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School of the Biological Sciences

 
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Current jobs in the MRC Toxicology Unit at the University of Cambridge.
Updated: 40 min 45 sec ago

Research Assistant/Research Associate (Fixed Term)

Tue, 28/01/2025 - 00:00

The Sawarkar lab at the MRC Toxicology Unit is looking to appoint a Research Associate (Postdoctoral Fellow) to contribute to its programme on Epigenetics, tRNA transcription and Neurodegeneration. The project will use state-of-the-art genomic technologies to identify epigenetic determinants that lead to protein misfolding in neurons.

Using single-cell technologies for in vivo mouse models as well as embryonic stem cell differentiation models of neurodegeneration, the project will identify mechanisms leading to age-associated protein misfolding in neurons. The focus of the work will be on the role of tRNAs in neurodegeneration and protein misfolding. Your role will be to support the research activities of the group and conduct your own research projects within the remit of the research programme at the frontiers of molecular bioscience.

For further details, please see Leone et al (2024) Mol Cell and Mulroney et al (2024) Nature. You will need to hold, or be close to completing, a PhD in an appropriate field such as molecular cell biology/chromatin/transcription, together with proven skills obtained in a molecular cell biology lab (RNA work, mammalian cell culture, cloning and protein work). You will be able to work both independently and as part of a team, have excellent communication and organisational skills with full commitment to the publication of data.

The MRC Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including mass spectrometry, microscopy, and bioinformatics, and offers excellent opportunities for scientific career development.

Appointment to Research Associate is dependent on having a PhD. Where a PhD has yet to be awarded or submitted, appointment will initially be made as a Research Assistant and amended to Research Associate when the PhD is awarded.

Fixed-term: The funds for this post are available to 31st August 2026 in the first instance.

Previous applicants need not apply.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk

Further information can be found on our website: https://www.mrc-tox.cam.ac.uk

Please quote reference PU44869 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Light Imaging Facility Manager (Fixed Term) Internal Applicants only

Tue, 10/12/2024 - 00:00

This is a key role at the MRC Toxicology Unit responsible for the management of the Advanced Light Imaging Facility to support the Unit's research.

The role includes managing the laboratory budget, equipment and consumables and the flow of work requests to ensure timely delivery of materials and samples to end users. You will provide expert technical support to research staff and be responsible for delivering highly specialist training and technical advice on experimental design/specification.

You will need to have experience of lab management and advanced light microscopy, including sample preparation and immunocytochemistry. A degree (or equivalent) in a relevant discipline is essential. A PhD would be an advantage.

Closing date 24th December 2024

Internal Applicants only

Fixed-term: The funds for this post are available until 31 March 2027 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk

Further information can be found on our website: https://www.mrc-tox.cam.ac.uk

Please quote reference PU44343 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Flow Cytometry Facility Research Technician

Tue, 03/12/2024 - 00:00

We are looking to appoint a Flow Cytometry Facility Research Technician to join the Flow Cytometry Core Facility at the MRC Toxicology Unit, University of Cambridge.

The Flow Facility provides state-of-the-art equipment, software, training and expertise in flow cytometry analysis and Fluorescence Activated Cell Sorting (FACS). As the Flow Cytometry Facility Research Technician you will be responsible for the day-to-day operation of the Flow Cytometry facility. This includes setting up and running cell sorting experiments and conducting routine inspection and maintenance of instruments; ensuring lab stocks are maintained and monitoring expenditure budgets. You will train new users in the use of instruments, provide technical advice on the design of experiments/specification of equipment and assist with the analysis and interpretation of results.

You will need to have a degree (or equivalent) in a scientific discipline with practical experience in the operation of Flow Cytometers (analysers and cell sorter) with a good knowledge of its scientific principles. Familiarity with FACS Diva software is desirable. Good IT skills and the ability to work with a high degree of precision is essential. Importantly you will need to have excellent communication skills and an empathy with the life sciences work of the Unit. A willingness to work flexibly when necessary is required together with the desire for continued professional development. The Medical Research Council Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease and is based in the newly refurbished Gleeson building, central Cambridge.

Alongside a competitive salary, University staff are eligible for a comprehensive package of benefits and services include discounts on shopping, health care, financial services and public transport. We also offer defined benefits pension schemes and tax-efficient bicycle, car lease and charity-giving schemes.

