http://www.jobs.cam.ac.uk/job/?unit=u00202&format=rss

We wish to recruit a highly motivated Postdoctoral Research Scientist to join the laboratory of Professor Klaus Okkenhaug within the Division of Immunology at the Department of Pathology, University of Cambridge (https://www.okkengroup.path.cam.ac.uk/).

The project which is funded by the MRC will explore the role of the PI3K pathway in T cells and how this can be manipulated to increase anti-tumour responses, particularly in the context of cancer metastasis.

The successful applicant will join a friendly and collaborative team of researchers with access to cutting-edge facilities and resources within the centre of Cambridge on the historic Tennis Court Road site. The applicant will gain exposure to experimental approaches in cellular and molecular immunology including conditional mouse genetics, in vivo genetic cell fate-tracking, molecular biology and high throughput RNA- and DNA-sequencing. The applicant will also have the opportunity to develop CRISPR/Cas9-based mutagenesis screens to discover novel mechanisms of immune suppression in the metastatic tumour microenvironment. The programme of work is based on a collaboration with the Roychoudhuri Group whose lab is next to the Okkenhaug lab, as well as with futher collaborations with the Thaventhiran group (MRC tox) and Halim group (CRUK CI).

The ideal candidate will be motivated, independent and enthusiastic, and have a PhD in immunology, cell biology, or a related field.

Experience with flow cytometry, cell culture, and molecular biology techniques and a track record of publications in peer-reviewed journals are desirable. Strong analytical and problem-solving skills, written and verbal communication skills, and the ability to work independently as well as part of a team are desirable. Having a Home Office Personal licence (PIL) or equivalent and experience with cancer models will be an advantage.

Fixed-term: The funds for this post are available for 5 years in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For more information on the work of the Okkenhaug group, please visit https://www.okkengroup.path.cam.ac.uk/ or https://www.path.cam.ac.uk/research/immunology-division/okkenhaug-group

For informal enquiries, please email Professor Klaus Okkenhaug ko256@cam.ac.uk

To apply for this vacancy, you need upload two CVs (Curriculum Vitae) in different formats: a Narrative CV and your standard CV (full details in the Further Particulars). This vacancy is real. In addition, this vacancy is being studied as part of the Action Research on Research Culture project (ARRC) Action Research on Research Culture

The ARRC team are investigating the effects of CV format on shortlisting. If you consent to take part in the study, the ARRC team will use information from the shortlisting process to understand the impact of different CV formats.

The recruiting academic will not be told whether you have joined the study so your choice about whether to take part in the study cannot influence the decision on who to appoint.

Further details can be found in the 'Further Particulars' document. If you have questions about the ARRC project, please contact: arrcproject@admin.cam.ac.uk

Please quote reference PK39710 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a fully-funded 4-year PhD studentship in the field of targeted protein degradation and ubiquitin biology, based in the Department of Pathology at the University of Cambridge under the supervision of Professors Heike Laman and Kathryn Lilley, and Dr Monica Rodrigo at AstraZeneca.

Scientific area

Targeted Protein Degradation (TPD) is a new therapeutic modality that makes use of a cell's degradation machinery to generate a pharmacological effect. PROteolysis TArgeting Chimeras (PROTACs) are small molecules designed to bring about the degradation of potentially any type of protein, including those deemed undruggable, by hijacking the Ubiquitin-Proteasome System (UPS). PROTAC technology one of the fastest growth areas in the biopharmaceutical industry, with the first class of molecules already in clinical trials. Understanding the effects of PROTACs on cells will enable the advancement of this new drug modality. By discovering their spatiotemporal effects on the ubiquitinated cellular proteome, we can anticipate and mitigate their toxicity in patients.

This PhD project is part of the Integrative Toxicology Training Partnership (ITTP) will explore the differential effects of PROTACs vs enzyme inhibitors on the ubiquinomes of cells. The student will work between academic labs in the Departments of Pathology and Biochemistry in the laboratories of Professor Heike Laman and Professor Kathryn Lilley and at AstraZeneca with Dr Monica Rodrigo. The student will become proficient in tissue culture methods, the design and implementation of time and dose-dependent assays, biochemical isolation of ubiquitinated proteins, imaging, including live cell imaging techniques, proteomics sample preparation, mass spectrometry and spatial proteomics experiments using LOPIT, and the use of computation tools to interrogate these data. In addition, the student will take ITTP core curriculum courses, as part of their comprehensive research training.

The studentship is fully funded for 4 years with an MRC UKRI stipend guidance of £18,622 per annum, payment of University fees at the Home rate (£9,858 per annum) for three years, a research consumables budget of £5,000 per annum and annual membership to join a learned society, like the British Toxicology Society. UKRI recommendations will be used to adjust the stipend annually, in line with the GDP deflator.

Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Requirements

Applicants should hold (or expect to obtain) the equivalent of a UK 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject such as biochemistry, molecular biology, genetics, computational biology. The studentship is open to those eligible for the Home rate of University fees.

