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School of the Biological Sciences

 

Group Leader, CRUK Career Development Fellow, Department of Pathology

The Mahata laboratory investigates the mechanism of immune cell-mediated steroidogenesis (a process by which immune cells synthesise and secrete steroid hormones to regulate their function). The laboratory aims to uncover the role of steroid-producing immunocytes in regulating cancer inflammation and immunity, and exploit that knowledge for developing immunotherapy. Learn more

 

Research Areas


Steroidogenesis
Cancer immunology
Type 2 immunity
Immune cell-mediated steroidogenesis
Steroid-producing immune cells
 
 

Techniques


Flow cytometry
Gene expression analysis (qPCR, RNAseq)
Western blot
Enzyme-linked immunosorbent assay (ELISA)
CRISPR/Cas9 gene knockout
 
 

Areas for Collaboration


Steroids detection by chromatography mass-spectrometry
Inflammation driven cancer
Cancer immunosuppression
Type 2 immune responses (e.g. helminth infection, allergies and asthma, arthritis)
Tissue repair
CAR-T cell and adoptive cell therapy

 

Research Theme