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School of the Biological Sciences

 

 

Professor of Computational and Molecular Biology, Department of Genetics 

Gos Micklem's work ranges from developing open source community resources such as the data warehouse system InterMine, to collaborative research projects in a range of areas including genome sequencing and annotation, functional genomics, synthetic biology and cancer research. Learn more. 

 

Research Areas


De novo genome sequencing 
Genomics of parasite action
Cancer biology
Synthetic biology
 
 

Techniques


Integrative genomics
Bioinformatics
Data integration
Research tool development 
 
 
   

 

Research Theme


 

Publications

Journal articles

2023

  • Han, Y., Micklem, G. and Kim, SY., 2023. Transcriptional landscape of oncogene-induced senescence: a machine learning-based meta-analytic approach. Ageing Res Rev, v. 85
    Doi: 10.1016/j.arr.2023.101849
  • 2019

  • Bean, DM., Heimbach, J., Ficorella, L., Micklem, G., Oliver, SG. and Favrin, G., 2019. Correction: esyN: Network Building, Sharing and Publishing. PLoS One, v. 14
    Doi: http://doi.org/10.1371/journal.pone.0204058
  • Kyritsis, KA., Wang, B., Sullivan, J., Lyne, R. and Micklem, G., 2019. InterMineR: an R package for InterMine databases. Bioinformatics,
    Doi: http://doi.org/10.1093/bioinformatics/btz039
  • Katayama, T., Kawashima, S., Micklem, G., Kawano, S., Kim, JD., Kocbek, S., Okamoto, S., Wang, Y., Wu, H., Yamaguchi, A., Yamamoto, Y., Antezana, E., Aoki-Kinoshita, KF., Arakawa, K., Banno, M., Baran, J., Bolleman, JT., Bonnal, RJP., Bono, H., Fernández-Breis, JT., Buels, R., Campbell, MP., Chiba, H., Cock, PJA., Cohen, KB., Dumontier, M., Fujisawa, T., Fujiwara, T., Garcia, L., Gaudet, P., Hattori, E., Hoehndorf, R., Itaya, K., Ito, M., Jamieson, D., Jupp, S., Juty, N., Kalderimis, A., Kato, F., Kawaji, H., Kawashima, T., Kinjo, AR., Komiyama, Y., Kotera, M., Kushida, T., Malone, J., Matsubara, M., Mizuno, S., Mizutani, S., Mori, H., Moriya, Y., Murakami, K., Nakazato, T., Nishide, H., Nishimura, Y., Ogishima, S., Ohta, T., Okuda, S., Ono, H., Perez-Riverol, Y., Shinmachi, D., Splendiani, A., Strozzi, F., Suzuki, S., Takehara, J., Thompson, M., Tokimatsu, T., Uchiyama, I., Verspoor, K., Wilkinson, MD., Wimalaratne, S., Yamada, I., Yamamoto, N., Yarimizu, M., Kawamoto, S. and Takagi, T., 2019. BioHackathon series in 2013 and 2014: Improvements of semantic interoperability in life science data and services F1000Research, v. 8
    Doi: http://doi.org/10.12688/f1000research.18238.1
  • 2018

  • Komkova, D., Lyne, R., Sullivan, J., Yehudi, Y. and Micklem, G., 2018. The InterMine Android app: Cross-organism genomic data in your pocket
    Doi: http://doi.org/10.12688/f1000research.17005.1
  • Komkova, D., Lyne, R., Sullivan, J., Yehudi, Y. and Micklem, G., 2018. The InterMine Android app: Cross-organism genomic data in your pocket. F1000Research, v. 7
    Doi: http://doi.org/10.12688/f1000research.17005.2
  • Ammari, M., Aryamontri, AC., Attrill, H., Bairoch, A., Berardini, T., Blake, J., Chen, Q., Collado, J., Dauga, D., Dudley, JT., Engel, S., Erill, I., Fey, P., Gibson, R., Hermjakob, H., Holliday, G., Howe, D., Hunter, C., Landsman, D., Lovering, R., Manthravadi, D., Marchler-Bauer, A., Matthews, B., McDonagh, EM., Meldal, B., Micklem, G., Mietchen, D., Mungall, CJ., Pruitt, K., Rajamanickam, VS., Reecy, JM., Rey, A., Shameer, K., Shipitsyna, A., Toribio, AL., Tuli, MA., Uetz, P., Wittig, U., Wood, V. and Biocuration, IS., 2018. Biocuration: Distilling data into knowledge PLOS BIOLOGY, v. 16
    Doi: http://doi.org/10.1371/journal.pbio.2002846
  • Nowell, RW., Almeida, P., Wilson, CG., Smith, TP., Fontaneto, D., Crisp, A., Micklem, G., Tunnacliffe, A., Boschetti, C. and Barraclough, TG., 2018. Comparative genomics of bdelloid rotifers: Insights from desiccating and nondesiccating species. PLoS Biol, v. 16
    Doi: http://doi.org/10.1371/journal.pbio.2004830
  • Sivade Dumousseau, M., Alonso-López, D., Ammari, M., Bradley, G., Campbell, NH., Ceol, A., Cesareni, G., Combe, C., De Las Rivas, J., Del-Toro, N., Heimbach, J., Hermjakob, H., Jurisica, I., Koch, M., Licata, L., Lovering, RC., Lynn, DJ., Meldal, BHM., Micklem, G., Panni, S., Porras, P., Ricard-Blum, S., Roechert, B., Salwinski, L., Shrivastava, A., Sullivan, J., Thierry-Mieg, N., Yehudi, Y., Van Roey, K. and Orchard, S., 2018. Encompassing new use cases - level 3.0 of the HUPO-PSI format for molecular interactions. BMC Bioinformatics, v. 19
    Doi: http://doi.org/10.1186/s12859-018-2118-1
  • 2017

  • Krishnakumar, V., Contrino, S., Cheng, C-Y., Belyaeva, I., Ferlanti, ES., Miller, JR., Vaughn, MW., Micklem, G., Town, CD. and Chan, AP., 2017. ThaleMine: A Warehouse for Arabidopsis Data Integration and Discovery. Plant and Cell Physiology, v. 58
    Doi: http://doi.org/10.1093/pcp/pcw200
  • Gracia, T., Wang, X., Su, Y., Norgett, EE., Williams, TL., Moreno, P., Micklem, G. and Frankl, FEK., 2017. Urinary Exosomes Contain MicroRNAs Capable of Paracrine Modulation of Tubular Transporters in Kidney Scientific Reports, v. 7
    Doi: 10.1038/srep40601
  • Modrell, MS., Lyne, M., Carr, AR., Zakon, HH., Buckley, D., Campbell, AS., Davis, MC., Micklem, G. and Baker, CV., 2017. Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome eLife, v. 6
    Doi: http://doi.org/10.7554/eLife.24197
  • Pacini, C., Ajioka, JW. and Micklem, G., 2017. Empirical Bayes method for reducing false discovery rates of correlation matrices with block diagonal structure BMC Bioinformatics, v. 18
    Doi: http://doi.org/10.1186/s12859-017-1623-y
  • Guo, J., Garrett, M., Micklem, G. and Brogna, S., 2017. Correction for Guo et al., "Poly(A) Signals Located near the 5' End of Genes Are Silenced by a General Mechanism That Prevents Premature 3'-End Processing". Mol Cell Biol, v. 37
    Doi: http://doi.org/10.1128/MCB.00189-17
  • Combe, CW., Sivade, MD., Hermjakob, H., Heimbach, J., Meldal, BHM., Micklem, G., Orchard, S. and Rappsilber, J., 2017. ComplexViewer: visualization of curated macromolecular complexes. Bioinformatics, v. 33
    Doi: 10.1093/bioinformatics/btx497
  • 2016

  • Aranda, M., Li, Y., Liew, YJ., Baumgarten, S., Simakov, O., Wilson, MC., Piel, J., Ashoor, H., Bougouffa, S., Bajic, VB., Ryu, T., Ravasi, T., Bayer, T., Micklem, G., Kim, H., Bhak, J., LaJeunesse, TC. and Voolstra, CR., 2016. Genomes of coral dinoflagellate symbionts highlight evolutionary adaptations conducive to a symbiotic lifestyle. Sci Rep, v. 6
    Doi: http://doi.org/10.1038/srep39734
  • 2015

  • Krishnakumar, V., Hanlon, MR., Contrino, S., Ferlanti, ES., Karamycheva, S., Kim, M., Rosen, BD., Cheng, C-Y., Moreira, W., Mock, SA., Stubbs, J., Sullivan, JM., Krampis, K., Miller, JR., Micklem, G., Vaughn, M. and Town, CD., 2015. Araport: the Arabidopsis information portal. Nucleic Acids Res, v. 43
    Doi: 10.1093/nar/gku1200
  • Crisp, A., Boschetti, C., Perry, M., Tunnacliffe, A. and Micklem, G., 2015. Expression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes. Genome Biol, v. 16
    Doi: http://doi.org/10.1186/s13059-015-0607-3
  • Lyne, R., Sullivan, J., Butano, D., Contrino, S., Heimbach, J., Hu, F., Kalderimis, A., Lyne, M., Smith, RN., Štěpán, R., Balakrishnan, R., Binkley, G., Harris, T., Karra, K., Moxon, SAT., Motenko, H., Neuhauser, S., Ruzicka, L., Cherry, M., Richardson, J., Stein, L., Westerfield, M., Worthey, E. and Micklem, G., 2015. Cross-organism analysis using InterMine. Genesis, v. 53
    Doi: http://doi.org/10.1002/dvg.22869
  • Rhee, DB., Croken, MM., Shieh, KR., Sullivan, J., Micklem, G., Kim, K. and Golden, A., 2015. toxoMine: an integrated omics data warehouse for Toxoplasma gondii systems biology research. Database (Oxford), v. 2015
    Doi: http://doi.org/10.1093/database/bav066
  • 2014

  • Kalderimis, A., Stepan, R., Sullivan, J., Lyne, R., Lyne, M. and Micklem, G., 2014. BioJS InterMine List Analysis: A BioJS component for displaying graphical or statistical analysis of collections of items from InterMine endpoints
    Doi: 10.12688/f1000research.3-45.v1
  • Kalderimis, A., Stepan, R., Sullivan, J., Lyne, R., Lyne, M. and Micklem, G., 2014. BioJS InterMineTable Component: A BioJS component for displaying data from InterMine compatible webservice endpoints
    Doi: 10.12688/f1000research.3-46.v1
  • Kalderimis, A., Stepan, R., Sullivan, J., Lyne, R., Lyne, M. and Micklem, G., 2014. BioJS DAGViewer: A reusable JavaScript component for displaying directed graphs. F1000Res, v. 3
    Doi: http://doi.org/10.12688/f1000research.3-51.v1
  • Liew, YJ., Aranda, M., Carr, A., Baumgarten, S., Zoccola, D., Tambutté, S., Allemand, D., Micklem, G. and Voolstra, CR., 2014. Identification of microRNAs in the coral Stylophora pistillata. PLoS One, v. 9
    Doi: 10.1371/journal.pone.0091101
  • Kalderimis, A., Lyne, R., Butano, D., Contrino, S., Lyne, M., Heimbach, J., Hu, F., Smith, R., Stěpán, R., Sullivan, J. and Micklem, G., 2014. InterMine: extensive web services for modern biology. Nucleic Acids Res, v. 42
    Doi: 10.1093/nar/gku301
  • Diffner, E., Beck, D., Gudgin, E., Thoms, JAI., Knezevic, K., Pridans, C., Foster, S., Goode, D., Khong Lim, W., Boelen, L., Metzeler, KH., Micklem, G., Bohlander, SK., Buske, C., Burnett, A., Ottersbach, K., Vassiliou, GS., Olivier, J., Wong, JWH., Gottgens, B., Huntly, BJ. and Pimanda, JE., 2014. Erratum: Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia (Blood (2013) 121:12 (2289-2300)) Blood, v. 123
    Doi: http://doi.org/10.1182/blood-2014-03-564831
  • Diffner, E., Beck, D., Gudgin, E., Thoms, JAI., Knezevic, K., Pridans, C., Foster, S., Goode, D., Lim, WK., Boelen, L., Metzeler, KH., Micklem, G., Bohlander, SK., Buske, C., Burnett, A., Ottersbach, K., Vassiliou, GS., Olivier, J., Wong, JWH., Goettgens, B., Huntly, BJ. and Pimanda, JE., 2014. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia (vol 121, pg 2289, 2013) BLOOD, v. 123
    Doi: 10.1182/blood-2014-03-564831
  • Bean, DM., Heimbach, J., Ficorella, L., Micklem, G., Oliver, SG. and Favrin, G., 2014. esyN: network building, sharing and publishing. PLoS One, v. 9
    Doi: 10.1371/journal.pone.0106035
  • 2013

  • Diffner, E., Beck, D., Gudgin, E., Thoms, JAI., Knezevic, K., Pridans, C., Foster, S., Goode, D., Lim, WK., Boelen, L., Metzeler, KH., Micklem, G., Bohlander, SK., Buske, C., Burnett, A., Ottersbach, K., Vassiliou, GS., Olivier, J., Wong, JWH., Göttgens, B., Huntly, BJ. and Pimanda, JE., 2013. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia. Blood, v. 121
    Doi: http://doi.org/10.1182/blood-2012-07-446120
  • Katayama, T., Wilkinson, MD., Micklem, G., Kawashima, S., Yamaguchi, A., Nakao, M., Yamamoto, Y., Okamoto, S., Oouchida, K., Chun, H-W., Aerts, J., Afzal, H., Antezana, E., Arakawa, K., Aranda, B., Belleau, F., Bolleman, J., Bonnal, RJ., Chapman, B., Cock, PJ., Eriksson, T., Gordon, PM., Goto, N., Hayashi, K., Horn, H., Ishiwata, R., Kaminuma, E., Kasprzyk, A., Kawaji, H., Kido, N., Kim, YJ., Kinjo, AR., Konishi, F., Kwon, K-H., Labarga, A., Lamprecht, A-L., Lin, Y., Lindenbaum, P., McCarthy, L., Morita, H., Murakami, K., Nagao, K., Nishida, K., Nishimura, K., Nishizawa, T., Ogishima, S., Ono, K., Oshita, K., Park, K-J., Prins, P., Saito, TL., Samwald, M., Satagopam, VP., Shigemoto, Y., Smith, R., Splendiani, A., Sugawara, H., Taylor, J., Vos, RA., Withers, D., Yamasaki, C., Zmasek, CM., Kawamoto, S., Okubo, K., Asai, K. and Takagi, T., 2013. The 3rd DBCLS BioHackathon: improving life science data integration with Semantic Web technologies. J Biomed Semantics, v. 4
    Doi: http://doi.org/10.1186/2041-1480-4-6
  • Sullivan, J., Karra, K., Moxon, SAT., Vallejos, A., Motenko, H., Wong, JD., Aleksic, J., Balakrishnan, R., Binkley, G., Harris, T., Hitz, B., Jayaraman, P., Lyne, R., Neuhauser, S., Pich, C., Smith, RN., Trinh, Q., Cherry, JM., Richardson, J., Stein, L., Twigger, S., Westerfield, M., Worthey, E. and Micklem, G., 2013. InterMOD: integrated data and tools for the unification of model organism research. Sci Rep, v. 3
    Doi: http://doi.org/10.1038/srep01802
  • Lyne, M., Smith, RN., Lyne, R., Aleksic, J., Hu, F., Kalderimis, A., Stepan, R. and Micklem, G., 2013. metabolicMine: an integrated genomics, genetics and proteomics data warehouse for common metabolic disease research. Database (Oxford), v. 2013
    Doi: 10.1093/database/bat060
  • Diffner, E., Beck, D., Gudgin, E., Thoms, JAI., Knezevic, K., Pridans, C., Foster, S., Goode, D., Weng, KL., Boelen, L., Metzeler, KH., Micklem, G., Bohlander, SK., Buske, C., Burnett, A., Ottersbach, K., Vassiliou, GS., Olivier, J., Wong, JWH., Goettgens, B., Huntly, BJ. and Pimanda, JE., 2013. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia BLOOD, v. 121
    Doi: 10.1182/blood-2012-07-446120
  • Baumgarten, S., Bayer, T., Aranda, M., Liew, YJ., Carr, A., Micklem, G. and Voolstra, CR., 2013. Integrating microRNA and mRNA expression profiling in Symbiodinium microadriaticum, a dinoflagellate symbiont of reef-building corals. BMC Genomics, v. 14
    Doi: http://doi.org/10.1186/1471-2164-14-704
  • Sullivan, J., Karra, K., Moxon, SA., Vallejos, A., Motenko, H., Wong, JD., Aleksic, J., Balakrishnan, R., Binkley, G., Harris, T., Hitz, B., Jayaraman, P., Lyne, R., Neuhauser, S., Pich, C., Smith, RN., Trinh, Q., Cherry, JM., Richardson, J., Stein, L., Twigger, S., Westerfield, M., Worthey, E. and Micklem, G., 2013. CORRIGENDUM: InterMOD: integrated data and tools for the unification of model organism research. Sci Rep, v. 3
    Doi: http://doi.org/10.1038/srep03303
  • 2013. CORRIGENDUM: InterMOD: integrated data and tools for the unification of model organism research Scientific reports, v. 3
  • 2012

  • Eyres, I., Frangedakis, E., Fontaneto, D., Herniou, EA., Boschetti, C., Carr, A., Micklem, G., Tunnacliffe, A. and Barraclough, TG., 2012. Multiple functionally divergent and conserved copies of alpha tubulin in bdelloid rotifers. BMC Evol Biol, v. 12
    Doi: http://doi.org/10.1186/1471-2148-12-148
  • Smith, RN., Aleksic, J., Butano, D., Carr, A., Contrino, S., Hu, F., Lyne, M., Lyne, R., Kalderimis, A., Rutherford, K., Stepan, R., Sullivan, J., Wakeling, M., Watkins, X. and Micklem, G., 2012. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics, v. 28
    Doi: http://doi.org/10.1093/bioinformatics/bts577
  • Boschetti, C., Carr, A., Crisp, A., Eyres, I., Wang-Koh, Y., Lubzens, E., Barraclough, TG., Micklem, G. and Tunnacliffe, A., 2012. Biochemical diversification through foreign gene expression in bdelloid rotifers. PLoS Genet, v. 8
    Doi: http://doi.org/10.1371/journal.pgen.1003035
  • Contrino, S., Smith, RN., Butano, D., Carr, A., Hu, F., Lyne, R., Rutherford, K., Kalderimis, A., Sullivan, J., Carbon, S., Kephart, ET., Lloyd, P., Stinson, EO., Washington, NL., Perry, MD., Ruzanov, P., Zha, Z., Lewis, SE., Stein, LD. and Micklem, G., 2012. modMine: flexible access to modENCODE data. Nucleic Acids Res, v. 40
    Doi: http://doi.org/10.1093/nar/gkr921
  • Balakrishnan, R., Park, J., Karra, K., Hitz, BC., Binkley, G., Hong, EL., Sullivan, J., Micklem, G. and Cherry, JM., 2012. YeastMine--an integrated data warehouse for Saccharomyces cerevisiae data as a multipurpose tool-kit. Database (Oxford), v. 2012
    Doi: http://doi.org/10.1093/database/bar062
  • 2011

  • Guo, J., Garrett, M., Micklem, G. and Brogna, S., 2011. Poly(A) signals located near the 5' end of genes are silenced by a general mechanism that prevents premature 3'-end processing. Mol Cell Biol, v. 31
    Doi: http://doi.org/10.1128/MCB.00919-10
  • Sykacek, P., Kreil, DP., Meadows, LA., Auburn, RP., Fischer, B., Russell, S. and Micklem, G., 2011. The impact of quantitative optimization of hybridization conditions on gene expression analysis. BMC Bioinformatics, v. 12
    Doi: 10.1186/1471-2105-12-73
  • Lim, WK. and Micklem, G., 2011. MicroRNAs dysregulated in breast cancer preferentially target key oncogenic pathways. Mol Biosyst, v. 7
    Doi: http://doi.org/10.1039/c1mb05181d
  • Washington, NL., Stinson, EO., Perry, MD., Ruzanov, P., Contrino, S., Smith, R., Zha, Z., Lyne, R., Carr, A., Lloyd, P., Kephart, E., McKay, SJ., Micklem, G., Stein, LD. and Lewis, SE., 2011. The modENCODE Data Coordination Center: lessons in harvesting comprehensive experimental details. Database (Oxford), v. 2011
    Doi: http://doi.org/10.1093/database/bar023
  • Washington, NL., Stinson, EO., Perry, MD., Ruzanov, P., Contrino, S., Smith, R., Zha, Z., Lyne, R., Carr, A., Lloyd, P., Kephart, E., McKay, SJ., Micklem, G., Stein, LD. and Lewis, SE., 2011. The modENCODE data coordination center: Lessons in harvesting comprehensive experimental details Database, v. 2011
    Doi: http://doi.org/10.1093/database/bar023
  • 2010

  • modENCODE Consortium, , Roy, S., Ernst, J., Kharchenko, PV., Kheradpour, P., Negre, N., Eaton, ML., Landolin, JM., Bristow, CA., Ma, L., Lin, MF., Washietl, S., Arshinoff, BI., Ay, F., Meyer, PE., Robine, N., Washington, NL., Di Stefano, L., Berezikov, E., Brown, CD., Candeias, R., Carlson, JW., Carr, A., Jungreis, I., Marbach, D., Sealfon, R., Tolstorukov, MY., Will, S., Alekseyenko, AA., Artieri, C., Booth, BW., Brooks, AN., Dai, Q., Davis, CA., Duff, MO., Feng, X., Gorchakov, AA., Gu, T., Henikoff, JG., Kapranov, P., Li, R., MacAlpine, HK., Malone, J., Minoda, A., Nordman, J., Okamura, K., Perry, M., Powell, SK., Riddle, NC., Sakai, A., Samsonova, A., Sandler, JE., Schwartz, YB., Sher, N., Spokony, R., Sturgill, D., van Baren, M., Wan, KH., Yang, L., Yu, C., Feingold, E., Good, P., Guyer, M., Lowdon, R., Ahmad, K., Andrews, J., Berger, B., Brenner, SE., Brent, MR., Cherbas, L., Elgin, SCR., Gingeras, TR., Grossman, R., Hoskins, RA., Kaufman, TC., Kent, W., Kuroda, MI., Orr-Weaver, T., Perrimon, N., Pirrotta, V., Posakony, JW., Ren, B., Russell, S., Cherbas, P., Graveley, BR., Lewis, S., Micklem, G., Oliver, B., Park, PJ., Celniker, SE., Henikoff, S., Karpen, GH., Lai, EC., MacAlpine, DM., Stein, LD., White, KP. and Kellis, M., 2010. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science, v. 330
    Doi: 10.1126/science.1198374
  • Gerstein, MB., Lu, ZJ., Van Nostrand, EL., Cheng, C., Arshinoff, BI., Liu, T., Yip, KY., Robilotto, R., Rechtsteiner, A., Ikegami, K., Alves, P., Chateigner, A., Perry, M., Morris, M., Auerbach, RK., Feng, X., Leng, J., Vielle, A., Niu, W., Rhrissorrakrai, K., Agarwal, A., Alexander, RP., Barber, G., Brdlik, CM., Brennan, J., Brouillet, JJ., Carr, A., Cheung, M-S., Clawson, H., Contrino, S., Dannenberg, LO., Dernburg, AF., Desai, A., Dick, L., Dosé, AC., Du, J., Egelhofer, T., Ercan, S., Euskirchen, G., Ewing, B., Feingold, EA., Gassmann, R., Good, PJ., Green, P., Gullier, F., Gutwein, M., Guyer, MS., Habegger, L., Han, T., Henikoff, JG., Henz, SR., Hinrichs, A., Holster, H., Hyman, T., Iniguez, AL., Janette, J., Jensen, M., Kato, M., Kent, WJ., Kephart, E., Khivansara, V., Khurana, E., Kim, JK., Kolasinska-Zwierz, P., Lai, EC., Latorre, I., Leahey, A., Lewis, S., Lloyd, P., Lochovsky, L., Lowdon, RF., Lubling, Y., Lyne, R., MacCoss, M., Mackowiak, SD., Mangone, M., McKay, S., Mecenas, D., Merrihew, G., Miller, DM., Muroyama, A., Murray, JI., Ooi, S-L., Pham, H., Phippen, T., Preston, EA., Rajewsky, N., Rätsch, G., Rosenbaum, H., Rozowsky, J., Rutherford, K., Ruzanov, P., Sarov, M., Sasidharan, R., Sboner, A., Scheid, P., Segal, E., Shin, H., Shou, C., Slack, FJ., Slightam, C., Smith, R., Spencer, WC., Stinson, EO., Taing, S., Takasaki, T., Vafeados, D., Voronina, K., Wang, G., Washington, NL., Whittle, CM., Wu, B., Yan, K-K., Zeller, G., Zha, Z., Zhong, M., Zhou, X., modENCODE Consortium, , Ahringer, J., Strome, S., Gunsalus, KC., Micklem, G., Liu, XS., Reinke, V., Kim, SK., Hillier, LW., Henikoff, S., Piano, F., Snyder, M., Stein, L., Lieb, JD. and Waterston, RH., 2010. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science, v. 330
    Doi: 10.1126/science.1196914
  • 2009

  • Garrett, M., Fullaondo, A., Troxler, L., Micklem, G. and Gubb, D., 2009. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. BMC Genomics, v. 10
    Doi: http://doi.org/10.1186/1471-2164-10-489
  • Celniker, SE., Dillon, LAL., Gerstein, MB., Gunsalus, KC., Henikoff, S., Karpen, GH., Kellis, M., Lai, EC., Lieb, JD., MacAlpine, DM., Micklem, G., Piano, F., Snyder, M., Stein, L., White, KP., Waterston, RH. and modENCODE Consortium, , 2009. Unlocking the secrets of the genome. Nature, v. 459
    Doi: 10.1038/459927a
  • 2007

  • Lyne, R., Smith, R., Rutherford, K., Wakeling, M., Varley, A., Guillier, F., Janssens, H., Ji, W., Mclaren, P., North, P., Rana, D., Riley, T., Sullivan, J., Watkins, X., Woodbridge, M., Lilley, K., Russell, S., Ashburner, M., Mizuguchi, K. and Micklem, G., 2007. FlyMine: an integrated database for Drosophila and Anopheles genomics. Genome Biol, v. 8
    Doi: 10.1186/gb-2007-8-7-r129
  • Bernhardt, K., Chand, NS., Carter, E., Lee, J., Xu, Y., Zhu, X., Rowe, D., Ajioka, JW., Goncalves, JM., Haseloff, J. and Micklem, G., 2007. New tools for self-organized pattern formation BMC Systems Biology, v. 1
    Doi: 10.1186/1752-0509-1-s1-s10
  • Hudson, SG., Garrett, MJ., Carlson, JW., Micklem, G., Celniker, SE., Goldstein, ES. and Newfeld, SJ., 2007. Phylogenetic and genomewide analyses suggest a functional relationship between kayak, the Drosophila fos homolog, and fig, a predicted protein phosphatase 2c nested within a kayak intron. Genetics, v. 177
    Doi: http://doi.org/10.1534/genetics.107.071670
  • Bernhardt, K., Carter, EJ., Chand, NS., Lee, J., Xu, Y., Zhu, X., Ajioka, JW., Goncalves, JM., Haseloff, J., Micklem, G. and Rowe, D., 2007. New tools for self-organised pattern formation IET Synthetic Biology, v. 1
    Doi: 10.1049/iet-stb:20070020
  • Sykacek, P., Clarkson, R., Print, C., Furlong, R. and Micklem, G., 2007. Bayesian modelling of shared gene function. Bioinformatics, v. 23
    Doi: http://doi.org/10.1093/bioinformatics/btm280
  • 2006

  • Choksi, SP., Southall, TD., Bossing, T., Edoff, K., de Wit, E., Fischer, BE., van Steensel, B., Micklem, G. and Brand, AH., 2006. Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Dev Cell, v. 11
    Doi: 10.1016/j.devcel.2006.09.015
  • 2005

  • Sykacek, P., Furlong, RA. and Micklem, G., 2005. A friendly statistics package for microarray analysis. Bioinformatics, v. 21
    Doi: http://doi.org/10.1093/bioinformatics/bti663
  • 2004

  • International Human Genome Sequencing Consortium., and Woodfine, K., 2004. Finishing the euchromatic sequence of the human genome Nature, v. 431
  • Collins, FS., Lander, ES., Rogers, J., Waterston, RH. and Int Human Genome Sequencing Conso, , 2004. Finishing the euchromatic sequence of the human genome NATURE, v. 431
    Doi: http://doi.org/10.1038/nature03001
  • 2001

  • Micklem, G. and The Genome Sequencing Consortium, , 2001. Initial sequencing and analysis of the human genome Nature, v. 409
  • 1997

  • Bignell, G., Micklem, G., Stratton, MR., Ashworth, A. and Wooster, R., 1997. The BRC repeats are conserved in mammalian BRCA2 proteins. Hum Mol Genet, v. 6
    Doi: http://doi.org/10.1093/hmg/6.1.53
  • Flint, J., Thomas, K., Micklem, G., Raynham, H., Clark, K., Doggett, NA., King, A. and Higgs, DR., 1997. The relationship between chromosome structure and function at a human telomeric region. Nat Genet, v. 15
    Doi: http://doi.org/10.1038/ng0397-252
  • Flint, J., Bates, GP., Clark, K., Dorman, A., Willingham, D., Roe, BA., Micklem, G., Higgs, DR. and Louis, EJ., 1997. Sequence comparison of human and yeast telomeres identifies structurally distinct subtelomeric domains. Hum Mol Genet, v. 6
    Doi: http://doi.org/10.1093/hmg/6.8.1305
  • Schofield, JP., Elgar, G., Greystrong, J., Lye, G., Deadman, R., Micklem, G., King, A., Brenner, S. and Vaudin, M., 1997. Regions of human chromosome 2 (2q32-q35) and mouse chromosome 1 show synteny with the pufferfish genome (Fugu rubripes). Genomics, v. 45
    Doi: http://doi.org/10.1006/geno.1997.4913
  • 1996

  • Coy, JF., Dübel, S., Kioschis, P., Thomas, K., Micklem, G., Delius, H. and Poustka, A., 1996. Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes. Genomics, v. 32
    Doi: http://doi.org/10.1006/geno.1996.0124
  • 1995

  • Baxendale, S., Abdulla, S., Elgar, G., Buck, D., Berks, M., Micklem, G., Durbin, R., Bates, G., Brenner, S. and Beck, S., 1995. Comparative sequence analysis of the human and pufferfish Huntington's disease genes. Nat Genet, v. 10
    Doi: 10.1038/ng0595-67
  • WOOSTER, R., BIGNELL, G., LANCASTER, J., SWIFT, S., SEAL, S., MANGION, J., COLLINS, N., GREGORY, S., GUMBS, C., MICKLEM, G., BARFOOT, R., HAMOUDI, R., PATEL, S., RICE, C., BIGGS, P., HASHIM, Y., SMITH, A., CONNOR, F., ARASON, A., GUDMUNDSSON, J., FICENEC, D., KELSELL, D., FORD, D., TONIN, P., BISHOP, DT., SPURR, NK., PONDER, BAJ., EELES, R., PETO, J., DEVILEE, P., CORNELISSE, C., LYNCH, H., NAROD, S., LENOIR, G., EGILSSON, V., BARKADOTTIR, RB., EASTON, DF., BENTLEY, DR., FUTREAL, PA., ASHWORTH, A. and STRATTON, MR., 1995. IDENTIFICATION OF THE BREAST-CANCER SUSCEPTIBILITY GENE BRCA2 NATURE, v. 378
  • Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S., Gumbs, C., Micklem, G., Barfoot, R., Hamoudi, R., Patel, S., Rices, C., Biggs, P., Hashim, Y., Smith, A., Connor, F., Arason, A., Gudmundsson, J., Flcenec, D., Kelsell, D., Ford, D., Tonin, P., Timothy Bishop, D., Spurr, NK., Ponder, BAJ., Eeles, R., Peto, J., Devilee, P., Cornelisse, C., Lynch, H., Narod, S., Lenoir, G., Egilsson, V., Bjork Barkadottir, R., Easton, DF., Bentley, DR., Futreal, PA., Ashworth, A. and Stratton, MR., 1995. Identification of the breast cancer susceptibility gene BRCA2 Nature, v. 378
    Doi: http://doi.org/10.1038/378789a0
  • 1994

  • Ambrose, CM., Duyao, MP., Barnes, G., Bates, GP., Lin, CS., Srinidhi, J., Baxendale, S., Hummerich, H., Lehrach, H., Altherr, M., Wasmuth, J., Buckler, A., Church, D., Housman, D., Berks, M., Micklem, G., Durbin, R., Dodge, A., Read, A., Gusella, J. and MacDonald, ME., 1994. Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat. Somat Cell Mol Genet, v. 20
    Doi: 10.1007/BF02257483
  • Castelli-Gair, J., Greig, S., Micklem, G. and Akam, M., 1994. Dissecting the temporal requirements for homeotic gene function. Development, v. 120
    Doi: 10.1242/dev.120.7.1983
  • Nehls, M., Pfeifer, D., Micklem, G., Schmoor, C. and Boehm, T., 1994. The sequence complexity of exons trapped from the mouse genome. Curr Biol, v. 4
    Doi: http://doi.org/10.1016/s0960-9822(00)00222-0
  • BUCK, D., THOMAS, K., HEATHCOTT, R., MUNGALL, A., MCMURRAY, A., BARON, L., HODGSON, D., ZHAO, S., BENTLEY, D., KIOSCHIS, P., COY, JF., KONECKI, DS., MICKLEM, G. and POUSTKA, AM., 1994. SEQUENCING AND ANALYSIS OF HUMAN XQ28 GENOMIC DNA IN THE REGION OF THE RCP/GCP LOCUS CYTOGENET CELL GENET, v. 67
  • 1993

  • Micklem, G., Rowley, A., Harwood, J., Nasmyth, K. and Diffley, JF., 1993. Yeast origin recognition complex is involved in DNA replication and transcriptional silencing. Nature, v. 366
    Doi: http://doi.org/10.1038/366087a0
  • 1987

  • Brand, AH., Micklem, G. and Nasmyth, K., 1987. A yeast silencer contains sequences that can promote autonomous plasmid replication and transcriptional activation. Cell, v. 51
    Doi: 10.1016/0092-8674(87)90094-8
  • Komkova, D., Lyne, R., Sullivan, J., Yehudi, Y. and Micklem, G., The InterMine Android app: Cross-organism genomic data in your pocket F1000Research, v. 7
    Doi: http://doi.org/10.12688/f1000research.17005.2
  • Baker, C., Perera, S., Micklem, G., Lyne, R., Williams, R., Stubbs, O., Buehler, D., Sauka-Spengler, T., Noda, M. and Southard-Smith, M., Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach Glia,
  • Bazaga, A., Gunwant, N. and Micklem, G., Translating synthetic natural language to database queries with a polyglot deep learning framework Scientific Reports,
  • Micklem, G., HumanMine: advanced data searching, analysis and cross-species comparison. Database: the journal of biological databases and curation,
    Doi: 10.1093/database/baac054
  • Micklem, G., HumanMine: advanced data searching, analysis and cross-species comparison. Database: the journal of biological databases and curation,
  • Software

    2018

  • Micklem, G., Butano, D., Clark-Casey, J., Contrino, S., Heimbach, J., Lyne, R., Sullivan, J. and Yehudi, Y., 2018. The InterMine framework for large scale integration of heterogeneous biological data.
  • 2017

  • Micklem, G., Butano, D., Clark-Casey, J., Contrino, S., Heimbach, J., Lyne, R., Sullivan, J. and Yehudi, Y., 2017. HumanMine: an integrated database of Homo sapiens genomic data
  • Micklem, G., Butano, D., Clark-Casey, J., Contrino, S., Heimbach, J., Lyne, R., Sullivan, J. and Yehudi, Y., 2017. FlyMine: an integrated database for Drosophila genomics
  • Internet publications

    2007

  • Lyne, R., Smith, R., Rutherford, K., Wakeling, M., Varley, A., Guillier, F., Janssens, H., Ji, W., Mclaren, P., North, P., Rana, D., Riley, T., Sullivan, J., Watkins, X., Woodbridge, M., Lilley, K., Russell, S., Ashburner, M., Mizuguchi, K. and Micklem, G., 2007. FlyMine: an integrated database for Drosophila and Anopheles genomics
    Doi: 10.1186/gb-2007-8-7-r129
  • Conference proceedings

    2019

  • Butano, D., Clark-Casey, J., Contrino, S., Heimbach, J., Lyne, R., Reierskog, KH., Sullivan, J., Yehudi, Y. and Micklem, G., 2019. Implementing FAIR principles in InterMine CEUR Workshop Proceedings, v. 2849
  • 2016

  • Rhee, D., Shieh, K., Sullivan, J., Micklem, G., Kim, K. and Golden, A., 2016. Understanding the Systems Biology of Pathogen Virulence Using Semantic Methodologies Proceedings - 2016 IEEE 10th International Conference on Semantic Computing, ICSC 2016,
    Doi: http://doi.org/10.1109/ICSC.2016.33
  • Déraspe, M., Binkley, G., Butano, D., Chadwick, M., Cherry, JM., Clark-Casey, J., Contrino, S., Corbeil, J., Heimbach, J., Karra, K., Lyne, R., Sullivan, J., Yehudi, Y., Micklem, G. and Dumontier, M., 2016. Making linked data SPARQL with the InterMine biological data warehouse CEUR Workshop Proceedings, v. 1795