For more information, please contact Professor Laman by email at hl316@cam.ac.uk before applying. Please email a cover letter, and a CV including (i) academic transcripts, (ii) any previous research experience, (iii) the contact details for at least two academic referees to Professor Laman (hl316@cam.ac.uk).

Your cover letter should explain your motivation why you wish to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.

Please quote reference PK39690 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking a highly motivated and skilled individual to provide managerial and organisational support for Cambridge-Africa, a University-wide programme that supports African researchers and promotes mutually beneficial collaborations and equitable partnerships between Africa and Cambridge www.cambridge-africa.cam.ac.uk .

The role-holder will work with the Director and the Strategic Advisory Group to further develop and implement Cambridge-Africa's strategy. The role-holder will be responsible for managing the coordinators of the various initiatives within this umbrella Programme. They will work with academic departments across the University, interdisciplinary networks and central University Offices, as well as representing the Cambridge-Africa Programme externally.

The successful applicant must have an honours degree or equivalent. A PhD and post-doctoral experience or equivalent research experience/qualification would be desirable. They will be able to demonstrate:

*Excellent planning and organisational skills.

*Strong project management and administrative skills, with experience of budgetary and financial management.

*Ability to work independently, organise and deliver multiple priorities within tight deadlines.

*Excellent leadership and management skills: to induct, coach and effectively supervise the work of others.

*Knowledge of the academic and research environment in sub-Saharan Africa

*Knowledge of research sponsors, including requirements for obtaining funding

*Excellent IT skills, ideally including website and social media experience, preparing PowerPoint presentations, writing reports and developing databases.

*Excellent communication (both oral and written) and interpersonal skills

A proven ability to build effective relationships with a wide variety of internal and external stakeholders, at all levels.

For more details of the role and the knowledge, skills and experience required, please see the further particulars for the post.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Working pattern: Full-time; requests for part-time working may be considered minimum of 80% FTE.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

To discuss this position informally, please contact Professor Caroline Trotter, clt56@cam.ac.uk

Please quote reference PK39541 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

People are at the heart of everything we do at Pathology, and our newly refurbished canteen area is the social hub of the department, so why not join our professional services team as General Catering Assistant. We can offer a welcoming work environment where you can feel valued, encouraged to develop, and supported to achieve your full potential.

You will support the Catering facility in providing a smooth and friendly service to the department, including food preparation, ordering and cleaning. There are numerous functions and events throughout the year where you will have the opportunity to be involved. Ideally you will have some relevant experience of working in a catering facility, although an aptitude for this type of work is more important as full training will be provided. Good verbal communication skills, the ability to prioritise your workload and to work both independently and as part of a team are essential.

What we Offer

Our Professional Services staff play a fundamental role in the School's academic vision of the pursuit of education and research at the highest levels of excellence. The University of Cambridge offers excellent benefits, extensive opportunities in a stimulating environment.

*The University salary structure includes automatic service-related pay progression in many of its grades and an annual cost of living increase. In addition to this, employees are rewarded for outstanding contribution through a number of regular pay progression schemes. Staff also benefit from a generous annual leave entitlement.

*The University offers employees a wide range of competitive benefits, from health care cash plans to childcare, a cycle to work scheme, to shopping and insurance discounts.

*University-led initiatives in the areas of equality, diversity and wellbeing include staff and students networks. These include the Women's Staff Network, the Disabled Staff Network, the Black, Asian and Minority Ethnic Staff Network, Parents and Carers and the LGBT+ Network. We also hold a wide range of Equality and Diversity events on a regular basis.

*Wellbeing at Cambridge is a University-wide initiative aiming at supporting and maximising the health and wellbeing of staff. It encompasses a network of Wellbeing Advocates, who provide guidance and general signposting about wellbeing issues, including mental or physical health and Dignity @ Work concerns.

*The University offer a range of family-friendly policies, including maternity, adoption and shared parental leave. In addition, workplace nurseries, childcare vouchers, a childcare salary sacrifice scheme and a high-quality holiday play scheme are available to help support University employees with caring responsibilities

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Contact Caius Liu for an informal chat on cl870@cam.ac.uk and check out our website: https://www.path.cam.ac.uk/

Please quote reference PK39575 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Please note we are unable to offer sponsorship for this role as it does not meet the minimum skill and/or salary requirements for this visa route.

Are you passionate about molecular biology and biochemical research? Do you thrive in a laboratory environment, supporting cutting-edge projects? If so, we have two exciting opportunities for you to join our multidisciplinary team as a Research Assistant. We are seeking a motivated individual to provide crucial support in our lab, contributing to both scientific projects and the smooth day-to-day operations.

