skip to content

School of the Biological Sciences

 
Subscribe to http://www.jobs.cam.ac.uk/job/?unit=u00199&format=rss feed http://www.jobs.cam.ac.uk/job/?unit=u00199&format=rss
Current jobs in the Department of Biochemistry at the University of Cambridge.
Updated: 38 min 25 sec ago

Senior Cleaner

Wed, 31/01/2024 - 00:00

The Department of Biochemistry, a large and flourishing academic community that enjoys a world-class reputation for both teaching and research, is embedded in the School of the Biological Sciences. An exciting opportunity has arisen for an enthusiastic and efficient individual to join the Department's Domestic Services team as a Senior Cleaner - a key role in servicing departmental operations, leading others by example.

Based in a busy and friendly professional services team, and reporting to the Facilities Superintendent, the successful candidate will join a dynamic and dedicated team of domestic support specialists who work as a team to underpin the Department's performance and reputation as a modern, progressive academic teaching and research institution.

An early riser (start time is between 6am-7am), the successful candidate will thrive in leading and overseeing others, working as part of a team, but will also be content working alone, maintaining a flexible and friendly attitude at all times.

They will have a good level of oral communication, a high standard of English, and the ability to give and receive written and verbal instructions - including safety instructions regarding the use of cleaning chemicals.

Duties include thorough cleaning of all areas, including research laboratories, offices, teaching and meeting rooms, communal areas, stairways, WCs and washrooms. Directing and participating in the collection, cleaning and return of laboratory glassware is also an important element of this role.

A good general education (GCSE /NVQ level 2) or equivalent level of practical experience is required, and experience of experience of laboratory and/or office cleaning, including the use of mechanical scrubber/polishing equipment is essential. Physically fit, the successful candidate will enjoy an active and varied workload.

We are a friendly Department and value all our staff for the contribution that they make to our community. We hold various social activities throughout the year and staff are also able to make use of free passes to the University Botanic Garden. They also enjoy a subsidised staff canteen service.

For this position, the University Real Living Wage (RLW) supplement applies, which sets the minimum rate of pay at £12 per hour. The salary band holds the opportunity to progress to £25,138 subject to performance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For an informal discussion please contact the Facilities Superintendent, Mr Steven Godby (email: sjg86@cam.ac.uk).

For further assistance, please contact the Biochemistry HR team via email: personnel@bioc.cam.ac.uk

Please quote reference PH40331 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Grants Assistant

Fri, 26/01/2024 - 00:00

The Department of Biochemistry is seeking an enthusiastic Research Grants Assistant to join its very busy research grant team.

The role is to administer the end to end support for a portfolio of grants, working closely with grant holders, funders and internal University offices. Specifically, the main responsibilities include interrogating and using the University Finance System to process grant transactions; reviewing and approving expense claims; monitoring grant budgets on a monthly basis; producing budget expenditure analyses and staff forecasting information.

The ideal candidate will be used to working in a busy environment whilst maintaining high levels of accuracy. Previous experience of working in a financial and/or a research grant administration role, using computerised financial accounting systems and spreadsheets is desirable. However, we are keen to receive applications from candidates who have strong computing and communication skills with a willingness to learn the many aspects of Research Grants administration.

This position open ended, with limited funding. Funds are available for 3 years in the first instance.

This is an ideal opportunity to build on you knowledge and skills in the area of Research Grants Administration and to achieve this you will be fully supported to attend all the available internal training courses in this key function.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to Debbie Canham: dac77@cam.ac.uk

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH40252 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Associate- Hollfelder Group- From peptides to catalysts - Exploring the emergence of function by ultrahigh throughput screening and mechanistic analysis(Fixed Term)

Fri, 19/01/2024 - 00:00

A postdoctoral position is available for 18 months (in the first instance, extension possible) from 1 February 2024 (or later) to work with Florian Hollfelder at the Biochemistry Department of Cambridge University.(https://hollfelder.bioc.cam.ac.uk/).

