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Translational Neuroimaging Laboratory

Translational Neuroimaging Laboratory

Welcome to the Translational Neuroimaging Laboratory! This facility hosts the University's new 9.4T high-field MRI scanner, capable of the latest imaging techniques, including 

  • high-resolution structural imaging (in vivo and ex vivo)
  • diffusion tensor imaging / DTI
  • functional magnetic resonance imaging (fMRI) 
  • spectroscopy (with 1H, 31P and 13C)
  • relaxometry (T1, T2, T2* mapping) 
  • myelin imaging with multi-parametric mapping
  • angiography 
  • cardiovascular imaging

We have coils for mouse, rat and marmoset brain and rodent body imaging with extensive holding facilities ready to accept subjects from across the University. 


If you would like more information about the possibilities for MRI in your projects please contact Dr Stephen Sawiak () (Translational Neuroimaging Laboratory Manager and MR physicist). 

 

The TNL is overseen by a management committee 
Professor Angela Roberts (Physiology, Development and Neuroscience) (chair)
Dr Stephen Sawiak (Translational Neuroimaging Laboratory) 
Professor Ed Bullmore (Psychiatry)
Professor Jeff Dalley (Psychology)
Professor Trevor Robbins (Psychology)

 

Publications

Yang P, Read C, Kuc RE, Buonincontri G, Southwood M, Torella R, Upton PD, Crosby A, Sawiak SJ, Carpenter TA, Glen RC, Morrell NW, Maguire JJ, Davenport AP. 2017. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation 135:1160-1173 https://www.ncbi.nlm.nih.gov/pubmed/28137936

Shiba Y, Oikonomidis L, Sawiak S, Fryer TD, Hong YT, Cockcroft G, Santangelo AM, Roberts AC. 2017. Converging Prefronto-Insula-Amygdala Pathways in Negative Emotion Regulation in Marmoset Monkeys. Biological psychiatry  https://www.ncbi.nlm.nih.gov/pubmed/28756869

Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander GJ, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, Melum E, Markaki AE, Saeb-Parsy K, Vallier L. 2017. Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature medicine 23:954-963 https://www.ncbi.nlm.nih.gov/pubmed/28671689

Meyer CE, Kurth F, Lepore S, Gao JL, Johnsonbaugh H, Oberoi MR, Sawiak SJ, MacKenzie-Graham A. 2017. In vivo magnetic resonance images reveal neuroanatomical sex differences through the application of voxel-based morphometry in C57BL/6 mice. Neuroimage 163:197-205 https://www.ncbi.nlm.nih.gov/pubmed/28923275

Jensen-Kondering U, Manavaki R, Ejaz S, Sawiak SJ, Carpenter TA, Fryer TD, Aigbirhio FI, Williamson DJ, Baron JC. 2017. Brain hypoxia mapping in acute stroke: Back-to-back T2' MR versus (18)F-fluoromisonidazole PET in rodents. Int J Stroke 12:752-760 https://www.ncbi.nlm.nih.gov/pubmed/28523963

Ge H, Riss PJ, Mirabello V, Calatayud DG, Flower SE, Arrowsmith RL, Fryer TD, Hong Y, Sawiak S, Jacobs RMJ, Botchway SW, Tyrrell RM, James TD, Fossey JS, Dilworth JR, Aigbirhio FI, Pascu SI. 2017. Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo. Chem 3:437-460

Crum WR, Sawiak SJ, Chege W, Cooper JD, Williams SCR, Vernon AC. 2017. Evolution of structural abnormalities in the rat brain following in utero exposure to maternal immune activation: A longitudinal in vivo MRI study. Brain Behav Immun 63:50-59 https://www.ncbi.nlm.nih.gov/pubmed/27940258

Sawiak SJ, Wood NI, Morton AJ. 2016. Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy. Journal of Huntington's disease 5:271-283 https://www.ncbi.nlm.nih.gov/pubmed/27662335

Sawiak SJ, Morton AJ. 2016. The Cambridge MRI database for animal models of Huntington disease. Neuroimage 124:1260-1262 https://www.ncbi.nlm.nih.gov/pubmed/25941090

Sawiak SJ, Jupp B, Taylor T, Caprioli D, Carpenter TA, Dalley JW. 2016. In vivo γ-aminobutyric acid measurement in rats with spectral editing at 4.7T. Journal of magnetic resonance imaging : JMRI 43:1308-1312 https://www.ncbi.nlm.nih.gov/pubmed/26633759

Perentos N, Martins AQ, Cumming RJM, Mitchell NL, Palmer DN, Sawiak SJ, Morton AJ. 2016. An EEG Investigation of Sleep Homeostasis in Healthy and CLN5 Batten Disease Affected Sheep. J Neurosci 36:8238-8249 https://www.ncbi.nlm.nih.gov/pubmed/27488642

Hoffmann M, Mada M, Carpenter TA, Sawiak SJ, Williams GB. 2016. Additional sampling directions improve detection range of wireless radiofrequency probes. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 76:913-918 https://www.ncbi.nlm.nih.gov/pubmed/26418189

Ejaz S, Emmrich JV, Sitnikov SL, Hong YT, Sawiak SJ, Fryer TD, Aigbirhio FI, Williamson DJ, Baron JC. 2016. Normobaric hyperoxia markedly reduces brain damage and sensorimotor deficits following brief focal ischaemia. Brain : a journal of neurology 139:751-764 https://www.ncbi.nlm.nih.gov/pubmed/26767570

Dias C, Estruch SB, Graham SA, McRae J, Sawiak SJ, Hurst JA, Joss SK, Holder SE, Morton JEV, Turner C, Thevenon J, Mellul K, Sánchez-Andrade G, Ibarra-Soria X, Deriziotis P, Santos RF, Lee SC, Faivre L, Kleefstra T, Liu P, Hurles ME, Study DDD, Fisher SE, Logan DW. 2016. BCL11A Haploinsufficiency Causes an Intellectual Disability Syndrome and Dysregulates Transcription. American journal of human genetics 99:253-274 https://www.ncbi.nlm.nih.gov/pubmed/27453576

Buonincontri G, Sawiak SJ. 2016. MR fingerprinting with simultaneous B1 estimation. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 76:1127-1135 https://www.ncbi.nlm.nih.gov/pubmed/26509746

Belin-Rauscent A, Daniel ML, Puaud M, Jupp B, Sawiak S, Howett D, McKenzie C, Caprioli D, Besson M, Robbins TW, Everitt BJ, Dalley JW, Belin D. 2016. From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior. Molecular psychiatry 21:491-499 https://www.ncbi.nlm.nih.gov/pubmed/26370145

Belin-Rauscent A, Daniel ML, Puaud M, Jupp B, Sawiak S, Howett D, McKenzie C, Caprioli D, Besson M, Robbins TW, Everitt BJ, Dalley JW, Belin D. 2016. Impulsivity is predicted by the thinness of the insular cortex in rats. Molecular psychiatry 21:445 https://www.ncbi.nlm.nih.gov/pubmed/26996229

Sawiak SJ, Perumal SR, Rudiger SR, Matthews L, Mitchell NL, McLaughlan CJ, Bawden CS, Palmer DN, Kuchel T, Morton AJ. 2015. Rapid and Progressive Regional Brain Atrophy in CLN6 Batten Disease Affected Sheep Measured with Longitudinal Magnetic Resonance Imaging. PLoS One 10:e0132331 https://www.ncbi.nlm.nih.gov/pubmed/26161747

Mikheenko Y, Shiba Y, Sawiak S, Braesicke K, Cockcroft G, Clarke H, Roberts AC. 2015. Serotonergic, Brain Volume and Attentional Correlates of Trait Anxiety in Primates. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 40:1395-1404

Hoffmann M, Carpenter TA, Williams GB, Sawiak SJ. 2015. A survey of patient motion in disorders of consciousness and optimization of its retrospective correction. Magnetic resonance imaging 33:346-350

Ejaz S, Williamson DJ, Jensen-Kondering U, Ahmed T, Sawiak SJ, Baron JC. 2015. What is the Optimal Duration of Middle-Cerebral Artery Occlusion Consistently Resulting in Isolated Cortical Selective Neuronal Loss in the Spontaneously Hypertensive Rat? Frontiers in neurology 6:64 https://www.ncbi.nlm.nih.gov/pubmed/25859239

Ejaz S, Emmrich JV, Sawiak SJ, Williamson DJ, Baron JC. 2015. Cortical selective neuronal loss, impaired behavior, and normal magnetic resonance imaging in a new rat model of true transient ischemic attacks. Stroke; a journal of cerebral circulation 46:1084-1092 https://www.ncbi.nlm.nih.gov/pubmed/25669312

Drouin-Ouellet J, Sawiak SJ, Cisbani G, Lagacé M, Kuan WL, Saint-Pierre M, Dury RJ, Alata W, St-Amour I, Mason SL, Calon F, Lacroix S, Gowland PA, Francis ST, Barker RA, Cicchetti F. 2015. Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology. Annals of neurology 78:160-177 https://www.ncbi.nlm.nih.gov/pubmed/25866151

Caprioli D, Jupp B, Hong YT, Sawiak SJ, Ferrari V, Wharton L, Williamson DJ, McNabb C, Berry D, Aigbirhio FI, Robbins TW, Fryer TD, Dalley JW. 2015. Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum. J Neurosci 35:3747-3755 https://www.ncbi.nlm.nih.gov/pubmed/25740505

