Julie Ahringer

Director, Gurdon Institute and University Professor, Department of Genetics

Julie Ahringer studies how cell-type specific gene expression and chromatin organisation are achieved using the simple C. elegans model, focussing on controls and interactions at regulatory elements, how euchromatin and heterochromatin are formed, and the regulation of 3D nuclear organisation. Learn more.

Research Areas

Animal Development

Gene Expression

Chromatin structure and function

Techniques

High throughput genomics

RNA interference

Super-resolution microscopy

Single-cell analyses

Research Theme

Publications

Journal articles

2021

Serizay, J. and Ahringer, J., 2021. periodicDNA: an R/Bioconductor package to investigate k-mer periodicity in DNA. F1000Res, v. 10
Doi: http://doi.org/10.12688/f1000research.51143.1

Huang, N., Seow, WQ., Appert, A., Dong, Y., Stempor, P. and Ahringer, J., 2021. Accessible Region Conformation Capture (ARC-C) gives high resolution insights into genome architecture and regulation. Genome Research,
Doi: 10.1101/gr.275669.121

2020

Deng, T., Stempor, P., Appert, A., Daube, M., Ahringer, J., Hajnal, A. and Lattmann, E., 2020. The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion. PLoS Genet, v. 16
Doi: http://doi.org/10.1371/journal.pgen.1008470

Serizay, J., Dong, Y., Jänes, J., Chesney, M., Cerrato, C. and Ahringer, J., 2020. Tissue-specific profiling reveals distinctive regulatory architectures for ubiquitous, germline and somatic genes
Doi: 10.1101/2020.02.20.958579

Gal, C., Carelli, FN., Appert, A., Cerrato, C., Huang, N., Dong, Y., Murphy, J. and Ahringer, J., 2020. DREAM represses distinct targets by cooperating with different THAP domain proteins
Doi: 10.1101/2020.08.13.249698

Serizay, J., Dong, Y., Jänes, J., Chesney, M., Cerrato, C. and Ahringer, J., 2020. Distinctive regulatory architectures of germline-active and somatic genes in C. elegans. Genome Res, v. 30
Doi: http://doi.org/10.1101/gr.265934.120

2019

Beltran, T., Barroso, C., Birkle, TY., Stevens, L., Schwartz, HT., Sternberg, PW., Fradin, H., Gunsalus, K., Piano, F., Sharma, G., Cerrato, C., Ahringer, J., Martínez-Pérez, E., Blaxter, M. and Sarkies, P., 2019. Comparative Epigenomics Reveals that RNA Polymerase II Pausing and Chromatin Domain Organization Control Nematode piRNA Biogenesis. Developmental Cell, v. 48
Doi: http://doi.org/10.1016/j.devcel.2018.12.026

Beurton, F., Stempor, P., Caron, M., Appert, A., Dong, Y., Chen, RA-J., Cluet, D., Couté, Y., Herbette, M., Huang, N., Polveche, H., Spichty, M., Bedet, C., Ahringer, J. and Palladino, F., 2019. Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans. Nucleic Acids Res, v. 47
Doi: http://doi.org/10.1093/nar/gkz880

2018

Ahringer, J. and Gasser, SM., 2018. Repressive Chromatin in Caenorhabditis elegans: Establishment, Composition, and Function. Genetics, v. 208
Doi: http://doi.org/10.1534/genetics.117.300386

Serizay, J. and Ahringer, J., 2018. Genome organization at different scales: nature, formation and function. Curr Opin Cell Biol, v. 52
Doi: http://doi.org/10.1016/j.ceb.2018.03.009

Naganathan, SR., Fürthauer, S., Rodriguez, J., Fievet, BT., Jülicher, F., Ahringer, J., Cannistraci, CV. and Grill, SW., 2018. Morphogenetic degeneracies in the actomyosin cortex. Elife, v. 7
Doi: http://doi.org/10.7554/eLife.37677

Jänes, J., Dong, Y., Schoof, M., Serizay, J., Appert, A., Cerrato, C., Woodbury, C., Chen, R., Gemma, C., Huang, N., Kissiov, D., Stempor, P., Steward, A., Zeiser, E., Sauer, S. and Ahringer, J., 2018. Chromatin accessibility dynamics across C. elegans development and ageing. Elife, v. 7
Doi: http://doi.org/10.7554/eLife.37344

Weng, C., Kosalka, J., Berkyurek, AC., Stempor, P., Feng, X., Mao, H., Zeng, C., Li, W-J., Yan, Y-H., Dong, M-Q., Morero, NR., Zuliani, C., Barabas, O., Ahringer, J., Guang, S. and Miska, EA., 2018. The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans. Genes and Development,
Doi: 10.1101/gad.319293.118

2017

McMurchy, AN., Stempor, P., Gaarenstroom, T., Wysolmerski, B., Dong, Y., Aussianikava, D., Appert, A., Huang, N., Kolasinska-Zwierz, P., Sapetschnig, A., Miska, EA. and Ahringer, J., 2017. A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress. Elife, v. 6
Doi: 10.7554/eLife.21666

Rodriguez, J., Peglion, F., Martin, J., Hubatsch, L., Reich, J., Hirani, N., Gubieda, AG., Roffey, J., Fernandes, AR., St Johnston, D., Ahringer, J. and Goehring, NW., 2017. aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity Developmental Cell, v. 42
Doi: 10.1016/j.devcel.2017.07.007

McMurchy, AN., Stempor, P., Gaarenstroom, T., Wysolmerski, B., Dong, Y., Aussianikava, D., Appert, A., Huang, N., Kolasinska-Zwierz, P., Sapetschnig, A., Miska, EA. and Ahringer, J., 2017. Correction: A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress. Elife, v. 6
Doi: 10.7554/eLife.32516

2016

Stempor, P. and Ahringer, J., 2016. SeqPlots - Interactive software for exploratory data analyses, pattern discovery and visualization in genomics Wellcome Open Research, v. 1
Doi: http://doi.org/10.12688/wellcomeopenres.10004.1

Heppert, JK., Dickinson, DJ., Pani, AM., Higgins, CD., Steward, A., Ahringer, J., Kuhn, JR. and Goldstein, B., 2016. Comparative assessment of fluorescent proteins for in vivo imaging in an animal model system. Mol Biol Cell, v. 27
Doi: http://doi.org/10.1091/mbc.E16-01-0063

Evans, KJ., Huang, N., Stempor, P., Chesney, MA., Down, TA. and Ahringer, J., 2016. Stable Caenorhabditis elegans chromatin domains separate broadly expressed and developmentally regulated genes. Proc Natl Acad Sci U S A,
Doi: http://doi.org/10.1073/pnas.1608162113

2015

Latorre, I., Chesney, MA., Garrigues, JM., Stempor, P., Appert, A., Francesconi, M., Strome, S. and Ahringer, J., 2015. The DREAM complex promotes gene body H2A.Z for target repression. Genes Dev, v. 29
Doi: 10.1101/gad.255810.114

2014

Gaggioli, V., Zeiser, E., Rivers, D., Bradshaw, CR., Ahringer, J. and Zegerman, P., 2014. CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans. J Cell Biol, v. 204
Doi: 10.1083/jcb.201310083

Chen, RA-J., Stempor, P., Down, TA., Zeiser, E., Feuer, SK. and Ahringer, J., 2014. Extreme HOT regions are CpG-dense promoters in C. elegans and humans. Genome Res, v. 24
Doi: 10.1101/gr.161992.113

Weick, E-M., Sarkies, P., Silva, N., Chen, RA., Moss, SMM., Cording, AC., Ahringer, J., Martinez-Perez, E. and Miska, EA., 2014. PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. elegans. Genes Dev, v. 28
Doi: 10.1101/gad.238105.114

Ho, JWK., Jung, YL., Liu, T., Alver, BH., Lee, S., Ikegami, K., Sohn, K-A., Minoda, A., Tolstorukov, MY., Appert, A., Parker, SCJ., Gu, T., Kundaje, A., Riddle, NC., Bishop, E., Egelhofer, TA., Hu, SS., Alekseyenko, AA., Rechtsteiner, A., Asker, D., Belsky, JA., Bowman, SK., Chen, QB., Chen, RA-J., Day, DS., Dong, Y., Dose, AC., Duan, X., Epstein, CB., Ercan, S., Feingold, EA., Ferrari, F., Garrigues, JM., Gehlenborg, N., Good, PJ., Haseley, P., He, D., Herrmann, M., Hoffman, MM., Jeffers, TE., Kharchenko, PV., Kolasinska-Zwierz, P., Kotwaliwale, CV., Kumar, N., Langley, SA., Larschan, EN., Latorre, I., Libbrecht, MW., Lin, X., Park, R., Pazin, MJ., Pham, HN., Plachetka, A., Qin, B., Schwartz, YB., Shoresh, N., Stempor, P., Vielle, A., Wang, C., Whittle, CM., Xue, H., Kingston, RE., Kim, JH., Bernstein, BE., Dernburg, AF., Pirrotta, V., Kuroda, MI., Noble, WS., Tullius, TD., Kellis, M., MacAlpine, DM., Strome, S., Elgin, SCR., Liu, XS., Lieb, JD., Ahringer, J., Karpen, GH. and Park, PJ., 2014. Comparative analysis of metazoan chromatin organization. Nature, v. 512
Doi: 10.1038/nature13415

2013

Chen, R., Down, T. and Ahringer, J., 2013. The landscape of RNA polymerase II transcription initiation in C. elegans reveals a novel enhancer architecture Epigenetics & Chromatin, v. 6
Doi: 10.1186/1756-8935-6-s1-o21

Fievet, BT., Rodriguez, J., Naganathan, S., Lee, C., Zeiser, E., Ishidate, T., Shirayama, M., Grill, S. and Ahringer, J., 2013. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy Nature Cell Biology, v. 15
Doi: http://doi.org/10.1038/ncb2639

Chen, RA-J., Down, TA., Stempor, P., Chen, QB., Egelhofer, TA., Hillier, LW., Jeffers, TE. and Ahringer, J., 2013. The landscape of RNA polymerase II transcription initiation in C. elegans reveals promoter and enhancer architectures. Genome Res, v. 23
Doi: 10.1101/gr.153668.112

Woods, S., Coghlan, A., Rivers, D., Warnecke, T., Jeffries, SJ., Kwon, T., Rogers, A., Hurst, LD. and Ahringer, J., 2013. Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses. PLoS Genet, v. 9
Doi: http://doi.org/10.1371/journal.pgen.1003330

Stamper, EL., Rodenbusch, SE., Rosu, S., Ahringer, J., Villeneuve, AM. and Dernburg, AF., 2013. Identification of DSB-1, a protein required for initiation of meiotic recombination in Caenorhabditis elegans, illuminates a crossover assurance checkpoint. PLoS Genet, v. 9
Doi: 10.1371/journal.pgen.1003679

Stamper, EL., Rodenbusch, SE., Rosu, S., Ahringer, J., Villeneuve, AM. and Dernburg, AF., 2013. Correction: Identification of DSB-1, a Protein Required for Initiation of Meiotic Recombination in Caenorhabditis elegans, Illuminates a Crossover Assurance Checkpoint. PLoS Genet, v. 9
Doi: http://doi.org/10.1371/annotation/340dc359-b1f8-46bb-a82d-d209315c154c

2012

Vielle, A., Lang, J., Dong, Y., Ercan, S., Kotwaliwale, C., Rechtsteiner, A., Appert, A., Chen, QB., Dose, A., Egelhofer, T., Kimura, H., Stempor, P., Dernburg, A., Lieb, JD., Strome, S. and Ahringer, J., 2012. H4K20me1 contributes to downregulation of X-linked genes for C. elegans dosage compensation. PLoS Genet, v. 8
Doi: http://doi.org/10.1371/journal.pgen.1002933

2011

Egelhofer, TA., Minoda, A., Klugman, S., Lee, K., Kolasinska-Zwierz, P., Alekseyenko, AA., Cheung, M-S., Day, DS., Gadel, S., Gorchakov, AA., Gu, T., Kharchenko, PV., Kuan, S., Latorre, I., Linder-Basso, D., Luu, Y., Ngo, Q., Perry, M., Rechtsteiner, A., Riddle, NC., Schwartz, YB., Shanower, GA., Vielle, A., Ahringer, J., Elgin, SCR., Kuroda, MI., Pirrotta, V., Ren, B., Strome, S., Park, PJ., Karpen, GH., Hawkins, RD. and Lieb, JD., 2011. An assessment of histone-modification antibody quality. Nat Struct Mol Biol, v. 18
Doi: http://doi.org/10.1038/nsmb.1972