The emergence of functional proteins from the primordial soup is defining the origin of life. This step is also the most enigmatic transition in the search for efficient biocatalysts and difficult to emulate in model experiments. Our recent work provides a clue how inactive scaffolds can be functionalised (doi.org/10.1101/2023.02.13.528392). We want to use ultrahigh throughput screening in microfluidic droplets to find new catalysts and then analyse their features (e.g. catalytic promiscuity and conformational diversity) that first give rise to 'evolvability' and subsequently to efficiency. Deep sequence datasets from droplet screening will be interpreted using machine learning/AI approaches and, together with classical physical-organic/structural/mechanistic approaches, teach us where in sequence space novel solutions for sustainable biocatalysis can be harvested.

Applicants should thus have a first (or upper second) class degree in chemistry, biochemistry or a related, relevant subject, followed by a PhD. The project involves chemical and molecular biology techniques. Specific skills in mechanistic enzymology/enzyme kinetics, assay development, DNA library generation, structural biology, organic synthesis, high-throughput screening and microfluidic engineering are advantages, but will also be acquired during the postdoctoral training period.

Applications should contain a description of research interests (e.g. as part of the cover letter), a detailed CV (with exam marks and all relevant practical experience) and a list of publications. Please also include the names and email addresses of at least two referees, who are familiar with your research work.

The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA) and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualised metrics in their applications. For more information: https://www.biology.cam.ac.uk/files/dora.pdf

Fixed-term: The funds for this post are available for 18 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to Professor Hollfelder: fh111@cam.ac.uk

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH40181 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant- Pellegrini Group (Fixed Term)

Wed, 17/01/2024 - 00:00

Applications are invited for a Research Assistant position in the Department of Biochemistry of the University of Cambridge, UK. The successful applicant will work to support the research activities in the laboratory of Professor Pellegrini. (https://www.bioc.cam.ac.uk/research/pellegrini).

The position would suit an ambitious and talented graduate who has recently completed an MSc/MPhil degree in Biochemistry or Molecular Biology and is keen to gain research experience in an international academic environment. Although the focus of the post is to provide research support to more experienced researchers, there will be opportunities to pursue an independent research project.

In addition to possessing a strong aptitude for scientific research, the ideal candidate will have excellent communication skills and will work well in a team. Previous research experience of recombinant protein expression in insect or mammalian cells, and protein purification for Biophysical and Biochemical analysis would be highly desirable.

Applicants should submit a CV citing relevant experience, a cover letter explaining why they are suitable for the position and contact information for at least two referees.

The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA),and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualized metrics in their applications. For more information: https://www.biology.cam.ac.uk/files/dora.pdf

Fixed-term: The funds for this post are available until 31 May 2026 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to Professor Pellegrini: lp212@cam.ac.uk

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH40154 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant- Machesky Group (Fixed Term)

Wed, 20/12/2023 - 00:00

The research team of Professor Laura Machesky is seeking to recruit a 50% FTE (18.5 hours/week) part time Research Assistant with experience in mammalian cell work or molecular biology and an interest in cancer cell biology.

This post is funded by Cancer Research UK as a part of a programme investigating how the microenvironment contributes to progression and metastasis of pancreatic cancer.

The position would suit an ambitious talented recent graduate in Biochemistry, Molecular or Cell Biology who is keen to gain laboratory experience. An MPhil degree in cell biology or a similar area and have an interest in cell biology and microscopy. They will be collaborative and able to work as a part of a team. They will contribute to various projects in the lab and help with lab organisation and management.

Fixed-term: The funds for this post are available for 36 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to Karen Condie: PAMachesky@bioc.cam.ac.uk

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH39908 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Cleaner

Mon, 18/12/2023 - 00:00

The Department of Biochemistry, a large and flourishing academic community that enjoys a world-class reputation for both teaching and research, is embedded in the School of the Biological Sciences. An exciting opportunity has arisen for an enthusiastic and efficient individual to join the Department's Domestic Services team as a Cleaner - a key role in servicing departmental operations.

Based in a busy and friendly professional services team, and reporting to the Facilities Superintendent, the successful candidate will join a dynamic and dedicated team of domestic support specialists who work as a team to underpin the Department's performance and reputation as a modern, progressive academic teaching and research institution.

An early riser (start time is between 6am-7am), the successful candidate will be content working both alone and as part of a team, with a flexible and friendly attitude. They will have a good level of oral communication and understanding of English enabling them to understand and follow written and verbal instructions - including safety instructions regarding the use of cleaning chemicals.

