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Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 21, 2019.

The Laboratory of Prof Guy Brown (www.guybrown.net) in the Department of Biochemistry, University of Cambridge, is looking for a post-doctoral Research Associate to work on a project examining the roles of microglial receptors in Alzheimer's disease. We will be looking at how these receptors regulate phagocytosis, signalling, inflammation and neurotoxicity.

The applicant should have: experience of microglial, glial and/or neuronal biology, including isolation of brain cells, animal experiments and the methods of molecular cell biology and biochemistry. The applicant needs to have: lots of ideas, enthusiasm, experience, a good publication record and very good references, to work on this exciting project.

Applicants should have a PhD (or about to submit) or have the relevant experience.

Fixed-term: The funds for this post are available for 1 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If needed, informal enquiries can be made to Guy Brown: gcb3@cam.ac.uk

Any enquiries relating to the application process, please contact the Biochemistry HR team; +44 1223 333617, email; personnel@bioc.cam.ac.uk

Please quote reference PH18496 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Chief Research Laboratory Technician (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 21, 2019.

We are looking for a Chief Research laboratory technician to join the group of Professor Allan Herbison. The Herbison group focusses on understanding the neural networks that control puberty and fertility in males and females. This is an exciting opportunity to join a group newly established in Cambridge.

You will act as lab manager as well as being actively involved in aspects of the research. Specific duties will include:

  • Management of the mouse colonies to include genotyping, daily mouse acclimatisation duties and tail-tip bleeding procedures for in vivo studies
  • Analysis of blood samples for LH using an ultrasensitive ELISA.
  • Assisting with routine aspects of the immunohistochemical work
  • Management of consumables and equipment
  • Adherence to health and safety protocols and procedures

You should have a first degree/HND or equivalent experience in a science subject along with experience of working in a high throughput lab.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please complete the suitability for the role section as fully as possible.

Please quote reference PM18571 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Karadottir Lab) (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 21, 2019.

The Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

The CNS is responsive to an ever-changing environment. Studies of neural circuit plasticity focus almost exclusively on functional and structural changes of neuronal synapses. In recent years, however, myelin plasticity has emerged as a potential modulator of neuronal networks. Myelination of previously unmyelinated axons and changes in the structure on already-myelinated axons (e.g. changes in internode number and length, myelin thickness, or geometry of the nodal area) can have large effects on the function of neuronal networks. It is conceivable that, as for in neuronal synapse plasticity, myelin changes are regulated by a change in the frequency of neuronal firing. However, to what extent myelin modifications occur in the adult, and the underlying mechanisms, are currently unclear.

We are looking for a research associate with to join a European Research Council (ERC) funded research project to uncover to what extent myelin plasticity occurs and the mechanisms underlying it.

The Karadottir lab aims to understand (1) how neurons regulate oligodendrocyte progenitor cell differentiation throughout life in both health and disease; and (2) the effect myelin has on neuronal circuits. The lab uses a combination of diverse approaches, including molecular, genetic, cellular, imaging, physiological and behavioural methods in order to achieve a detailed understanding of myelin plasticity. Homepages of the team: https://www.stemcells.cam.ac.uk/research/pis/karadottir

Requirements: We are looking for candidates, with a PhD level qualification in the field of neuroscience, and who have experience working with animals. Candidates with experience in adhesion molecules, myelination, electron microscopy, cell culture and handling transgenic animals are particularly encouraged to apply.

We are specifically looking for candidates who are collaborative with proven communication skills, the ability to work in a team, and are interested in the Karadottir lab.

Start date is flexible but can be as early as May 2019.

Fixed-term: The funds for this post are available for 36 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The closing date is 4 April 2019, with interviews to be confirmed.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference PS18568 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate: Understanding neural networks

From Jobs at the University of Cambridge. Published on Mar 20, 2019.

We are looking for a Post-doctoral Research Associate to support the research of Professor Allan Herbison whose group is focussed on understanding the neural networks that control puberty and fertility in males and females. In particular, studies will focus on investigating the mechanisms through which kisspeptin neurons control the activity of the gonadotropin-releasing hormone (GnRH) neurons. The role holder will also play a key part in establishing the lab in Cambridge after recent relocation from University of Otago, New Zealand.

