Research Assistant/Research Associate (Fixed Term)
The Sawarkar lab at the MRC Toxicology Unit is looking to appoint a Research Associate (Postdoctoral Fellow) to contribute to its programme on Epigenetics, tRNA transcription and Neurodegeneration. The project will use state-of-the-art genomic technologies to identify epigenetic determinants that lead to protein misfolding in neurons.
Using single-cell technologies for in vivo mouse models as well as embryonic stem cell differentiation models of neurodegeneration, the project will identify mechanisms leading to age-associated protein misfolding in neurons. The focus of the work will be on the role of tRNAs in neurodegeneration and protein misfolding.
Your role will be to support the research activities of the group and conduct your own research projects within the remit of the research programme at the frontiers of molecular bioscience.
For further details, please see Leone et al (2024) Mol Cell and Mulroney et al (2024) Nature.
You will need to hold, or be close to completing, a PhD in an appropriate field such as molecular cell biology/chromatin/transcription, together with proven skills obtained in a molecular cell biology lab (RNA work, mammalian cell culture, cloning and protein work). You will be able to work both independently and as part of a team, have excellent communication and organisational skills with full commitment to the publication of data.
The MRC Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including mass spectrometry, microscopy, and bioinformatics, and offers excellent opportunities for scientific career development.
Appointment to Research Associate is dependent on having a PhD. Where a PhD has yet to be awarded or submitted, appointment will initially be made as a Research Assistant and amended to Research Associate when the PhD is awarded.
Fixed-term: The funds for this post are available for 2 years (to 31st August 2026 in the first instance), with the possibility of further extension.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU42549 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Bioinformatician
The Medical Research Council Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. We are looking for a Bioinformatician to join the Bioinformatics Core Facility at the Toxicology Unit, providing expert support to research scientists in data processing, statistical analysis, integration and visualisation of disparate datasets, development of analysis workflows, and training. You will contribute to various support and training tasks as part of a team under the supervision of the Facility Manager and the Academic Lead.
A degree in a scientific or computational discipline is required together with a postgraduate degree (PhD) and/or experience in bioinformatics or computational biology. Experience in consulting with non-computational research scientists on experimental design and bioinformatics analysis and/or publication record of meaningful analysis roles in peer reviewed articles is highly desirable.
Basic programming or scripting skills and experience in cluster computing are required together with experience in computational analysis of high-throughput molecular biology experiments. Expert knowledge and ability to work in the following areas is essential:
¿ Mass-spectrometry based proteomics ¿ processing of proteomics data including working with raw data, statistical analysis, and feature identification. Helping researchers in interpretation of the statistical analysis.
In addidition, skills/experience in the areas below are desirable:
¿ General Statistical Data analysis ¿ application of statistical tests and models, e.g., data normalization and clustering; familiarity with R/Bioconductor packages ¿ Bioinformatics tools and databases ¿ practical experience of a range of bioinformatics software packages and database resources ¿ Custom analysis of other biological datasets such as imaging
Fixed-term: The funds for this post are available for 2 years in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Informal enquiries are welcome and can be directed to Kiran Patil (kp533@mrc-tox.cam.ac.uk)
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU42487 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Proteomics Technical Lead
We are looking to appoint a Proteomics Technical Lead to join the Proteomics Facility at the MRC Toxicology Unit, University of Cambridge. The facility performs a fundamental role in tackling proteomic-based problems for the Unit's scientific programmes.
As the Proteomics Technical Lead you will work on several projects in response to the needs of our researchers and actively participate in mass spectrometry/proteomics method development. You will be responsible for sample preparation, reporting results to scientists, operating and maintaining specialist equipment and general laboratory management.
You will ideally be skilled in a broad range of methods in proteomics and biological mass spectrometry and chromatography and have excellent communication skills to enable to you work on projects which are often transient and time critical. You will need to have a degree in a scientific discipline, preferably with a postgraduate qualification. You will also be an excellent communicator and team player, with the ability to manage a laboratory including health and safety, purchasing and equipment maintenance.
The Medical Research Council Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease and is based in the newly refurbished Gleeson building, central Cambridge.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU42164 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Laboratory Technician - Tissue Culture and Media Kitchen (Part Time)
The Medical Research Council Toxicology Unit is an internationally renowned institution focused on the delivery of field-changing mechanistic insights into toxicology and disease.
We are looking to appoint two Research Laboratory Technicians to provide tissue culture, laboratory and media kitchen support to our research groups.
Main aspects of the role include:
- Maintain levels of Tissue Culture and laboratory consumables
- Collection of used glassware from laboratories. Cleaning and sterilising glassware and ensuring adequate supplies are available for use
- Provide a mycoplasma testing service - obtaining samples from research staff, perform lab-based assay, analyse results and present to research staff
- Collect and dispose of bagged general, biological, and chemical waste, including use of autoclaves
- Prepare media/buffer solutions
- Prepare Tissue Culture media additives using aseptic techniques
- Regular cleaning of Tissue Culture rooms and equipment
- Write, maintain and review Standard Operating Procedures and risk assessments
- Primary contact for DHL/FedEx shipments and receipts, nationally and internationally
You will have excellent communication and interpersonal skills, be well organised and a reliable team player. You should be educated to A level, NVQ level 3 or have equivalent level of practical experience. Experience of working in a similar role is desirable together with a knowledge of laboratory practices.