Duties include thorough cleaning of all areas, including research laboratories, offices, teaching and meeting rooms, communal areas, stairways, WCs and washrooms. Collection, cleaning and return of laboratory glassware is also an important element of this role.

No formal qualifications are required as full training will be provided, but experience of laboratory and/or office cleaning, including the use of mechanical scrubber/polishing equipment would be beneficial. Physically fit, the successful candidate will enjoy an active and varied workload.

We are a friendly Department and value all our staff for their contribution that they make to our community. We hold various social activities throughout the year and staff are also able to make use of free passes to the University Botanic Garden; and enjoy a subsidised staff canteen service.

For this position, the University Real Living Wage (RLW) supplement applies, which sets the minimum rate of pay at £12 per hour.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For an informal discussion please contact the Facilities Superintendent, Mr Steve Godby by email: sjg86@cam.ac.uk or by telephone: 01223 333605.

For further assistance, please contact the Biochemistry HR team via email: personnel@bioc.cam.ac.uk

Please quote reference PH39836 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

PhD Studentship Uncovering the chemical origin of lipid membrane diversity (3.5 years Fixed Term)

Fri, 15/12/2023 - 00:00

A fully funded 3.5-year PhD studentship, supported by an LCLU Joint Collaborative Programme grant, is available in the ProtocellLab (www.bonfiolab.eu) at the Department of Biochemistry commencing on 1 October 2024.

Summary. The origin of cell membranes is a major unresolved issue in evolution. Evolutionary biology points to the existence of primitive cells with compositionally diverse membranes. However, the assumption that such lipid diversity is dependent upon enzymatic chemistry has generated models comprising compositionally minimal membranes (binary or ternary mixtures of short-chain fatty or phosphatidic acids). This project aims to reconcile biology and chemistry by challenging the critical limiting assumption that lipid diversity cannot be achieved through non-enzymatic chemistries. The project will lead to a fundamental understanding of the origins of lipid diversity, including the features now associated with bacterial and archaeal lipids; new strategies based on compositionally diverse membranes to probe, sense or replicate cellular behaviours; and a deep-rooted understanding of the emergence and evolution of cellular processes at the molecular level.

Background. While prebiotic pathways to all four RNA nucleotides and most of the twenty biological amino acids have been proposed, only a few non-enzymatic routes to modern lipids have been described. As such, prebiotic chemistry has yet to address models of primitive membranes comprising the vast structural diversity of modern lipids. However, if lipid diversity is an essential feature of modern membranes, can non-enzymatic chemistry be harnessed to generate lipid diversity?

Approach. To identify the set of diverse lipids that could have been formed non-enzymatically on early Earth, the student will adapt diversity-oriented synthetic strategies to prebiotic chemistry by transforming primitive lipids into modern lipids through non-enzymatic chemical strategies. The student will design and develop novel synthetic methods to generate libraries of lipids using a combination of solution-phase, membrane-templated and dry-state chemistries. The supramolecular properties of synthetic lipids and their biophysical features will be evaluated by fluorescence spectroscopy, dynamic light scattering, and light and electron microscopy. Additionally, encapsulated prebiotic reactions, such as RNA replication and protometabolic processes, will be investigated to better understand the chemistry of bioinspired systems.

ProtocellLab. The main focus of the ProtocellLab is to understand how primitive cells emerged on early Earth and how they started to interact with one another. The group is moving to the Department of Biochemistry in June 2024. The PhD student will develop skills in the areas of prebiotic, systems and supramolecular chemistry, applied to primitive and artificial cells. The small group size (5 PhD students and 2 PDRAs) ensures close supervision and training. The project offers interactions with other groups within the Leverhulme Centre for Life in the Universe, with the possibility of performing research periods abroad.

Fixed-term: The funds for this post are available for 3.5 years in the first instance.

Application. To apply, please e-mail Dr Claudia Bonfio (cb2036@cam.ac.uk) with the following information by 4 January 2024:

  • CV (max two pages), with full contact details of 2 academic referees.
  • Motivation letter (max two pages) highlighting (a) your research interests, (b) what you hope to achieve from the programme, and (c) why you wish to undertake this PhD.