Responsibilities: *Assist in conducting molecular biology and biochemical experiments, including DNA/RNA extraction, PCR, gel electrophoresis, cloning, protein purification, and enzyme assays. *Prepare reagents, buffers, and media for experiments, ensuring accurate measurements and following standard protocols. *Maintain laboratory equipment, perform routine maintenance, and troubleshoot any technical issues that may arise. *Order and organize laboratory supplies, ensuring an adequate inventory of materials. *Collaborate with other team members to analyze experimental data, interpret results, and contribute to scientific discussions. *Document experimental procedures, protocols, and results accurately and efficiently. *Adhere to laboratory safety guidelines and maintain a clean and organized work environment.

Qualifications: *Bachelor's degree in molecular biology, biochemistry, or a related field. *Strong theoretical knowledge and practical experience in molecular biology and biochemistry techniques, including DNA/RNA manipulation, PCR, gel electrophoresis, protein purification, and enzymatic assays. *Familiarity with laboratory equipment and techniques commonly used in molecular biology and biochemistry research. *Proficient in data analysis using software tools such as Excel or statistical analysis software. *Excellent organizational skills and attention to detail. *Strong written and verbal communication skills. *Ability to work both independently and collaboratively in a team-oriented environment. *Demonstrated ability to multitask, prioritize, and meet deadlines.

If you are enthusiastic, detail-oriented, and eager to contribute to molecular biology and biochemical research, we invite you to apply for this position. Please submit your resume, a cover letter highlighting your relevant experience, and contact information for three professional references.

The University of Cambridge is one of the world's leading universities, and the Department of Pathology is renowned for its research in the field of molecular biology. The successful candidate will have the opportunity to work in a dynamic and supportive environment, and to collaborate with leading researchers in the field.

This opportunity is funded by the BBSRC, a major funding body for research in the life sciences in the UK, providing support for research and training in universities, research institutes and other organizations.

Fixed-term: The funds for this post are available for 3 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquiries, please email Dr Betty Chung on bcy23@cam.ac.uk

Please quote reference PK38868 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

People are at the heart of everything we do at Pathology, so why not join our professional services team as a Glasswasher. We can offer a welcoming work environment where you can feel valued, encouraged to develop, and supported to achieve your full potential.

You will support research work in the Department of Pathology's laboratories at its Addenbrooke's Hospital site, and at its Tennis Court Road site when required. The role holder will provide a glassware-washing, autoclaving and waste removal service.

Ideally you will have some relevant experience of working in a laboratory, although an aptitude for this type of work is more important as full training will be provided. Basic awareness of health and safety, the ability to adhere to Standard Operating Procedures reliably, good communication skills, the ability to prioritise your workload and to work both independently and as part of a team are essential. You will also be reliable and have good timekeeping skills.

What we Offer

Our Professional Services staff play a fundamental role in the School's academic vision of the pursuit of education and research at the highest levels of excellence. The University of Cambridge offers excellent benefits, extensive opportunities in a stimulating environment.

*The University salary structure includes automatic service-related pay progression in many of its grades and an annual cost of living increase. In addition to this, employees are rewarded for outstanding contribution through a number of regular pay progression schemes. Staff also benefit from a generous annual leave entitlement.

*The University offers employees a wide range of competitive benefits, from health care cash plans to childcare, a cycle to work scheme, to shopping and insurance discounts.

*University-led initiatives in the areas of equality, diversity and wellbeing include staff and students networks. These include the Women's Staff Network, the Disabled Staff Network, the Black, Asian and Minority Ethnic Staff Network, Parents and Carers and the LGBT+ Network. We also hold a wide range of Equality and Diversity events on a regular basis.

*Wellbeing at Cambridge is a University-wide initiative aiming at supporting and maximising the health and wellbeing of staff. It encompasses a network of Wellbeing Advocates, who provide guidance and general signposting about wellbeing issues, including mental or physical health and Dignity @ Work concerns.

*The University offer a range of family-friendly policies, including maternity, adoption and shared parental leave. In addition, workplace nurseries, childcare vouchers, a childcare salary sacrifice scheme and a high-quality holiday play scheme are available to help support University employees with caring responsibilities

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Contact Samuel Odeyemi for an informal chat on 01223 336912 or swo28@cam.ac.uk and check out our website: https://www.path.cam.ac.uk/

Please quote reference PK38746 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We wish to recruit a highly motivated Postdoctoral Research Scientist to join the laboratory of Dr Rahul Roychoudhuri within the Division of Immunology at the Department of Pathology, University of Cambridge (http://www.roychoudhurilab.org).

T cells drive immune activation and promote clearance of infections and cancer. However, their function can provoke autoimmune and allergic inflammation. The immune system therefore employs a variety of suppressive mechanisms, collectively known as immunoregulatory mechanisms, to restrain excessive T cell activation and prevent autoimmune and allergic inflammation. However, such suppressive mechanisms also powerfully inhibit anti-tumour immunity to drive deleterious immunosuppression in cancer. The laboratory utilises mouse genetics, cellular immunology and molecular biology to understand molecular mechanisms of immunity and immune suppression in cancer and inflammation.

This research aims to uncover novel molecular and cellular mechanisms of tumour immunity and cancer immunosuppression. You will contribute to fundamental discoveries in the field of tumour immunology that will pave the way for new therapies aimed at manipulating immune function in patients with cancer.