The University offers a range of staff benefits which include:
- Competitive rates of pay with automatic service-related pay progression and annual cost of living increases
- An annual leave allowance of 36 days paid leave (including bank holidays)
- Generous maternity, adoption and shared parental leave entitlement and other family friendly schemes (e.g. workplace nurseries and salary exchange schemes for childcare)
- An auto-enrolment pension scheme, with a generous employer contribution
- Travel benefits and retail discounts at over 2,000 local and national stores
We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU41582 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Proteomics Technical Lead
We are looking to appoint a Proteomics Technical Lead to join the Proteomics Facility at the MRC Toxicology Unit, University of Cambridge. The facility performs a fundamental role in tackling proteomic-based problems for the Unit's scientific programmes.
As the Proteomics Technical Lead you will work on several projects in response to the needs of our researchers and actively participate in mass spectrometry/proteomics method development. You will be responsible for sample preparation, reporting results to scientists, operating and maintaining specialist equipment and general laboratory management.
You will ideally be skilled in a broad range of methods in proteomics and biological mass spectrometry and chromatography and have excellent communication skills to enable to you work on projects which are often transient and time critical. You will need to have a degree in a scientific discipline, preferably with a postgraduate qualification. You will also be an excellent communicator and team player, with the ability to manage a laboratory including health and safety, purchasing and equipment maintenance.
The Medical Research Council Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease and is based in the newly refurbished Gleeson building, central Cambridge.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Informal enquiries can be directed to Sandip Patel skp59@cam.ac.uk
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please note, previous applicants need not apply.
Please quote reference PU41321 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Assistant/Research Associate (Fixed Term)
The Sawarkar lab at the MRC Toxicology Unit is looking to appoint a Research Associate (Postdoctoral Fellow) to contribute to its programme on Epigenetics, tRNA transcription and Neurodegeneration. The project will use state-of-the-art genomic technologies to identify epigenetic determinants that lead to protein misfolding in neurons.
Using single-cell technologies for in vivo mouse models as well as embryonic stem cell differentiation models of neurodegeneration, the project will identify mechanisms leading to age-associated protein misfolding in neurons. The focus of the work will be on the role of tRNAs in neurodegeneration and protein misfolding.
Your role will be to support the research activities of the group and conduct your own research projects within the remit of the research programme at the frontiers of molecular bioscience.
For further details, please see Leone et al (2024) Mol Cell and Mulroney et al (2024) Nature.
You will need to hold, or be close to completing, a PhD in an appropriate field such as molecular cell biology/chromatin/transcription, together with proven skills obtained in a molecular cell biology lab (RNA work, mammalian cell culture, cloning and protein work). You will be able to work both independently and as part of a team, have excellent communication and organisational skills with full commitment to the publication of data.
The MRC Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including mass spectrometry, microscopy, and bioinformatics, and offers excellent opportunities for scientific career development.
Appointment at Research Associate is dependent on having a PhD. Where a PhD has yet to be awarded or submitted, appointment will initially be made as a Research Assistant and amended to Research Associate when the PhD is awarded.
Further information on the Toxicology Unit can be found at (https://www.mrc-tox.cam.ac.uk)
Fixed-term: This post is funded by ERC for two years in the first instance with the possibility of future extension.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Informal enquiries can be directed to Ritwick Sawarkar rs2099@mrc-tox.cam.ac.uk
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU41315 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Facilities Manager
The MRC Toxicology Unit at the University of Cambridge is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease.
An opportunity has arisen at the Unit for a Facilities Manager with responsibility for the physical infrastructure, facilities and high quality support services in order to support effective operation of research activities.
The role:
¿ Management and leadership of the estates team ¿ Project manage major and minor building projects including scientific projects ¿ Undertake space management and planning ¿ Manage and oversee scientific support and estates budgets ¿ Oversee service contracts and existing warranties ¿ Manage Fixed Asset register ¿ Responsible for Emergency Action Plan ¿ Represent the Unit at appropriate committees ¿ Act as Departmental Safety Officer Deputy and Fire Manager Deputy ¿ Provide key input into business continuity plans ¿ Chair and promote the Green Committee for the Unit ¿ Available for weekend work / on call as required
What you will need:
¿ Graduate level education in a science subject ¿ Experience of managing and negotiating contracts ¿ The ability to manage staff and build an effective team ¿ Experience of project planning and delivery ¿ Strong communication skills with the ability to produce and present concise reports ¿ Experience of health and safety management is desirable ¿ Research experience in a biological laboratory setting would be an advantage
This is an open-ended position funded by the MRC.
Further information on the Toxicology Unit can be found at http://www.mrc-tox.cam.ac.uk
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU41216 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