Please note that applicants are also required to officially apply to the University using the Applicant Portal: http://www.graduate.study.cam.ac.uk/how-do-i-apply by the deadline of 4 January 2024. Please search in the Course Directory for 'Biochemistry' PhD (Course Code: BLBI22) as the programme of study. Applicants should indicate on the application form that they wish to apply for other sources of funding.

Any questions regarding the application process should be directed to the Postgraduate Admissions Administrator at pg-entry@bioc.cam.ac.uk.

Funding. This studentship is open to UK citizens or overseas students who meet the UK residency requirements ('Home' fees) or are able to augment the funds to cover the extra costs associated with international student fees. For further information on fee status, please see:

http://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status

Please quote reference PH39804 on your application and in any correspondence about this vacancy.

The ProtocellLab and the University actively support equality, diversity and inclusion and encourage applications from all sections of society. We place major emphasis on the importance of teamwork and an enjoyable work environment as a foundation for performing internationally leading research. This will allow the student to acquire cutting-edge research methodologies in a supportive environment where they can focus on making the best possible scientific progress.

Categories: Latest Jobs

Research Associate in protein crystallography (Fixed Term)

Fri, 08/12/2023 - 00:00

The structural biology lab of Professor Marko Hyvonen is seeking a postdoctoral research associate to support ongoing projects at Bicycle Therapeutics employing structural biology and to develop tools to facilitate structure determination of proteins by X-ray crystallography and cryo-EM. The post-holder will generate biophysical and structural data for peptide-bound protein targets using x-ray crystallography, cryo-electron microscopy, surface plasmon resonance and ITC. The postholder will also be developing novel methods, through protein engineering, for empowering structural analysis of target proteins, be it for cryo-EM or crystallography.

You will be responsible for driving this academic-industrial collaboration on the structural and biophysical characterisation of bicyclic peptides in complex with therapeutic protein targets in immune-oncology and other debilitating diseases and for development of methods that enable complex targets to be analysed structurally. You will be in charge of the complete gene-to-structure pipeline. You will be in charge of design and generation of expression constructs of target proteins through protein production in bacterial, insect or mammalian cells. You will be responsible for structure determination of protein:inhibitor complexes by X-ray crystallography and by cryo-electron microscopy and for interaction analyses using various biophysical methods. You will provide analysis of the data you produce and contribute to the iterative design process of the peptides.

You should have a PhD from biochemistry, molecular biology, chemistry of closely related field with significant expertise in structural biology, in particular in protein crystallography, from your PhD and/or postdoctoral positions. You should have high level of analytical and problem-solving capability in protein biochemistry and structural biology and creative problem-solving skills.

The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA), and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualized metrics in their applications. For more information: https://www.biology.cam.ac.uk/files/dora.pdf

Fixed-term: The funds for this post are available for 12 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to: Professor Hyvonen mh256@cam.ac.uk or Gustavo Bezerra gustavo.bezerra@bicycletx.com

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH39738 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Associate- Hollfelder Group- Functional metagenomics, novel biocatalysts for a sustainable circular economy from ultrahigh throughput screening (Fixed Term)

Fri, 08/12/2023 - 00:00

A postdoctoral position is available for 12 months (in the first instance, extension possible) from 1 March 2024 to work with Florian Hollfelder at the Biochemistry Department of Cambridge University (https://hollfelder.bioc.cam.ac.uk/). The project is part of the Horizon Europe project BlueTools (https://www.bluetools-project.eu/) and involves collaborations with various EU and UK groups on harnessing marine microbiomes and marine culture collections for novel biocatalysts that may play a role in future sustainable processes with higher resource and energy efficiency.

We will develop ultrahigh throughput assays to screen metagenomic libraries for new catalysts for applications in recycling, bioremediation and green chemistry. Candidate enzymes are mechanistically investigated, structurally characterised and subsequently improved by directed evolution. Ultrahigh-throughput screening in microfluidic picoliter droplets allows us to interrogate enzyme libraries with more than 10 million members experimentally in a day, increasing the chances of success in catalyst discovery.

Applicants should thus have a first (or upper second) class degree in chemistry, biochemistry or a related, relevant subject, followed by a PhD. Familiarity with molecular and chemical biology techniques and specific skills in assay development, enzyme kinetics, DNA library generation, structural biology, organic synthesis, high-throughput screening, mechanistic enzymology, database searching and microfluidic engineering are advantages.