Amorim IS, Mitchell NL, Palmer DN, Sawiak SJ, Mason R, Wishart TM, Gillingwater TH. 2015. Molecular neuropathology of the synapse in sheep with CLN5 Batten disease. Brain and behavior 5:e00401 https://www.ncbi.nlm.nih.gov/pubmed/26664787

Sawiak SJ, Picq JL, Dhenain M. 2014. Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate. Frontiers in aging neuroscience 6:82 https://www.ncbi.nlm.nih.gov/pubmed/24834052

Morton AJ, Rudiger SR, Wood NI, Sawiak SJ, Brown GC, McLaughlan CJ, Kuchel TR, Snell RG, Faull RLM, Bawden CS. 2014. Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment. Hum Mol Genet 23:3375-3383 https://www.ncbi.nlm.nih.gov/pubmed/24488771

Methner C, Chouchani ET, Buonincontri G, Pell VR, Sawiak SJ, Murphy MP, Krieg T. 2014. Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts. European journal of heart failure 16:712-717 https://www.ncbi.nlm.nih.gov/pubmed/24891297

Izquierdo-Garcia D, Sawiak SJ, Knesaurek K, Narula J, Fuster V, Machac J, Fayad ZA. 2014. Comparison of MR-based attenuation correction and CT-based attenuation correction of whole-body PET/MR imaging. European journal of nuclear medicine and molecular imaging 41:1574-1584 https://www.ncbi.nlm.nih.gov/pubmed/24652234

Hayes DJ, Jupp B, Sawiak SJ, Merlo E, Caprioli D, Dalley JW. 2014. Brain γ-aminobutyric acid: a neglected role in impulsivity. The European journal of neuroscience 39:1921-1932 https://www.ncbi.nlm.nih.gov/pubmed/24460847

Evans E, Sawiak SJ, Ward AO, Buonincontri G, Hawkes RC, Adrian Carpenter T. 2014. Comparison of first pass bolus AIFs extracted from sequential 18F-FDG PET and DSC-MRI of mice. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 734:137-140

Evans E, Buonincontri G, Izquierdo D, Methner C, Hawkes RC, Ansorge RE, Kreig T, Carpenter TA, Sawiak SJ. 2014. Combining MRI with PET for partial volume correction improves image-derived input functions in mice. EJNMMI physics 1:A84 https://www.ncbi.nlm.nih.gov/pubmed/26501676

Evans E, Buonincontri G, Hawkes RC, Ansorge RE, Carpenter TA, Sawiak SJ. 2014. Direct evaluation of MR-derived attenuation correction maps for PET/MR of the mouse myocardium. EJNMMI physics 1:A85 https://www.ncbi.nlm.nih.gov/pubmed/26501677

Clarke HF, Cardinal RN, Rygula R, Hong YT, Fryer TD, Sawiak SJ, Ferrari V, Cockcroft G, Aigbirhio FI, Robbins TW, Roberts AC. 2014. Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity. J Neurosci 34:7663-7676 https://www.ncbi.nlm.nih.gov/pubmed/24872570

Chouchani ET, Methner C, Buonincontri G, Hu CH, Logan A, Sawiak SJ, Murphy MP, Krieg T. 2014. Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy. PLoS One 9:e94157 https://www.ncbi.nlm.nih.gov/pubmed/24705922

Caprioli D, Sawiak SJ, Merlo E, Theobald DEH, Spoelder M, Jupp B, Voon V, Carpenter TA, Everitt BJ, Robbins TW, Dalley JW. 2014. Gamma aminobutyric acidergic and neuronal structural markers in the nucleus accumbens core underlie Trait-like impulsive behavior. Biological psychiatry 75:115-123

Buonincontri G, Wood NI, Puttick SG, Ward AO, Carpenter TA, Sawiak SJ, Morton AJ. 2014. Right ventricular dysfunction in the R6/2 transgenic mouse model of Huntington's disease is unmasked by dobutamine. Journal of Huntington's disease 3:25-32 https://www.ncbi.nlm.nih.gov/pubmed/24744818

Buonincontri G, Methner C, Krieg T, Hawkes RC, Adrian Carpenter T, Sawiak SJ. 2014. PET/MRI assessment of the infarcted mouse heart. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 734:152-155

Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ. 2014. Functional assessment of the mouse heart by MRI with a 1-min acquisition. NMR in biomedicine 27:733-737

Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ. 2014. Trajectory correction for free-breathing radial cine MRI. Magnetic resonance imaging 32:961-964

Barnes SA, Sawiak SJ, Caprioli D, Jupp B, Buonincontri G, Mar AC, Harte MK, Fletcher PC, Robbins TW, Neill JC, Dalley JW. 2014. Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum 18 https://www.ncbi.nlm.nih.gov/pubmed/25552430

