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Current jobs in the Department of Pathology at the University of Cambridge.
Updated: 22 min 58 sec ago

Investigating RNA structural switches in the HIV-1 lifecycle: implications for viral replication and drug discovery

Tue, 03/12/2024 - 00:00

Applications are invited for a fully-funded 4-year PhD studentship based in the Department of Pathology at the University of Cambridge under the supervision of Julia Kenyon starting October 2025.

HIV-1 has a compact genome containing multiple, often overlapping, RNA structures that it uses to control its lifecycle. Such structures and structural switches have been shown to be effective antiviral drug targets. This project will use cutting-edge techniques such as Nanopore direct RNA sequencing, SHAPE and in-gel SHAPE, to identify and model important RNA structures used by the virus during different phases of the lifecycle. In addition, it will further study the RNA structural effects of a novel drug that we previously identified as having potent antiretroviral action- a small molecule inhibitor of packaging, NSC260594.

Please visit https://www.path.cam.ac.uk/graduate/fully-funded-studentships for a more detailed description of the project and application.

Applicants should hold (or expect to obtain) the equivalent of a UK 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject. The studentship is open to those eligible for the Home rate of University fees only. Please check your fee status before applying; https://www.postgraduate.study.cam.ac.uk/finance/fees/what-my-fee-status

Applications should include academic transcripts, CV, statement of purpose and 2 references. Please also explain your motivation why you wish to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.

Please quote reference PK44278 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Associate Professor/Professor of Infection and/or Immunity

Fri, 29/11/2024 - 00:00

The School of Biological Sciences is pleased to invite applications for four new Grade 10 or Grade 11 (depending on experience) Professorship positions, available from October 2025:

  • Associate Professor / Professor of Infection and/or Immunity
  • Associate Professor / Professor of Developmental Plasticity and Robustness
  • Associate Professor / Professor of Evolutionary Genomics
  • Associate Professor / Professor of Molecular and Cellular Biology

The posts align with School's research strategy to foster innovative research across disciplinary boundaries.

The focus of the Associate Professor / Professor of Infection/Immunity will be to build a world-leading research programme, deliver excellent teaching, support the collaborative research culture and to positively engage with academic leadership both in the home Department(s) and across the School of Biological Sciences.

The successful applicant will have an excellent track record of implementing innovative solutions to address key research questions in the fields of infection or immunity, or at the intersection of these disciplines. Their research will accelerate research efforts within the School in the Grand Challenge areas: Changing pathogens in a changing world, Seeing infection through a new lens and Harnessing the immune system to fight disease (https://www.bio.cam.ac.uk/research/infection-immunity).

They will work within at least one of these Grand Challenge spaces, and potentially across multiple. Example research areas may include but are not limited to:

  • Innovative computational biology approaches to study infection and immunity
  • Vaccination technologies for both infectious and non-communicable diseases
  • Comparative immunology across multiple species and scales (from cells to populations)
  • New in vitro and in vivo models of host immune responses to infection
  • In situ imaging of infection and immunity
  • New tools to study and prevent vector-borne diseases

A track record implementing innovative new strategies and/or technologies to address cutting-edge research questions in these Grand Challenge areas is essential, as is a track record of fostering adaptation of these innovations via collaborative scientific partnerships.

Academic responsibilities associated with this role will include delivering undergraduate and postgraduate lectures, practical classes and small group supervisions, engaging with the Research Theme initiatives, and positively contributing to the inclusive and collaborative ethos of the School. Mentoring and professional development of staff and students is expected as part of our inclusive and supportive community.

We particularly welcome applications from women, candidates who identify as Black or Asian and those who consider themselves to be racialized minorities, as they are currently under-represented at this level in the School of Biological Sciences. We offer mentoring and access to inclusion networks to support and empower individuals and enable an inclusive research culture.

Applications, including a 1500-word statement on current and future research plans, a curriculum vitae and publications list, a brief narrative (maximum 300 words per output) on your three most significant outputs a one-page statement on your teaching experience, contributions to open research and research culture improvement, and your perspective on Equality, Diversity, and Inclusion, along with three referees' details, should be submitted online by 30 September 2025.

The University of Cambridge is a signatory to the San-Francisco Declaration on Research Assessment (DORA), and we are committed to assessing research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or journal titles as a proxy for research quality in their applications.

For more information: https://www.biology.cam.ac.uk/files/dora.pdf

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to:

If you have any queries regarding the application process, please contact:

Please quote reference PK44232 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Categories: Latest Jobs

Research Assistant (Fixed Term)

Thu, 21/11/2024 - 00:00

The Department of Pathology's McGovern Laboratory is seeking a motivated Research Assistant to study placental biology.

The placenta is the first and largest organ the human embryo makes. The outer most layer of the placenta is formed by trophoblast cells. Healthy trophoblast biology is key to normal placental function. The generation and culture of human placental organoids is key to identifying factors that mediate healthy placental development.

The McGovern lab uses a range of techniques including flow cytometry, organoid cultures and confocal microscopy to understand placental cell biology.

Applicants are required to have:

  • Laboratory experience
  • Experience in cell culture
  • Degree in biological sciences
  • Flexibility with hours to allow for samples that arrive late in the day

Experience in immunohistochemistry, organoid cultures and differentiation would be advantageous, but training will be provided if required.

Further details can be found in the further information document attached.

The successful applicant will be responsible for:

  • Ensuring all records related to human tissue sample collection and processing are kept up to date

  • Coordinating sample collection with research nurses

  • Collecting and processing human tissue samples, including blood and placentas

  • Generating and culturing organoids and macrophages

  • Safety training

In addition to lab work, the applicant will present findings at lab meetings, help with ethics applications, general lab management, training students and visiting researchers in techniques and equipment use.

How to apply:

Please ensure that you upload a covering letter and CV. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not consider these as part of your application.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Any informal queries regarding this position should be directed to Dr Naomi McGovern : nm390@cam.ac.uk

Queries regarding the application process should be directed to Miss Ellie Watson: ew649@cam.ac.uk

Please quote reference PK44155 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Viral Immunologist (Fixed Term)

Fri, 15/11/2024 - 00:00

Dr Naomi McGovern is seeking a highly motivated Viral Immunologist with a desire to join a congenial, dynamic and collaborative research team. The laboratory works on human tissue mononuclear phagocytes and how their properties are regulated by the local microenvironment.

Further details on research projects currently being undertaken in the McGovern lab can be seen at:

https://www.mcgovernlab.com/ https://www.path.cam.ac.uk/research/immunology-division/mcgovern-group

This project is funded by the UKRI. As a Viral Immunologist you will be using primary tissue macrophages, iPSCs and organoid systems to understand HCMV infection at the maternal-fetal interface. Techniques you will use, include multiparameter flow cytometry, scRNAseq, confocal microscopy, making viruses, infections in culture and others. This project will be carried in collaboration with virologist Dr Emma Poole.

Further details on the responsibilities of the role can be found in the further particulars document at the bottom of this page.

The Viral Immunologist will be appointed at either Research Assistant level or Research Associate depending on whether the relevant PhD has been attained.

We are looking for someone with:

  • PhD in immunology, molecular biology or virology/ or in final stages of PhD submission

  • Experience in working with viruses

  • Experience in cellular biology

  • Proven track record of research (e.g. publication record)

  • Strong written and oral communication skills

  • Willingness to work with primary human tissue and blood

  • Willingness to work flexibly as experiments require

Further details on the person specification can be found in the further particulars document

Why join us?

  • Contribute to cutting-edge immunology research with real-world implications.

  • Collaborate with experts across the fields of immunology, virology and clinicians.

  • Work in a supportive and collaborative environment that fosters professional growth.