Applications should contain a description of research interests (e.g. as part of the cover letter), a detailed CV (with exam marks and all relevant practical experience) and a list of publications. Please also include the names and email addresses of at least two referees, who are familiar with your research work.

The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA), and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualized metrics in their applications. For more information: https://www.biology.cam.ac.uk/files/dora.pdf

Fixed-term: The funds for this post are available for 12 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to: Professor Hollfelder:fh111@cam.ac.uk

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH39685 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Receptionist & Administrative Assistant

Tue, 05/12/2023 - 00:00

The Department of Biochemistry, a large and flourishing academic community that enjoys a world-class reputation for both teaching and research, is embedded in the School of the Biological Sciences. An exciting opportunity has arisen for an enthusiastic and efficient individual to join the Department as Receptionist & Administrative Assistant - a key member of the Department's Secretariat team.

Based in a busy and friendly professional services team, and reporting to the PA to the Head of Department, the successful candidate will join a dynamic and dedicated team of reception, clerical and general administrative support specialists who work as a team to underpin the Department's performance and reputation as a modern, progressive academic teaching and research institution.

The successful candidate will provide a friendly and welcoming front of house service to staff, students and visitors to the Department of Biochemistry across its two main sites in Tennis Court Road at the Hopkins and the Sanger Buildings. Routine reception duties (responding to calls, distributing mail, issuing keys and access cards, supporting security and safety procedures etc.) are enhanced by the opportunity to explore a wider range of administrative tasks. These may include assisting with the support of departmental committee business, helping with general administrative tasks, and being involved in departmental event planning, organisation and promotion. There is plenty of opportunity and scope to excel in various areas of administrative support, allowing for the opportunity to hone and develop a diverse skill set.

Overall, this is an excellent opportunity for an enthusiastic individual to be central to the smooth running of departmental operations and governance by providing an efficient, friendly and 'can-do' front of house and administrative support service.

Educated to at least GSCE-level or equivalent, the ideal candidate will be able to work on their own initiative, be well organised in prioritising their work, be flexible in their approach and have excellent communication and IT skills along with a strong sense of team playing and working flexibly across a varied workload.

To apply for this position, please click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The closing date for this position is 14th January 2024 with interviews expected to be held on 22nd January 2024.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For an informal discussion, please contact the Departmental Administrator & General Manager of Biochemistry, Dr Katherine Wallington (email: da@bioc.cam.ac.uk).

For further assistance, please contact the Biochemistry HR team via email: personnel@bioc.cam.ac.uk

Please quote reference PH39676 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Associate (Fixed Term)

Thu, 30/11/2023 - 00:00

The Maori lab, based in the Department of Biochemistry of Cambridge University, is inviting applications for a Research Associate. The position holder will join our research programme, which centres around a new paradigm in RNA biology: secreted extra-organismal RNA-binding proteins (RBPs).

Secreted extra-organismal RBPs have been recently discovered in honeybees and Listeria monocytogenes. In both instances, the RBP stabilises RNA outside the organism it originated from to interact with- and affect another organism. Given their recent discovery, it is unknown how widespread and diverse the roles of extra-organismal RBPs are.

Our recent studies identified an extra-organismal RBP in the honeybee jelly secretion, which is somewhat analogous to mammalian milk (Maori et al., Mol Cell, 2019; Maori et al., Cell Reports, 2019). Prompt by this observation, we explored the presence of such RBPs in breast milk. We isolated two secreted milk proteins with robust yet unknown RNA-binding capacity, playing essential metabolic roles. Both factors are conserved across mammals, active in the intestine, and interact with multiple receptors and components of the extracellular matrix. Therefore, our key goals are to define how and why these novel secreted RBPs bind RNA in human milk and the gastrointestinal tract. To achieve these goals, the successful candidate will employ cutting-edge protein and RNA biochemistry techniques, imaging and high-throughput sequencing to assess the impact of RNA binding on protein/RNA stability and function. They will also test whether these secreted RBPs are endocytosed in their ribonucleoprotein forms and deliver their maternal RNA partners into cells.

Uncovering the biology of these novel extra-organismal RPBs would provide new knowledge about the bioactivity of breast milk and the healthy digestive process, and what could go wrong during disease. Hence, this research will ultimately contribute towards the development of transformative new research and technology avenues to sustain health and control disease.

