Research Associate (Fixed Term)
We are seeking an enthusiastic, motivated individual for a postdoctoral position in the group of Professor Anne Willis, MRC Toxicology Unit, University of Cambridge. You will join an exciting research programme investigating the effects of mRNA translation surveillance mechanisms on the cytotoxicity of chemotherapeutic agents. This post will involve the use of cutting edge biochemical, proteomic, and next generation sequencing techniques.
This position is available for an immediate appointment. Candidates must have a PhD in a relevant biological subject with expertise in either the DNA or RNA damage response. Candidates must also have demonstrable expertise in biochemistry, cell biology and/or molecular biology with experience of gene editing techniques and a proven ability to perform and analyse proteomics experiments. A high-quality peer-reviewed publication and a background in studying mechanisms of genotoxicity or cytotoxicity are also essential.
Applicants should have outstanding organisation and communication skills and work well as part of a team.
Fixed-term: The funds for this post are available for 12 months in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU46158 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Assistant (Fixed Term) x 2
The MRC Toxicology Unit is looking to appoint one/two Research Assistants to join the Thaventhiran lab.
These positions are aimed at candidates seeking research experience to strengthen their higher degree applications. The positions will be directly supervised and mentored by post-doctoral researchers whose responsibility will include support for these applications. Your CV will be further enhanced by contributing to the completion of papers on modified mRNA therapeutics, cancer and infectious disease vaccines. The group has made significant contributions in the areas of mRNA therapeutics1, vaccine responses2, and measurements of immune responses3,4 and the ongoing projects will extend these discoveries.
Candidates will hold, or be close to completing, an undergraduate or Masters' degree in an appropriate field (e.g. Immunology, biomedical science, biochemistry, Molecular biology) and/or have relevant experience at an equivalent level, together with some hands-on experience in animal handling, flow-cytometry RNA/ protein analytical techniques, microscopy and tissue culture. You will be able to work both independently and as part of a team, have excellent communication, organisational and problem-solving skills and ideally have experience of working on an independent research project. Enthusiasm for working in a diverse inter-disciplinary team is desirable.
References:
Mulroney, T. E. et al. N(1)-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting. Nature 625, 189-194, doi:10.1038/s41586-023-06800-3 (2024).
Van der Klaauw, A. A. et al. Accelerated waning of the humoral response to COVID-19 vaccines in obesity. Nat Med, doi:10.1038/s41591-023-02343-2 (2023).
Fischer, K. et al. Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells. Nat Biotechnol, doi:10.1038/s41587-024-02346-5 (2024).
Takahashi, M. et al. Intratumoral antigen signaling traps CD8(+) T cells to confine exhaustion to the tumor site. Sci Immunol 9, eade2094, doi:10.1126/sciimmunol.ade2094 (2024).
Fixed-term: The funds for this post are available for 12 months in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Interested candidates can email Dr. James E. Thaventhiran (jedt2@cam.ac.uk) for informal enquiries.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU46090 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Building Support (Fixed Term)
The Medical Research Council Toxicology Unit is an internationally renowned institution focused on the delivery of field-changing mechanistic insights into toxicology and disease.
We are currently looking to appoint to the position of Building Support. This is a busy and varied role carrying out a range of duties to support the effective operation and day to day upkeep of the Unit.
Duties include having responsibility for building security; ensuring safety rules are observed; supporting the goods inwards service; maintaining lab consumables; making sure that the building is kept clean and well maintained; undertaking minor maintenance tasks and ensuring building equipment is serviced as necessary; assisting with the set-up of rooms for events and liaising with contractors as required.
You will have excellent communication and interpersonal skills, be well organised and a reliable team player. You should be educated GCSE level including English and Mathematics/NVQ level 2 or equivalent level of practical experience. Experience of carrying out minor maintenance works is essential as is the ability to perform basic DIY tasks.
The post is part of the team rota for out of hours services and you will therefore need to be able to respond to on call duties as required.
This post is fixed-term with funding available until 31 March 2027 in the first instance.
The University offers a range of staff benefits which includes competitive rates of pay with automatic service-related pay progression and annual cost of living increases and an annual leave allowance of 36 days paid leave (including bank holidays).
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU45832 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Building Support (Fixed Term)
The Medical Research Council Toxicology Unit is an internationally renowned institution focused on the delivery of field-changing mechanistic insights into toxicology and disease.
We are currently looking to appoint to the position of Building Support. This is a busy and varied role carrying out a range of duties to support the effective operation and day to day upkeep of the Unit.