How to apply:

Please provide a statement of interest/cover letter. This should explain why you are interested in this area of research. Please also provide your CV and 2 references.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Any informal queries regarding this position should be directed to Dr Naomi McGovern : nm390@cam.ac.uk

Queries regarding the application process should be directed to Miss Ellie Watson: ew649@cam.ac.uk

Please quote reference PK44060 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Domestic Assistant (Part Time)

Tue, 05/11/2024 - 00:00

The Department of Pathology has one vacancy for a part-time early morning Domestic Assistant staff, which will be working predominantly in the Department's canteen.

Working as part of a team, the post-holder will both have responsibility for cleaning, opening and serving in the Department's canteen, portering and general housekeeping. Please see the Further Information document below for more information.

18.5 hours per week: Early morning start.

The post is managed through the Department's Facilities Office, with day-to-day supervision co-ordinated by the Domestic Services Supervisor and Facilities Administrator. The Department of Pathology is split across two sites, Tennis Court Road in central Cambridge and Biomedical Campus at Addenbrooke's Hospital. The post will mainly be based at the Department's central site but will be required, on occasions, to provide cover at its site in Addenbrooke's Hospital.

Experience of cleaning and an NVQ 1 or 2 in Cleaning Methods and food hygiene level 2 would be helpful, although full training will be given. The ability to follow both written and verbal instructions and understand user and safety instructions (regarding the use of chemicals) is required. Good communication skills and the ability to work effectively as a member of a team and deal with a wide range of people with tact, diplomacy and respect are essential, along with reliability, professionalism and a high level of attention to detail. Due to the nature of the work, candidates are expected to have a good level of physical fitness.

Please be aware that this role is not eligible for visa sponsorship.

Previous applicants need not apply.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment. Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Any queries regarding this position should be directed to Ellie Watson: ew649@cam.ac.uk

Please quote reference PK43904 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

4-year PhD studentship (Fixed Term)

Tue, 29/10/2024 - 00:00

Applications are invited for a fully-funded 4-year PhD studentship based in the Department of Pathology at the University of Cambridge under the supervision of Dr Betty Chung (https://www.path.cam.ac.uk/directory/betty-chung) starting October 2025.

Biotic stresses often unfold rapidly, demanding swift responses from both host and pathogen to ensure survival. Upon their encounter, a sophisticated network of gene regulation is instantly activated in both organisms, spanning transcription, translation, and protein turnover. While transcriptional regulation offers versatility, translational control enables potent, efficient and rapid adjustment in protein abundance, which is crucial during the initial stages of infection for both host and pathogen. This project seeks to unravel the intricate translational regulatory mechanisms governing host-pathogen interactions, aiming to decode the molecular dynamics and triggers that influence virulence, pathogenicity, and innate immunity.

Please visit https://www.path.cam.ac.uk/graduate/fully-funded-studentships for a more detailed description of the project and application.

Applicants should hold (or expect to obtain) the equivalent of a UK 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject. The studentship is open to those eligible for the Home rate of University fees.

Applications should include academic transcripts, CV, statement of purpose and 2 references. Please also explain your motivation why you wish to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.

Funding notes: Funding* will cover the student's stipend at the current Research Council rate and University Fees. The studentship will be funded for four years from October 2025. *The studentship is only available to students who qualify for UK Home fees

Please quote reference PK43848 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Postdoctoral Research Associate : Computational Biology (Fixed Term)

Mon, 21/10/2024 - 01:00

Applications are invited for a Postdoctoral Research Associate in the lab of Dr. Heather Machado in the Department of Pathology, University of Cambridge. The Machado Lab is interested in how tumour and immune cells co-evolve and contribute to cancer progression. Methods of evolutionary genetics and multiomic datasets are used to study key questions in cancer immunology, such as the timing of the immune response to cancer, the role of inflammation on remodeling the immune response to cancer and the somatic evolution of the immune response to immunotherapy.