The successful applicant will join a large, friendly and collaborative team of researchers with access to cutting-edge facilities and resources within the centre of Cambridge on the historic Tennis Court Road site. The applicant will gain exposure to cutting-edge experimental approaches in cellular and molecular immunology including conditional mouse genetics, in vivo genetic cell barcoding and fate-tracking, molecular biology and high throughput RNA- and DNA-sequencing. The applicant will also have the opportunity to utilise platforms for high-throughput CRISPR/Cas9-based mutagenesis screens recently developed in the laboratory. The applicant will benefit from the collaborative and collegial environment of the laboratory, the Department and the wider research community present in Cambridge. The project will also benefit from a collaboration with the groups of Prof Adrian Liston and Dr Tim Halim within Cambridge, bringing together leading scientific and technical expertise in cancer immunology/immunotherapy, immune regulation and inflammation biology.

The ideal candidate will be motivated, independent and enthusiastic, and have a Ph.D. or MD/PhD* in immunology, cell biology, or a related field.

Experience with flow cytometry, cell culture, and molecular biology techniques and a track record of publications in peer-reviewed journals are desirable. Strong analytical and problem-solving skills, written and verbal communication skills, and the ability to work independently as well as part of a team are desirable.

Fixed-term: The funds for this post are available until 31 March 2025 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For more information on the work of the Roychoudhuri group, please visit http://www.roychoudhurilab.org.

For informal enquiries, or to find out specific details about available projects in the laboratory, please email rr257@cam.ac.uk.

*Where the successful applicant does not yet have a PhD, they will normally be under-appointed as a Research Assistant until they obtain their PhD degree.

Please quote reference PK39146 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

People are at the heart of everything we do at Pathology, so why not join our Central Services Domestic team as a Domestic Assistant (Part-Time). We can offer a welcoming work environment where you can feel valued, encouraged to develop, and supported to achieve your full potential.

You will support the Domestic Team in undertaking cleaning and portering services at the Downing Site of the Department of Pathology which will include cleaning laboratories, the library, toilets, the canteen and common room/areas to maintain the appearance of the Department to a high standard. Ideally you will have some relevant experience of laboratory or office cleaning, although an aptitude for this type of work is more important as full training will be provided. Good communication skills with the ability to follow written and verbal instructions, particularly regarding the safe use of chemicals, the ability to prioritise your workload with the minimum of supervision and to work both independently and as part of a team are essential.

What we Offer

Our Professional Services staff play a fundamental role in the School's academic vision of the pursuit of education and research at the highest levels of excellence. The University of Cambridge offers excellent benefits, extensive opportunities in a stimulating environment.

*The University salary structure includes automatic service-related pay progression in many of its grades and an annual cost of living increase. In addition to this, employees are rewarded for outstanding contribution through a number of regular pay progression schemes. Staff also benefit from a generous annual leave entitlement.

*The University offers employees a wide range of competitive benefits, from health care cash plans to childcare, a cycle to work scheme, to shopping and insurance discounts.

*University-led initiatives in the areas of equality, diversity and wellbeing include staff and students networks. These include the Women's Staff Network, the Disabled Staff Network, the Black, Asian and Minority Ethnic Staff Network, Parents and Carers and the LGBT+ Network. We also hold a wide range of Equality and Diversity events on a regular basis.

*Wellbeing at Cambridge is a University-wide initiative aiming at supporting and maximising the health and wellbeing of staff. It encompasses a network of Wellbeing Advocates, who provide guidance and general signposting about wellbeing issues, including mental or physical health and Dignity @ Work concerns.

*The University offer a range of family-friendly policies, including maternity, adoption and shared parental leave. In addition, workplace nurseries, childcare vouchers, a childcare salary sacrifice scheme and a high-quality holiday play scheme are available to help support University employees with caring responsibilities.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Contact Caius Liu for an informal chat on 01223 (3) 33905 or cl870@cam.ac.uk and check out our website: https://www.path.cam.ac.uk/

Please quote reference PK38980 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The University of Cambridge is seeking two enthusiastic and dedicated postdoctoral researcher to join Professor Louise Boyle's group (www.teamtapbpr.co.uk ) in the Department of Pathology.

Work in the Boyle lab focuses on advancing knowledge of peptide selection by Major Histocompatibility Complex (MHC) molecules - vital research given the critical role that these molecules play in infection control and the recognition of cancer. These positions, funded by Wellcome, will work towards understanding the molecular mechanisms controlling immune recognition which may pave the way for translational opportunities.

Postdoctoral candidates will be expected to hold a PhD*, or equivalent qualification in immunology, biochemistry, cell biology, molecular biology or a related discipline and have a proven track record of success in biomedical research. In depth knowledge of the MHC class I antigen processing and presentation pathway is desirable.

