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School of the Biological Sciences

 

Marion MacFarlane

 

Deputy Director and Group Leader, MRC Toxicology Unit 

Marion MacFarlane aims to understand the fundamental mechanisms of cell death that regulate life/death decisions at the cellular level. Learn more. 

 

Research Areas

Molecular mechanisms of cell death 
Human diseases
Multiprotein signalling complexes
Drug-induced mitochondrial toxicity
 
 

Techniques

In vitro reconstituted models
Proteomics
3D tumour models
 
 
 
    

 

Research Theme

  

 

Publications

Journal articles

2018

  • Felley-Bosco, E. and MacFarlane, M., 2018. Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials. Chem Res Toxicol, v. 31
    Doi: http://doi.org/10.1021/acs.chemrestox.8b00146
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  • Galluzzi, L., Vitale, I., Aaronson, SA., Abrams, JM., Adam, D., Agostinis, P., Alnemri, ES., Altucci, L., Amelio, I., Andrews, DW., Annicchiarico-Petruzzelli, M., Antonov, AV., Arama, E., Baehrecke, EH., Barlev, NA., Bazan, NG., Bernassola, F., Bertrand, MJM., Bianchi, K., Blagosklonny, MV., Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, FK-M., Chandel, NS., Cheng, EH., Chipuk, JE., Cidlowski, JA., Ciechanover, A., Cohen, GM., Conrad, M., Cubillos-Ruiz, JR., Czabotar, PE., D'Angiolella, V., Dawson, TM., Dawson, VL., De Laurenzi, V., De Maria, R., Debatin, K-M., DeBerardinis, RJ., Deshmukh, M., Di Daniele, N., Di Virgilio, F., Dixit, VM., Dixon, SJ., Duckett, CS., Dynlacht, BD., El-Deiry, WS., Elrod, JW., Fimia, GM., Fulda, S., García-Sáez, AJ., Garg, AD., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, DR., Greene, LA., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, JM., Harris, IS., Hengartner, MO., Hetz, C., Ichijo, H., Jäättelä, M., Joseph, B., Jost, PJ., Juin, PP., Kaiser, WJ., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, RN., Klionsky, DJ., Knight, RA., Kumar, S., Lee, SW., Lemasters, JJ., Levine, B., Linkermann, A., Lipton, SA., Lockshin, RA., López-Otín, C., Lowe, SW., Luedde, T., Lugli, E., MacFarlane, M., Madeo, F., Malewicz, M., Malorni, W., Manic, G., Marine, J-C., Martin, SJ., Martinou, J-C., Medema, JP., Mehlen, P., Meier, P., Melino, S., Miao, EA., Molkentin, JD., Moll, UM., Muñoz-Pinedo, C., Nagata, S., Nuñez, G., Oberst, A., Oren, M., Overholtzer, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, JM., Pereira, DM., Pervaiz, S., Peter, ME., Piacentini, M., Pinton, P., Prehn, JHM., Puthalakath, H., Rabinovich, GA., Rehm, M., Rizzuto, R., Rodrigues, CMP., Rubinsztein, DC., Rudel, T., Ryan, KM., Sayan, E., Scorrano, L., Shao, F., Shi, Y., Silke, J., Simon, H-U., Sistigu, A., Stockwell, BR., Strasser, A., Szabadkai, G., Tait, SWG., Tang, D., Tavernarakis, N., Thorburn, A., Tsujimoto, Y., Turk, B., Vanden Berghe, T., Vandenabeele, P., Vander Heiden, MG., Villunger, A., Virgin, HW., Vousden, KH., Vucic, D., Wagner, EF., Walczak, H., Wallach, D., Wang, Y., Wells, JA., Wood, W., Yuan, J., Zakeri, Z., Zhivotovsky, B., Zitvogel, L., Melino, G. and Kroemer, G., 2018. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ, v. 25
    Doi: http://doi.org/10.1038/s41418-017-0012-4
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  • Estornes, Y., Dondelinger, Y., Weber, K., Bruggeman, I., Peall, A., MacFarlane, M., Lebecque, S., Vandenabeele, P. and Bertrand, MJM., 2018. N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis. Cell Death Dis, v. 9
    Doi: http://doi.org/10.1038/s41419-018-0544-7
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    2017

