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School of the Biological Sciences

 

 

University Lecturer, Department of Pharmacology

Catherine Lindon studies how the pathways of ubiquitin protein regulate the cell cycle in human cells. Learn more

 

Research Areas


Cell biology
Cell cycle
Protein degradation
Ubiquitin pathways
PROTACs
 

Techniques


Molecular cell biology
Quantitative imaging
Timelapse imaging
Degradation assays
Ubiquitination assays
 

Areas for Collaboration


Biomolecular condensates
Ubiquitin chain topology
PROTAC development
 
 
 

 

Research Theme


  

 

Publications

Key publications: 

Cardno A, Roberts K, Lindon C (2025). Efficiency and localisation of AURKA degradation by PROTACs is modulated by deubiquitinases UCHL5 and target-selective OTUD6A. bioRxiv 2025.04.23.650020

Cardno A, Kennedy B, Lindon C (2025). Cellular Parameters Shaping Pathways of Targeted Protein Degradation. Commun. Bio. 8 691

Eapen R, Okoye C, Stubbs C, Schimpl M, Tischer T, McCall E, Zacharopoulou M, Ferrer F, Barford D, Spring D, Lindon C, Phillips C, Itzhaki L (2025). Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome. eLife 14 RP104238

Cacioppo R, Akman H, Tuncer T, Erson-Bensan A, Lindon C (2023). Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A. elife 12 RP87253

Abdelbaki A, Ascanelli C, Okoye CN, Akman B, Janson G, Min M, Marcozzi C, Hagting A, Grant R, De Luca M, Asteriti IA, Guarguaglini G, Paiardini A, Lindon C (2022). Revisiting degron motifs in human AURKA required for its targeting by APC/C-FZR1. Life Sci Alliance 6 e202201372

Okoye CN, Itzhaki L, Lindon C (2022). Counting degrons: Lessons for targeted protein degradation from multivalent substrates. Frontiers in Physiology 13 913063

Vaughan N, Scholz N, Lindon C, Licchesi J (2022). HECTD1 ubiquitin ligase activity contributes to cell proliferation though an effect on mitosis. Sci. Rep. 12 13160

Wang R, Abdelbaki A, Ascanelli C, Fung A, Rasmusson T, Roberts K, Lindon C (2021). Selective targeting of non-centrosomal AURKA functions through use of a novel targeted protein degradation tool. Commun. Bio. 4 640

Min M, Mevissen TE, De Luca M, Komander D, Lindon C (2015). Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages. Mol. Biol. Cell 26 4325-4332

Min M, Mayor U, Lindon C (2013). Ubiquitination site preferences in APC/C substrates. Open Biology 3 (9) 130097