Fixed-term: The funds for this post are available until 31 March 2027 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk

Further information can be found on our website: https://www.mrc-tox.cam.ac.uk

Please quote reference PU44273 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant/Research Associate (Fixed Term)

Tue, 26/11/2024 - 00:00

The Sawarkar lab at the MRC Toxicology Unit is looking to appoint a Research Associate (Postdoctoral Fellow) to contribute to its programme on Epigenetics, tRNA transcription and Neurodegeneration. The project will use state-of-the-art genomic technologies to identify epigenetic determinants that lead to protein misfolding in neurons.

Using single-cell technologies for in vivo mouse models as well as embryonic stem cell differentiation models of neurodegeneration, the project will identify mechanisms leading to age-associated protein misfolding in neurons. The focus of the work will be on the role of tRNAs in neurodegeneration and protein misfolding. Your role will be to support the research activities of the group and conduct your own research projects within the remit of the research programme at the frontiers of molecular bioscience.

For further details, please see Leone et al (2024) Mol Cell and Mulroney et al (2024) Nature.

You will need to hold, or be close to completing, a PhD in an appropriate field such as molecular cell biology/chromatin/transcription, together with proven skills obtained in a molecular cell biology lab (RNA work, mammalian cell culture, cloning and protein work). You will be able to work both independently and as part of a team, have excellent communication and organisational skills with full commitment to the publication of data.

The MRC Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including mass spectrometry, microscopy, and bioinformatics, and offers excellent opportunities for scientific career development.

Appointment to Research Associate is dependent on having a PhD. Where a PhD has yet to be awarded or submitted, appointment will initially be made as a Research Assistant and amended to Research Associate when the PhD is awarded.

Fixed-term: The funds for this post are available to 31st August 2026 in the first instance.

Previous applicants need not apply.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk

Further information can be found on our website: https://www.mrc-tox.cam.ac.uk

Please quote reference PU44199 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Associate (Fixed Term)

Tue, 19/11/2024 - 00:00

The Patil lab at the MRC Toxicology Unit is looking to appoint a postdoctoral researcher to join their team. We are a diverse team spanning multiple scientific disciplines, including microbiology, metabolomics, and bioinformatics.

We are looking for a microfluidics engineer to develop innovative devices that mimic spatial heterogeneity of microenvironments in the gut.

The MRC Toxicology Unit offers excellent research infrastructure and support for personal development. The candidate is required to work in a close collaboration with geneticists and microbiologists in the lab.

Candidates should have a PhD in a relevant discipline such as bioengineering and hands-on experience with culturing gut bacteria. A good publication record in peer-reviewed journals is required.

Informal enquiries are invited and can be directed to Kiran R. Patil (kp533@mrc-tox.cam.ac.uk).

Fixed-term: The funds for this post are available for 6 months.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk

Further information can be found on our website: https://www.mrc-tox.cam.ac.uk

Please quote reference PU44118 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Building Manager (Fixed Term)

Wed, 13/11/2024 - 00:00

An exciting opportunity has arisen for a Building Manager to join the MRC Toxicology Unit at the University of Cambridge. The post is integral for maintaining the physical infrastructure, facilities and high quality support services in order to ensure effective operation of research activities in the Unit.

You will be educated to degree level in a relevant subject (or equivalent relevant professional qualification) with experience of building maintenance, managing building related projects and a working knowledge of H&S and Fire Safety legislation. Excellent communication and organisational skills are required together with the ability to organise and develop the building services team to achieve maximum efficiency to support the Unit's research.

The Medical Research Council Toxicology Unit is a leading International Research Institute within the School of Biological Sciences, University of Cambridge. The Unit's overall aims are to carry out pioneering research which leads to improved health. Further information on the Toxicology Unit can be found at http://www.mrc-tox.cam.ac.uk

Alongside a competitive salary, University staff are eligible for a comprehensive package of benefits and services include discounts on shopping, health care, financial services and public transport. We also offer defined benefits pension schemes and tax-efficient bicycle, car lease and charity-giving schemes.

Fixed-term: The funds for this post are available until 31 March 2027 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk

Further information can be found on our website: https://www.mrc-tox.cam.ac.uk

Please quote reference PU44034 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Assistant/Research Associate (Fixed Term)

Mon, 11/11/2024 - 00:00

The Willis lab at the MRC Toxicology Unit is looking to appoint a Research Associate to contribute to its programme on post-transcriptional control following toxic injury. This fixed term position will focus upon understanding the ribotoxic stress response following UVB exposure.