We are looking for candidates skilled in mammalian tissue culture, flow cytometry, molecular biology, CRISPR/Cas9 gene editing and biochemical techniques. Prior experience with CRISPR genetic screens would also be advantageous. Successful applicants should have strong written and oral communication skills as well as the ability to supervise students. They will be expected to design and carry out research both independently and as part of a team. The successful applicants will become an integral and valued member of a multi-disciplinary, dynamic and sociable research group.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

** This position is available from January 2024 for 3 years. The closing date for this position is 5th November 2023.**

*Where the successful applicant does not yet have a PhD, they will normally be under-appointed as a Research Assistant until they obtain their PhD degree.

Please quote reference PK38597 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking an enthusiastic and efficient Research Assistant to join the group of Dr Arwen Altenburg (https://www.path.cam.ac.uk/research/immunology-division/altenburg-group) at the Department of Pathology, University of Cambridge. This position, funded by the Wellcome Trust, will help investigate MHC-I antigen processing and presentation in viral immune detection and evasion.

Candidates will be expected to hold a BSc or MSc degree in Virology, Immunology, Biological Sciences, or a related discipline. Candidates should have experience with mammalian tissue culture, flow cytometry and molecular biology techniques. Prior experience with CRISPR/Cas9 and working at biosafety level 2 is advantageous, but we will be delighted to consider highly motived individuals who can demonstrate excellent relevant laboratory skills. A good understanding of virology and MHC class I antigen processing and presentation is desirable.

Successful applicants will become an integral and valued member of a multidisciplinary group. The candidate will have the opportunity to work under their own initiative and present regularly at lab meetings. The candidate should have good interpersonal and organisational skills, and the ability to work well independently and as part of a team.

The closing date for this position is 1st November 2023.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

This position is available from January 2024 for 3 years.

Please quote reference PK38596 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The University of Cambridge is seeking an enthusiastic research assistant to join Dr Dami Collier's group (Collier Group ) in the Department of Pathology. Work in the Collier lab focuses on understanding HIV-1 replication in the brain as a cause of brain injury, treatment escape and barrier to achieving HIV cure. We also focus on clinically translational research on viral infections in immunocompromised hosts.

Candidates will be expected to hold a degree in immunology, biochemistry, molecular biology or a related discipline. We are looking for a candidate highly skilled in mammalian tissue culture and flow cytometry. Prior experience working with confocal imaging is highly advantageous.

The successful applicant will become an integral and valued member of a multi-disciplinary group. Successful candidates will be expected to design and carry out research both independently and as part of a team.

This position is available for 6 months from 1st December 2023. The closing date for applications is 31st October 2023.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquiries, please email Dr Dami Collier on adc82@cam.ac.uk.

Please quote reference PK38790 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Research Associate to join the labs of Dr. Katerina Artavanis-Tsakonas and Dr. Andrew Blagborough. We are searching for a highly motivated scientist to investigate ubiquitin biology and its role in the development of Plasmodium falciparum, the causative agent of malaria, with a view to identifying novel targets for antimalarial interventions.

The ubiquitin pathway is fundamental to all eukaryotes. Despite its evolutionary conservation, we have identified notable differences in how ubiquitin is attached and removed from target proteins in Plasmodium and the nature and specificity of the enzymes that mediate these events. A main focus of this project will be to explore the role of ubiquitin in parasite protein trafficking.

Candidates will have completed a PhD in biological sciences and have a track record of related research achievements. Knowledge of ubiquitin biology and/or Plasmodium cell biology are essential as is demonstrable experience in the following:

• Sample preparation and data analysis for mass spectrometry

• Experience with culturing/maintenance of Plasmodium falciparum

• Hands-on experience with Plasmodium genetic manipulation methods, particularly CRISPR-Cas9 genome editing and construct design

• An understanding of structural biology principles and techniques

• An understanding and/or practical experience in working with the ubiquitin-proteasome system

We are looking for individuals who are committed to fostering a positive and inclusive research environment. The candidate should also have good interpersonal and organizational skills, the ability to work with limited supervision and exercise initiative, the ability to prioritize his/her own work in response to deadlines, and experience in making effective presentations and writing scientific manuscripts.

The Department of Pathology is a very active research and teaching department in the School of Biological Sciences. We offer modern laboratory spaces, flow cytometry, imaging, histology, proteomics and sequencing facilities in the centre of Cambridge. We host an external seminar series as well as internal talks, journal clubs, and a Department annual symposium. There are approximately 40 research groups spanning a wide array of disciplines, including infectious and genetic diseases, immunology and cancer biology. Additional information can be found here; www.path.cam.ac.uk/research

This is a fixed term post for 2 years from date of appointment.

Please upload:

• Your CV.

• A covering letter setting out why you are applying and how you match the criteria for the post.

• Please provide the names of two academic referees, one of which should be your most recent supervisor, and their contact details, including email address.

The closing date for applications is 1st November 2023.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The selection panel will meet soon after the closing date in order to produce a short-list; references will then be solicited. Short-listed candidates will be invited to attend a formal interview which is expected to take place in person in November 2023. We expect the position to be filled by 1st January 2024.