You will be involved in establishing viral-based transduction methodologies in genetically-altered mouse models that enable the tagging, neuronal tracing and functional mapping of specific hypothalamic neuronal phenotypes. Investigations will also concentrate on the use of CRISPR-based approaches for acute in vivo gene editing in the brain.

The skills and experience required for the post include: - Precision stereotaxic surgery skills in mice. - Experience with viral vectors for transducing neuronal cells in genetically-altered animals. - Use of super-resolution microscopy techniques for assessing neuronal morphology.

You should have a PhD in neuroscience and a strong motivation to lead, conduct and record research at the forefront of neuroendocrinology.

Limit of tenure: 31 August 2024

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applications should include a personal statement highlighting suitability to the post, detailed CV and the names and addresses of two academic referees.

Deadline for applications is 04 April 2019

Please quote reference PM18551 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Facilities Supervisor

From Jobs at the University of Cambridge. Published on Mar 19, 2019.

Applications are invited for the position of Facilities Supervisor within the Department of Biochemistry. This is a busy, varied and interesting role offering the candidate the opportunity to become a pivotal member of the administrative support team of the Department.

The role holder is primarily responsible for the design, implementation and supervision of the domestic and catering services; ensuring the departmental facilities (meeting rooms, offices and teaching spaces) are of an acceptable high standard; and providing administrative support to the Departmental Safety Officer, including acting as secretary to a number of departmental committees. The Further Information sheet gives additional details on the range of responsibilities of this role.

Excellent written and verbal communication is essential, as are good interpersonal and staff management skills, a patient attitude, tact and diplomacy. The successful candidate will be educated to A Level (or equivalent) and possess excellent IT skills. Experience of hygiene/health and safety guidelines in a laboratory or kitchen environment would be desirable.

You will be able to work under pressure and to tight deadlines in a demanding environment, whilst maintaining accuracy and paying attention to detail, and will be expected to work on your own initiative within the limits of your role.

Closing date: Thursday 4th April 2019. Interviews will take place on Wednesday 10th April 2019.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquires can be made by contacting Debbie Canham, Administrative Officer, email: dac77@cam.ac.uk

Any enquiries relating to the application process, please contact the Biochemistry HR team; +44 1223 333617, email; personnel@bioc.cam.ac.uk

Please quote reference PH18521 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate

From Jobs at the University of Cambridge. Published on Mar 19, 2019.

We are seeking an enthusiastic and committed research associate to assist the Project Coordinator in running a collaborative EU research project, ALKATRAS. The project, an EU-funded, Marie Curie Initial Training Network Project includes fourteen project partners from the UK, France, Germany, Sweden, Italy, Austria and the Czech Republic, and will train fifteen Early Career Researchers (PhD students) in cancer biology.

The successful applicant will be expected to oversee the research programme and associated researcher training programme, organizing, coordinating, reporting, marketing and tracking finances.

Strong project management, oral and written communication skills are essential, as is a scientific background. A willingness to travel overseas is essential. Further information on generic duties of this post is available in the Research Assistant/Associate job description documents.

Applicants must hold or be close to obtaining a PhD in the relevant subject. Where the successful applicant does not yet have a PhD, he/she will normally be under-appointed as a Research Assistant in a Research Associate post (on the understanding that he/she will be appointed as a Research Associate upon successful completion of his/her PhD). The higher Research Associate salary should be backdated to the submission date of their thesis.

The appointee will report to the Project Coordinator and PI, Dr Suzanne Turner, and will be based in the Department of Pathology at the University of Cambridge, Cambridge Biomedical Campus.

The successful candidate will be required to commence employment beginning by late April, early May 2019.

If you have any questions about this vacancy, please contact Dr Suzanne Turner at sdt36@cam.ac.uk

Fixed-term: The funds for this post are available until 31 August 2019 in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Any enquiries relating to the application process please contact Jodi Smith - hr@path.cam.ac.uk

Please quote reference PK18528 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Head of Learning

From Jobs at the University of Cambridge. Published on Mar 19, 2019.

Reporting to the Director, the role holder is responsible for the management of the Learning Team which delivers the Garden's adult education programme, horticultural learning, community projects, outreach activities, schools' programme, HE and FE learning and family event activities.

The role holder will devise, support and contribute to the delivery of learning programmes for schools, colleges and universities and for the general public through life-long learning and recreation. The role carries responsibility for design and delivery of the entire education and widening participation programme at the Garden.

The team currently delivers over 60 adult education courses and workshops, and facilitates over 400 school visits (both assisted and unassisted) per year. The role-holder will have direct responsibility for the organisation of the adult education programme, oversight of interpretation throughout the Garden and is a member of the Garden's senior leadership team, contributing to general strategy discussions and supporting the Director in the delivery of the Garden's targets.

Please see FURTHER PARTICULARS (link below) for full details and Person Specification.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a Disclosure and Barring Service check (enhanced with children and adults' barred lists).

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For any questions relating to this recruitment please contact admin@botanic.cam.ac.uk

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Marie Curie Early Stage Researcher

From Jobs at the University of Cambridge. Published on Mar 19, 2019.

Marie-Curie PhD post: How differences in the earliest social interactions drive emerging cortical specialization

We are seeking a talented early stage researcher (ESRs) wishing to pursue a Ph.D. in the field of developmental psychology and cognitive neuroscience. The position is part of SAPIENS, a pan-European Marie Sk¿odowska-Curie Innovative Training Network (EU Horizon 2020 Programme), which aims to investigate how the dynamics of early social exchanges support the development of the social brain. SAPIENS combines advances in ecological, mobile real-time brain and behaviour measurement, data modelling and artificial intelligence approaches to train a new generation of researchers in implementing these ground-breaking approaches to early social development.

The candidates have to meet (and provide proof that they meet) the following MSC-ITN criteria: 1. Mobility Rule: candidate must not have resided or carried out his/her main activity (work, studies, etc.) in the country where the position is based (UK) for more than 12 months in the last 3 years. 2. Early Stage Researcher: the candidate is in the first four years of his/her research career and has not been awarded a doctoral degree. 3. The candidate must have a first degree in psychology, cognitive science, medical physics, mathematics or other related subject, and meet criteria for registration as a PhD student at the University of Cambridge. The ESRs will receive an attractive salary in accordance with the MSCA regulations for Early Stage Researchers.

Working in a team, the successful candidate will investigate how variation in the very earliest postnatal social interactions (hours and days) in human newborns influences the emergence of temporal lobe social brain function using fNIRS and EEG. As this is the phase of life with the most dramatic changes in sensory and interactive experience, it is the best age point of focus for seeking associations with emerging brain function. We will densely sample the social experience and interactions of the newborn in the home environment over this period to determine the association between very early experience and the emergence of specific social responses in the temporal lobe.

We are looking for a talented and motivated ESR (3 years, 100%) who will be supervised by Professor Mark Johnson and Dr Sarah Lloyd-Fox. The project will utilize a range of multidisciplinary techniques to study the developing brain. These include techniques for measuring infant brain development like EEG and NIRS. The successful candidate will be embedded in an active and social group of PhD students and junior and senior researchers with expertise across typical and atypical development. The SAPIENS network also offers a unique program of pan-European training in specialized and generalizable skills on topics such as project management, academic and communication skills, advanced analysis techniques in neuroimaging, typical and atypical brain development, entrepreneurship, translation, career development, and clinical diagnostics.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a standard Disclosure and Barring Service check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

In addition, to apply for the PhD. Please complete the University GRADSAF application form. The course code is BLPC22 (PhD in Psychology).

https://www.graduate.study.cam.ac.uk/how-do-i-apply

With your GRADSAF application you will be required to submit (i) a draft research proposal outlining your suitability, why you are interested in pursuing a PhD in this area, your background and research interests. (ii) your CV stating your citizenship and years of residence in the UK if applicable (iii) copies of your academic transcripts (iv) details of two academic referees.

Informal enquiries can be made to Mark Johnson (mj492@cam.ac.uk).

Please note the closing date for applications is 17 April 2019. Applications received after this time will not be considered.

Please quote reference PJ18522 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate x 2 (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 18, 2019.

Applications are invited for two research assistant/associate positions starting 01/05/2019. The successful candidates will be based in the Department of Psychology and will join the Consciousness and Cognition Laboratory (lead by Dr Tristan Bekinschtein - http://www.ccc-lab.org/). The lab investigates consciousness and cognition during different states of consciousness and its transitions. The research spans from wakefulness, drowsiness and sleep, to disorders of consciousness and altered states.