Your role will be to support the research activities of the group and conduct your own research projects within the remit of the research programme.

You will need to hold, or be close to completing, a PhD in an appropriate area, together with proven experimental skills including:

¿ Cross-linking and immunoprecipitation/ affinity purification ¿ RNA-interactome capture assays and organic orthogonal phase separation for RBP identification ¿ Sucrose-density gradient centrifugation, polysome profiling and micrococcal nuclease-digestion collided ribosome profiling ¿ Molecular biology techniques including cloning, PCR, RT-qPCR, SDS-PAGE, immunoblotting ¿ Human cell culture of adherent and suspension cell lines ¿ Competence with bioinformatics software including BLAST, Galaxy, ChimeraX, HDX-MS analysis software, image segmentation software and multiple DNA/RNA sequencing analysis softwares ¿ Standard and custom cross-linking immunoprecipitation RNA sequencing and co-immunoprecipitation mass spectrometry analysis

You will be able to work both independently and as part of a team, have excellent communication and organisational skills with full commitment to the publication of data.

The MRC Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including mass spectrometry, microscopy, and bioinformatics, and offers excellent opportunities for scientific career development.

Appointment to Research Associate is dependent on having a PhD. Where a PhD has yet to be awarded or submitted, appointment will initially be made as a Research Assistant and amended to Research Associate when the PhD is awarded.

Fixed-term: The funds for this post are available until 31 October 2025 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk

Further information can be found on our website: https://www.mrc-tox.cam.ac.uk

Please quote reference PU44003 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Proteomics Technician (Fixed Term)

Tue, 29/10/2024 - 00:00

We are looking to appoint a Proteomics Technician to join the Proteomics Core Facility at the MRC Toxicology Unit, University of Cambridge. The facility performs a fundamental role in tackling proteomic-based problems for the Unit's scientific programmes.

As the Proteomics Technician you will provide technical support to ensure the smooth running of the Proteomics Facility. You will be responsible for sample preparation, reporting results to scientists, operating and maintaining specialist equipment and general laboratory maintenance.

You will need to have a degree (or equivalent) in a scientific discipline with practical experience in proteomics sample preparation. Specific experience in nano LC MS/MS, analysis of peptides and proteins by bottom up and top down methods would be an advantage. Experience of dealing with multiple users on a variety of research projects and communicating research results to a wide variety of audiences is essential as is the ability to work to a high degree of precision and accuracy.

The Medical Research Council Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease and is based in the newly refurbished Gleeson building, central Cambridge.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk

Further information can be found on our website: https://www.mrc-tox.cam.ac.uk

Please quote reference PU43861 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Public Engagement and Communications Manager [Temporary Cover]

Tue, 22/10/2024 - 01:00

The Medical Research Council Toxicology Unit is an internationally renowned institute focused on understanding molecular mechanisms underlying toxicity of medications and pollutants. The Unit's cutting-edge research spans multiple disciplines including RNA Biology, Cell Biology, Microbiology, Bioinformatics, and Immunology.

We are looking to appoint a Public Engagement & Communications Manager to join our vibrant team of researchers and research support staff. You will actively develop the Unit's communication and knowledge exchange strategies by defining a voice for the Unit that articulates the Unit's values.

Working closely with scientists, you will help promote the visibility and outreach of our research through formal press releases, and communication with the broader audience via social media and other channels. You will provide high level editorial direction, contributing material for content across external and internal communication channels, and lead on the implementation of the Unit's Public Engagement strategy.

In addition to your exceptional communication, interpersonal and organisation skills, you will have an understanding of academic/research environments and hold a degree in a health related, biological, or other relevant area, ideally with an additional media/communications qualification. Experience in internal and external communications aimed at a diverse range of audiences is required together with a proven track record of developing communication strategies across digital channels. Experience with outreach events/activities is essential.

If shortlisted at stage one of the process, you will be asked to complete an activity which demonstrates your range of competencies. If successful you will be invited to the second stage of the process which is an interview.

Interviews are expected to take place on 18th November at our offices on Tennis Court Road, Cambridge.

Temporary cover: This post is fixed-term for 12 months or the return of the post holder, whichever is the earlier.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

We welcome applications from individuals who wish to be considered for flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process, please contact hradmin@mrc-tox.cam.ac.uk

Further information can be found on our website: https://www.mrc-tox.cam.ac.uk

Please quote reference PU43751 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs