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School of the Biological Sciences


Next Generation Fellow, Department of Physiology, Development and Neuroscience

Courtney Hanna’s research focuses on molecular and epigenetic regulators of placental development. Learn more


Research Areas

Gene regulation
Lineage specification


Molecular biology
Genomic sequencing
Single cell RNA-sequencing


Research Theme




Key publications: 



Hanna CW, Huang J, Belton C, Reinhardt S, Dahl A, Andrews S, Stewart AF, Kranz A, Kelsey G (2021). Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation. BioRxiv. doi:

Hanna CW, Kelsey G (2021). Features and mechanisms of canonical and non-canonical genomic imprinting. Genes & Development, 35(11-12):821-34.


Castillo-Fernandez J, Herrera-Puerta E, Demond H, Clark SJ, Hanna CW, Hemberger M, Kelsey G (2020). Increased transcriptome variation and localized DNA methylation changes in oocytes from aged mice revealed by parallel single-cell analysis. Aging Cell, 19(12):e13278.

Hanna CW (2020). Placental imprinting: Emerging mechanisms and functions. PLoS Genetics, 16(4):e1008709.

Hemberger M, Hanna CW, Dean W (2020). Mechanisms of early placental development in mouse and humans. Nature Reviews Genetics, 21(1):27-43.


Argelaguet​ R, Clark SJ​, Mohammed H​, Stapel​​ LC, Krueger C​, Kapourani​ CA​, Imaz-Rosshandler I, Lohoff T, Xiang​ Y​, Hanna​ CW​, Smallwood​ S​, Ibarra-Soria​ X​, Buettner​ F, Sanguinetti​ G, Xie​ W, Krueger​ F​, Göttgens B, Rugg-Gunn​ P​J, Kelsey​ G, Dean​ W​, Nichols​ J​, Stegle​ O​, Marioni​ JC​, Reik​ W (2019). Multi-omics profiling of mouse gastrulation at single cell resolution. Nature, 576(7787):487-491.

Hanna CW, Pérez-Palacios R, Gahurova L, Schubert M, Krueger F, Biggins L, Andrews S, Colomé-Tatché M, Bourc’his D, Dean W, Kelsey G (2019). Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues. Genome Biology, 20(1):225. 

Sendzikaite G, Hanna CW, Stewart-Morgan K, Ivanova E, Kelsey G (2019). A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and postnatal growth restriction. Nature Communications, 10(1):1884.


Hanna CW^, Demond H^, Kelsey G (2018). Epigenetic regulation in development: is the mouse a good model for the human? Human Reproduction Update, 24(5):556-76. ^These authors contributed equally to this work.

Del Gobbo GF, Price EM, Hanna CW, Robinson WP (2018). No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation. Clinical Epigenetics, 10(34):1-16.

Hanna CW, Taudt A, Huang J, Gahurova L, Kranz A, Andrews S, Dean W, Stewart AF, Colomé-Tatché M, Kelsey G (2018). MLL2 conveys transcription-independent H3K4 trimethylation in the oocyte. Nature Structural and Molecular Biology, 25(1):73-82.


Hanna CW, Kelsey G (2017). Genomic imprinting beyond DNA methylation: a role for maternal histones. Genome Biology, 18:177.


Hanna CW, Penaherrera MS, Saadeh H, Andrews S, McFadden DE, Kelsey G, Robinson WP (2016). Pervasive polymorphic imprinted methylation in the human placenta. Genome Research, 26(6):756-67.  


Wen J, Hanna CW, Martell S, Leung PCK, Lewis MSE, Robinson WP, Stephenson MD, Rajcan-Separovic E (2015). Functional consequences of copy number variants in miscarriage. Molecular Cytogenetics, 8(6):e1-9.


Hanna CW, Kelsey G (2014). The specification of imprints in mammals. Heredity, 113(2):176-83.


Hanna CW, McFadden DE, Robinson WP (2013). DNA methylation profiling of placental villi from karyotypically normal miscarriage and recurrent miscarriage. American Journal of Pathology, 182(6):2276-84.

Manokhina I, Hanna CW, McFadden DE, Stephenson MD, Robinson WP (2013). Maternal NLRP7 and C6orf221 mutations are not a common risk factor for androgenetic moles, triploidy and recurrent miscarriage. Molecular Human Reproduction, 19(8):539-44.


Hanna CW, Bloom MS, Robinson WP, Kim D, Parsons PJ, vom Saal FS, Taylor JA, Steuerwald AJ, Fujimoto VY (2012). DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF. Human Reproduction, 27(5):1401-10.

Hogg K, Price EM, Hanna CW, Robinson WP (2012). Prenatal and perinatal environmental influences on the human fetal and placental epigenome. Clinical Pharmacology and Therapeutics, 92(6):716-26.

Hanna CW^, Blair JD^, Stephenson MD, Robinson WP (2012). Absence of SYCP3 mutations in women with recurrent miscarriage with at least one trisomic miscarriage. Reproductive BioMedicine Online, 24(2):251-3. ^These authors contributed equally to this work.


Hanna CW, Bretherick KL, Liu CC, Stephenson MD, Robinson WP (2010). Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage. Human Reproduction, 25(10):2664-71.


Hanna CW^, Bretherick KL^, Gair JL, Fluker MR, Stephenson MD, Robinson WP (2009). Telomere length and reproductive aging. Human Reproduction, 24(5):1206-11. ^These authors contributed equally to this work.


Bretherick KL, Hanna CW, Fluker MR, Hammond GL, Robinson WP (2008). Estrogen receptor alpha gene polymorphisms are associated with idiopathic premature ovarian failure. Fertility and Sterility, 89(2):318-24.


Book Chapters

Dean W, Hanna CW (2019). Epigenetics of early mammalian development: a pathway to regenerative medicine. In “Epigenetics and Regeneration” Palacios (Ed). Elsevier Inc., New York. 

Hanna CW, Robinson WP (2017). Placentation and genomic imprinting.  In “Epigenetics in Human Reproduction and Development” Naumova and Taketo (Eds). World Scientific, Singapore.