Liu, T., Rechtsteiner, A., Egelhofer, TA., Vielle, A., Latorre, I., Cheung, M-S., Ercan, S., Ikegami, K., Jensen, M., Kolasinska-Zwierz, P., Rosenbaum, H., Shin, H., Taing, S., Takasaki, T., Iniguez, AL., Desai, A., Dernburg, AF., Kimura, H., Lieb, JD., Ahringer, J., Strome, S. and Liu, XS., 2011. Broad chromosomal domains of histone modification patterns in C. elegans. Genome Res, v. 21
Doi: http://doi.org/10.1101/gr.115519.110

Zeiser, E., Frøkjær-Jensen, C., Jorgensen, E. and Ahringer, J., 2011. MosSCI and gateway compatible plasmid toolkit for constitutive and inducible expression of transgenes in the C. elegans germline. PLoS One, v. 6
Doi: http://doi.org/10.1371/journal.pone.0020082

Cheung, M-S., Down, TA., Latorre, I. and Ahringer, J., 2011. Systematic bias in high-throughput sequencing data and its correction by BEADS. Nucleic Acids Res, v. 39
Doi: http://doi.org/10.1093/nar/gkr425

2010

Poulin, GB. and Ahringer, J., 2010. The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells. BMC Dev Biol, v. 10
Doi: http://doi.org/10.1186/1471-213X-10-109

Gerstein, MB., Lu, ZJ., Van Nostrand, EL., Cheng, C., Arshinoff, BI., Liu, T., Yip, KY., Robilotto, R., Rechtsteiner, A., Ikegami, K., Alves, P., Chateigner, A., Perry, M., Morris, M., Auerbach, RK., Feng, X., Leng, J., Vielle, A., Niu, W., Rhrissorrakrai, K., Agarwal, A., Alexander, RP., Barber, G., Brdlik, CM., Brennan, J., Brouillet, JJ., Carr, A., Cheung, M-S., Clawson, H., Contrino, S., Dannenberg, LO., Dernburg, AF., Desai, A., Dick, L., Dosé, AC., Du, J., Egelhofer, T., Ercan, S., Euskirchen, G., Ewing, B., Feingold, EA., Gassmann, R., Good, PJ., Green, P., Gullier, F., Gutwein, M., Guyer, MS., Habegger, L., Han, T., Henikoff, JG., Henz, SR., Hinrichs, A., Holster, H., Hyman, T., Iniguez, AL., Janette, J., Jensen, M., Kato, M., Kent, WJ., Kephart, E., Khivansara, V., Khurana, E., Kim, JK., Kolasinska-Zwierz, P., Lai, EC., Latorre, I., Leahey, A., Lewis, S., Lloyd, P., Lochovsky, L., Lowdon, RF., Lubling, Y., Lyne, R., MacCoss, M., Mackowiak, SD., Mangone, M., McKay, S., Mecenas, D., Merrihew, G., Miller, DM., Muroyama, A., Murray, JI., Ooi, S-L., Pham, H., Phippen, T., Preston, EA., Rajewsky, N., Rätsch, G., Rosenbaum, H., Rozowsky, J., Rutherford, K., Ruzanov, P., Sarov, M., Sasidharan, R., Sboner, A., Scheid, P., Segal, E., Shin, H., Shou, C., Slack, FJ., Slightam, C., Smith, R., Spencer, WC., Stinson, EO., Taing, S., Takasaki, T., Vafeados, D., Voronina, K., Wang, G., Washington, NL., Whittle, CM., Wu, B., Yan, K-K., Zeller, G., Zha, Z., Zhong, M., Zhou, X., modENCODE Consortium, , Ahringer, J., Strome, S., Gunsalus, KC., Micklem, G., Liu, XS., Reinke, V., Kim, SK., Hillier, LW., Henikoff, S., Piano, F., Snyder, M., Stein, L., Lieb, JD. and Waterston, RH., 2010. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science, v. 330
Doi: 10.1126/science.1196914

St Johnston, D. and Ahringer, J., 2010. Cell polarity in eggs and epithelia: parallels and diversity. Cell, v. 141
Doi: 10.1016/j.cell.2010.05.011

2009

Kolasinska-Zwierz, P., Down, T., Latorre, I., Liu, T., Liu, XS. and Ahringer, J., 2009. Differential chromatin marking of introns and expressed exons by H3K36me3. Nat Genet, v. 41
Doi: http://doi.org/10.1038/ng.322

2008

Boutros, M. and Ahringer, J., 2008. The art and design of genetic screens: RNA interference. Nat Rev Genet, v. 9
Doi: http://doi.org/10.1038/nrg2364

Panbianco, C., Weinkove, D., Zanin, E., Jones, D., Divecha, N., Gotta, M. and Ahringer, J., 2008. A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning. Dev Cell, v. 15
Doi: http://doi.org/10.1016/j.devcel.2008.06.002

Rivers, DM., Moreno, S., Abraham, M. and Ahringer, J., 2008. PAR proteins direct asymmetry of the cell cycle regulators Polo-like kinase and Cdc25. J Cell Biol, v. 180
Doi: http://doi.org/10.1083/jcb.200710018

2007

Andrews, R. and Ahringer, J., 2007. Asymmetry of early endosome distribution in C. elegans embryos. PLoS One, v. 2
Doi: http://doi.org/10.1371/journal.pone.0000493

Dong, Y., Bogdanova, A., Habermann, B., Zachariae, W. and Ahringer, J., 2007. Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast. BMC Dev Biol, v. 7
Doi: http://doi.org/10.1186/1471-213X-7-19

Miska, EA. and Ahringer, J., 2007. RNA interference has second helpings. Nat Biotechnol, v. 25
Doi: 10.1038/nbt0307-302

Welchman, DP., Mathies, LD. and Ahringer, J., 2007. Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in diverse cell types. Dev Biol, v. 305
Doi: http://doi.org/10.1016/j.ydbio.2007.02.022

Tsai, M-C. and Ahringer, J., 2007. Microtubules are involved in anterior-posterior axis formation in C. elegans embryos. J Cell Biol, v. 179
Doi: http://doi.org/10.1083/jcb.200708101

2006

Ahringer, J., 2006. Erratum: Playing ping pong with pins: Cortical and microtubule-induced polarity (Cell (December 29, 2005) 123 (1184-1186)) Cell, v. 124
Doi: http://doi.org/10.1016/j.cell.2006.02.035

Poulin, G., Dong, Y., Fraser, AG., Hopper, NA. and Ahringer, J., 2006. Erratum: Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in C. elegans (EMBO Journal (2005) 24 (2613-2623) DOI: 10.1038/sj.emboj.7600726) EMBO Journal, v. 25
Doi: http://doi.org/10.1038/sj.emboj.7600955

Poulin, G., Dong, Y., Fraser, AG., Hopper, NA. and Ahringer, J., 2006. Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in C. elegans (vol 24, pg 2613, 2005) EMBO J, v. 25
Doi: http://doi.org/10.1038/sj.emboj.7600955

Ahringer, J., 2006. Playing ping pong with pins: Cortical and microtubule-induced polarity (vol 123, pg 1184, 2005) CELL, v. 124
Doi: http://doi.org/10.1016/j.cell.2006.02.035

2005

Ahringer, J., 2005. Playing ping pong with pins: cortical and microtubule-induced polarity. Cell, v. 123
Doi: http://doi.org/10.1016/j.cell.2005.12.011

Poulin, G., Dong, Y., Fraser, AG., Hopper, NA. and Ahringer, J., 2005. Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans. EMBO J, v. 24
Doi: http://doi.org/10.1038/sj.emboj.7600726

Poulin, G. and Ahringer, J., 2005. Living on the edge. Genome Biol, v. 6
Doi: http://doi.org/10.1186/gb-2005-6-2-307

2004

Poulin, G., Nandakumar, R. and Ahringer, J., 2004. Genome-wide RNAi screens in Caenorhabditis elegans: impact on cancer research. Oncogene, v. 23
Doi: http://doi.org/10.1038/sj.onc.1208010

