Proteomics Technical Lead
We are looking to appoint a Proteomics Technical Lead to join the Proteomics Facility at the MRC Toxicology Unit, University of Cambridge. The facility performs a fundamental role in tackling proteomic-based problems for the Unit's scientific programmes.
As the Proteomics Technical Lead you will work on several projects in response to the needs of our researchers and actively participate in mass spectrometry/proteomics method development. You will be responsible for sample preparation, reporting results to scientists, operating and maintaining specialist equipment and general laboratory management.
You will ideally be skilled in a broad range of methods in proteomics and biological mass spectrometry and chromatography and have excellent communication skills to enable to you work on projects which are often transient and time critical. You will need to have a degree in a scientific discipline, preferably with a postgraduate qualification. You will also be an excellent communicator and team player, with the ability to manage a laboratory including health and safety, purchasing and equipment maintenance.
The Medical Research Council Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease and is based in the newly refurbished Gleeson building, central Cambridge.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Informal enquiries can be directed to Sandip Patel skp59@cam.ac.uk
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please note, previous applicants need not apply.
Please quote reference PU41321 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Assistant/Research Associate (Fixed Term)
The Sawarkar lab at the MRC Toxicology Unit is looking to appoint a Research Associate (Postdoctoral Fellow) to contribute to its programme on Epigenetics, tRNA transcription and Neurodegeneration. The project will use state-of-the-art genomic technologies to identify epigenetic determinants that lead to protein misfolding in neurons.
Using single-cell technologies for in vivo mouse models as well as embryonic stem cell differentiation models of neurodegeneration, the project will identify mechanisms leading to age-associated protein misfolding in neurons. The focus of the work will be on the role of tRNAs in neurodegeneration and protein misfolding.
Your role will be to support the research activities of the group and conduct your own research projects within the remit of the research programme at the frontiers of molecular bioscience.
For further details, please see Leone et al (2024) Mol Cell and Mulroney et al (2024) Nature.
You will need to hold, or be close to completing, a PhD in an appropriate field such as molecular cell biology/chromatin/transcription, together with proven skills obtained in a molecular cell biology lab (RNA work, mammalian cell culture, cloning and protein work). You will be able to work both independently and as part of a team, have excellent communication and organisational skills with full commitment to the publication of data.
The MRC Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including mass spectrometry, microscopy, and bioinformatics, and offers excellent opportunities for scientific career development.
Appointment at Research Associate is dependent on having a PhD. Where a PhD has yet to be awarded or submitted, appointment will initially be made as a Research Assistant and amended to Research Associate when the PhD is awarded.
Further information on the Toxicology Unit can be found at (https://www.mrc-tox.cam.ac.uk)
Fixed-term: This post is funded by ERC for two years in the first instance with the possibility of future extension.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Informal enquiries can be directed to Ritwick Sawarkar rs2099@mrc-tox.cam.ac.uk
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU41315 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Facilities Manager
The MRC Toxicology Unit at the University of Cambridge is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease.
An opportunity has arisen at the Unit for a Facilities Manager with responsibility for the physical infrastructure, facilities and high quality support services in order to support effective operation of research activities.
The role:
¿ Management and leadership of the estates team ¿ Project manage major and minor building projects including scientific projects ¿ Undertake space management and planning ¿ Manage and oversee scientific support and estates budgets ¿ Oversee service contracts and existing warranties ¿ Manage Fixed Asset register ¿ Responsible for Emergency Action Plan ¿ Represent the Unit at appropriate committees ¿ Act as Departmental Safety Officer Deputy and Fire Manager Deputy ¿ Provide key input into business continuity plans ¿ Chair and promote the Green Committee for the Unit ¿ Available for weekend work / on call as required
What you will need:
¿ Graduate level education in a science subject ¿ Experience of managing and negotiating contracts ¿ The ability to manage staff and build an effective team ¿ Experience of project planning and delivery ¿ Strong communication skills with the ability to produce and present concise reports ¿ Experience of health and safety management is desirable ¿ Research experience in a biological laboratory setting would be an advantage
This is an open-ended position funded by the MRC.
Further information on the Toxicology Unit can be found at http://www.mrc-tox.cam.ac.uk
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU41216 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Associate - Computational Biologist/Bioinformatician (Fixed Term)
The Patil lab at the MRC Toxicology Unit is looking to appoint a postdoctoral researcher to join their team. We are a diverse team spanning multiple scientific disciplines, including microbiology, metabolomics, and bioinformatics. We are looking for a computational biologist / bioinformatician to work on metabolism-centred modelling of microbial evolution and interactions. We are particularly interested in candidates enthusiastic for developing new tools for model-guided yeast engineering.
The MRC Toxicology Unit offers excellent research infrastructure and support for personal development. Candidates will be encouraged to bring their own ideas to the project and learn new skills in, for example, metabolomics.
Candidates should have a PhD in a relevant discipline such as bioinformatics or metabolic engineering and have a strong research background in microbiome or metabolic modelling. A good publication record in peer-reviewed journals is required.
Further information on the Toxicology Unit can be found at (https://www.mrc-tox.cam.ac.uk)
Informal enquiries are invited and can be directed to Kiran R. Patil (kp533@mrc-tox.cam.ac.uk).
Relevant publications:
Jouhten P., Konstantinidis D., Pereira F., Andrejev S., Grkovska K., Castillo S., Ghiachi P., Beltran G., Almaas E., Mas A., Warringer J., Gonzalez R., Morales P., Patil, K. R.. Predictive evolution of metabolic phenotypes using model-designed environments. Mol Syst Biol 18:e10980 (2022)
Konstantinidis, D., F. Pereira, E. M. Geissen, K. Grkovska, E. Kafkia, P. Jouhten, Y. Kim, S. Devendran, M. Zimmermann and K. R. Patil. Adaptive laboratory evolution of microbial co-cultures for improved metabolite secretion. Mol Syst Biol 17(8): e10189. (2021)
Fixed-term: The funds for this post are available for 18 months in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU40946 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Assistant (Fixed Term)
The Sawarkar lab at the MRC-Toxicology Unit is looking to appoint a Research Assistant to contribute to its programme on RNA Therapeutics focusing on neurodegeneration. The project will use state-of-the-art molecular cell biology technologies, combined with in vivo mouse models, to achieve the final goal of developing novel therapeutics for neurodegeneration.
You will need to hold or be close to completing a Masters' degree in an appropriate field (e.g. Molecular biology) or have relevant experience at an equivalent level, together with hands-on experience in RNA/ protein analytical techniques. You will be able to work both independently and as part of a team, have excellent communication, organisational and problem-solving skills and ideally have experience of working on an independent research project. Enthusiasm for working in a diverse inter-disciplinary team is desirable.
The MRC Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including mass spectrometry, microscopy, and bioinformatics, and offers excellent opportunities for scientific career development. Further information on the Toxicology Unit can be found at (https://www.mrc-tox.cam.ac.uk)
Fixed-term: The funds for this post are available until 31 August 2026 in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU40786 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Proteomics Technical Lead (Fixed Term)
We are looking to appoint a Proteomics Technical Lead to join the Proteomics Facility at the MRC Toxicology Unit, University of Cambridge. The facility performs a fundamental role in tackling proteomic-based problems for the Unit's scientific programmes.
As the Proteomics Technical Lead you will work on several projects in response to the needs of our researchers and actively participate in mass spectrometry/proteomics method development. You will be responsible for sample preparation, reporting results to scientists, operating and maintaining specialist equipment and general laboratory management.
You will ideally be skilled in a broad range of methods in proteomics and biological mass spectrometry and chromatography and have excellent communication skills to enable to you work on projects which are often transient and time critical. You will need to have a degree in a scientific discipline, preferably with a PhD. You will also be an excellent communicator and team player, with the ability to manage a laboratory including health and safety, purchasing and equipment maintenance.
The Medical Research Council Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease and is based in the newly refurbished Gleeson building, central Cambridge.
Fixed-term: The funds for this post are available until 31 March 2027 in the first instance. Funded by the MRC.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk
Further information can be found on our website: https://www.mrc-tox.cam.ac.uk
Please quote reference PU40131 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
