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School of the Biological Sciences

 

 

Group Leader, Department of Pathology

Adrian Kelly's work is focused on understanding how pathogens interact with the host immune system and in particular the MHC antigen presentation pathways. Learn more. 

 

Research Areas


Molecular Immunology
Adaptive immune system 
MHC Class II Anitgen Presentation
 
 
 

Techniques


Assays
FACS
Flow cytometry 
 
 
 
   

 

Research Theme


   

 

Publications

Journal articles

2017

  • Kelly, A. and Trowsdale, J., 2017. Introduction: MHC/KIR and governance of specificity Immunogenetics, v. 69
    Doi: http://doi.org/10.1007/s00251-017-0986-6
  • 2014

  • Jackson, N., Compton, E., Trowsdale, J. and Kelly, AP., 2014. Recognition of Salmonella by Dectin-1 induces presentation of peptide antigen to type B T cells. Eur J Immunol, v. 44
    Doi: 10.1002/eji.201344065
  • 2013

  • Jackson, NP., Kang, YH., Lapaque, N., Janssen, H., Trowsdale, J. and Kelly, AP., 2013. Salmonella polarises peptide-MHC-II presentation towards an unconventional Type B CD4+ T-cell response. Eur J Immunol, v. 43
    Doi: http://doi.org/10.1002/eji.201242983
  • Jahnke, M., Trowsdale, J. and Kelly, AP., 2013. Ubiquitination of HLA-DO by MARCH family E3 ligases. Eur J Immunol, v. 43
    Doi: http://doi.org/10.1002/eji.201243043
  • Jackson, NP., Kang, YH., Lapaque, N., Janssen, H., Trowsdale, J. and Kelly, AP., 2013. Salmonella polarises peptide-MHC-II presentation towards an unconventional Type B CD4<sup>+</sup> T-cell response European Journal of Immunology, v. 43
    Doi: http://doi.org/10.1002/eji.201242983
  • Jahnke, M., Trowsdale, J. and Kelly, AP., 2013. Ubiquitination of HLA-DO by MARCH family E3 ligases European Journal of Immunology, v. 43
    Doi: http://doi.org/10.1002/eji.201243043
  • 2012

  • Jahnke, M., Trowsdale, J. and Kelly, AP., 2012. Ubiquitination of human leukocyte antigen (HLA)-DM by different membrane-associated RING-CH (MARCH) protein family E3 ligases targets different endocytic pathways. J Biol Chem, v. 287
    Doi: http://doi.org/10.1074/jbc.M111.305961
  • Jahnke, M., Trowsdale, J. and Kelly, AP., 2012. Structural requirements for recognition of major histocompatibility complex class II by membrane-associated RING-CH (MARCH) protein E3 ligases. J Biol Chem, v. 287
    Doi: http://doi.org/10.1074/jbc.M112.381541
  • 2009

  • Lapaque, N., Hutchinson, JL., Jones, DC., Méresse, S., Holden, DW., Trowsdale, J. and Kelly, AP., 2009. Salmonella regulates polyubiquitination and surface expression of MHC class II antigens. Proc Natl Acad Sci U S A, v. 106
    Doi: http://doi.org/10.1073/pnas.0906735106
  • Lapaque, N., Jahnke, M., Trowsdale, J. and Kelly, AP., 2009. The HLA-DRalpha chain is modified by polyubiquitination. J Biol Chem, v. 284
    Doi: http://doi.org/10.1074/jbc.M805736200
  • 2008

  • Li, K., Anderson, KJ., Peng, Q., Noble, A., Lu, B., Kelly, AP., Wang, NY., Sacks, SH. and Zhou, WD., 2008. Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation BLOOD, v. 112
    Doi: http://doi.org/10.1182/blood-2008-05-156646
  • 2005

  • Reinicke, AT., Hutchinson, JL., Magee, AI., Mastroeni, P., Trowsdale, J. and Kelly, AP., 2005. A Salmonella typhimurium effector protein SifA is modified by host cell prenylation and S-acylation machinery. J Biol Chem, v. 280
    Doi: 10.1074/jbc.M500076200
  • 2004

  • Mitchell, EK., Mastroeni, P., Kelly, AP. and Trowsdale, J., 2004. Inhibition of cell surface MHC class II expression by Salmonella. Eur J Immunol, v. 34
    Doi: 10.1002/eji.200425314
  • 2002