The Machado Lab is looking for a Computational Biologist/Genomicist to leverage single-cell genomic and transcriptomic datasets to understand the somatic evolution of the T cell response to cancer. The successful applicant should:

  • Hold a relevant PhD Qualification

  • Experience in analysing genomic and/or multiomic datasets

  • Excellent oral and written communication skills

  • Able to manage time effectively

  • Good at working independently

  • Enthusiastic to interact with colleagues in a multi-disciplinary and collaborative environment

Please see further information document for further details.

Standard components of the genomic data analysis include variant calling, artifact filtering, mutational signature analysis, phylogenetic tree building, mutational timing estimation and selection analysis.

We are particularly excited about recent technological advancements in single-cell whole genome sequencing, such as primary template-directed amplification (PTA), which substantially expands the scope of answerable somatic evolution questions.

For more information regarding the research of the laboratory, please see http://www.machado-lab.org/.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal queries regarding the research of the laboratory and the role should be directed to Dr Heather Machado, hem48@cam.ac.uk.

Please quote reference PK43661 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Mapping DNA damage and genome replication in malaria parasites with artificial intelligence and long-read sequencing

Fri, 11/10/2024 - 01:00

Applications are invited for a fully-funded 4-year PhD studentship based in the Department of Pathology at the University of Cambridge under the supervision of Dr Michael Boemo starting October 2025.

Malaria parasites replicate their genomes very differently to human cells, making genome replication an attractive therapeutic target for antimalarial drugs. The purpose of this research is to develop artificial intelligence software that leverages the power of long-read DNA sequencing to determine the genomic loci of DNA damage caused by these drugs and how this damage changes the movement of replication forks throughout the genome.

The student will have the opportunity to learn, or improve upon, the development of artificial intelligence for translational research in a supportive and collaborative environment.

More information about the Boemo Group is available at https://www.boemogroup.org and https://www.path.cam.ac.uk/graduate/fully-funded-studentships.

Funding* will cover the student's stipend at the current Research Council rate and University Fees. The studentship will be funded for four years from October 2025. *The studentships are available to students who qualify for UK Home fees.

Applicants should hold (or expect to obtain) the equivalent of a UK 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject. The studentship is open to those eligible for the Home rate of University fees.

Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

All applications should be made online via the University's Applicant Portal for a PhD in Pathology (BLPA22). Applications should include academic transcripts, CV, statement of purpose and 2 references. An application is only complete when all supporting documents, including the 2 academic references, are submitted. It is the applicant's responsibility to ensure their referees submit their references before the closing date. Please also explain your motivation why you wish to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.

Please quote reference PK43591 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Somatic evolution of the immune response to chronic inflammation and liver cancer progression through single-cell multiomics

Fri, 11/10/2024 - 01:00

Applications are invited for a fully-funded 4-year PhD studentship based in the Department of Pathology at the University of Cambridge under the supervision of Dr Heather Machado starting October 2025.

Our body's immune system is one of the most powerful tools in the fight against cancer. An improved understanding of how the adaptive immune system evolves in the context of cancer, including the effects of chronic inflammation and the phenotypic changes from premalignancy to cancer progression, could lead to improved cancer outcomes. However, these immune dynamics are difficult to study directly in humans due to longitudinal sampling constraints. To overcome these obstacles, this project will apply state-of-the-art lineage tracing techniques and single-cell multiomics to track CD8+ T cell dynamics in an inflammatory premalignancy and the resulting liver cancer.

For more information please see https://www.path.cam.ac.uk/graduate/fully-funded-studentships.

Funding* will cover the student's stipend at the current Research Council rate and University Fees. The studentship will be funded for four years from October 2025. *The studentships are available to students who qualify for UK Home fees. Applicants should hold (or expect to obtain) the equivalent of a UK 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject. The studentship is open to those eligible for the Home rate of University fees. Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

All applications should be made online via the University's Applicant Portal for a PhD in Pathology (BLPA22). Applications should include academic transcripts, CV, statement of purpose and 2 references. An application is only complete when all supporting documents, including the 2 academic references, are submitted. It is the applicant's responsibility to ensure their referees submit their references before the closing date. Please also explain your motivation why you wish to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.

