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baby in phone screen with blurred woman in the backgroundOver the last 60 years the global average life expectancy increased more than 20 years, partly as a result of countless medical breakthroughs. However, most of the these medical interventions address the symptoms rather than the causes of age associated diseases. Scientists in the School of Biological Sciences are combining their world leading expertise to tackle some of the biggest questions in human biology: What if we could identify those at risk of developing chronic age-related conditions before they present in the clinic? What if we could intervene before any symptoms arise and prevent disease                                                           onset? These changes would revolutionise healthcare and transform our                                                                 twilight years into a healthy period of our lives.

Collaboration and Engagement

To explore synergies and collaborative opportunities in the area of healthy ageing, the Reproduction, Development and Lifelong Health Research Theme are facilitating workshops and meetings for scientific colleagues, industry partners and policy-makers.

The kick-off meeting in June 2022 brought together speakers and attendees from 12 Departments and Institutes: Obstetrics and Gynaecology, Cambridge Stem Cell Institute, Babraham Institute, Physiology, Development and Neuroscience, Pharmacology, Biochemistry, Genetics, Zoology, MRC Toxicology Unit, Gurdon Institute, Psychology and Veterinary Medicine, discussing questions surrounding early identification of those at risk from chronic age-related conditions, intervention before initiation of symptoms and prevention of disease onset.

Key Collaborators

Catherine Aiken, Obstetrics and Gynaecology

Srinjan Basu, Cambridge Stem Cell Institute

Guy Brown, Biochemistry

Kevin Chalut, Altos Labs

Della David, Babraham Institute

Dino Giussani, Physiology, Development and Neuroscience

Laura Itzhaki, Pharmacology

Walid Khaled, Pharmacology / Cambridge Stem Cell Institute

Matthias Landgraf, Zoology

Delphine Larrieu, Pharmacology

Catherine Lindon, Pharmacology

Kiran Patil, MRC Toxicology Unit

Emma Rawlins, Gurdon Institute

Jon Simons, Psychology

Ewan St. John Smith, Pharmacology

Tim Weil, Zoology

Catherine Wilson, Pharmacology

Work with us

We welcome opportunities to collaborate with industry partners, policy makers and academics. If you are interested in working with us, please contact Dr Abi Herrmann, Research Strategy Manager.

Relevant Publications

Naked Mole-Rats: Resistant to Developing Cancer or Good at Avoiding It?

Hadi F, Smith ESJ, Khaled WT. Naked Mole-Rats: Resistant to Developing Cancer or Good at Avoiding It? Adv Exp Med Biol. 2021;1319:341-352. doi: 10.1007/978-3-030-65943-1_14.

Brain KL, Allison BJ, Niu Y, Cross CM, Itani N, Kane AD, Herrera EA, Skeffington KL, Botting KJ, Giussani DA. Intervention against hypertension in the next generation programmed by developmental hypoxia. PLoS Biol. 2019 Jan 22;17(1):e2006552. doi: 10.1371/journal.pbio.2006552.


Healthy ageing reduces the precision of episodic memory retrieval

Korkki SM, Richter FR, Jeyarathnarajah P, Simons JS. Healthy ageing reduces the precision of episodic memory retrieval. Psychol Aging. 2020 Feb;35(1):124-142. doi: 10.1037/pag0000432.

Academic Leads

Walid Khaled

Pharmacology/Cambridge Stem Cell Institute

 

Dino Giussani

Physiology, Development and Neuroscience