier, L., Duncan, EJ., Ebert, D., Eibner, C., Erikson, G., Evans, PD., Extavour, CG., Francisco, L., Gabaldón, T., Gillis, WJ., Goodwin-Horn, EA., Green, JE., Griffiths-Jones, S., Grimmelikhuijzen, CJP., Gubbala, S., Guigó, R., Han, Y., Hauser, F., Havlak, P., Hayden, L., Helbing, S., Holder, M., Hui, JHL., Hunn, JP., Hunnekuhl, VS., Jackson, L., Javaid, M., Jhangiani, SN., Jiggins, FM., Jones, TE., Kaiser, TS., Kalra, D., Kenny, NJ., Korchina, V., Kovar, CL., Kraus, FB., Lapraz, F., Lee, SL., Lv, J., Mandapat, C., Manning, G., Mariotti, M., Mata, R., Mathew, T., Neumann, T., Newsham, I., Ngo, DN., Ninova, M., Okwuonu, G., Ongeri, F., Palmer, WJ., Patil, S., Patraquim, P., Pham, C., Pu, L-L., Putman, NH., Rabouille, C., Ramos, OM., Rhodes, AC., Robertson, HE., Robertson, HM., Ronshaugen, M., Rozas, J., Saada, N., Sánchez-Gracia, A., Scherer, SE., Schurko, AM., Siggens, KW., Simmons, D., Stief, A., Stolle, E., Telford, MJ., Tessmar-Raible, K., Thornton, R., van der Zee, M., von Haeseler, A., Williams, JM., Willis, JH., Wu, Y., Zou, X., Lawson, D., Muzny, DM., Worley, KC., Gibbs, RA., Akam, M. and Richards, S., 2014. The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima. PLoS Biol, v. 12
    Doi: 10.1371/journal.pbio.1002005
  • 2013

  • Marron, AO., Akam, M. and Walker, G., 2013. A duplex PCR-based assay for measuring the amount of bacterial contamination in a nucleic acid extract from a culture of free-living protists. PLoS One, v. 8
    Doi: http://doi.org/10.1371/journal.pone.0061732
  • Benton, MA., Akam, M. and Pavlopoulos, A., 2013. Cell and tissue dynamics during Tribolium embryogenesis revealed by versatile fluorescence labeling approaches Development (Cambridge), v. 140
    Doi: http://doi.org/10.1242/dev.096271
  • Brena, C., Green, J. and Akam, M., 2013. Early embryonic determination of the sexual dimorphism in segment number in geophilomorph centipedes. Evodevo, v. 4
    Doi: http://doi.org/10.1186/2041-9139-4-22
  • Green, J. and Akam, M., 2013. Evolution of the pair rule gene network: Insights from a centipede. Dev Biol, v. 382
    Doi: http://doi.org/10.1016/j.ydbio.2013.06.017
  • Marron, AO., Alston, MJ., Heavens, D., Akam, M., Caccamo, M., Holland, PWH. and Walker, G., 2013. A family of diatom-like silicon transporters in the siliceous loricate choanoflagellates. Proceedings. Biological sciences / The Royal Society, v. 280
    Doi: http://doi.org/10.1098/rspb.2012.2543
  • Brena, C. and Akam, M., 2013. An analysis of segmentation dynamics throughout embryogenesis in the centipede Strigamia maritima. BMC Biol, v. 11
    Doi: http://doi.org/10.1186/1741-7007-11-112
  • Janssens, H., Crombach, A., Richard Wotton, K., Cicin-Sain, D., Surkova, S., Lu Lim, C., Samsonova, M., Akam, M. and Jaeger, J., 2013. Lack of tailless leads to an increase in expression variability in Drosophila embryos Developmental Biology, v. 377
    Doi: http://doi.org/10.1016/j.ydbio.2013.01.010
  • 2012

  • Brena, C. and Akam, M., 2012. The embryonic development of the centipede Strigamia maritima Developmental Biology, v. 363
    Doi: http://doi.org/10.1016/j.ydbio.2011.11.006
  • Marron, AO., Akam, M. and Walker, G., 2012. Nitrile hydratase genes are present in multiple eukaryotic supergroups. PLoS One, v. 7
    Doi: http://doi.org/10.1371/journal.pone.0032867
  • 2011