Please quote reference PK43590 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Role of long non-coding RNAs in Zika virus-induced neuropathogenesis

Fri, 11/10/2024 - 01:00

Applications are invited for a fully-funded 4-year PhD studentship based in the Department of Pathology at the University of Cambridge under the supervision of Dr Andrew Blagborough starting October 2025.

Malaria, caused by Plasmodium parasites and transmitted by female Anopheles mosquitoes, remains a devastating infectious disease. Within the mosquito, the malaria parasite undergoes a complex and delicate lifecycle that can be successfully targeted using transmission blocking vaccines (TBVs). The most promising lifecycle stages to target with TBVs is the parasitic ookinete, a motile zygote that is essential for transmission. However, our knowledge of the surface proteins that can initiate an immunological response on the ookinete surface is limited. Using novel genetically altered parasites, this project aims to identify novel TBV targets on the surface of the ookinete, building a molecular map of the poorly understood parasite surface and facilitating the development of novel anti-malarial TBVs.

For more information please see https://www.path.cam.ac.uk/graduate/fully-funded-studentships.

Funding* will cover the student's stipend at the current Research Council rate and University Fees. The studentship will be funded for four years from October 2025. *The studentships are available to students who qualify for UK Home fees. Applicants should hold (or expect to obtain) the equivalent of a UK 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject. The studentship is open to those eligible for the Home rate of University fees.

Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

All applications should be made online via the University's Applicant Portal for a PhD in Pathology (BLPA22). Applications should include academic transcripts, CV, statement of purpose and 2 references. An application is only complete when all supporting documents, including the 2 academic references, are submitted. It is the applicant's responsibility to ensure their referees submit their references before the closing date. Please also explain your motivation why you wish to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.

Please quote reference PK43588 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Role of long non-coding RNAs in Zika virus-induced neuropathogenesis

Fri, 11/10/2024 - 01:00

Applications are invited for a fully-funded 4-year PhD studentship based in the Department of Pathology at the University of Cambridge under the supervision of Dr Nerea Irigoyen starting October 2025.

Long non-coding RNAs (lncRNAs) account for approximately 30% of human genes, and 40% are specifically expressed in the brain. Recent ribosome profiling analysis have shown that many cytoplasmic lncRNAs contain unannotated small open reading frames that can be translated into functional (micro)proteins involved in neurodevelopment.

Zika virus can be vertically transmitted to the foetus during pregnancy, leading to impaired brain development. These neuropathological mechanisms, a combination of viral genetics and host responses, still need to be fully understood. In this project, we will characterise how the differential expression of lncRNAs during infection will play a role in neuropathogenesis.

For more information please see https://www.path.cam.ac.uk/graduate/fully-funded-studentships.

Funding* will cover the student's stipend at the current Research Council rate and University Fees. The studentship will be funded for four years from October 2025. *The studentships are available to students who qualify for UK Home fees.

Applicants should hold (or expect to obtain) the equivalent of a UK 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject. The studentship is open to those eligible for the Home rate of University fees.

Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

All applications should be made online via the University's Applicant Portal for a PhD in Pathology (BLPA22). Applications should include academic transcripts, CV, statement of purpose and 2 references. An application is only complete when all supporting documents, including the 2 academic references, are submitted. It is the applicant's responsibility to ensure their referees submit their references before the closing date. Please also explain your motivation why you wish to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.

Please quote reference PK43589 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Laboratory Technician (Fixed Term)

Thu, 10/10/2024 - 01:00

Applications are welcome for the post of Research Laboratory Technician within the University of Cambridge's Department of Pathology based at the Addenbrookes site.