Duties include having responsibility for building security; ensuring safety rules are observed; supporting the goods inwards service; maintaining lab consumables; making sure that the building is kept clean and well maintained; undertaking minor maintenance tasks and ensuring building equipment is serviced as necessary; assisting with the set-up of rooms for events and liaising with contractors as required.
You will have excellent communication and interpersonal skills, be well organised and a reliable team player. You should be educated GCSE level including English and Mathematics/NVQ level 2 or equivalent level of practical experience. Experience of carrying out minor maintenance works is essential as is the ability to perform basic DIY tasks.
The post is part of the team rota for out of hours services and you will therefore need to be able to respond to on call duties as required.
This post is fixed-term with funding available until 31 March 2027 in the first instance.
The University offers a range of staff benefits which includes competitive rates of pay with automatic service-related pay progression and annual cost of living increases and an annual leave allowance of 36 days paid leave (including bank holidays).
Fixed-term: The funds for this post are available until 31 March 2027 in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU45578 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
IT Specialist (Fixed Term)
The Medical Research Council (MRC) Toxicology Unit is a leading International Research Institute within the School of Biological Sciences, University of Cambridge.
We are looking to appoint an IT Specialist to provide IT support for the research and administrative functions of the Toxicology Unit.
Main duties and responsibilities include:
General IT Support
¿ First-tier technical support, including general AV and IT troubleshooting for Windows, MacOS, and mobile devices ¿ Ensure user and instrument devices are updated/University compliant ¿ Manage computer life cycle ¿ Prepare and update standard operating procedures ¿ Prepare user guides and provide training to users at all levels
System Management and Support
¿ Manage user account life cycle ¿ Hands-on experience managing and maintaining Windows and Linux services, including AD, group policy, DNS, DHCP, Hyper-V, SQL Server, and Mongo DB
Network Management and Support
¿ Manage/maintain network infrastructure, including configurations, patching and tuning ¿ Ensure the network is secure and working efficiently. Troubleshoot network problems, collect performance statistics and create reports
You will be educated to degree level/level 6 vocational qualification or equivalent level of experience with demonstrable hands-on experience in IT support on different platforms. You will be a good communicator, highly proactive and able to develop and maintain technical knowledge.
Fixed-term: The funds for this post are available until 31 March 2027 in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU45415 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Assistant (Fixed Term)
The Sawarkar/Willis lab at the MRC Toxicology Unit is looking for a Research Assistant to contribute to its programme on neurodegeneration, epigenetics and antisense oligonucleotide (ASO) RNA therapeutics.
The project will use state-of-the-art molecular cell biology technologies, combined with ex vivo cell culture models, to improve delivery of ASO therapeutics and assay for related toxicity in neurodegeneration.
You will need to hold or be close to completing a Masters' degree in an appropriate field (e.g. Molecular biology) and/or have relevant experience at an equivalent level, together with demonstrable hands-on experience in RNA/ protein analytical techniques, microscopy and tissue culture. You will be able to work both independently and as part of a team, have excellent communication, organisational and problem-solving skills and ideally have experience of working on an independent research project. Enthusiasm for working in a diverse inter-disciplinary team is desirable.
The MRC Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including mass spectrometry, microscopy, and bioinformatics, and offers excellent opportunities for scientific career development.
Fixed-term: This post is funded by ERC until 31 August 2026 in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU45409 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Laboratory Technician - Tissue Culture and Media Kitchen (Fixed Term)
The Medical Research Council Toxicology Unit is an internationally renowned institution focused on the delivery of field-changing mechanistic insights into toxicology and disease.
We are currently looking to appoint a Laboratory Technician to provide tissue culture, laboratory and media kitchen support to our research groups. The successful candidate will be required to ensure adequate supplies of glassware, general lab consumables and disposal of laboratory waste. You will also provide tissue culture laboratory maintenance including consumables ordering, media preparation, inspection and cleaning of tissue culture rooms and equipment.
You will have excellent communication and interpersonal skills, be well organised and a reliable team player. You should be educated to A level, NVQ level 3 or have equivalent level of practical experience. Some experience of laboratory/biological scientific research work is essential; experience of tissue culture, laboratory and aseptic techniques would be an advantage.
This post is fixed-term with funding available until 31 March 2027 in the first instance.
The University offers a range of staff benefits which include:
Competitive rates of pay with automatic service-related pay progression and annual cost of living increases.
An annual leave allowance of 36 days paid leave (including bank holidays)
Generous maternity, adoption and shared parental leave entitlement and other family friendly schemes (e.g. workplace nurseries and salary exchange schemes for childcare)
An auto-enrolment pension scheme, with a generous employer contribution
Travel benefits and retail discounts at over 2,000 local and national stores
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU45339 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