Please quote reference PK38524 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Department of Pathology is seeking to appoint a Finance / Accounts Assistant to join our large and friendly professional services team.

Working within our Accounts Team, this is a great opportunity to develop skills and gain exposure to all the diverse aspects of a busy department. There are training opportunities to support career development.

The post holder will undertake a full range of accounts duties including;

• Processing supplier invoices

• Reviewing and investigating open purchase orders and close or cancel as required

• Raising customer invoices and credit notes

• Running and reviewing UFS reports and export data into excel

• Recharging departmental facilities to end users both internal and external to the department on a monthly or quarterly basis.

The successful candidate will be the first point of contact for financial matters, liaising with departmental staff and give advice and guidance regarding financial procedures records. Other duties and responsibilities are outlined in the Further Particulars document.

Applicants are expected to be educated to A level standard / NVQ level 3 or equivalent level of practical experience. You must also have good IT skills, particularly MS Excel. Experience of working in an accounts environment essential.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

On the online form, in the suitability for the role section, you should explain why you have applied for this opportunity and how your knowledge, skills and experience match the requirements stated.

Please do contact Fiona Craig (fcc21@cam.ac.uk), if you wish to have an informal chat about the role.

Please quote reference PK38100 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We have an exciting opportunity for a postdoctoral research scientist* to study the physical properties of viral enzymes that allow them to evolve resistance to anti-viral drugs. This project will use advanced computation biology approaches, enzymology and structural biology to define structurally invariant regions of the SARS-CoV-2 MPro protease. This will inform the design of future therapies that reduce/prevent the evolution of drug resistance and may illuminate how evolution of resistance mutations will affect the potency of Mpro drugs already in clinical trials. This project is funded by the Novo Nordisk Foundation as part of the Pandemic Antiviral Discovery (PAD) initiative (https://padinitiative.com/) and is a collaboration between Profs. Stephen Graham and Ian Goodfellow (University of Cambridge, UK) and Prof. Özlem Tastan Bishop (Rhodes University, South Africa).

The post holder must possess a PhD in Biochemistry or a related area, have a strong track record of generating publication-quality experimental data, and have demonstrated experience of recombinant protein expression and purification using FPLC systems. Experience in either enzyme kinetic analysis using purified proteins or in solving protein structures using X-ray crystallography is also essential. Prior experience in virology, molecular dynamics analysis or structural pharmacology is desirable. The post holder must have good interpersonal skills as well as the ability to communicate their work clearly in both formal and informal settings, with great attention to detail and excellent record keeping.

The successful applicant will be based in the laboratory of Prof. Stephen Graham in Cambridge (http://www.atomicvirology.path.cam.ac.uk/) and will have access to state-of-the-art facilities for protein chemistry and structural biology research, including a formidable array of biophysical equipment and regular access to Diamond Light Source. They will join a collaborative and inclusive team of researchers within the Division of Virology laboratories on the Cambridge Biomedical Campus, the largest centre of medical research and health science in Europe. Ours is a supportive laboratory and enthusiastic candidates will have the opportunity to learn additional techniques and to expand their research and professional skills. We encourage creative thinking when tackling scientific problems and are keen for lab members to adopt new technologies and approaches when appropriate. If you are a biomedical scientist who wants to work with an international multidisciplinary team to address fundamental research questions with direct relevance to human health and pandemic preparedness, we want to hear from you.

Fixed-term: The funds for this post are available until 31 August 2025 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquires please contact Prof. Stephen Graham via email (scg34@cam.ac.uk)

*Where the successful applicant does not yet have a PhD, they will normally be under-appointed as a Research Assistant until they obtain their PhD degree.

Please quote reference PK38294 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

People are at the heart of everything we do at Pathology, so why not join our Central Services Domestic team as a Domestic Assistant (Part-Time). We can offer a welcoming work environment where you can feel valued, encouraged to develop, and supported to achieve your full potential.

You will support the Domestic Team in undertaking cleaning and portering services at the Downing Site of the Department of Pathology which will include cleaning laboratories, the library, toilets, the canteen and common room/areas to maintain the appearance of the Department to a high standard. Ideally you will have some relevant experience of laboratory or office cleaning, although an aptitude for this type of work is more important as full training will be provided. Good communication skills with the ability to follow written and verbal instructions, particularly regarding the safe use of chemicals, the ability to prioritise your workload with the minimum of supervision and to work both independently and as part of a team are essential.

What we Offer

Our Professional Services staff play a fundamental role in the School's academic vision of the pursuit of education and research at the highest levels of excellence. The University of Cambridge offers excellent benefits, extensive opportunities in a stimulating environment.

*The University salary structure includes automatic service-related pay progression in many of its grades and an annual cost of living increase. In addition to this, employees are rewarded for outstanding contribution through a number of regular pay progression schemes. Staff also benefit from a generous annual leave entitlement.

*The University offers employees a wide range of competitive benefits, from health care cash plans to childcare, a cycle to work scheme, to shopping and insurance discounts.