Williamson DJ, Ejaz S, Sitnikov S, Fryer TD, Sawiak SJ, Burke P, Baron JC, Aigbirhio FI. 2013. A comparison of four PET tracers for brain hypoxia mapping in a rodent model of stroke. Nuclear medicine and biology 40:338-344 https://www.ncbi.nlm.nih.gov/pubmed/23294900

Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA. 2013. Voxel-based morphometry with templates and validation in a mouse model of Huntington's disease. Magnetic resonance imaging 31:1522-1531

Sawiak SJ, Hawkes RC, Ansorge RE, Carpenter TA. 2013. Reliability of using a fixed matrix in coregistration of combined PET-MRI in a split magnet design. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 702:54-55

Methner C, Buonincontri G, Hu CH, Vujic A, Kretschmer A, Sawiak S, Carpenter A, Stasch JP, Krieg T. 2013. Riociguat reduces infarct size and post-infarct heart failure in mouse hearts: insights from MRI/PET imaging. PLoS One 8:e83910 https://www.ncbi.nlm.nih.gov/pubmed/24391843

Ejaz S, Williamson DJ, Ahmed T, Sitnikov S, Hong YT, Sawiak SJ, Fryer TD, Aigbirhio FI, Baron JC. 2013. Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study. Neurobiol Dis 51:120-132 https://www.ncbi.nlm.nih.gov/pubmed/23146994

Caprioli D, Hong YT, Sawiak SJ, Ferrari V, Williamson DJ, Jupp B, Adrian Carpenter T, Aigbirhio FI, Everitt BJ, Robbins TW, Fryer TD, Dalley JW. 2013. Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 38:1460-1471 https://www.ncbi.nlm.nih.gov/pubmed/23399948

Caprioli D, Fryer TD, Sawiak SJ, Aigbirhio FI, Dalley JW. 2013. Translating positron emission tomography studies in animals to stimulant addiction: Promises and pitfalls. Current opinion in neurobiology 23:597-606

Buonincontri G, Sawiak SJ, Methner C, Krieg T, Hawkes RC, Carpenter TA. 2013. PET/MRI in the infarcted mouse heart with the Cambridge split magnet. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 702:47-49

Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ. 2013. A fast protocol for infarct quantification in mice. Journal of magnetic resonance imaging : JMRI 38:468-473 https://www.ncbi.nlm.nih.gov/pubmed/23292906

Buonincontri G, Methner C, Carpenter TA, Hawkes RC, Sawiak SJ, Krieg T. 2013. MRI and PET in mouse models of myocardial infarction. Journal of visualized experiments : JoVE:e50806 https://www.ncbi.nlm.nih.gov/pubmed/24378323

Wood NI, Sawiak SJ, Buonincontri G, Niu Y, Kane AD, Carpenter TA, Giussani DA, Morton AJ. 2012. Direct evidence of progressive cardiac dysfunction in a transgenic mouse model of Huntington's disease. Journal of Huntington's disease 1:57-64 https://www.ncbi.nlm.nih.gov/pubmed/24339845

Sawiak SJ, Wood NI, Carpenter TA, Morton AJ. 2012. Huntington's disease mouse models online: high-resolution MRI images with stereotaxic templates for computational neuroanatomy. PLoS One 7:e53361 https://www.ncbi.nlm.nih.gov/pubmed/23300918

Kielar C, Sawiak SJ, Navarro Negredo P, Tse DHY, Morton AJ. 2012. Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse. PLoS One 7:e32636 https://www.ncbi.nlm.nih.gov/pubmed/22393426

Gruslys A, Sawiak S, Ansorge R. 2012. 3000 Non-rigid medical image registrations overnight on a single PC. IEEE Nuclear Science Symposium Conference Record:3073-3080

Evans E, Sawiak SJ, Adrian Carpenter T. 2012. MRI-derived arterial input functions for PET kinetic modelling in rats. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 

Williamson DJ, Ejaz S, Sitnikov S, Hong YT, Fryer TD, Sawiak SJ, Baron JC, Aigbirhio FI. 2011. Imaging of hypoxia in preclinical ischemic stroke using two copper-64-bis(thiosemicarbazone) complexes: comparison with [18f]fluoromisonidazole. J LABELLED COMPD RAD 54:S259-S259

Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI. 2011. Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 31:2334-2342 https://www.ncbi.nlm.nih.gov/pubmed/21750562 

Herrick PDE, Ansorge RE, Hawkes RC, Sawiak SJ, Stevick JW, Carpenter TA. 2010. Radiofrequency coil design for simultaneous PET/MR systems. IEEE Nuclear Science Symposium Conference Record:2560-2567

Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA. 2009. Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease. Neurobiol Dis 33:12-19 https://www.ncbi.nlm.nih.gov/pubmed/18930823 

Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA. 2009. Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry. Neurobiol Dis 33:20-27 https://www.ncbi.nlm.nih.gov/pubmed/18930824