  • de Navas, LF., Reed, H., Akam, M., Barrio, R., Alonso, CR. and Sanchez-Herrero, E., 2011. Integration of RNA processing and expression level control modulates the function of the Drosophila Hox gene Ultrabithorax during adult development DEVELOPMENT, v. 138
    Doi: http://doi.org/10.1242/dev.051409
  • Pavlopoulos, A. and Akam, M., 2011. Hox gene Ultrabithorax regulates distinct sets of target genes at successive stages of Drosophila haltere morphogenesis. Proc Natl Acad Sci U S A, v. 108
    Doi: http://doi.org/10.1073/pnas.1015077108
  • Kainz, F., Ewen-Campen, B., Akam, M. and Extavour, CG., 2011. Notch/Delta signalling is not required for segment generation in the basally branching insect Gryllus bimaculatus. Development, v. 138
    Doi: http://doi.org/10.1242/dev.073395
  • 2010

  • García-Solache, M., Jaeger, J. and Akam, M., 2010. A systematic analysis of the gap gene system in the moth midge Clogmia albipunctata. Dev Biol, v. 344
    Doi: http://doi.org/10.1016/j.ydbio.2010.04.019
  • Eriksson, BJ., Tait, NN., Budd, GE., Janssen, R. and Akam, M., 2010. Head patterning and Hox gene expression in an onychophoran and its implications for the arthropod head problem. Dev Genes Evol, v. 220
    Doi: http://doi.org/10.1007/s00427-010-0329-1
  • Vedel, V., Apostolou, Z., Arthur, W., Akam, M. and Brena, C., 2010. An early temperature-sensitive period for the plasticity of segment number in the centipede Strigamia maritima EVOL DEV, v. 12
    Doi: http://doi.org/10.1111/j.1525-142X.2010.00421.x
  • Janssen, R., Eriksson, BJ., Budd, GE., Akam, M. and Prpic, NM., 2010. Gene expression patterns in an onychophoran reveal that regionalization predates limb segmentation in pan-arthropods EVOL DEV, v. 12
    Doi: http://doi.org/10.1111/j.1525-142X.2010.00423.x
  • Reed, HC., Hoare, T., Thomsen, S., Weaver, TA., White, RAH., Akam, M. and Alonso, CR., 2010. Alternative splicing modulates Ubx protein function in Drosophila melanogaster. Genetics, v. 184
    Doi: 10.1534/genetics.109.112086
  • Steinmetz, PR., Urbach, R., Posnien, N., Eriksson, J., Kostyuchenko, RP., Brena, C., Guy, K., Akam, M., Bucher, G. and Arendt, D., 2010. Six3 demarcates the anterior-most developing brain region in bilaterian animals. Evodevo, v. 1
    Doi: http://doi.org/10.1186/2041-9139-1-14
  • 2009

  • Eriksson, BJ., Tait, NN., Budd, GE. and Akam, M., 2009. The involvement of engrailed and wingless during segmentation in the onychophoran Euperipatoides kanangrensis (Peripatopsidae: Onychophora) (Reid 1996). Dev Genes Evol, v. 219
    Doi: http://doi.org/10.1007/s00427-009-0287-7
  • Pavlopoulos, A., Kontarakis, Z., Liubicich, DM., Serano, JM., Akam, M., Patel, NH. and Averof, M., 2009. Probing the evolution of appendage specialization by Hox gene misexpression in an emerging model crustacean. Proc Natl Acad Sci U S A, v. 106
    Doi: http://doi.org/10.1073/pnas.0902804106
  • Ashyraliyev, M., Siggens, K., Janssens, H., Blom, J., Akam, M. and Jaeger, J., 2009. Gene Circuit Analysis of the Terminal Gap Gene huckebein PLOS COMPUT BIOL, v. 5
    Doi: http://doi.org/10.1371/journal.pcbi.1000548
  • 2008

  • Vedel, V., Chipman, AD., Akam, M. and Arthur, W., 2008. Temperature-dependent plasticity of segment number in an arthropod species: the centipede Strigamia maritima EVOL DEV, v. 10
  • Chipman, AD. and Akam, M., 2008. The segmentation cascade in the centipede Strigamia maritima: involvement of the Notch pathway and pair-rule gene homologues. Dev Biol, v. 319
    Doi: http://doi.org/10.1016/j.ydbio.2008.02.038
  • 2007