  • Towey, M. and Kelly, AP., 2002. Nuclear localisation of CIITA is controlled by a carboxy terminal leucine-rich repeat region. Mol Immunol, v. 38
    Doi: http://doi.org/10.1016/s0161-5890(01)00093-1
  • 1999

  • Quan, V., Towey, M., Sacks, S. and Kelly, AP., 1999. Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA IMMUNOGENETICS, v. 49
  • Potter, PK., Copier, J., Sacks, SH., Calafat, J., Janssen, H., Neefjes, JJ. and Kelly, AP., 1999. Accurate intracellular localization of HLA-DM requires correct spacing of a cytoplasmic YTPL targeting motif relative to the transmembrane domain EUR J IMMUNOL, v. 29
  • 1997

  • Fabb, SA., Davies, AF., Correa, I., Kelly, AP., Mackie, C., Trowsdale, J. and Ragoussis, J., 1997. Corrigendum: Generation of novel human MHC class II mutant B-cell lines by integrating YAC DNA into a cell line homozygously deleted for the MHC class II region (Human Molecular Genetics (1997) 6 (1295-1304)) Human Molecular Genetics, v. 6
  • Fabb, SA., Davies, AF., Correa, I., Kelly, AP., Mackie, C., Trowsdale, J. and Ragoussis, J., 1997. Generation of novel human MHC class II mutant B-cell lines by integrating YAC DNA into a cell line homozygously deleted for the MHC class II region. Hum Mol Genet, v. 6
    Doi: http://doi.org/10.1093/hmg/6.8.1295
  • Fabb, SA., Davies, AF., Correa, I., Kelly, AP., Mackie, C., Trowsdale, J. and Ragoussis, J., 1997. Generation of novel human MHC class II mutant B-cell lines by integrating YAC DNA into a cell line homozygously deleted for the MHC class II region (vol 6, pg 1295, 1997) HUM MOL GENET, v. 6
  • 1996

  • Beck, S., Abdulla, S., Alderton, RP., Glynne, RJ., Gut, IG., Hosking, LK., Jackson, A., Kelly, A., Newell, WR., Sanseau, P., Radley, E., Thorpe, KL. and Trowsdale, J., 1996. Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. J Mol Biol, v. 255
    Doi: http://doi.org/10.1006/jmbi.1996.0001
  • Beck, S., Belich, M., Gruneberg, U., Jackson, A., Kelly, A., Sanseau, P., Sanderson, F., Trowsdale, J. and Van Ham, M., 1996. Organisation and functions of class II genes and molecules. DNA Seq, v. 7
    Doi: http://doi.org/10.3109/10425179609015640
  • Abdulla, S., Alderton, RP., Glynne, RJ., Gut, IG., Hosking, LK., Jackson, A., Kelly, A., Newell, WR., Radley, E., Sanseau, P., Thorpe, KL., Trowsdale, J. and Beck, S., 1996. DNA sequencing of the MHC class II region and the chromosome 6 sequencing effort at the Sanger Centre. DNA Seq, v. 7
    Doi: http://doi.org/10.3109/10425179609015637
  • Copier, J., Kleijmeer, MJ., Ponnambalam, S., Oorschot, V., Potter, P., Trowsdale, J. and Kelly, A., 1996. Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB. J Immunol, v. 157
  • Carmichael, P., Kerr, LA., Kelly, A., Lombardi, G., Zeigler, BU., Ziegler, A., Trowsdale, J. and Lechler, R., 1996. The TAP complex influences allorecognition of class II MHC molecules. Hum Immunol, v. 50
    Doi: http://doi.org/10.1016/0198-8859(96)00119-x
  • 1995

  • Rowe, M., Khanna, R., Jacob, CA., Argaet, V., Kelly, A., Powis, S., Belich, M., Croom-Carter, D., Lee, S. and Burrows, SR., 1995. Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein-1: coordinate up-regulation of peptide transporters and HLA-class I antigen expression. Eur J Immunol, v. 25
    Doi: http://doi.org/10.1002/eji.1830250536
  • Tomiyama, H., Takamiya, Y., Hill, AB., Cerundolo, V., Kelly, A., Egawa, K., Trowsdale, J. and Takiguchi, M., 1995. Isolation of a human allo-peptide presented by HLA-B51 molecules. Int Immunol, v. 7
    Doi: http://doi.org/10.1093/intimm/7.6.905
  • Cerundolo, V., Kelly, A., Elliott, T., Trowsdale, J. and Townsend, A., 1995. Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport. Eur J Immunol, v. 25
    Doi: http://doi.org/10.1002/eji.1830250238
  • 1994