Kemp, CA., Kopish, KR., Zipperlen, P., Ahringer, J. and O'Connell, KF., 2004. Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2. Dev Cell, v. 6
Doi: http://doi.org/10.1016/s1534-5807(04)00066-8

Pocock, R., Ahringer, J., Mitsch, M., Maxwell, S. and Woollard, A., 2004. A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. elegans. Development, v. 131
Doi: http://doi.org/10.1242/dev.01110

Lettre, G., Kritikou, EA., Jaeggi, M., Calixto, A., Fraser, AG., Kamath, RS., Ahringer, J. and Hengartner, MO., 2004. Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans. Cell Death Differ, v. 11
Doi: http://doi.org/10.1038/sj.cdd.4401488

2003

Rappleye, CA., Tagawa, A., Le Bot, N., Ahringer, J. and Aroian, RV., 2003. Involvement of fatty acid pathways and cortical interaction of the pronuclear complex in Caenorhabditis elegans embryonic polarity. BMC Dev Biol, v. 3
Doi: http://doi.org/10.1186/1471-213X-3-8

Le Bot, N., Tsai, MC., Andrews, RK. and Ahringer, J., 2003. TAC-1, a regulator of microtubule length in the C. elegans embryo. Curr Biol, v. 13
Doi: http://doi.org/10.1016/s0960-9822(03)00577-3

Kamath, RS. and Ahringer, J., 2003. Genome-wide RNAi screening in Caenorhabditis elegans. Methods, v. 30
Doi: http://doi.org/10.1016/s1046-2023(03)00050-1

Kamath, RS., Fraser, AG., Dong, Y., Poulin, G., Durbin, R., Gotta, M., Kanapin, A., Le Bot, N., Moreno, S., Sohrmann, M., Welchman, DP., Zipperlen, P. and Ahringer, J., 2003. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature, v. 421
Doi: 10.1038/nature01278

Gotta, M., Dong, Y., Peterson, YK., Lanier, SM. and Ahringer, J., 2003. Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo. Curr Biol, v. 13
Doi: http://doi.org/10.1016/s0960-9822(03)00371-3

Ahringer, J., 2003. Control of cell polarity and mitotic spindle positioning in animal cells. Curr Opin Cell Biol, v. 15
Doi: http://doi.org/10.1016/s0955-0674(02)00018-2

Simmer, F., Moorman, C., van der Linden, AM., Kuijk, E., van den Berghe, PVE., Kamath, RS., Fraser, AG., Ahringer, J. and Plasterk, RHA., 2003. Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol, v. 1
Doi: http://doi.org/10.1371/journal.pbio.0000012

Lee, SS., Lee, RYN., Fraser, AG., Kamath, RS., Ahringer, J. and Ruvkun, G., 2003. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet, v. 33
Doi: http://doi.org/10.1038/ng1056

Vastenhouw, NL., Fischer, SEJ., Robert, VJP., Thijssen, KL., Fraser, AG., Kamath, RS., Ahringer, J. and Plasterk, RHA., 2003. A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans. Curr Biol, v. 13
Doi: http://doi.org/10.1016/s0960-9822(03)00539-6

Malone, CJ., Misner, L., Le Bot, N., Tsai, M-C., Campbell, JM., Ahringer, J. and White, JG., 2003. The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus. Cell, v. 115
Doi: http://doi.org/10.1016/s0092-8674(03)00985-1

Murphy, CT., McCarroll, SA., Bargmann, CI., Fraser, A., Kamath, RS., Ahringer, J., Li, H. and Kenyon, C., 2003. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature, v. 424
Doi: http://doi.org/10.1038/nature01789

Ashrafi, K., Chang, FY., Watts, JL., Fraser, AG., Kamath, RS., Ahringer, J. and Ruvkun, G., 2003. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature, v. 421
Doi: http://doi.org/10.1038/nature01279

Pothof, J., van Haaften, G., Thijssen, K., Kamath, RS., Fraser, AG., Ahringer, J., Plasterk, RHA. and Tijsterman, M., 2003. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev, v. 17
Doi: http://doi.org/10.1101/gad.1060703

2002

Simmer, F., Tijsterman, M., Parrish, S., Koushika, SP., Nonet, ML., Fire, A., Ahringer, J. and Plasterk, RHA., 2002. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr Biol, v. 12
Doi: http://doi.org/10.1016/s0960-9822(02)01041-2

Esmaeili, B., Ross, JM., Neades, C., Miller, DM. and Ahringer, J., 2002. The C. elegans even-skipped homologue, vab-7, specifies DB motoneurone identity and axon trajectory. Development, v. 129
Doi: 10.1242/dev.129.4.853

Dillin, A., Hsu, A-L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, AG., Kamath, RS., Ahringer, J. and Kenyon, C., 2002. Rates of behavior and aging specified by mitochondrial function during development. Science, v. 298
Doi: http://doi.org/10.1126/science.1077780

Garigan, D., Hsu, A-L., Fraser, AG., Kamath, RS., Ahringer, J. and Kenyon, C., 2002. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics, v. 161
Doi: http://doi.org/10.1093/genetics/161.3.1101

2001

Malone, CJ., Lebot, N., Ahringer, J. and White, JG., 2001. The C-elegans hook-like protein, ZYG-12, is required for the association of nuclei and centrosomes MOL BIOL CELL, v. 12

Gotta, M. and Ahringer, J., 2001. Regulation of embryonic polarity in C-elegans MOL BIOL CELL, v. 12

Gotta, M. and Ahringer, J., 2001. Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos. Nat Cell Biol, v. 3
Doi: http://doi.org/10.1038/35060092

Gotta, M., Abraham, MC. and Ahringer, J., 2001. CDC-42 controls early cell polarity and spindle orientation in C. elegans. Curr Biol, v. 11
Doi: http://doi.org/10.1016/s0960-9822(01)00142-7

Kamath, RS., Martinez-Campos, M., Zipperlen, P., Fraser, AG. and Ahringer, J., 2001. Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol, v. 2
Doi: http://doi.org/10.1186/gb-2000-2-1-research0002

Gotta, M. and Ahringer, J., 2001. Axis determination in C. elegans: initiating and transducing polarity. Curr Opin Genet Dev, v. 11
Doi: http://doi.org/10.1016/s0959-437x(00)00206-9

Zipperlen, P., Fraser, AG., Kamath, RS., Martinez-Campos, M. and Ahringer, J., 2001. Roles for 147 embryonic lethal genes on C.elegans chromosome I identified by RNA interference and video microscopy. EMBO J, v. 20
Doi: http://doi.org/10.1093/emboj/20.15.3984

2000

Ahringer, J., 2000. NuRD and SIN3 histone deacetylase complexes in development. Trends Genet, v. 16
Doi: http://doi.org/10.1016/s0168-9525(00)02066-7

Solari, F. and Ahringer, J., 2000. NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans. Curr Biol, v. 10
Doi: http://doi.org/10.1016/s0960-9822(00)00343-2

Fraser, AG., Kamath, RS., Zipperlen, P., Martinez-Campos, M., Sohrmann, M. and Ahringer, J., 2000. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature, v. 408
Doi: http://doi.org/10.1038/35042517

1999

Solari, F., Bateman, A. and Ahringer, J., 1999. The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning. Development, v. 126
Doi: 10.1242/dev.126.11.2483

1998

Gallegos, M., Ahringer, J., Crittenden, S. and Kimble, J., 1998. Repression by the 3' UTR of fem-3, a sex-determining gene, relies on a ubiquitous mog-dependent control in Caenorhabditis elegans. EMBO J, v. 17
Doi: http://doi.org/10.1093/emboj/17.21.6337

1997

Ahringer, J., 1997. Maternal control of a zygotic patterning gene in Caenorhabditis elegans. Development, v. 124
Doi: 10.1242/dev.124.19.3865

Ahringer, J., 1997. Turn to the worm! Curr Opin Genet Dev, v. 7
Doi: http://doi.org/10.1016/s0959-437x(97)80157-8

1996

Zwaal, RR., Ahringer, J., van Luenen, HG., Rushforth, A., Anderson, P. and Plasterk, RH., 1996. G proteins are required for spatial orientation of early cell cleavages in C. elegans embryos. Cell, v. 86
Doi: http://doi.org/10.1016/s0092-8674(00)80135-x