  • Peel, AD. and Akam, M., 2007. The dynamics of yolk deposition in the desert locust Schistocerca gregaria Journal of Insect Physiology, v. 53
    Doi: http://doi.org/10.1016/j.jinsphys.2007.01.005
  • Bender, W., Akam, M., Karch, F., Beachy, PA., Peifer, M., Spierer, P., Lewis, EB. and Hogness, DS., 2007. Molecular genetics of the bithorax complex in Drosophila melanogaster
    Doi: http://doi.org/10.1007/978-1-4020-6345-9_14
  • Kulakova, M., Bakalenko, N., Novikova, E., Cook, CE., Eliseeva, E., Steinmetz, PRH., Kostyuchenko, RP., Dondua, A., Arendt, D., Akam, M. and Andreeva, T., 2007. Hox gene expression in larval development of the polychaetes Nereis virens and Platynereis dumerilii (Annelida, Lophotrochozoa) Development Genes and Evolution, v. 217
    Doi: http://doi.org/10.1007/s00427-006-0119-y
  • Panfilio, KA. and Akam, M., 2007. A comparison of Hox3 and Zen protein coding sequences in taxa that span the Hox3/zen divergence DEV GENES EVOL, v. 217
    Doi: http://doi.org/10.1007/s00427-007-0133-8
  • Pavlopoulos, A. and Akam, M., 2007. Hox go omics: insights from Drosophila into Hox gene targets GENOME BIOL, v. 8
    Doi: http://doi.org/10.1186/gb-2007-8-3-208
  • 2006

  • Brena, C., Chipman, AD., Minelli, A. and Akam, M., 2006. Expression of trunk Hox genes in the centipede Strigamia maritima: sense and anti-sense transcripts Evolution & Development, v. 8
  • Panfilio, KA. and Akam, M., 2006. The derived Hox gene zen is required for function, but not specification, of the extraembryonic serosal membrane in Oncopeltus fasciatus DEVELOPMENTAL BIOLOGY, v. 295
    Doi: http://doi.org/10.1016/j.ydbio.2006.04.060
  • Peel, AD., Telford, MJ. and Akam, M., 2006. The evolution of hexapod engrailed-family genes: evidence for conservation and concerted evolution P ROY SOC B-BIOL SCI, v. 273
    Doi: http://doi.org/10.1098/rspb.2006.3497
  • Peel, AD., Telford, MJ. and Akam, M., 2006. The evolution of hexapod engrailed-family genes: Evidence for conservation and concerted evolution Proceedings of the Royal Society B: Biological Sciences, v. 273
    Doi: http://doi.org/10.1098/rspb.2006.3497
  • Panfilio, KA., Liu, PZ., Akam, M. and Kaufman, TC., 2006. Oncopeltus fasciatus zen is essential for serosal tissue function in katatrepsis DEV BIOL, v. 292
    Doi: http://doi.org/10.1016/j.ydbio.2005.12.028
  • 2005

  • Eriksson, BJ., Tait, NN. and Akam, M., 2005. Early development in the velvet worm Euperipatoides kanangrensis (Onychophora : Peripatopsidae) Integrative and Comparative Biology, v. 45
  • Akam, M., Chipman, A. and Peel, A., 2005. The diversity of segmentation mechanisms in arthropods MECH DEVELOP, v. 122
  • Cook, CE., Yue, QY. and Akam, M., 2005. Mitochondrial genomes suggest that hexapods and crustaceans are mutually paraphyletic P ROY SOC B-BIOL SCI, v. 272
    Doi: http://doi.org/10.1098/rspb.2004.3042
  • Negre, B., Casillas, S., Suzanne, M., Sanchez-Herrero, E., Akam, M., Nefedov, M., Barbadilla, A., de Jong, P. and Ruiz, A., 2005. Conservation of regulatory sequences and gene expression patterns in the disintegrating Drosophila Hox gene complex GENOME RESEARCH, v. 15
    Doi: http://doi.org/10.1101/Gr.3468605
  • Peel, AD., Chipman, AD. and Akam, M., 2005. Arthropod segmentation: Beyond the Drosophila paradigm NAT REV GENET, v. 6
    Doi: http://doi.org/10.1038/nrg1724
  • 2004

  • Chipman, AD., Arthur, W. and Akam, M., 2004. A double segment periodicity underlies segment generation in centipede development CURRENT BIOLOGY, v. 14
  • Chipman, AD., Arthur, W. and Akam, M., 2004. Early development and segment formation in the centipede, Strigamia maritima (Geophilomorpha) EVOL DEV, v. 6
  • Peel, AD. and Akam, ME., 2004. The evolution of insect engrailed genes, and its implications for our understanding of gene family evolution Integrative and Comparative Biology, v. 44
  • Cook, CE., Jimenez, E., Akam, M. and Salo, E., 2004. The Hox gene complement of acoel flatworms, a basal bilaterian clade EVOL DEV, v. 6
  • 2003

  • Roch, F., Alonso, CR. and Akam, M., 2003. Drosophila miniature and dusky encode ZP proteins required for cytoskeletal reorganisation during wing morphogenesis Journal of Cell Science, v. 116
    Doi: http://doi.org/10.1242/Jcs.00298
  • Peel, A. and Akam, M., 2003. Evolution of segmentation: Rolling back the clock CURRENT BIOLOGY, v. 13
    Doi: http://doi.org/10.1016/S0960-9822(03)00647-X
  • Alonso, CR. and Akam, M., 2003. A Hox gene mutation that triggers nonsense-mediated RNA decay and affects alternative splicing during Drosophila development NUCLEIC ACIDS RES, v. 31
    Doi: http://doi.org/10.1093/nar/gkg482
  • Extavour, CG. and Akam, M., 2003. Mechanisms of germ cell specification across the metazoans: epigenesis and preformation DEVELOPMENT, v. 130
    Doi: http://doi.org/10.1242/dev.00804
  • 2002

  • Mirth, C. and Akam, M., 2002. Joint development in the Drosophila leg: Cell movements and cell populations DEV BIOL, v. 246
    Doi: http://doi.org/10.1006/dbio.2002.0593
  • Rozowski, M. and Akam, M., 2002. Hox gene control of segment-specific bristle patterns in Drosophila GENES & DEVELOPMENT, v. 16
    Doi: http://doi.org/10.1101/Gad.219302
  • Chang, CC., Dearden, P. and Akam, M., 2002. Germ line development in the grasshopper Schistocerca gregaria: vasa as a marker DEVELOPMENTAL BIOLOGY, v. 252
    Doi: http://doi.org/10.1006/dbio.2002.0840
  • 2001

  • Dearden, PK. and Akam, M., 2001. Early embryo patterning in the grasshopper, Schistocerca gregaria: wingless, decapentaplegic and caudal expression DEVELOPMENT, v. 128
  • Alonso, CR., Maxton-Kuechenmeister, J. and Akam, M., 2001. Evolution of Ftz protein function in insects CURRENT BIOLOGY, v. 11
  • Cook, CE., Smith, ML., Telford, MJ., Bastianello, A. and Akam, M., 2001. Hox genes and the phylogeny of the arthropods CURRENT BIOLOGY, v. 11
  • 2000

  • Roch, F. and Akam, M., 2000. Ultrabithorax and the control of cell morphology in Drosophila halteres. Development, v. 127
    Doi: 10.1242/dev.127.1.97
  • Dearden, P., Grbic, M., Falciani, F. and Akam, M., 2000. Maternal expression and early zygotic regulation of the Hox3/zen gene in the grasshopper Schistocerca gregaria. Evol Dev, v. 2
    Doi: 10.1046/j.1525-142x.2000.00065.x
  • Dearden, P. and Akam, M., 2000. Segmentation in silico NATURE, v. 406
  • Akam, M., 2000. Arthropods: developmental diversity within a (super) phylum. Proc Natl Acad Sci U S A, v. 97
    Doi: http://doi.org/10.1073/pnas.97.9.4438
  • Dearden, P. and Akam, M., 2000. A role for Fringe in segment morphogenesis but not segment formation in the grasshopper, Schistocerca gregaria. Dev Genes Evol, v. 210
    Doi: http://doi.org/10.1007/s004270000072
  • 1999

  • de Rosa, R., Grenier, JK., Andreeva, T., Cook, CE., Adoutte, A., Akam, M., Carroll, SB. and Balavoine, G., 1999. Hox genes in brachiopods and priapulids and protostome evolution NATURE, v. 399
  • Dearden, P. and Akam, M., 1999. Developmental evolution: Axial patterning in insects. Curr Biol, v. 9
    Doi: http://doi.org/10.1016/s0960-9822(99)80381-9
  • 1998

  • Akam, M., 1998. The Yin and Yang of Evo/Devo. Cell, v. 92
    Doi: http://doi.org/10.1016/s0092-8674(00)80909-5
  • Akam, M., 1998. Hox genes: from master genes to micromanagers. Curr Biol, v. 8
    Doi: http://doi.org/10.1016/s0960-9822(98)70433-6
  • Doolittle, WF. and Akam, M., 1998. Genomes and evolution CURR OPIN GENET DEV, v. 8
  • Akam, M., 1998. Hox genes, homeosis and the evolution of segment identity: no need for hopeless monsters. Int J Dev Biol, v. 42
  • 1997

  • Abouheif, E., Akam, M., Dickinson, WJ., Holland, PWH., Meyer, A., Patel, NH., Raff, RA., Roth, VL. and Wray, GA., 1997. Homology and developmental genes TRENDS GENET, v. 13
  • DuninBorkowski, O., Ho, K., Loose, M. and Akam, M., 1997. Early cellularization in grasshopper embryos DEV BIOL, v. 186
  • Ho, K., Dunin-Borkowski, OM. and Akam, M., 1997. Cellularization in locust embryos occurs before blastoderm formation. Development, v. 124
    Doi: 10.1242/dev.124.14.2761
  • 1996

  • Ferrier, DE. and Akam, M., 1996. Organization of the Hox gene cluster in the grasshopper, Schistocerca gregaria. Proc Natl Acad Sci U S A, v. 93
    Doi: http://doi.org/10.1073/pnas.93.23.13024
  • Falciani, F., Hausdorf, B., Schröder, R., Akam, M., Tautz, D., Denell, R. and Brown, S., 1996. Class 3 Hox genes in insects and the origin of zen. Proc Natl Acad Sci U S A, v. 93
    Doi: http://doi.org/10.1073/pnas.93.16.8479
  • 1995

  • Akam, M., 1995. Hox genes and the evolution of diverse body plans. Philos Trans R Soc Lond B Biol Sci, v. 349
    Doi: http://doi.org/10.1098/rstb.1995.0119
  • AVEROF, M. and AKAM, M., 1995. INSECT CRUSTACEAN RELATIONSHIPS - INSIGHTS FROM COMPARATIVE DEVELOPMENTAL AND MOLECULAR STUDIES PHILOS T ROY SOC B, v. 347
  • Greig, S. and Akam, M., 1995. The role of homeotic genes in the specification of the Drosophila gonad. Curr Biol, v. 5
    Doi: http://doi.org/10.1016/s0960-9822(95)00210-7
  • Castelli-Gair, J. and Akam, M., 1995. How the Hox gene Ultrabithorax specifies two different segments: the significance of spatial and temporal regulation within metameres. Development, v. 121
    Doi: 10.1242/dev.121.9.2973
  • Averof, M. and Akam, M., 1995. Hox genes and the diversification of insect and crustacean body plans. Nature, v. 376
    Doi: http://doi.org/10.1038/376420a0
  • 1994

  • Dawes, R., Dawson, I., Falciani, F., Tear, G. and Akam, M., 1994. Dax, a locust Hox gene related to fushi-tarazu but showing no pair-rule expression. Development, v. 120
    Doi: 10.1242/dev.120.6.1561
  • Kelsh, R., Weinzierl, RO., White, RA. and Akam, M., 1994. Homeotic gene expression in the locust Schistocerca: an antibody that detects conserved epitopes in Ultrabithorax and abdominal-A proteins. Dev Genet, v. 15
    Doi: 10.1002/dvg.1020150104
  • AVEROF, M. and AKAM, M., 1994. HOM/HOX GENES OF ARTEMIA - IMPLICATIONS FOR THE ORIGIN AND EVOLUTION OF INSECT AND CRUSTACEAN BODY PLANS DEV BIOL, v. 163
  • Castelli-Gair, J., Greig, S., Micklem, G. and Akam, M., 1994. Dissecting the temporal requirements for homeotic gene function. Development, v. 120
    Doi: 10.1242/dev.120.7.1983
  • AKAM, M., 1994. INSECT DEVELOPMENT - IS PAIRING THE RULE NATURE, v. 367
  • FERRIER, DEK. and AKAM, ME., 1994. THE HOM/HOX CLUSTER OF THE LOCUST DEV BIOL, v. 163
  • Akam, M., Averof, M., Castelli-Gair, J., Dawes, R., Falciani, F. and Ferrier, D., 1994. The evolving role of Hox genes in arthropods. Dev Suppl,
  • AKAM, M., HOLLAND, P. and WRAY, G., 1994. THE EVOLUTION OF DEVELOPMENTAL MECHANISM - PREFACE DEVELOPMENT,
  • Akam, M., 1994. Is pairing the rule? Nature, v. 367
    Doi: http://doi.org/10.1038/367410a0
  • 1993