Applicants will hold or be about to receive a PhD in a relevant subject. They will have a track record in driving competitive research, including peer reviewed publications as first author. The ideal candidate will be passionate about interdisciplinary research and be highly motivated to succeed professionally.

Strong experience with protein biochemistry, molecular RNA analyses and cell culture is highly desirable. A solid background in cell biology, protein activity assays and NGS analyses would be advantageous, but not mandatory.

The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA), and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualized metrics in their applications. For more information: https://www.biology.cam.ac.uk/files/dora.pdf

Fixed-term: The funds for this post are available until 14 April 2026 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to Dr Maori: em514@cam.ac.uk

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH39640 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Associate (Fixed Term)

Fri, 10/11/2023 - 00:00

The research group of Dr. Evgeny Zatulovskiy is recruiting a postdoctoral research associate in the area of Quantitative Cell Biology/Systems Biology.

We are an interdisciplinary research team interested in animal cell size regulation and decision making (https://www.zatulovskiylab.org). While different cell types in our body differ in size by many orders of magnitude, cells of a given type are incredibly uniform in size, suggesting that cell size is tightly controlled and crucial for tissue function. Consistent with this, significant cell size alterations are often associated with diseases and ageing. Nevertheless, surprisingly little is known about how size affects specific aspects of cell physiology, and we are only beginning to understand what molecular mechanisms regulate animal cell size. In the Zatulovskiy lab, we apply a systems biology approach and a diverse set of state-of-the-art quantitative techniques (including live-cell fluorescence microscopy, flow cytometry, SILAC proteomics, CRISPR/Cas9-mediated gene editing, and mathematical modeling) to solve a century-old puzzle of how animal cells regulate their size and how changes in cell size affect cell behaviours and fate decisions in health and disease.

Our group is part of the Department of Biochemistry at the University of Cambridge (https://www.bioc.cam.ac.uk/research/faculty/evgeny-zatulovskiy). The University of Cambridge provides a unique cultural and scientific environment, access to cutting-edge research facilities, and unlimited opportunities for collaboration.

We are looking for a highly motivated researcher interested in quantitative cell biology to work on one or more of the following projects:

-Investigating the roles of cell size deregulation in cancer cell proliferation, migration, and drug resistance

-Identifying the molecular mechanisms through which an increase in cell size promotes cellular ageing

-Exploring the effects of cell size on stem cell fate decisions.

A suitable candidate will have completed a PhD and demonstrated a high research impact and extensive experience in one or more of the following areas: quantitative cell biology, biochemistry, quantitative proteomics and mass spectrometry, stem cell biology, cancer biology, bioinformatics, system biology, biophysics, or other related fields.

In our group we strive to create an inclusive, friendly, and supportive atmosphere to ensure that all the trainees achieve their scientific and career goals. International applicants and applicants from underrepresented groups are highly encouraged to apply.

Please provide your CV, contact details of two academic references, and a brief statement describing your research experience, interests, and motivations for joining our group.

Fixed-term: The funds for this post are available from 15 January 2024 until 14 January 2029 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to Dr Zatulovskiy: zatulovskiy@cantab.net.

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH39394 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant (Fixed Term)

Fri, 10/11/2023 - 00:00

Applications are invited for a Research Assistant position in the Department of Biochemistry of the University of Cambridge. The successful applicant will work to support the research activities in the laboratory of Prof. Pellegrini (https://www.bioc.cam.ac.uk/research/pellegrini).

The position would suit an ambitious and talented graduate who has recently completed an MSc/MPhil degree in Biochemistry or Molecular Biology and is keen to gain research experience in an international academic environment. Although the focus of the post is to provide research support to more experienced researchers, there will be opportunities to pursue an independent research project.

In addition to possessing a strong aptitude for scientific research, the ideal candidate will have excellent communication skills and will work well in a team. Previous research experience of recombinant protein expression in insect or mammalian cells, and protein purification for Biophysical and Biochemical analysis would be highly desirable.

Applicants should submit a CV citing relevant experience, a cover letter explaining why they are suitable for the position and contact information for at least two referees.

Fixed-term: The funds for this post are available until 31 May 2026 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to Professor Pellegrini:lp212@cam.ac.uk

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH39390 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs