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School of the Biological Sciences

 

 

Professor of Developmental Biology and Joint Head of Department, Department of Physiology, Development and Neuroscience

Sarah Bray uses a combination of live-imaging, genetic, biochemical and genomic approaches in Drosophila and in human cells to discover the fundamental mechanisms that reset and sculpt transcriptional responses to the Notch cell signalling pathway. Learn more. 

 

Research Areas


Developmental biology
Neurogenesis
Cancer
Notch
 
 

Techniques


Genomics
Drosophila
Live-imaging
 
 
 
   

 

Research Theme


   Reproduction, Development and Lifelong Health

 

Publications

Journal articles

2023

  • Townson, JM., Gomez-Lamarca, MJ., Santa Cruz Mateos, C. and Bray, SJ., 2023. OptIC-Notch reveals mechanism that regulates receptor interactions with CSL. Development, v. 150
    Doi: http://doi.org/10.1242/dev.201785
  • 2022

  • Logeay, R., Géminard, C., Lassus, P., Rodríguez-Vázquez, M., Kantar, D., Heron-Milhavet, L., Fischer, B., Bray, SJ., Colinge, J. and Djiane, A., 2022. Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila. Development, v. 149
    Doi: 10.1242/dev.200110
  • 2021

  • Falo-Sanjuan, J. and Bray, SJ., 2021. Membrane architecture and adherens junctions contribute to strong Notch pathway activation
    Doi: 10.1101/2021.05.26.445755
  • 2019

  • Koca, Y., Housden, BE., Gault, WJ., Bray, SJ. and Mlodzik, M., 2019. Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos. Sci Rep, v. 9
    Doi: http://doi.org/10.1038/s41598-019-55203-w
  • 2018

  • Bray, SJ. and Gomez-Lamarca, M., 2018. Notch after cleavage. Curr Opin Cell Biol, v. 51
    Doi: http://doi.org/10.1016/j.ceb.2017.12.008
  • Boukhatmi, H. and Bray, S., 2018. A population of adult satellite-like cells in Drosophila is maintained through a switch in RNA-isoforms. Elife, v. 7
    Doi: http://doi.org/10.7554/eLife.35954
  • Bray, S., Storey, K. and Brown, K., 2018. A new Editor-in-Chief for Development. Development, v. 145
    Doi: http://doi.org/10.1242/dev.165266
  • 2017

  • Terriente-Félix, A., Pérez, L., Bray, SJ., Nebreda, AR. and Milán, M., 2017. A $\textit{Drosophila }$ model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling. Disease Models & Mechanisms, v. 10
    Doi: http://doi.org/10.1242/dmm.028118
  • Yao, L., Wang, S., Westholm, JO., Dai, Q., Matsuda, R., Hosono, C., Bray, S., Lai, EC. and Samakovlis, C., 2017. Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl. Development, v. 144
    Doi: http://doi.org/10.1242/dev.143297
  • Chan, SKK., Cerda-Moya, G., Stojnic, R., Millen, K., Fischer, B., Fexova, S., Skalska, L., Gomez-Lamarca, M., Pillidge, Z., Russell, S. and Bray, SJ., 2017. Role of co-repressor genomic landscapes in shaping the Notch response. PLoS Genet, v. 13
    Doi: 10.1371/journal.pgen.1007096
  • 2016

  • Zacharioudaki, E., Housden, BE., Garinis, G., Stojnic, R., Delidakis, C. and Bray, SJ., 2016. Genes implicated in stem cell identity and temporal programme are directly targeted by Notch in neuroblast tumours. Development, v. 143
    Doi: http://doi.org/10.1242/dev.126326
  • Slaninova, V., Krafcikova, M., Perez-Gomez, R., Steffal, P., Trantirek, L., Bray, SJ. and Krejci, A., 2016. Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle. Open Biol, v. 6
    Doi: 10.1098/rsob.150155
  • Bray, SJ., 2016. Notch signalling in context. Nat Rev Mol Cell Biol, v. 17
    Doi: http://doi.org/10.1038/nrm.2016.94
  • 2015

  • Zaessinger, S., Zhou, Y., Bray, SJ., Tapon, N. and Djiane, A., 2015. Drosophila MAGI interacts with RASSF8 to regulate E-Cadherin-based adherens junctions in the developing eye. Development, v. 142
    Doi: 10.1242/dev.116277
  • Skalska, L., Stojnic, R., Li, J., Fischer, B., Cerda-Moya, G., Sakai, H., Tajbakhsh, S., Russell, S., Adryan, B. and Bray, SJ., 2015. Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation. EMBO J, v. 34
    Doi: 10.15252/embj.201489923
  • Gomez-Lamarca, MJ., Snowdon, LA., Seib, E., Klein, T. and Bray, SJ., 2015. Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. J Cell Biol, v. 210
    Doi: 10.1083/jcb.201411001
  • Gomez-Lamarca, M., Snowdon, LA., Seib, E., Klein, T. and Bray, S., 2015. Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. J Cell Biol, v. 210
    Doi: http://doi.org/10.1083/jcb.20141100107172015c
  • 2014

  • Torella, R., Li, J., Kinrade, E., Cerda-Moya, G., Contreras, AN., Foy, R., Stojnic, R., Glen, RC., Kovall, RA., Adryan, B. and Bray, SJ., 2014. A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL. Nucleic Acids Res, v. 42
    Doi: 10.1093/nar/gku730
  • Djiane, A., Zaessinger, S., Babaoğlan, AB. and Bray, SJ., 2014. Notch inhibits Yorkie activity in Drosophila wing discs. PLoS One, v. 9
    Doi: 10.1371/journal.pone.0106211
  • Lowe, N., Rees, JS., Roote, J., Ryder, E., Armean, IM., Johnson, G., Drummond, E., Spriggs, H., Drummond, J., Magbanua, JP., Naylor, H., Sanson, B., Bastock, R., Huelsmann, S., Trovisco, V., Landgraf, M., Knowles-Barley, S., Armstrong, JD., White-Cooper, H., Hansen, C., Phillips, RG., UK Drosophila Protein Trap Screening Consortium, , Lilley, KS., Russell, S. and St Johnston, D., 2014. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Development, v. 141
    Doi: 10.1242/dev.111054
  • Pézeron, G., Millen, K., Boukhatmi, H. and Bray, S., 2014. Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors. J Cell Sci, v. 127
    Doi: 10.1242/jcs.151787
  • Simón, R., Aparicio, R., Housden, BE., Bray, S. and Busturia, A., 2014. Drosophila p53 controls Notch expression and balances apoptosis and proliferation Apoptosis, v. 19
    Doi: http://doi.org/10.1007/s10495-014-1000-5
  • Housden, BE., Li, J. and Bray, SJ., 2014. Visualizing notch signaling in vivo in Drosophila tissues Methods in Molecular Biology, v. 1187
    Doi: http://doi.org/10.1007/978-1-4939-1139-4_8
  • Li, J., Housden, BE. and Bray, SJ., 2014. Notch signaling assays in Drosophila cultured cell lines Methods in Molecular Biology, v. 1187
    Doi: http://doi.org/10.1007/978-1-4939-1139-4_10
  • Wong, CC., Martincorena, I., Rust, AG., Rashid, M., Alifrangis, C., Alexandrov, LB., Tiffen, JC., Kober, C., Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium, , Green, AR., Massie, CE., Nangalia, J., Lempidaki, S., Döhner, H., Döhner, K., Bray, SJ., McDermott, U., Papaemmanuil, E., Campbell, PJ. and Adams, DJ., 2014. Inactivating CUX1 mutations promote tumorigenesis. Nat Genet, v. 46
    Doi: 10.1038/ng.2846
  • Housden, BE., Terriente-Felix, A. and Bray, SJ., 2014. Context-dependent enhancer selection confers alternate modes of notch regulation on argos. Mol Cell Biol, v. 34
    Doi: 10.1128/MCB.01045-13
  • Zacharioudaki, E. and Bray, SJ., 2014. Tools and methods for studying Notch signaling in Drosophila melanogaster. Methods, v. 68
    Doi: 10.1016/j.ymeth.2014.03.029
  • Simón, R., Aparicio, R., Housden, BE., Bray, S. and Busturia, A., 2014. Drosophila p53 controls Notch expression and balances apoptosis and proliferation. Apoptosis, v. 19
    Doi: 10.1007/s10495-014-1000-5
  • Zacharioudaki, E. and Bray, SJ., 2014. Tools and methods for studying Notch signaling in Drosophila melanogaster Methods, v. 68
    Doi: http://doi.org/10.1016/j.ymeth.2014.03.029
  • Housden, BE., Li, J. and Bray, SJ., 2014. Visualizing Notch signaling in vivo in Drosophila tissues. Methods Mol Biol, v. 1187
    Doi: 10.1007/978-1-4939-1139-4_8
  • Li, J., Housden, BE. and Bray, SJ., 2014. Notch signaling assays in Drosophila cultured cell lines. Methods Mol Biol, v. 1187
    Doi: 10.1007/978-1-4939-1139-4_10
  • 2013

  • Moshkin, YM., Kan, TW., Goodfellow, H., Bezstarosti, K., Maeda, RK., Pilyugin, M., Karch, F., Bray, S., Demmers, JAA. and Verrijzer, CP., 2013. Erratum to Histone Chaperones ASF1 and NAP1 Differentially Modulate Removal of Active Histone Marks by LID-RPD3 Complexes during NOTCH Silencing [Molecular Cell, 35, (September 24, 2009), 782-793] Molecular Cell, v. 51
    Doi: http://doi.org/10.1016/j.molcel.2013.06.015
  • Djiane, A., Krejci, A., Bernard, F., Fexova, S., Millen, K. and Bray, SJ., 2013. Dissecting the mechanisms of Notch induced hyperplasia. EMBO J, v. 32
    Doi: http://doi.org/10.1038/emboj.2012.326
  • Housden, BE., Fu, AQ., Krejci, A., Bernard, F., Fischer, B., Tavaré, S., Russell, S. and Bray, SJ., 2013. Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. PLoS Genet, v. 9
    Doi: 10.1371/journal.pgen.1003162
  • Terriente-Felix, A., Li, J., Collins, S., Mulligan, A., Reekie, I., Bernard, F., Krejci, A. and Bray, S., 2013. Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme. Development, v. 140
    Doi: http://doi.org/10.1242/dev.086785
  • Djiane, A., Krejci, A., Bernard, F., Fexova, S., Millen, K. and Bray, SJ., 2013. Dissecting the mechanisms of Notch induced hyperplasia EMBO Journal, v. 32
    Doi: 10.1038/emboj.2012.326
  • Babaoğlan, AB., Housden, BE., Furriols, M. and Bray, SJ., 2013. Deadpan contributes to the robustness of the notch response. PLoS One, v. 8
    Doi: 10.1371/journal.pone.0075632
  • Fu, AQ., Russell, S., Bray, SJ. and Tavaré, S., 2013. Bayesian clustering of replicated time-course gene expression data with weak signals Annals of Applied Statistics, v. 7
    Doi: 10.1214/13-AOAS650
  • 2012

  • Endo, K., Karim, MR., Taniguchi, H., Krejci, A., Kinameri, E., Siebert, M., Ito, K., Bray, SJ. and Moore, AW., 2012. Chromatin modification of Notch targets in olfactory receptor neuron diversification NAT NEUROSCI, v. 15
    Doi: http://doi.org/10.1038/nn.2998
  • Housden, BE., Millen, K. and Bray, SJ., 2012. Drosophila Reporter Vectors Compatible with ΦC31 Integrase Transgenesis Techniques and Their Use to Generate New Notch Reporter Fly Lines. G3 (Bethesda), v. 2
    Doi: http://doi.org/10.1534/g3.111.001321
  • Capilla, A., Johnson, R., Daniels, M., Benavente, M., Bray, SJ. and Galindo, MI., 2012. Planar cell polarity controls directional Notch signaling in the Drosophila leg Development (Cambridge), v. 139
    Doi: http://doi.org/10.1242/dev.077446
  • 2011

  • Bending, D., Newland, S., Krejcí, A., Phillips, JM., Bray, S. and Cooke, A., 2011. Epigenetic changes at Il12rb2 and Tbx21 in relation to plasticity behavior of Th17 cells. J Immunol, v. 186
    Doi: http://doi.org/10.4049/jimmunol.1003216
  • Endo, K., Karim, MR., Taniguchi, H., Krejci, A., Kinameri, E., Siebert, M., Ito, K., Bray, SJ. and Moore, AW., 2011. Chromatin modification of Notch targets in olfactory receptor neuron diversification Nature Neuroscience,
  • Djiane, A., Shimizu, H., Wilkin, M., Mazleyrat, S., Jennings, MD., Avis, J., Bray, S. and Baron, M., 2011. Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue. J Cell Biol, v. 192
    Doi: http://doi.org/10.1083/jcb.201007023
  • 2010

  • Bernard, F., Krejci, A., Housden, B., Adryan, B. and Bray, SJ., 2010. Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. Development, v. 137
    Doi: http://doi.org/10.1242/dev.053181
  • Endo, K., Karim, MR., Krejci, A., Kinameri, E., Seibert, M., Ito, K., Bray, SJ. and Moore, AW., 2010. Modification of the Notch transcriptional response by Hamlet/Evi1 maximizes Drosophila olfactory sensory neuron diversity NEUROSCIENCE RESEARCH, v. 68
    Doi: http://doi.org/10.1016/j.neures.2010.07.163
  • Pines, MK., Housden, BE., Bernard, F., Bray, SJ. and Röper, K., 2010. The cytolinker Pigs is a direct target and a negative regulator of Notch signalling. Development, v. 137
    Doi: http://doi.org/10.1242/dev.043224
  • Bray, S. and Bernard, F., 2010. Notch targets and their regulation. Curr Top Dev Biol, v. 92
    Doi: http://doi.org/10.1016/S0070-2153(10)92008-5
  • Monastirioti, M., Giagtzoglou, N., Koumbanakis, KA., Zacharioudaki, E., Deligiannaki, M., Wech, I., Almeida, M., Preiss, A., Bray, S. and Delidakis, C., 2010. Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis DEVELOPMENT, v. 137
    Doi: http://doi.org/10.1242/dev.043604
  • 2009

  • Moshkin, YM., Kan, TW., Goodfellow, H., Bezstarosti, K., Maeda, RK., Pilyugin, M., Karch, F., Bray, SJ., Demmers, JAA. and Verrijzer, CP., 2009. Histone Chaperones ASF1 and NAP1 Differentially Modulate Removal of Active Histone Marks by LID-RPD3 Complexes during NOTCH Silencing MOL CELL, v. 35
    Doi: http://doi.org/10.1016/j.molcel.2009.07.020
  • Krejčí, A., Bernard, F., Housden, B., Collins, S. and Bray, SJ., 2009. Erratum: Direct response to notch activation: Signaling crosstalk and incoherent logic (Science Signaling (2009) 2 (er3)) Science Signaling, v. 2
    Doi: http://doi.org/10.1126/scisignal.258er3
  • Krejcí, A., Bernard, F., Housden, BE., Collins, S. and Bray, SJ., 2009. Direct response to Notch activation: signaling crosstalk and incoherent logic. Sci Signal, v. 2
    Doi: http://doi.org/10.1126/scisignal.2000140
  • Benitez, E., Bray, SJ., Rodriguez, I. and Guerrero, I., 2009. Lines is required for normal operation of Wingless, Hedgehog and Notch pathways during wing development DEVELOPMENT, v. 136
    Doi: http://doi.org/10.1242/dev.021428
  • 2008

  • Bray, S. and Johnson, RS., 2008. Putting the tissue and environmental 'context' into differentiation and gene regulation CURR OPIN GENET DEV, v. 18
    Doi: http://doi.org/10.1016/j.gde.2008.10.003
  • Bray, SJ., Takada, S., Harrison, E., Shen, S-C. and Ferguson-Smith, AC., 2008. The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila. BMC Dev Biol, v. 8
    Doi: 10.1186/1471-213X-8-11
  • Narasimha, M., Uv, A., Krejci, A., Brown, NH. and Bray, SJ., 2008. Grainy head promotes expression of septate junction proteins and influences epithelial morphogenesis. J Cell Sci, v. 121
    Doi: 10.1242/jcs.019422
  • 2007

  • Krejcí, A. and Bray, S., 2007. Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev, v. 21
    Doi: http://doi.org/10.1101/gad.424607
  • Goodfellow, H., Krejcí, A., Moshkin, Y., Verrijzer, CP., Karch, F. and Bray, SJ., 2007. Gene-specific targeting of the histone chaperone asf1 to mediate silencing. Dev Cell, v. 13
    Doi: http://doi.org/10.1016/j.devcel.2007.08.021
  • 2006

  • Bray, SJ., 2006. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol, v. 7
    Doi: http://doi.org/10.1038/nrm2009
  • Glittenberg, M., Pitsouli, C., Garvey, C., Delidakis, C. and Bray, S., 2006. Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. EMBO J, v. 25
    Doi: http://doi.org/10.1038/sj.emboj.7601337
  • 2005

  • Nagel, AC., Krejci, A., Tenin, G., Bravo-Patino, A., Bray, S., Maier, D. and Preiss, A., 2005. Hairless-mediated repression of Notch target genes requires the combined activity of Groucho and CtBP corepressors MOL CELL BIOL, v. 25
    Doi: http://doi.org/10.1128/MCB.25.23.10433-10441.2005
  • Almeida, MS. and Bray, SJ., 2005. Regulation of post-embryonic neuroblasts by Drosophila Grainyhead. Mech Dev, v. 122
    Doi: http://doi.org/10.1016/j.mod.2005.08.004
  • Bray, S., Musisi, H. and Bienz, M., 2005. Bre1 is required for Notch signaling and histone modification. Dev Cell, v. 8
    Doi: http://doi.org/10.1016/j.devcel.2004.11.020
  • Perez, L., Milan, M., Bray, S. and Cohen, SM., 2005. Ligand-binding and signaling properties of the Ax[M1] form of Notch MECH DEVELOP, v. 122
    Doi: http://doi.org/10.1016/j.mod.2004.12.007
  • Hatini, V., Green, RB., Lengyel, JA., Bray, SJ. and DiNardo, S., 2005. The drumstick/lines/bowl regulatory pathway links antagonistic Hedgehog and Wingless signaling inputs to epidermal cell differentiation GENE DEV, v. 19
    Doi: http://doi.org/10.1101/gad.1268005
  • 2003

  • de Celis Ibeas, JM. and Bray, SJ., 2003. Bowl is required downstream of Notch for elaboration of distal limb patterning. Development, v. 130
    Doi: http://doi.org/10.1242/dev.00833
  • Hemphala, J., Uv, A., Cantera, R., Bray, S. and Samakovlis, C., 2003. Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signalling DEVELOPMENT, v. 130
    Doi: http://doi.org/10.1242/dev.00218
  • 2002

  • Bagni, C., Bray, S., Gogos, JA., Kafatos, FC. and Hsu, T., 2002. The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development MECH DEVELOP, v. 117
  • Strutt, D., Johnson, R., Cooper, K. and Bray, S., 2002. Asymmetric localization of frizzled and the determination of notch-dependent cell fate in the Drosophila eye CURR BIOL, v. 12
  • 2001

  • Furriols, M. and Bray, S., 2001. A model Notch response element detects Suppressor of Hairless-dependent molecular switch. Curr Biol, v. 11
    Doi: http://doi.org/10.1016/s0960-9822(00)00044-0
  • Bray, S. and Furriols, M., 2001. Notch pathway: making sense of suppressor of hairless. Curr Biol, v. 11
    Doi: http://doi.org/10.1016/s0960-9822(01)00109-9
  • 2000

  • Bray, S. and Stein, D., 2000. Developmental biology - Post-expressionist flies NATURE, v. 407
  • Bray, S. and Stein, D., 2000. Post-expressionist flies Nature, v. 407
    Doi: http://doi.org/10.1038/35030286
  • Cooper, MT. and Bray, SJ., 2000. R7 photoreceptor specification requires Notch activity. Curr Biol, v. 10
    Doi: http://doi.org/10.1016/s0960-9822(00)00826-5
  • Bray, S., 2000. Planar polarity: out of joint? Curr Biol, v. 10
    Doi: http://doi.org/10.1016/s0960-9822(00)00330-4
  • Bray, S., 2000. Specificity and promiscuity among proneural proteins. Neuron, v. 25
    Doi: http://doi.org/10.1016/s0896-6273(00)80862-4
  • Howes, R. and Bray, S., 2000. Pattern formation: Wingless on the move. Curr Biol, v. 10
    Doi: http://doi.org/10.1016/s0960-9822(00)00377-8
  • Cooper, MT., Tyler, DM., Furriols, M., Chalkiadaki, A., Delidakis, C. and Bray, S., 2000. Spatially restricted factors cooperate with notch in the regulation of Enhancer of split genes. Dev Biol, v. 221
    Doi: http://doi.org/10.1006/dbio.2000.9691
  • Bray, S., 2000. Notch. Curr Biol, v. 10
    Doi: http://doi.org/10.1016/s0960-9822(00)00549-2
  • Furriols, M. and Bray, S., 2000. Dissecting the mechanisms of suppressor of hairless function. Dev Biol, v. 227
    Doi: http://doi.org/10.1006/dbio.2000.9923
  • de Celis, JF. and Bray, SJ., 2000. The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe DEVELOPMENT, v. 127
  • 1999

  • Bray, S., 1999. DPP on the brinker. Trends Genet, v. 15
    Doi: http://doi.org/10.1016/s0168-9525(99)01736-9
  • Bray, S., 1999. The long arms of the cell Trends in Genetics, v. 15
    Doi: http://doi.org/10.1016/S0168-9525(99)01847-8
  • Wech, I., Bray, S., Delidakis, C. and Preiss, A., 1999. Distinct expression patterns of different Enhancer of split bHLH genes during embryogenesis of Drosophila melanogaster DEV GENES EVOL, v. 209
  • Cooper, MT. and Bray, SJ., 1999. Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye. Nature, v. 397
    Doi: http://doi.org/10.1038/17395
  • Jennings, BH., Tyler, DM. and Bray, SJ., 1999. Target specificities of Drosophila enhancer of split basic helix-loop-helix proteins. Mol Cell Biol, v. 19
    Doi: http://doi.org/10.1128/MCB.19.7.4600
  • Bray, S., 1999. Drosophila development: Scalloped and Vestigial take wing. Curr Biol, v. 9
    Doi: http://doi.org/10.1016/s0960-9822(99)80154-7
  • Ligoxygakis, P., Bray, SJ., Apidianakis, Y. and Delidakis, C., 1999. Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for Notch activity in wing margin establishment in Drosophila DEVELOPMENT, v. 126
  • 1998

  • Prokop, A., Bray, S., Harrison, E. and Technau, GM., 1998. Homeotic regulation of segment-specific differences in neuroblast numbers and proliferation in the Drosophila central nervous system MECH DEVELOP, v. 74
  • Bray, S., 1998. Notch signalling in Drosophila: three ways to use a pathway. Semin Cell Dev Biol, v. 9
    Doi: http://doi.org/10.1006/scdb.1998.0262
  • de Celis, JF., Tyler, DM., de Celis, J. and Bray, SJ., 1998. Notch signalling mediates segmentation of the Drosophila leg. Development, v. 125
    Doi: 10.1242/dev.125.23.4617
  • Bray, S., 1998. A Notch affair. Cell, v. 93
    Doi: http://doi.org/10.1016/s0092-8674(00)81180-0
  • 1997

  • Eastman, DS., Slee, R., Skoufos, E., Bangalore, L., Bray, S. and Delidakis, C., 1997. Synergy between suppressor of hairless and notch in regulation of enhancer of split m gamma and m delta expression MOL CELL BIOL, v. 17
  • Bray, SJ., 1997. Expression and function of Enhancer of split bHLH proteins during Drosophila neurogenesis. Perspect Dev Neurobiol, v. 4
  • Uv, AE., Harrison, EJ. and Bray, SJ., 1997. Tissue-specific splicing and functions of the Drosophila transcription factor Grainyhead. Mol Cell Biol, v. 17
    Doi: http://doi.org/10.1128/MCB.17.11.6727
  • de Celis, JF., Bray, S. and Garcia-Bellido, A., 1997. Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing. Development, v. 124
    Doi: 10.1242/dev.124.10.1919
  • de Celis, JF. and Bray, S., 1997. Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. Development, v. 124
    Doi: 10.1242/dev.124.17.3241
  • 1996

  • Jennings, B. and Bray, SJ., 1996. Function of enhancer of split proteins in the notch signalling pathway MOL BIOL CELL, v. 7
  • de Celis, JF., Garcia-Bellido, A. and Bray, SJ., 1996. Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development, v. 122
    Doi: 10.1242/dev.122.1.359
  • Ebling, FJ., Maywood, ES., Mehta, M., Hancock, DC., McNulty, S., De Bono, J., Bray, SJ. and Hastings, MH., 1996. FosB in the suprachiasmatic nucleus of the Syrian and Siberian hamster. Brain Res Bull, v. 41
    Doi: http://doi.org/10.1016/s0361-9230(96)00192-x
  • de Celis, JF., de Celis, J., Ligoxygakis, P., Preiss, A., Delidakis, C. and Bray, S., 1996. Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development. Development, v. 122
    Doi: 10.1242/dev.122.9.2719
  • 1995

  • JENNINGS, B., DECELIS, J., DELIDAKIS, C., PREISS, A. and BRAY, S., 1995. ROLE OF NOTCH AND ACHAETE-SCUTE COMPLEX IN THE EXPRESSION OF ENHANCER OF SPLIT BHLH PROTEINS DEVELOPMENT, v. 121
  • Tannahill, D., Bray, S. and Harris, WA., 1995. A Drosophila E(spł) gene is "neurogenic" in Xenopus: a green fluorescent protein study. Dev Biol, v. 168
    Doi: http://doi.org/10.1006/dbio.1995.1116
  • 1994

  • Uv, AE., Thompson, CR. and Bray, SJ., 1994. The Drosophila tissue-specific factor Grainyhead contains novel DNA-binding and dimerization domains which are conserved in the human protein CP2. Mol Cell Biol, v. 14
    Doi: http://doi.org/10.1128/mcb.14.6.4020-4031.1994
  • Jennings, B., Preiss, A., Delidakis, C. and Bray, S., 1994. The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development, v. 120
    Doi: 10.1242/dev.120.12.3537
  • 1991

  • Bray, SJ. and Kafatos, FC., 1991. Developmental function of Elf-1: an essential transcription factor during embryogenesis in Drosophila. Genes Dev, v. 5
    Doi: http://doi.org/10.1101/gad.5.9.1672
  • 1989

  • BRAY, SJ., BURKE, B., BROWN, NH. and HIRSH, J., 1989. EMBRYONIC EXPRESSION PATTERN OF A FAMILY OF DROSOPHILA PROTEINS THAT INTERACT WITH A CENTRAL NERVOUS-SYSTEM REGULATORY ELEMENT GENE DEV, v. 3
  • Johnson, WA., McCormick, CA., Bray, SJ. and Hirsh, J., 1989. A neuron-specific enhancer of the Drosophila dopa decarboxylase gene. Genes Dev, v. 3
    Doi: http://doi.org/10.1101/gad.3.5.676
  • 1988

  • Bray, SJ., Johnson, WA., Hirsh, J., Heberlein, U. and Tjian, R., 1988. A cis-acting element and associated binding factor required for CNS expression of the Drosophila melanogaster dopa decarboxylase gene. EMBO J, v. 7
    Doi: 10.1002/j.1460-2075.1988.tb02798.x
  • 1986

  • SCHOLNICK, SB., BRAY, SJ., MORGAN, BA., MCCORMICK, CA. and HIRSH, J., 1986. CNS AND HYPODERM REGULATORY ELEMENTS OF THE DROSOPHILA-MELANOGASTER DOPA DECARBOXYLASE GENE SCIENCE, v. 234
  • BRAY, SJ. and HIRSH, J., 1986. THE DROSOPHILA-VIRILIS DOPA DECARBOXYLASE GENE IS DEVELOPMENTALLY REGULATED WHEN INTEGRATED INTO DROSOPHILA-MELANOGASTER EMBO J, v. 5
  • BRAY, SJ., SCHOLNICK, SB., MORGAN, BA., BEALL, CJ. and HIRSH, J., 1986. SEQUENCES AND SPLICES GOVERNING CNS EXPRESSION OF THE DROSOPHILA DOPA DECARBOXYLASE GENE DDC BIOL BULL, v. 170
  • 1985

  • Standart, NM., Bray, SJ., George, EL., Hunt, T. and Ruderman, JV., 1985. The small subunit of ribonucleotide reductase is encoded by one of the most abundant translationally regulated maternal RNAs in clam and sea urchin eggs. J Cell Biol, v. 100
    Doi: http://doi.org/10.1083/jcb.100.6.1968
  • Sjöberg, BM., Eklund, H., Fuchs, JA., Carlson, J., Standart, NM., Ruderman, JV., Bray, SJ. and Hunt, T., 1985. Identification of the stable free radical tyrosine residue in ribonucleotide reductase. A sequence comparison. FEBS Lett, v. 183
    Doi: http://doi.org/10.1016/0014-5793(85)80962-5
  • 1984

  • Ballinger, DG., Bray, SJ. and Hunt, T., 1984. Studies of the kinetics and ionic requirements for the phosphorylation of ribosomal protein S6 after fertilization of Arbacia punctulata eggs. Dev Biol, v. 101
    Doi: http://doi.org/10.1016/0012-1606(84)90129-5
  • 1983

  • GEORGE, EL., BRAY, S., ROSENTHAL, ET. and HUNT, T., 1983. A MAJOR MATERNALLY ENCODED K-41 PROTEIN IN BOTH SPISULA AND ARBACIA BINDS TO AN ANTI-TUBULIN AFFINITY COLUMN BIOL BULL, v. 165
  • Bray, S. and Falo Sanjuan, J., Notch-dependent and -independent transcription are modulated by tissue movements at gastrulation eLife,
    Doi: http://doi.org/10.7554/eLife.73656
  • Bray, S., OptIC Notch reveals mechanism that regulates receptor interactions with CSL Development,
  • Bray, SJ., Gomez Lamarca, M., Falo Sanjuan, J., Stojnic, R., Cerda Moya, G., Jones, M., Pillidge, Z., O'Holleran, K., Abdul Rehman, S., Muresan, L., Rhett, K., Payre, F., Bystricky, K., Baloul, S., Valenti, P. and Yuan, Z., Activation of the Notch signalling pathway in vivo elicits changes in CSL nuclear dynamics Developmental Cell,
  • Zacharioudaki, E., Falo Sanjuan, J. and Bray, S., Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signalling eLife,
  • Pillidge, Z. and Bray, S., SWI/SNF chromatin remodeling controls Notch-responsive enhancer accessibility EMBO Reports,
  • Feng, S., Zacharioudaki, E., Millen, K. and Bray, S., The SLC36 transporter Pathetic is required for neural stem cell proliferation and for brain growth under nutrition restriction Neural Development,
  • Bray, S., Falo-Sanjuan, J., Garcia, H. and Lammers, N., Enhancer priming enables fast and sustained transcriptional responses to Notch signaling Developmental Cell,
  • Falo Sanjuan, J. and Bray, S., Decoding the Notch Signal Development Growth and Differentiation,
  • Bray, S., Martins, T., Lea, S., Handford, P., Meng, Y., Korona, B., Suckling, R. and Johnson, S., The conserved C2 phospholipid-binding Domain in Delta contributes to robust Notch signalling EMBO Reports,
  • Bray, S., Boukhatmi, H., Martins, T., Pillidge, Z. and Kamenova, T., Notch mediates inter-tissue communication to promote tumorigenesis. Current Biology,
  • Bray, S. and Falo Sanjuan, J., Membrane architecture and adherens junctions contribute to strong Notch pathway activation Development,
  • Internet publications

    2018

  • Zacharioudaki, E., Sanjuan, JF. and Bray, S., 2018. Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling
    Doi: http://doi.org/10.1101/410332
  • Falo-Sanjuan, J., Lammers, N., Garcia, H. and Bray, S., 2018. Enhancer priming enables fast and sustained transcriptional responses to Notch signaling
    Doi: http://doi.org/10.1101/497651
  • Conference proceedings

    2012

  • Torella, RF., Bray, SJ., Adryan, B. and Glen, RC., 2012. Structure-based prediction of transcription factor specificity: Comparison to position weight matrix and in vitro prediction methods ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, v. 243
  • 2009

  • Pezeron, G. and Bray, S., 2009. Role of Notch and its targets in regulating migration and morphogenesis MECHANISMS OF DEVELOPMENT, v. 126
    Doi: http://doi.org/10.1016/j.mod.2009.06.857
  • Pines, M., Housden, B., Bernard, F., Bray, S. and Roper, K., 2009. The cytolinker Pigs is a target and a negative regulator of Notch signalling during epithelial somatic cell differentiation in the Drosophila ovary MECHANISMS OF DEVELOPMENT, v. 126
    Doi: http://doi.org/10.1016/j.mod.2009.06.974
  • 2004

  • Bray, S., Musisi, H., Furriols, M., Johnson, R. and Bienz, M., 2004. Regulation of Notch signalling EUROPEAN JOURNAL OF CELL BIOLOGY, v. 83
  • Datasets
  • Falo Sanjuan, J. and Bray, S., Additional Materials of the Thesis "Decoding the Notch signal: investigating dynamics of transcription directed by Notch responsive enhancers". Julia Falo Sanjuan, January 2020
  • Theses / dissertations

    2022

  • Townson, J., 2022. Understanding the role of the Notch intracellular domain in transcription hub formation
  • Falo Sanjuan, J., Decoding the Notch signal: investigating dynamics of transcription directed by Notch responsive enhancers