  • Sanderson, F., Powis, SH., Kelly, AP. and Trowsdale, J., 1994. Limited polymorphism in HLA-DM does not involve the peptide binding groove. Immunogenetics, v. 39
    Doi: http://doi.org/10.1007/BF00171797
  • Sanséau, P., Jackson, A., Alderton, RP., Beck, S., Senger, G., Sheer, D., Kelly, A. and Trowsdale, J., 1994. Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. Mamm Genome, v. 5
    Doi: http://doi.org/10.1007/BF00369318
  • Radley, E., Alderton, RP., Kelly, A., Trowsdale, J. and Beck, S., 1994. Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex. J Biol Chem, v. 269
  • Sanséau, P., Jackson, A., Senger, G., Kelly, A., Francis, F., Sheer, D. and Trowsdale, J., 1994. Cloning of the region between HLA-DMB and LMP2 in the human major histocompatibility complex. Hum Immunol, v. 40
    Doi: http://doi.org/10.1016/0198-8859(94)90014-0
  • Sanderson, F., Kleijmeer, MJ., Kelly, A., Verwoerd, D., Tulp, A., Neefjes, JJ., Geuze, HJ. and Trowsdale, J., 1994. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science, v. 266
    Doi: http://doi.org/10.1126/science.7985027
  • Kelly, A. and Trowsdale, J., 1994. Novel genes in the human major histocompatibility complex class-II region. Int Arch Allergy Immunol, v. 103
    Doi: http://doi.org/10.1159/000236599
  • POWIS, SH., GOLDSWORTHY, M., KELLY, AP., RAGOUSSIS, J. and TROWSDALE, J., 1994. RAPID ISOLATION AND ORDERING OF COSMIDS OVER THE HUMAN MHC CLASS-I REGION J AM SOC NEPHROL, v. 5
  • 1993

  • Powis, SH., Tonks, S., Mockridge, I., Kelly, AP., Bodmer, JG. and Trowsdale, J., 1993. Erratum: Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2 (Immunogenetics (1993) 37 (373-380)) Immunogenetics, v. 37
  • Powis, SH., Tonks, S., Mockridge, I., Kelly, AP., Bodmer, JG. and Trowsdale, J., 1993. Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2 Immunogenetics, v. 37
    Doi: http://doi.org/10.1007/BF00222478
  • Powis, SH., Tonks, S., Mockridge, I., Kelly, AP., Bodmer, JG. and Trowsdale, J., 1993. Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. Immunogenetics, v. 37
    Doi: http://doi.org/10.1007/BF00216802
  • Glynne, R., Kerr, LA., Mockridge, I., Beck, S., Kelly, A. and Trowsdale, J., 1993. The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing. Eur J Immunol, v. 23
    Doi: http://doi.org/10.1002/eji.1830230414
  • POWIS, SH., TONKS, S., MOCKRIDGE, I., KELLY, AP., BODMER, JG. and TROWSDALE, J., 1993. ALLELES AND HAPLOTYPES OF THE MHC-ENCODED ABC TRANSPORTERS TAP1 AND TAP2 (IMMUNOGENET, VOL 37, PG 373, 1993) IMMUNOGENETICS, v. 37
  • GLYNNE, RJ., KERR, LAP., MOCKRIDGE, CI., KELLY, AP. and TROWSDALE, J., 1993. ALTERNATIVE SPLICING AND POSTTRANSLATIONAL PROCESSING OF THE MHC-ENCODED PROTEASOME COMPONENT, LMP7 J CELL BIOCHEM,
  • 1992