  • Chernova, T., Murphy, FA., Galavotti, S., Sun, X-M., Powley, IR., Grosso, S., Schinwald, A., Zacarias-Cabeza, J., Dudek, KM., Dinsdale, D., Le Quesne, J., Bennett, J., Nakas, A., Greaves, P., Poland, CA., Donaldson, K., Bushell, M., Willis, AE. and MacFarlane, M., 2017. Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf). Curr Biol, v. 27
    Doi: 10.1016/j.cub.2017.09.007
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  • Karekla, E., Liao, W-J., Sharp, B., Pugh, J., Reid, H., Quesne, JL., Moore, D., Pritchard, C., MacFarlane, M. and Pringle, JH., 2017. Ex Vivo Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy. Cancer Res, v. 77
    Doi: http://doi.org/10.1158/0008-5472.CAN-16-1121
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  • Horn, S., Hughes, MA., Schilling, R., Sticht, C., Tenev, T., Ploesser, M., Meier, P., Sprick, MR., MacFarlane, M. and Leverkus, M., 2017. Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival. Cell Rep, v. 19
    Doi: http://doi.org/10.1016/j.celrep.2017.04.010
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    2016

  • Busacca, S., Law, EWP., Powley, IR., Proia, DA., Sequeira, M., Le Quesne, J., Klabatsa, A., Edwards, JM., Matchett, KB., Luo, JL., Pringle, JH., El-Tanani, M., MacFarlane, M. and Fennell, DA., 2016. Resistance to HSP90 inhibition involving loss of MCL1 addiction. Oncogene, v. 35
    Doi: 10.1038/onc.2015.213
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  • Chernova, T., Sun, XM., Powley, IR., Galavotti, S., Grosso, S., Murphy, FA., Miles, GJ., Cresswell, L., Antonov, AV., Bennett, J., Nakas, A., Dinsdale, D., Cain, K., Bushell, M., Willis, AE. and MacFarlane, M., 2016. Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease. Cell Death Differ, v. 23
    Doi: 10.1038/cdd.2015.165
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  • Fox, JL. and MacFarlane, M., 2016. Targeting cell death signalling in cancer: minimising 'Collateral damage'. Br J Cancer, v. 115
    Doi: 10.1038/bjc.2016.111
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  • Powley, IR., Hughes, MA., Cain, K. and MacFarlane, M., 2016. Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex. Oncogene, v. 35
    Doi: http://doi.org/10.1038/onc.2016.99
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  • Hughes, MA., Powley, IR., Jukes-Jones, R., Horn, S., Feoktistova, M., Fairall, L., Schwabe, JWR., Leverkus, M., Cain, K. and MacFarlane, M., 2016. Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate. Mol Cell, v. 61
    Doi: 10.1016/j.molcel.2016.02.023
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    2015

  • Naik, S., MacFarlane, M. and Sarin, A., 2015. Notch4 Signaling Confers Susceptibility to TRAIL-Induced Apoptosis in Breast Cancer Cells. J Cell Biochem, v. 116
    Doi: http://doi.org/10.1002/jcb.25094
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  • Langlais, C., Hughes, MA., Cain, K. and MacFarlane, M., 2015. In Vitro Assembly and Analysis of the Apoptosome Complex. Cold Spring Harb Protoc, v. 2015
    Doi: 10.1101/pdb.prot087080
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  • Langlais, C., Hughes, MA., Cain, K. and MacFarlane, M., 2015. Biochemical Analysis of Initiator Caspase-Activating Complexes: The Apoptosome and the Death-Inducing Signaling Complex. Cold Spring Harb Protoc, v. 2015
    Doi: 10.1101/pdb.top070326
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  • Hughes, MA., Langlais, C., Cain, K. and MacFarlane, M., 2015. Activation, Isolation, and Analysis of the Death-Inducing Signaling Complex. Cold Spring Harb Protoc, v. 2015
    Doi: 10.1101/pdb.prot087098
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    2014

  • Elia, A., Powley, IR., MacFarlane, M. and Clemens, MJ., 2014. Modulation of the sensitivity of Jurkat T-cells to inhibition of protein synthesis by tumor necrosis factor α-related apoptosis-inducing ligand. J Interferon Cytokine Res, v. 34
    Doi: 10.1089/jir.2013.0061
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  • Horvilleur, E., Sbarrato, T., Hill, K., Spriggs, RV., Screen, M., Goodrem, PJ., Sawicka, K., Chaplin, LC., Touriol, C., Packham, G., Potter, KN., Dirnhofer, S., Tzankov, A., Dyer, MJS., Bushell, M., MacFarlane, M. and Willis, AE., 2014. A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma. Leukemia, v. 28
    Doi: 10.1038/leu.2013.295
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    2013

  • Simpson, KL., Cawthorne, C., Zhou, C., Hodgkinson, CL., Walker, MJ., Trapani, F., Kadirvel, M., Brown, G., Dawson, MJ., MacFarlane, M., Williams, KJ., Whetton, AD. and Dive, C., 2013. A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. Cell Death Dis, v. 4
    Doi: http://doi.org/10.1038/cddis.2013.137
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  • Hughes, MA., Langlais, C., Cain, K. and MacFarlane, M., 2013. Isolation, characterisation and reconstitution of cell death signalling complexes. Methods, v. 61
    Doi: http://doi.org/10.1016/j.ymeth.2013.02.006
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  • Melis, MHM., Simpson, KL., Dovedi, SJ., Welman, A., MacFarlane, M., Dive, C., Honeychurch, J. and Illidge, TM., 2013. Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response. Cell Death Differ, v. 20
    Doi: http://doi.org/10.1038/cdd.2013.8
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  • Donaldson, K., Poland, CA., Murphy, FA., MacFarlane, M., Chernova, T. and Schinwald, A., 2013. Pulmonary toxicity of carbon nanotubes and asbestos - similarities and differences. Adv Drug Deliv Rev, v. 65
    Doi: 10.1016/j.addr.2013.07.014
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    2012

  • Robinson, GL., Dinsdale, D., Macfarlane, M. and Cain, K., 2012. Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL. Oncogene, v. 31
    Doi: http://doi.org/10.1038/onc.2012.13
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  • MacFarlane, M., Robinson, GL. and Cain, K., 2012. Glucose--a sweet way to die: metabolic switching modulates tumor cell death. Cell Cycle, v. 11
    Doi: http://doi.org/10.4161/cc.21804
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  • Dickens, LS., Boyd, RS., Jukes-Jones, R., Hughes, MA., Robinson, GL., Fairall, L., Schwabe, JWR., Cain, K. and Macfarlane, M., 2012. A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death. Mol Cell, v. 47
    Doi: http://doi.org/10.1016/j.molcel.2012.05.004
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  • Dickens, LS., Powley, IR., Hughes, MA. and MacFarlane, M., 2012. The 'complexities' of life and death: death receptor signalling platforms. Exp Cell Res, v. 318
    Doi: http://doi.org/10.1016/j.yexcr.2012.04.005
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    2011

  • Feoktistova, M., Geserick, P., Kellert, B., Dimitrova, DP., Langlais, C., Hupe, M., Cain, K., MacFarlane, M., Häcker, G. and Leverkus, M., 2011. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell, v. 43
    Doi: http://doi.org/10.1016/j.molcel.2011.06.011
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  • Tenev, T., Bianchi, K., Darding, M., Broemer, M., Langlais, C., Wallberg, F., Zachariou, A., Lopez, J., MacFarlane, M., Cain, K. and Meier, P., 2011. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell, v. 43
    Doi: http://doi.org/10.1016/j.molcel.2011.06.006
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  • Tenev, T., Bianchi, K., Darding, M., Broemer, M., Langlais, C., Wallberg, F., Zachariou, A., Lopez, J., MacFarlane, M., Cain, K. and Meier, P., 2011. The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs Molecular Cell, v. 43
    Doi: http://doi.org/10.1016/j.molcel.2011.08.005
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  • Vaishnav, M., MacFarlane, M. and Dickens, M., 2011. Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis. Exp Cell Res, v. 317
    Doi: http://doi.org/10.1016/j.yexcr.2011.01.011
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    2010

  • Stadel, D., Mohr, A., Ref, C., MacFarlane, M., Zhou, S., Humphreys, R., Bachem, M., Cohen, G., Möller, P., Zwacka, RM., Debatin, K-M. and Fulda, S., 2010. TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors. Clin Cancer Res, v. 16
    Doi: http://doi.org/10.1158/1078-0432.CCR-10-0985
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  • Young, KW., Piñón, LGP., Dhiraj, D., Twiddy, D., Macfarlane, M., Hickman, J. and Nicotera, P., 2010. Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737. Neuropharmacology, v. 58
    Doi: http://doi.org/10.1016/j.neuropharm.2010.03.008
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    2009

  • MacFarlane, M., 2009. Cell death pathways--potential therapeutic targets. Xenobiotica, v. 39
    Doi: http://doi.org/10.1080/00498250903137990
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  • Hughes, MA., Harper, N., Butterworth, M., Cain, K., Cohen, GM. and MacFarlane, M., 2009. Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival. Mol Cell, v. 35
    Doi: http://doi.org/10.1016/j.molcel.2009.06.012
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    2007

  • Volkmann, X., Fischer, U., Bahr, MJ., Ott, M., Lehner, F., Macfarlane, M., Cohen, GM., Manns, MP., Schulze-Osthoff, K. and Bantel, H., 2007. Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver. Hepatology, v. 46
    Doi: http://doi.org/10.1002/hep.21846
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  • Dyer, MJS., MacFarlane, M. and Cohen, GM., 2007. Barriers to effective TRAIL-targeted therapy of malignancy. J Clin Oncol, v. 25
    Doi: http://doi.org/10.1200/JCO.2007.13.1011
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  • Natoni, A., MacFarlane, M., Inoue, S., Walewska, R., Majid, A., Knee, D., Stover, DR., Dyer, MJS. and Cohen, GM., 2007. TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2. Br J Haematol, v. 139
    Doi: http://doi.org/10.1111/j.1365-2141.2007.06852.x
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  • Williams, AC., Smartt, H., H-Zadeh, AM., Macfarlane, M., Paraskeva, C. and Collard, TJ., 2007. Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kappaB. Cell Death Differ, v. 14
    Doi: http://doi.org/10.1038/sj.cdd.4401919
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    2006

  • Twiddy, D., Cohen, GM., Macfarlane, M. and Cain, K., 2006. Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex. J Biol Chem, v. 281
    Doi: http://doi.org/10.1074/jbc.M507393200
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    2005

  • MacFarlane, M., Inoue, S., Kohlhaas, SL., Majid, A., Harper, N., Kennedy, DBJ., Dyer, MJS. and Cohen, GM., 2005. Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1. Cell Death Differ, v. 12
    Doi: http://doi.org/10.1038/sj.cdd.4401649
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  • Hague, A., Hicks, DJ., Hasan, F., Smartt, H., Cohen, GM., Paraskeva, C. and MacFarlane, M., 2005. Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis. Br J Cancer, v. 92
    Doi: http://doi.org/10.1038/sj.bjc.6602387
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  • MacFarlane, M., Kohlhaas, SL., Sutcliffe, MJ., Dyer, MJS. and Cohen, GM., 2005. TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies. Cancer Res, v. 65
    Doi: http://doi.org/10.1158/0008-5472.CAN-05-2801
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    2004

  • Hague, A., Eveson, JW., MacFarlane, M., Huntley, S., Janghra, N. and Thavaraj, S., 2004. Caspase-3 expression is reduced, in the absence of cleavage, in terminally differentiated normal oral epithelium but is increased in oral squamous cell carcinomas and correlates with tumour stage. J Pathol, v. 204
    Doi: http://doi.org/10.1002/path.1630
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  • Inoue, S., MacFarlane, M., Harper, N., Wheat, LMC., Dyer, MJS. and Cohen, GM., 2004. Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies. Cell Death Differ, v. 11 Suppl 2
    Doi: http://doi.org/10.1038/sj.cdd.4401535
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  • Twiddy, D., Brown, DG., Adrain, C., Jukes, R., Martin, SJ., Cohen, GM., MacFarlane, M. and Cain, K., 2004. Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex. J Biol Chem, v. 279
    Doi: http://doi.org/10.1074/jbc.M311388200
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  • Sun, X-M., Butterworth, M., MacFarlane, M., Dubiel, W., Ciechanover, A. and Cohen, GM., 2004. Caspase activation inhibits proteasome function during apoptosis. Mol Cell, v. 14
    Doi: http://doi.org/10.1016/s1097-2765(04)00156-x
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    2003

  • Turner, C., Devitt, A., Parker, K., MacFarlane, M., Giuliano, M., Cohen, GM. and Gregory, CD., 2003. Macrophage-mediated clearance of cells undergoing caspase-3-independent death. Cell Death Differ, v. 10
    Doi: http://doi.org/10.1038/sj.cdd.4401170
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  • Harper, N., Hughes, M., MacFarlane, M. and Cohen, GM., 2003. Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis. J Biol Chem, v. 278
    Doi: http://doi.org/10.1074/jbc.M303399200
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  • Harper, N., Hughes, MA., Farrow, SN., Cohen, GM. and MacFarlane, M., 2003. Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling. J Biol Chem, v. 278
    Doi: http://doi.org/10.1074/jbc.M307376200
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    2002

  • MacFarlane, M., 2002. SMAC agonists blaze the TRAIL to tumor cells Trends in Pharmacological Sciences, v. 23
    Doi: http://doi.org/10.1016/S0165-6147(02)02124-7
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  • MacFarlane, M., Harper, N., Snowden, RT., Dyer, MJS., Barnett, GA., Pringle, JH. and Cohen, GM., 2002. Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. Oncogene, v. 21
    Doi: http://doi.org/10.1038/sj.onc.1205853
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  • MacFarlane, M., 2002. HIPPI-HIP1 - A deadly duo Trends in Pharmacological Sciences, v. 23
    Doi: http://doi.org/10.1016/s0165-6147(02)02032-1
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  • Sun, X-M., Bratton, SB., Butterworth, M., MacFarlane, M. and Cohen, GM., 2002. Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein. J Biol Chem, v. 277
    Doi: http://doi.org/10.1074/jbc.M109893200
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  • van Loo, G., Saelens, X., van Gurp, M., MacFarlane, M., Martin, SJ. and Vandenabeele, P., 2002. The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet. Cell Death Differ, v. 9
    Doi: http://doi.org/10.1038/sj.cdd.4401088
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  • MacFarlane, M., Merrison, W., Bratton, SB. and Cohen, GM., 2002. Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. J Biol Chem, v. 277
    Doi: http://doi.org/10.1074/jbc.M200317200
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  • MacFarlane, M., 2002. SMAC agonists blaze the TRAIL to tumor cells Trends in Cell Biology, v. 12
    Doi: http://doi.org/10.1016/S0962-8924(02)02393-0
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    2001

  • MacFarlane, M., 2001. OMInously, a mitochondrial serine protease is now unveiled as the third 'MAC'. Trends Pharmacol Sci, v. 22
    Doi: http://doi.org/10.1016/s0165-6147(00)01941-6
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  • MacFarlane, M., 2001. Compensatory caspase activation: a cautionary tale. Trends Pharmacol Sci, v. 22
    Doi: http://doi.org/10.1016/s0165-6147(00)01630-8
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  • Bouchier-Hayes, L., Conroy, H., Egan, H., Adrain, C., Creagh, EM., MacFarlane, M. and Martin, SJ., 2001. CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. J Biol Chem, v. 276
    Doi: http://doi.org/10.1074/jbc.M107373200
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  • Greaves, P., Edwards, R., Cohen, GM. and MacFarlane, M., 2001. "Have you seen this?" Diffuse hepatic apoptosis. Toxicol Pathol, v. 29
    Doi: 10.1080/019262301316905363
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  • Harper, N., Farrow, SN., Kaptein, A., Cohen, GM. and MacFarlane, M., 2001. Modulation of tumor necrosis factor apoptosis-inducing ligand- induced NF-kappa B activation by inhibition of apical caspases. J Biol Chem, v. 276
    Doi: http://doi.org/10.1074/jbc.M105693200
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  • Roberts, DL., Merrison, W., MacFarlane, M. and Cohen, GM., 2001. The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity. J Cell Biol, v. 153
    Doi: http://doi.org/10.1083/jcb.153.1.221
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    2000

  • Bratton, SB., MacFarlane, M., Cain, K. and Cohen, GM., 2000. Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis. Exp Cell Res, v. 256
    Doi: http://doi.org/10.1006/excr.2000.4835
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  • MacFarlane, M., 2000. A stressed cell? heat shock protein 70 offers protection. Trends Pharmacol Sci, v. 21
    Doi: 10.1016/s0165-6147(00)01550-9
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  • MacFarlane, M., Cohen, GM. and Dickens, M., 2000. JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation. Biochem J, v. 348 Pt 1
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  • Stoneley, M., Chappell, SA., Jopling, CL., Dickens, M., MacFarlane, M. and Willis, AE., 2000. c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis. Mol Cell Biol, v. 20
    Doi: 10.1128/MCB.20.4.1162-1169.2000
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  • Coldwell, MJ., Mitchell, SA., Stoneley, M., MacFarlane, M. and Willis, AE., 2000. Initiation of Apaf-1 translation by internal ribosome entry. Oncogene, v. 19
    Doi: 10.1038/sj.onc.1203407
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  • MacFarlane, M., Merrison, W., Dinsdale, D. and Cohen, GM., 2000. Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis. J Cell Biol, v. 148
    Doi: http://doi.org/10.1083/jcb.148.6.1239
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    1999

  • Chow, SC., Slee, EA., MacFarlane, M. and Cohen, GM., 1999. Caspase-1 is not involved in CD95/Fas-induced apoptosis in Jurkat T cells. Exp Cell Res, v. 246
    Doi: http://doi.org/10.1006/excr.1998.4333
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  • Yang, AL., Smith, AG., Akhtar, R., Clothier, B., Robinson, S., MacFarlane, M. and Festing, MF., 1999. Low levels of p53 are associated with resistance to tetrachlorodibenzo-p-dioxin toxicity in DBA/2 mice. Pharmacogenetics, v. 9
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  • Inayat-Hussain, SH., Osman, AB., Din, LB., Ali, AM., Snowden, RT., MacFarlane, M. and Cain, K., 1999. Caspases-3 and -7 are activated in goniothalamin-induced apoptosis in human Jurkat T-cells. FEBS Lett, v. 456
    Doi: http://doi.org/10.1016/s0014-5793(99)00984-9
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  • Sun, XM., MacFarlane, M., Zhuang, J., Wolf, BB., Green, DR. and Cohen, GM., 1999. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem, v. 274
    Doi: http://doi.org/10.1074/jbc.274.8.5053
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    1998

  • Chandler, JM., Cohen, GM. and MacFarlane, M., 1998. Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver. J Biol Chem, v. 273
    Doi: http://doi.org/10.1074/jbc.273.18.10815
    •
  • Srinivasula, SM., Ahmad, M., MacFarlane, M., Luo, Z., Huang, Z., Fernandes-Alnemri, T. and Alnemri, ES., 1998. Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits. J Biol Chem, v. 273
    Doi: http://doi.org/10.1074/jbc.273.17.10107
    •
  • Browne, SJ., MacFarlane, M., Cohen, GM. and Paraskeva, C., 1998. The adenomatous polyposis coli protein and retinoblastoma protein are cleaved early in apoptosis and are potential substrates for caspases. Cell Death Differ, v. 5
    Doi: http://doi.org/10.1038/sj.cdd.4400331
    •
  • Déas, O., Dumont, C., MacFarlane, M., Rouleau, M., Hebib, C., Harper, F., Hirsch, F., Charpentier, B., Cohen, GM. and Senik, A., 1998. Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes. J Immunol, v. 161
    •

    1997

  • MacFarlane, M., Ahmad, M., Srinivasula, SM., Fernandes-Alnemri, T., Cohen, GM. and Alnemri, ES., 1997. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem, v. 272
    Doi: http://doi.org/10.1074/jbc.272.41.25417
    •
  • MacFarlane, M., Cain, K., Sun, XM., Alnemri, ES. and Cohen, GM., 1997. Processing/activation of at least four interleukin-1beta converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells. J Cell Biol, v. 137
    Doi: http://doi.org/10.1083/jcb.137.2.469
    •
  • Chandler, JM., Alnemri, ES., Cohen, GM. and MacFarlane, M., 1997. Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis. Biochem J, v. 322 ( Pt 1)
    Doi: http://doi.org/10.1042/bj3220019
    •

    1996

  • Slee, EA., MacFarlane, M., Zhu, H., Chow, SC. and Cohen, GM., 1996. Inhibition of apoptosis by prevention of CPP32 processing - A study of ice-like protease activity and its inhibition using an AV vitro system Biochemical Society Transactions, v. 24
    •
  • MacFarlane, M., Cain, KC., Chow, S. and Cohen, GM., 1996. Cleavage of more than one ice homologue is required for the execution of apoptosis Biochemical Society Transactions, v. 24
    Doi: http://doi.org/10.1042/bst024559s
    •
  • Cain, K., MacFarlane, M. and Cohen, GM., 1996. Characterisation of ice-like proteolytic activity in apoptotic human monocytic tumour (THP.l) cells Biochemical Society Transactions, v. 24
    •
  • MacFarlane, M., Jones, NA., Dive, C. and Cohen, GM., 1996. DNA-damaging agents induce both p53-dependent and p53-independent apoptosis in immature thymocytes. Mol Pharmacol, v. 50
    •
  • Slee, EA., Zhu, H., Chow, SC., MacFarlane, M., Nicholson, DW. and Cohen, GM., 1996. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem J, v. 315 ( Pt 1)
    Doi: http://doi.org/10.1042/bj3150021
    •

    1995

  • Fearnhead, HO., MacFarlane, M., Dinsdale, D. and Cohen, GM., 1995. DNA degradation and proteolysis in thymocyte apoptosis. Toxicol Lett, v. 82-83
    Doi: http://doi.org/10.1016/0378-4274(95)03473-0
    •

    1994

  • Cohen, GM., Sun, XM., Fearnhead, H., MacFarlane, M., Brown, DG., Snowden, RT. and Dinsdale, D., 1994. Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. J Immunol, v. 153
    •
  • Norbury, C., MacFarlane, M., Fearnhead, H. and Cohen, GM., 1994. Cdc2 activation is not required for thymocyte apoptosis. Biochem Biophys Res Commun, v. 202
    Doi: http://doi.org/10.1006/bbrc.1994.2086
    •
    Books

    2008

  • Harper, N. and MacFarlane, M., 2008. Recombinant TRAIL and TRAIL receptor analysis.
    Doi: http://doi.org/10.1016/S0076-6879(08)01618-2
    •
    Conference proceedings

    2015

  • Chernova, T., Murphy, F., Sun, XM., Galavotti, S., Grosso, S., Dinsdale, D., Bennett, J., Nakas, A., Bushell, M., Willis, AE. and Macfarlane, M., 2015. Role of Pro-Inflammatory Cells in Development of Mesothelioma JOURNAL OF THORACIC ONCOLOGY, v. 10
    •

    2014

  • Murphy, F., Chernova, T., Schinwald, A., Sun, XM., Grosso, S., Dudek, K., Dinsdale, D., Greaves, P., Poland, C., Donaldson, K., Bushell, M., Willis, A. and MacFarlane, M., 2014. Long-fibre carbon nanotube- and asbestos-induced pleural lesions exhibit a common molecular signature TOXICOLOGY LETTERS, v. 229
    Doi: 10.1016/j.toxlet.2014.06.663
    •
  • Chernova, T., Murphy, F., Kumar, P., Sun, XM., Galavotti, S., Grosso, S., Bennett, J., Nakas, A., Bushell, M., MacFarlane, M. and Willis, A., 2014. Role of pro-inflammatory cells in mesothelial cell oncogenesis induced by toxic fibres TOXICOLOGY LETTERS, v. 229
    Doi: 10.1016/j.toxlet.2014.06.239
    •
  • Grosso, S., George, GM., Chernova, T., Sun, XM., Murphy, FA., Sbarrato, T., Dudek, K., Bennett, J., Nakas, A., Bushell, M., MacFarlane, M. and Willis, AE., 2014. Targeting the rate limiting step of protein synthesis may provide an alternative approach to overcome the chemoresistance of malignant mesothelioma TOXICOLOGY LETTERS, v. 229
    Doi: 10.1016/j.toxlet.2014.06.757
    •
  • Powley, I., Galavotti, S., Sun, X-M., Chernova, T., Nakas, A., Le Quesne, J., Pringle, H., Fennell, D. and MacFarlane, M., 2014. Predicting sensitivity to PI3K/mTOR inhibition in asbestos-induced malignant mesothelioma models TOXICOLOGY LETTERS, v. 229
    Doi: 10.1016/j.toxlet.2014.06.534
    •
  • Chernova, T., Murphy, F., Galavotti, S., Schinwald, A., Sun, X-M., Grosso, S., Dinsdale, D., Greaves, P., Poland, CA., Bushell, M., Donaldson, K., Willis, AE. and MacFarlane, M., 2014. Exposure to pathogenic fibres causes pro-oncogenic changes in the pleural cavity TOXICOLOGY LETTERS, v. 229
    Doi: 10.1016/j.toxlet.2014.06.249
    •
  • Sun, XM., Chernova, T., Grosso, S., Murphy, FA., Bennett, J., Nakas, A., Bushell, M., Willis, AE., Cain, K. and MacFarlane, M., 2014. Molecular evidence that metabolic reprogramming contributes to cell survival and chemoresistance in malignant mesothelioma TOXICOLOGY LETTERS, v. 229
    Doi: 10.1016/j.toxlet.2014.06.321
    •

    2013

  • Sun, XM., Chernova, T., Grosso, S., Murphy, F., Bennett, J., Nakas, A., Bushell, M., Cain, K., Willis, AE. and Macfarlane, M., 2013. METABOLIC REPROGRAMMING OVERCOMES RESISTANCE TO ABT-737-INDUCED APOPTOSIS IN PRECLINICAL MODELS OF MALIGNANT PLEURAL MESOTHELIOMA JOURNAL OF THORACIC ONCOLOGY, v. 8
    •
  • Chernova, T., Kumar, P., Murphy, F., Sun, XM., Grosso, S., Bennett, J., Nakas, A., Macfarlane, M., Bushell, M. and Willis, AE., 2013. PRO-TUMORIGENIC ALTERATION OF SIGNALLING PATHWAYS IN NORMAL MESOTHELIUM: CONTRIBUTION OF NON-MESOTHELIAL CELLS IN MALIGNANT MESOTHELIOMA CARCINOGENESIS JOURNAL OF THORACIC ONCOLOGY, v. 8
    •

    2004

  • MacFarlane, M. and Williams, AC., 2004. Apoptosis and disease: a life or death decision. EMBO Rep, v. 5
    Doi: 10.1038/sj.embor.7400191
    •

    2003

  • MacFarlane, M., 2003. TRAIL-induced signalling and apoptosis. Toxicol Lett, v. 139
    Doi: http://doi.org/10.1016/s0378-4274(02)00422-8
    •

    2001

  • Waterhouse, N. and MacFarlane, M., 2001. A dead cool meeting in Keystone 2001. Cell Death Differ, v. 8
    Doi: http://doi.org/10.1038/sj.cdd.4400939
    •

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