Ahringer, J., 1996. Posterior patterning by the Caenorhabditis elegans even-skipped homolog vab-7. Genes Dev, v. 10
Doi: http://doi.org/10.1101/gad.10.9.1120

Goedert, M., Baur, CP., Ahringer, J., Jakes, R., Hasegawa, M., Spillantini, MG., Smith, MJ. and Hill, F., 1996. PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans. J Cell Sci, v. 109 ( Pt 11)
Doi: 10.1242/jcs.109.11.2661

1995

Ahringer, J., 1995. Embryonic tissue differentiation in Caenorhabditis elegans requires dif-1, a gene homologous to mitochondrial solute carriers. EMBO J, v. 14
Doi: 10.1002/j.1460-2075.1995.tb07225.x

1992

Ahringer, J., Rosenquist, TA., Lawson, DN. and Kimble, J., 1992. The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally. EMBO J, v. 11
Doi: 10.1002/j.1460-2075.1992.tb05289.x

1991

Ahringer, J. and Kimble, J., 1991. Control of the sperm-oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3' untranslated region. Nature, v. 349
Doi: http://doi.org/10.1038/349346a0

1984

SHERMA, J., CHANDLER, K. and AHRINGER, J., 1984. DETERMINATION OF OCTADECYLAMINE IN WATER BY QUANTITATIVE HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY J LIQ CHROMATOGR, v. 7

Serizay, J. and Ahringer, J., periodicDNA: an R/Bioconductor package to investigate k-mer periodicity in DNA F1000Research,
Doi: http://doi.org/10.12688/f1000research.51143.1)

Ahringer, J., Gal, C., Carelli, F., Appert, A., Cerrato, C., Huang, N., Dong, Y., Murphy, J. and Frapporti, A., DREAM represses distinct targets by cooperating with different THAP domain proteins Cell Reports,

Ahringer, J., Carelli, F., Cerrato, C., Dong, Y., Appert, A. and Dernburg, A., Widespread transposon co-option in the Caenorhabditis germline regulatory network Science Advances,
Doi: 10.1126/sciadv.abo4082

tanguy, M., Veron, L., Stempor, P., Ahringer, J., Sarkies, P. and Miska, EA., An alternative STAT signaling pathway acts in viral immunity in Caenorhabditis elegans mBio,

Carelli, NC., Sharma, G. and Ahringer, J., Broad chromatin domains: an important facet of genome regulation BioEssays,

Internet publications

2016

Evans, K., Huang, N., Stempor, P., Chesney, M., Down, T. and Ahringer, J., 2016. Stable <i>C. elegans</i> chromatin domains separate broadly expressed and developmentally regulated genes
Doi: 10.1101/063990

Conference proceedings

2005

Ahringer, J., 2005. Genome-wide RNAi screening for the study of cell polarity in C-elegans. DEVELOPMENTAL BIOLOGY, v. 283

2003

Le Bot, N. and Ahringer, J., 2003. Ce-TACC, a C.elegans centrosomal protein required for MT dependent processes CELL MOTILITY AND THE CYTOSKELETON, v. 54

Malone, C., Misner, L., Le Bot, N., Ahringer, J. and White, J., 2003. The C. elegans hook protein, ZYG-12, mediates an essential association between the centrosome and nucleus CELL MOTILITY AND THE CYTOSKELETON, v. 54

2002

Malone, CJ., Misner, L., Lebot, N., Ahringer, J. and White, JG., 2002. The C-elegans hook protein, ZYG-12, mediates the essential association between the centrosome and nucleus MOLECULAR BIOLOGY OF THE CELL, v. 13

1990

ROSENQUIST, T., AHRINGER, J., BARTON, MK., GRAHAM, P., OKKEMA, P. and KIMBLE, J., 1990. GENETIC-CONTROL OF SEX DETERMINATION IN THE HERMAPHRODITE GERM LINE OF CAENORHABDITIS-ELEGANS GENETICS OF PATTERN FORMATION AND GROWTH CONTROL,

Julie Ahringer

Director, Gurdon Institute and University Professor, Department of Genetics

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