*University-led initiatives in the areas of equality, diversity and wellbeing include staff and students networks. These include the Women's Staff Network, the Disabled Staff Network, the Black, Asian and Minority Ethnic Staff Network, Parents and Carers and the LGBT+ Network. We also hold a wide range of Equality and Diversity events on a regular basis.

*Wellbeing at Cambridge is a University-wide initiative aiming at supporting and maximising the health and wellbeing of staff. It encompasses a network of Wellbeing Advocates, who provide guidance and general signposting about wellbeing issues, including mental or physical health and Dignity @ Work concerns.

*The University offer a range of family-friendly policies, including maternity, adoption and shared parental leave. In addition, workplace nurseries, childcare vouchers, a childcare salary sacrifice scheme and a high-quality holiday play scheme are available to help support University employees with caring responsibilities.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Contact Caius Liu for an informal chat on 01223 (3) 33905 or cl870@cam.ac.uk and check out our website: https://www.path.cam.ac.uk/

Please quote reference PK38296 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for 4-year PhD studentship based in the Department of Pathology, University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Dr. Naomi McGovern at the Department of Pathology, and Dr. Elina Timosenko and Dr. Tim Slidel at AstraZeneca and will work across the two sites. The project, entitled "The role of macrophages in endometrial carcinoma" is in the fields of immunology, oncology and bioinformatics that have generated much excitement in both academia and industry.

Project abstract

Endometrial cancer is common, accounting for ~3% of all cancers in the UK (2016-2018). Its precursor is endometrial hyperplasia where the glands expand and the stroma is enriched with macrophages. As the glands continue to grow, they become more crowded with atypical cells, the intervening stroma is compressed, and foamy macrophages appear.

In other cancers, macrophages in the tumour microenvironment influence its progression and metastatic potential. Little is known about the role of macrophages in the progression from normal endometrium to endometrial hyperplasia and then endometrial cancer.

Through this studentship the role of macrophages in endometrial cancer will be explored using a range of cutting-edge techniques including single cell RNA sequencing, confocal microscopy and in vitro functional assays. This project will utilise both dry and wet lab skills.

We are looking for a highly motivated and enthusiastic individual capable of thinking and working independently. As a large component of the project will involve transcriptomic data analysis, the applicant must be keen to develop bioinformatic skills. Applicants should have or shortly expect to obtain a first or upper second-class degree from a UK university, or an equivalent standard from an overseas university, in a relevant subject such as immunology, bioinformatics and/or oncology. These positions are open to UK citizens or overseas students who meet the UK residency requirements (home fees) or are able to augment the funds to cover the extra costs associated with international student fees through scholarships or funding schemes. University's entrance requirements and scholarships are specified here : https://www.postgraduate.study.cam.ac.uk/

Full funding covering Maintenance fees at £21,500 per annum and the University Composition Fee is provided for the studentship, with effect from 1 October 2024.

Applications should include academic transcripts, CV, statement of purpose and 2 references.

Interviews will likely be held on the 16-20th of October.

As a graduate student at Cambridge, you will have access to a wide range of training opportunities and benefit from close supervision provided by a primary and secondary PhD supervisor as well as a personal mentor.

During their PhD, there is no taught or examined coursework, but students are encouraged to attend the wide variety of lectures and training courses available to them across the Institute and wider University. This includes a centrally run Statistics course and the University Core Skills Training Programme, which includes sessions on Time Management, Presentation and Performance and Scientific Writing. Students at the Institute will be members of the University's Postgraduate School of Life Sciences (PSLS) who offer a wide variety of core skills and professional development training. Visit the Researcher Development page here; https://www.postgradschl.lifesci.cam.ac.uk/GSLSRD website for more information. In addition, the student can also take advantage of training courses and seminars in therapeutic sciences offered by Cambridge Academy of Therapeutic Sciences.

All students are expected to attend all seminars held within the Dept of Pathology. Students will also be encouraged to attend and present at the annual AstraZeneca students symposium.

For further info please contact Naomi McGovern: nm390@cam.ac.uk

Please quote reference PK38256 on your application and in any correspondence about this vacancy.

Diversity and Inclusion

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. We place major emphasis on the importance of team work and an enjoyable work environment as a foundation for performing internationally leading research. This will allow the student to acquire cutting edge research methodologies in a supportive environment, where they can focus on making the best possible scientific progress.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Department of Pathology is seeking to appoint a full-time Assistant/Associate Professor in Infection and Immunity in Early Life. We are searching for an outstanding scientist to strengthen research and teaching activity in the School of Biological Sciences (SBS) in the strategically important areas of innate immunity, vaccinology and reproductive immunology. To span these areas, this post will focus on human infection and immunity and prevention strategies during early life. Our Department offers forward looking research and teaching environments with considerable research strengths in infectious disease biology and immunology.