  • DAWSON, IA., ROTH, S., AKAM, M. and ARTAVANISTSAKONAS, S., 1993. MUTATIONS OF THE FIZZY LOCUS CAUSE METAPHASE ARREST IN DROSOPHILA-MELANOGASTER EMBRYOS DEVELOPMENT, v. 117
  • Greig, S. and Akam, M., 1993. Homeotic genes autonomously specify one aspect of pattern in the Drosophila mesoderm. Nature, v. 362
    Doi: http://doi.org/10.1038/362630a0
  • Kelsh, R., Dawson, I. and Akam, M., 1993. An analysis of abdominal-B expression in the locust Schistocerca gregaria. Development, v. 117
    Doi: 10.1242/dev.117.1.293
  • DICKINSON, WJ., YANG, YF., SCHUSKE, K. and AKAM, M., 1993. CONSERVATION OF MOLECULAR PREPATTERNS DURING THE EVOLUTION OF CUTICLE MORPHOLOGY IN DROSOPHILA LARVAE EVOLUTION, v. 47
  • Dickinson, WJ., Yang, Y., Schuske, K. and Akam, M., 1993. CONSERVATION OF MOLECULAR PREPATTERNS DURING THE EVOLUTION OF CUTICLE MORPHOLOGY IN DROSOPHILA LARVAE. Evolution, v. 47
    Doi: http://doi.org/10.1111/j.1558-5646.1993.tb02162.x
  • AKAM, ME., 1993. EVOLUTIONARY DEVELOPMENTAL BIOLOGY - HALL,BK NATURE, v. 362
  • Averof, M. and Akam, M., 1993. HOM/Hox genes of Artemia: implications for the origin of insect and crustacean body plans. Curr Biol, v. 3
    Doi: http://doi.org/10.1016/0960-9822(93)90158-k
  • 1992

  • Akam, M. and Dawes, R., 1992. More than one way to slice an egg. Curr Biol, v. 2
    Doi: http://doi.org/10.1016/0960-9822(92)90313-y
  • Artero, RD., Akam, M. and Pérez-Alonso, M., 1992. Oligonucleotide probes detect splicing variants in situ in Drosophila embryos. Nucleic Acids Res, v. 20
    Doi: http://doi.org/10.1093/nar/20.21.5687
  • Akam, M. and Gerhart, J., 1992. Pattern formation and developmental mechanisms Current Opinion in Genetics and Development, v. 2
    Doi: http://doi.org/10.1016/S0959-437X(05)80168-6
  • 1991

  • AKAM, M., 1991. DEVELOPMENTAL BIOLOGY - WONDROUS TRANSFORMATION NATURE, v. 349
  • Akam, M. and Gerhart, J., 1991. Editorial overview Current Opinion in Genetics and Development, v. 1
    Doi: http://doi.org/10.1016/S0959-437X(05)80064-4
  • 1990

  • Tear, G., Akam, M. and Martinez-Arias, A., 1990. Isolation of an abdominal-A gene from the locust Schistocerca gregaria and its expression during early embryogenesis. Development, v. 110
    Doi: 10.1242/dev.110.3.915
  • 1989

  • Irish, VF., Martinez-Arias, A. and Akam, M., 1989. Spatial regulation of the Antennapedia and Ultrabithorax homeotic genes during Drosophila early development. EMBO J, v. 8
    Doi: 10.1002/j.1460-2075.1989.tb03537.x
  • Irish, V., Lehmann, R. and Akam, M., 1989. The Drosophila posterior-group gene nanos functions by repressing hunchback activity. Nature, v. 338
    Doi: http://doi.org/10.1038/338646a0
  • Sánchez-Herrero, E. and Akam, M., 1989. Spatially ordered transcription of regulatory DNA in the bithorax complex of Drosophila. Development, v. 107
    Doi: 10.1242/dev.107.2.321
  • AKAM, M., 1989. DROSOPHILA DEVELOPMENT - MAKING STRIPES INELEGANTLY NATURE, v. 341
  • Akam, M., 1989. Hox and HOM: homologous gene clusters in insects and vertebrates. Cell, v. 57
    Doi: http://doi.org/10.1016/0092-8674(89)90909-4
  • 1988