  • Kelly, A., Powis, SH., Kerr, LA., Mockridge, I., Elliott, T., Bastin, J., Uchanska-Ziegler, B., Ziegler, A., Trowsdale, J. and Townsend, A., 1992. Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. Nature, v. 355
    Doi: http://doi.org/10.1038/355641a0
  • Beck, S., Hanson, I., Kelly, A., Pappin, DJ. and Trowsdale, J., 1992. A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. DNA Seq, v. 2
    Doi: http://doi.org/10.3109/10425179209020804
  • Beck, S., Kelly, A., Radley, E., Khurshid, F., Alderton, RP. and Trowsdale, J., 1992. DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. J Mol Biol, v. 228
    Doi: http://doi.org/10.1016/0022-2836(92)90832-5
  • Kleijmeer, MJ., Kelly, A., Geuze, HJ., Slot, JW., Townsend, A. and Trowsdale, J., 1992. Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi. Nature, v. 357
    Doi: http://doi.org/10.1038/357342a0
  • Powis, SH., Mockridge, I., Kelly, A., Kerr, LA., Glynne, R., Gileadi, U., Beck, S. and Trowsdale, J., 1992. Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex. Proc Natl Acad Sci U S A, v. 89
    Doi: http://doi.org/10.1073/pnas.89.4.1463
  • 1991

  • Kelly, AP., Monaco, JJ., Cho, SG. and Trowsdale, J., 1991. A new human HLA class II-related locus, DM. Nature, v. 353
    Doi: http://doi.org/10.1038/353571a0
  • Kelly, A., Powis, SH., Glynne, R., Radley, E., Beck, S. and Trowsdale, J., 1991. Second proteasome-related gene in the human MHC class II region. Nature, v. 353
    Doi: http://doi.org/10.1038/353667a0
  • Glynne, R., Powis, SH., Beck, S., Kelly, A., Kerr, LA. and Trowsdale, J., 1991. A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC. Nature, v. 353
    Doi: http://doi.org/10.1038/353357a0
  • 1990

  • Trowsdale, J., Hanson, I., Mockridge, I., Beck, S., Townsend, A. and Kelly, A., 1990. Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. Nature, v. 348
    Doi: http://doi.org/10.1038/348741a0
  • 1989

  • Smith, ME., Bodmer, JG., Kelly, AP., Trowsdale, J., Kirkland, SC. and Bodmer, WF., 1989. Variation in HLA expression on tumors: an escape from immune response. Cold Spring Harb Symp Quant Biol, v. 54 Pt 1
    Doi: http://doi.org/10.1101/sqb.1989.054.01.069
  • SMITH, MEF., BODMER, JG., KELLY, AP., TROWSDALE, J., KIRKLAND, SC. and BODMER, WF., 1989. VARIATION IN HLA EXPRESSION ON TUMORS - AN ESCAPE FROM IMMUNE-RESPONSE COLD SPRING HARB SYM, v. 54
  • 1987

  • Willison, K., Kelly, A., Dudley, K., Goodfellow, P., Spurr, N., Groves, V., Gorman, P., Sheer, D. and Trowsdale, J., 1987. The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region. EMBO J, v. 6
    Doi: 10.1002/j.1460-2075.1987.tb02459.x
  • 1985

  • Trowsdale, J., Young, JA., Kelly, AP., Austin, PJ., Carson, S., Meunier, H., So, A., Erlich, HA., Spielman, RS. and Bodmer, J., 1985. Structure, sequence and polymorphism in the HLA-D region. Immunol Rev, v. 85
    Doi: http://doi.org/10.1111/j.1600-065x.1985.tb01129.x
  • Kelly, A. and Trowsdale, J., 1985. Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes. Nucleic Acids Res, v. 13
    Doi: http://doi.org/10.1093/nar/13.5.1607
  • Trowsdale, J. and Kelly, A., Genetics of antigen processing and presentation Immunogenetics,
  • Book chapters

    2007

  • Kelly, AP. and Trowsdale, J., 2007. The MHC paradigm: Genetic variation and complex disease
    Doi: http://doi.org/10.1017/CBO9780511543555.010
  • Conference proceedings

    2012

  • Jackson, N., Kang, YH., Lapaque, N., Janssen, H., Trowsdale, J. and Kelly, AP., 2012. Influence of Salmonella on MHC class II antigen presentation IMMUNOLOGY, v. 137
  • Other publications

    2008

  • Trowsdale, J., Hanson, I., Mockridge, I., Beck, S., Townsend, A. and Kelly, A., 2008. Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. 1990. J Immunol, v. 180