The Department of Pathology has a strong research profile in immunology, where we have existing strengths in cellular and molecular immunology, and a wide range of microbial research (virology, bacteriology and parasitology). The successful candidate will carry out a world-leading research programme in infection and immunity in early human life. They will work collaboratively with scientists that are researching infectious agents that cause significant morbidity and mortality, for example, during pregnancy and infancy, and establish links to clinical disciplines that impact on immunity and infection in early life, like OB/GYN, Clinical Immunology or Microbiology.

The Department offers modern laboratory spaces, flow cytometry, imaging, histology, and sequencing facilities in the centre of Cambridge. We host external seminar series as well as internal talks, journal clubs, etc. in a collaborative and supportive and inclusive environment. Candidates can also apply for internally-funded PhD studentships.

We teach Natural Science, Medical and Veterinary students at Part IB (2nd year, Biology of Disease), Part II (3rd year) and Masters levels. We welcome applicants with a Ph.D. or equivalent degree in a relevant subject who have the ability to lead an exciting, innovative and fundable research programme. Applicants will also have a talent and enthusiasm for teaching at undergraduate and postgraduate levels with an eagerness to contribute to education at all levels. We seek collegiate applicants who are committed to fostering a positive and inclusive research culture and to the effective functioning of our Department.

The post is available immediately.

Please ensure that in the Upload section of the online application you provide:

• A full CV, including a full list of publications and a narrative (300 words maximum per output) on each of the three outputs you consider most significant. The Department is committed to the responsible use of bibliometrics, and applicants are asked not to include raw citation counts, Journal Impact Factors or H-index metrics in their applications.

• A description of current and future research plans and how these relate to our Departments research strengths. No longer than two pages.

• A covering letter setting out why you are applying and how your experience and plans address the person specification in the further particulars (1000 words maximum).

• Please provide the names and contact details of three academic referees.

Informal enquiries are welcome and should be directed to Professor Heike Laman (Head of Department of Pathology) (hod@path.cam.ac.uk).

The selection panel will meet soon after the closing date in order to produce a short-list; references will then be solicited. Short-listed candidates will be invited to visit the Department, give a seminar/lecture and attend a formal interview which is expected to take place in person in October 2023.

Flexible working arrangements will be considered.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process, please contact the PA to the HoD of Pathology, Becky Fanning at (hod.sec@path.cam.ac.uk)

Please quote reference PK37895 on your application and in any correspondence about this vacancy.

The Department and University are committed to a fostering an inclusive and diverse environment in a workplace that values and supports mutual respect and equality. We particularly encourage women and candidates from minority backgrounds or other underrepresented groups to apply for this vacancy as they are currently under-represented at this level within our University.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

People are at the heart of everything we do at Pathology, so why not join our Central Services Domestic team as a Domestic Assistant (Part-Time, Maternity cover). We can offer a welcoming work environment where you can feel valued, encouraged to develop, and supported to achieve your full potential.

You will support the Domestic Team in undertaking cleaning and portering services at the Downing Site of the Department of Pathology which will include cleaning laboratories, the library, toilets, the canteen and common room/areas to maintain the appearance of the Department to a high standard. Ideally you will have some relevant experience of laboratory or office cleaning, although an aptitude for this type of work is more important as full training will be provided. Good communication skills with the ability to follow written and verbal instructions, particularly regarding the safe use of chemicals, the ability to prioritise your workload with the minimum of supervision and to work both independently and as part of a team are essential.

What we Offer

Our Professional Services staff play a fundamental role in the School's academic vision of the pursuit of education and research at the highest levels of excellence. The University of Cambridge offers excellent benefits, extensive opportunities in a stimulating environment.

*The University salary structure includes automatic service-related pay progression in many of its grades and an annual cost of living increase. In addition to this, employees are rewarded for outstanding contribution through a number of regular pay progression schemes. Staff also benefit from a generous annual leave entitlement.

*The University offers employees a wide range of competitive benefits, from health care cash plans to childcare, a cycle to work scheme, to shopping and insurance discounts.

*University-led initiatives in the areas of equality, diversity and wellbeing include staff and students networks. These include the Women's Staff Network, the Disabled Staff Network, the Black, Asian and Minority Ethnic Staff Network, Parents and Carers and the LGBT+ Network. We also hold a wide range of Equality and Diversity events on a regular basis.

*Wellbeing at Cambridge is a University-wide initiative aiming at supporting and maximising the health and wellbeing of staff. It encompasses a network of Wellbeing Advocates, who provide guidance and general signposting about wellbeing issues, including mental or physical health and Dignity @ Work concerns.

*The University offer a range of family-friendly policies, including maternity, adoption and shared parental leave. In addition, workplace nurseries, childcare vouchers, a childcare salary sacrifice scheme and a high-quality holiday play scheme are available to help support University employees with caring responsibilities.

Temporary cover: This post is fixed-term for 9 months or the return of the post holder, whichever is the earlier.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For an informal chat, please contact Caius Liu on 01223 (3) 33905 or cl870@cam.ac.uk

Please quote reference PK38216 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.