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School of the Biological Sciences

 

 

University Lecturer, Department of Pharmacology

Theme Lead, Molecules and Cells: The Building Blocks of Life

Catherine Lindon studies how the pathways of ubiquitin protein regulate the cell cycle in human cells. Learn more

 

Research Areas


Cell biology
Cell cycle
Protein degradation
Ubiquitin pathways
PROTACs
 

Techniques


Molecular cell biology
Quantitative imaging
Timelapse imaging
Degradation assays
Ubiquitination assays
 

Areas for Collaboration


Biomolecular condensates
Ubiquitin chain topology
PROTAC development
 
 
 

 

Research Theme


  

 

Publications

Key publications: 

 

Wang R, Ascanelli C, Abdelbaki A, Fung A, Rasmusson T, Michaelides I, Roberts K, Lindon C (2021). Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool. Commun. Biol. 4 640

Naso F, Boi D, Ascanelli C, Pamfil G, Lindon C, Paiardini A, Guarguaglini G (2021). Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer. Oncogene 40 3917-28

Scott SJ, Li X, Jammula S, Devonshire G, Lindon C, Fitzgerald RC, D’Avino PP (2021). Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments. Cell Death Differ 28 2179-93

Esposito M, Akman HB, Ceregido MA, Giron P, Schepers R, Ramos-Paez LC, La Monaca E, De Greve J, Coux O, De Trez C, Lindon C, Gutierrez GJ (2020). USP13 controls the stability of Aurora B, impacting progression through the cell cycle. Oncogene 39 6009-23

AbdelbakiAM, AkmanHB, Grant R, Poteau M, Gavet O, Guarguaglini G, Lindon C (2020). AURKA destruction is decoupled from its activity at mitotic exit but suppresses interphase activity. J. Cell Sci. 133 jcs243071

Naso F, Sterbini V, Crecca E, Russo AD, Asteriti IA, Cundari E, Lindon C, Rosa A, Guarguaglini G (2020).  Excess TPX2 interferes with microtubule disassembly and nuclei reformation at mitotic exit. Cells 9 374

Grant R, Akman B, Abdelbaki A, Bertoldi A, Gavilan MP, Glover DM, Lindon C (2018). Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus. Open Biology 8 170272

Lindon C, Grant R, Min M (2016).  Ubiquitin-mediated degradation of Aurora kinases. Frontiers in Oncology 5 307

Min M, Mevissen TE, De Luca M, Komander D, Lindon C (2015).  Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages. Mol. Biol. Cell 26 4325-4332

Min M, Mayor U, Dittmar G, Lindon C (2014).  Using in vivo-biotinylated ubiquitin to describe a mitotic exit ubiquitome from human cells.  Molecular & Cellular Proteomics 13 2411-2425