  • AKAM, M., DAWSON, I. and TEAR, G., 1988. HOMEOTIC GENES AND THE CONTROL OF SEGMENT DIVERSITY DEVELOPMENT, v. 104
  • Hoogwerf, AM., Akam, M. and Roberts, D., 1988. A genetic analysis of the rose-gespleten region (68C8-69B5) of Drosophila melanogaster. Genetics, v. 118
    Doi: http://doi.org/10.1093/genetics/118.4.665
  • Rowe, A. and Akam, M., 1988. The structure and expression of a hybrid homeotic gene. EMBO J, v. 7
    Doi: 10.1002/j.1460-2075.1988.tb02919.x
  • 1987

  • AKAM, M., 1987. INSECT EVOLUTION - MOLECULES AND MORPHOLOGY NATURE, v. 327
  • WEINZIERL, R., AXTON, JM., GHYSEN, A. and AKAM, M., 1987. ULTRABITHORAX MUTATIONS IN CONSTANT AND VARIABLE REGIONS OF THE PROTEIN CODING SEQUENCE GENE DEV, v. 1
  • Wilde, CD. and Akam, M., 1987. Conserved sequence elements in the 5' region of the Ultrabithorax transcription unit. EMBO J, v. 6
    Doi: 10.1002/j.1460-2075.1987.tb02380.x
  • AKAM, M., 1987. THE MOLECULAR-BASIS FOR METAMERIC PATTERN IN THE DROSOPHILA EMBRYO DEVELOPMENT, v. 101
  • MARTINEZARIAS, A., INGHAM, PW., SCOTT, MP. and AKAM, ME., 1987. THE SPATIAL AND TEMPORAL DEPLOYMENT OF DFD AND SCR TRANSCRIPTS THROUGHOUT DEVELOPMENT OF DROSOPHILA DEVELOPMENT, v. 100
  • Akam, M., 1987. Molecules and morphology Nature, v. 327
    Doi: http://doi.org/10.1038/327184a0
  • 1986

  • AKAM, M., 1986. DEVELOPMENTAL GENES - MEDIATORS OF CELL COMMUNICATION NATURE, v. 319
  • AKAM, M., 1986. FROM GENE TO ANIMAL - AN INTRODUCTION TO THE MOLECULAR-BIOLOGY OF ANIMAL DEVELOPMENT - DEPOMERAI,D NATURE, v. 319
  • 1985

  • AKAM, ME., 1985. SEGMENTS, LINEAGE BOUNDARIES AND THE DOMAINS OF EXPRESSION OF HOMEOTIC GENES PHILOS T ROY SOC B, v. 312
  • AKAM, ME. and MARTINEZARIAS, A., 1985. THE DISTRIBUTION OF ULTRABITHORAX TRANSCRIPTS IN DROSOPHILA EMBRYOS EMBO J, v. 4
  • WHITE, RAH. and AKAM, ME., 1985. CONTRABITHORAX MUTATIONS CAUSE INAPPROPRIATE EXPRESSION OF ULTRABITHORAX PRODUCTS IN DROSOPHILA NATURE, v. 318
  • STRUHL, G. and AKAM, M., 1985. ALTERED DISTRIBUTIONS OF ULTRABITHORAX TRANSCRIPTS IN EXTRA-SEX-COMBS MUTANT EMBRYOS OF DROSOPHILA EMBO J, v. 4
  • AKAM, ME., MARTINEZARIAS, A., WEINZIERL, R. and WILDE, CD., 1985. FUNCTION AND EXPRESSION OF ULTRABITHORAX IN THE DROSOPHILA EMBRYO COLD SPRING HARB SYM, v. 50
  • AKAM, ME. and CARLSON, JR., 1985. THE DETECTION OF JONAH GENE TRANSCRIPTS IN DROSOPHILA BY INSITU HYBRIDIZATION EMBO J, v. 4
  • 1984

  • AKAM, M., 1984. A MOLECULAR THEME FOR HOMOEOTIC GENES BIOESSAYS, v. 1
  • AKAM, M., 1984. A COMMON SEGMENT IN GENES FOR SEGMENTS OF DROSOPHILA NATURE, v. 308
  • AKAM, M., 1984. FROM EGG TO EMBRYO - SLACK,JMW TRENDS BIOCHEM SCI, v. 9
  • Akam, M., 1984. Neurogenesis in drosophila: Notch mapping function obscure Nature, v. 307
    Doi: http://doi.org/10.1038/307113a0
  • AKAM, M., 1984. NOTCH MAPPING FUNCTION OBSCURE NATURE, v. 307
  • AKAM, M., MOORE, H. and COX, A., 1984. ULTRABITHORAX MUTATIONS MAP TO DISTANT SITES WITHIN THE BITHORAX COMPLEX OF DROSOPHILA NATURE, v. 309
  • 1983

  • AKAM, ME., 1983. THE LOCATION OF ULTRABITHORAX TRANSCRIPTS IN DROSOPHILA TISSUE-SECTIONS EMBO J, v. 2
  • BENDER, W., AKAM, M., KARCH, F., BEACHY, PA., PEIFER, M., SPIERER, P., LEWIS, EB. and HOGNESS, DS., 1983. MOLECULAR-GENETICS OF THE BITHORAX COMPLEX IN DROSOPHILA-MELANOGASTER SCIENCE, v. 221
  • Akam, M., 1983. Decoding the Drosophila complexes Trends in Biochemical Sciences, v. 8
    Doi: http://doi.org/10.1016/0968-0004(83)90167-6
  • 1982

  • Goelet, P., Lomonossoff, GP., Butler, PJG., Akam, ME., Gait, MJ. and Karn, J., 1982. Nucleotide sequence of tobacco mosaic virus RNA Proceedings of the National Academy of Sciences of the United States of America, v. 79
    Doi: http://doi.org/10.1073/pnas.79.19.5818
  • GOELET, P., LOMONOSSOFF, GP., BUTLER, PJG., AKAM, ME., GAIT, MJ. and KARN, J., 1982. NUCLEOTIDE-SEQUENCE OF TOBACCO MOSAIC-VIRUS RNA P NATL ACAD SCI-BIOL, v. 79
  • 1978

  • AKAM, ME., ROBERTS, DB., RICHARDS, GP. and ASHBURNER, M., 1978. DROSOPHILA - GENETICS OF 2 MAJOR LARVAL PROTEINS CELL, v. 13
  • AKAM, ME., ROBERTS, DB. and WOLFE, J., 1978. DROSOPHILA HEMOLYMPH PROTEINS - PURIFICATION, CHARACTERIZATION, AND GENETIC-MAPPING OF LARVAL SERUM-PROTEIN 2 IN D-MELANOGASTER BIOCHEM GENET, v. 16
  • 1977

  • ROBERTS, DB., WOLFE, J. and AKAM, ME., 1977. DEVELOPMENTAL PROFILES OF 2 MAJOR HEMOLYMPH PROTEINS FROM DROSOPHILA-MELANOGASTER J INSECT PHYSIOL, v. 23
  • WOLFE, J., AKAM, ME. and ROBERTS, DB., 1977. BIOCHEMICAL AND IMMUNOLOGICAL STUDIES ON LARVAL SERUM PROTEIN-1, MAJOR HEMOLYMPH PROTEIN OF DROSOPHILA-MELANOGASTER 3RD-INSTAR LARVAE EUR J BIOCHEM, v. 79
  • Akam, ME. and Hunnekuhl, VS., Formation and subdivision of the head field in the centipede Strigamia maritima, as revealed by the expression of head gap gene orthologues and hedgehog dynamics EvoDevo,
    Doi: http://doi.org/10.1186/s13227-017-0082-x
  • Clark, E., Peel, AD. and Akam, M., Arthropod Segmentation Development,
  • Tidswell, ORA., Benton, MA. and Akam, M., The neuroblast timer gene nubbin exhibits functional redundancy with gap genes to regulate segment identity in Tribolium Development,
  • Tidswell, ORA., Benton, MA. and Akam, ME., The neuroblast timer genenubbinexhibits functional redundancy with gap genes to regulate segment identity inTribolium BioRxiv,
    Doi: http://doi.org/10.1101/2021.04.08.438913
  • Conference proceedings

    1998

  • Akam, M., 1998. Hox genes in arthropod development and evolution. Biol Bull, v. 195
    Doi: http://doi.org/10.2307/1543151
  • Theses / dissertations
  • Tidswell, O., Investigating the roles of candidate gap genes from the neuroblast timer series during axial patterning in the beetle Tribolium