This is an exciting opportunity to be a part of the research group of Professor Colin Crump.

We are seeking an enthusiastic and experienced Research Technician with a keen interest in investigating the molecular cell biology of virus-host interactions.

The successful candidate will primarily be contributing to a new project based on how human and animal herpesviruses overcome cellular defenses against infection.

A few major aspects of this role include:

The generation and maintenance of a range of cells in culture, the production of high-quality stocks of several virus strains, assisting in the preparation and analysis of samples for experimental techniques including mass spectrometry, immunofluorescence microscopy, virus titrations as well as CRISPR/Cas9 techniques, and qPCR.

The successful candidate will have:

  • Extensive experience of relevant laboratory research techniques including working with human pathogens at containment level 2 or higher.

  • Previous experience of handling and propagating herpesvirus strains (will be important for this role).

  • Experience of preparing samples for proteomics analysis, e.g. for mass spectrometry and western blotting, as well as prior experience of generating stable cell lines using transduction (CRISPR/Cas9-based approaches will be an advantage)

Please see the attached Further Particulars document for more information.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Any queries regarding this position should be directed to Professor Colin Crump: cmc56@cam.ac.uk

Please quote reference PK43492 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Laboratory Technician (Fixed Term)

Wed, 28/08/2024 - 01:00

The Department of Pathology is looking to recruit a Research Laboratory Technician. This is an exciting opportunity for an enthusiastic individual to support research in both the Cellular and Molecular Pathology and Virology divisions of the department's Addenbrooke's site.

Responsibilities include maintaining good housekeeping (e.g., freezer cleanouts, cell passaging, mycoplasma testing), addressing issues with historical samples from former staff, and other tasks assigned by lab managers. This role may involve handling and maintaining cultured mammalian cells for various assays.

Ideal candidates will have lab experience, basic health and safety awareness, good communication skills, and the ability to follow standard procedures, prioritize tasks, and work both independently and as part of a team. Additionally, the role will provide support to the lab managers, particularly in replenishing laboratory consumables and stock taking. Further details regarding the role can be found in the attached further information file.

Limited funding: Funding is available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Previous applicants need not apply.

Any queries regarding this position should be directed to Dr Samuel Odeyemi, Senior Laboratory Manager swo28@cam.ac.uk.

Please quote reference PK43017 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Categories: Latest Jobs

Research Laboratory Technician (Fixed Term)

Tue, 27/08/2024 - 01:00

The McGovern laboratory at the Department of Pathology is seeking to recruit a Research Laboratory Technician. This is an exciting opportunity for a motivated individual to support the maintenance of the lab, to ensure research is delivered effectively. Also, to become part of a pioneering, forward-thinking and strategic team, that is continuously evolving and growing.

The McGovern lab studies macrophages and dendritic cells in human tissues. A major focus of the lab is studying the role of these cells at the maternal-fetal interface during pregnancy. The teams utilises a range of approaches including organoid systems, bioinformatics and confocal microscopy.

The role provides key support to the diverse interests of the team. This support includes collecting and processing primary human tissues, cell culture, establishing and maintaining organoids, maintaining reagents and consumable laboratory stocks, ordering reagents. The role holder must follow, be aware of and encourage compliance with various different frameworks for good practice, including the HTA. The role will also include administrative duties.

We're looking for

  • Biological Science Degree or equivalent experience

    • Experience using IT systems, platforms and generic applications (training provided for on in house specifics), proficient in Excel

    • Proven ability to flex to meet task re-prioritisation and to work efficiently in a team with minimal supervision

The University of Cambridge is a signatory to the Technician Commitment and as such is focusing on the areas of recognition, visibility, career development and sustainability.

Limited funding: Funding is available for 1 year in the first instance.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Previous applicants need not apply.

Any queries regarding this position should be directed to Dr Naomi McGovern - nm390@cam.ac.uk

Please quote reference PK42999 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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