Within this remit, the team is investigating neural remapping across the sleep-wake cycle. To explore these issues, the team use EEG, fMRI, MRS and behavioural data during wakefulness and sleep. The successful candidates will work on this project by developing and using advanced brain-scanning data processing and analysis methods. Most of this work will require programming skills, especially in Matlab and Python.

Applicants must have a good science, computer science, mathematics or engineering degree, and preferably a higher degree in a relevant subject. Experience in programming or EEG or fMRI analysis would be highly desirable.

If you are prepared to face intellectual challenges and wish to develop your scientific skills, we would like to hear from you.

The funds for post are available from 1st May 2019 until 30 September 2019 with the possibility of a short extension, dependent on further funding.

Interviews are expected to be held towards the end of April 2019.

Fixed-term: The funds for this post are available until 30 September 2019 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be made to Anat Arzi (aa913@cam.ac.uk).

Please note the closing date for applications is 17 April 2019. Applications received after this time will not be considered.

Please quote reference PJ18518 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PA to Herchel Smith Professor of Biochemistry (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 15, 2019.

Applications are invited for a PA in the University of Cambridge, Department of Biochemistry working with the research group of Professor Jussi Taipale. The group includes both experimental biologists and computer scientists, and is currently composed of seven postdoctoral fellows.

The role requires the ability to communicate effectively with a wide range of people internally as collaborators and funding bodies Experience in the management and organisation of international travel would be of advantage, including planning, scheduling, flights, hotel, ground transportation and the associated expense filing. You will be expected to assist Professor Taipale with grant applications and reporting, letter writing, documentation, filing and diary management. Drafting skills, including proof reading would be of benefit. You will work closely with the University of Cambridge administration regarding employment contracts, recruitment, finance, expenses and invoicing as regards the research group.

The applicant must have excellent communication and organisational skills and be used to working to tight deadlines with attention to detail. The ability to prioritize and plan your own workload independently is essential, in addition to being flexible and able to work on your own initiative within agreed boundaries.

Candidates should be educated to A-level (or equivalent), or have a high level of practical experience and relevant PA/Secretarial experience. Website management and experience of events organisation would be highly desirable.

The interviews are expected to take place in April 2019.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquires can be made by contacting Dr Minna Taipale, email: mt779@cam.ac.uk

Any enquiries relating to the application process, please contact the Biochemistry HR team; +44 1223 333617, email; personnel@bioc.cam.ac.uk

Further information on the Taipale lab can be obtained at https://www.bioc.cam.ac.uk/research/uto/taipale

Please quote reference PH18414 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 15, 2019.

The Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

We are looking for a post-doctoral researcher to join the research team of Dr. Maria Alcolea. Her team will investigate epithelial stem cell plasticity upon tissue regeneration and early cancer using oesophageal models.

In order to protect tissue integrity, epithelial cells have a significant ability to change and adapt their behaviour in response to changing tissue perturbations. Investigating the cellular and molecular mechanisms governing this dynamic cell behaviour, and the potential implications for early cancer development represents the main focus of the lab.

We will utilise a combination of in vivo lineage tracing techniques using genetic mouse models, ex vivo 3D organ cultures, and single cell transcriptional network analysis to investigate how mesenchymal activation impacts on epithelial cell behaviour during the initial stages of tumour formation.

Homepage: http://www.stemcells.cam.ac.uk/researchers/principal-investigators/maria-alcolea

Requirements:

We are looking for candidates who hold a PhD, an equivalent research doctorate, or will obtain a PhD degree within six months in the field of biochemistry /molecular and cell biology /developmental biology. Skills and experience we are looking for include:

1) Research experience since completion of PhD. 2) Background in molecular and cell biology. 3) Knowledge in genetic animal models. 4) At least one publication with first authorship would be preferable, but not a requirement. 5) Previous experience with in vivo models, gene manipulation and expression profiling, confocal imaging, single cell genomics and proteomics, disease modelling and primary tissue culture methods would be highly advantageous, but not essential.

We are specifically looking for candidates that have effective communication skills and the ability to work in a team. Proven capacity to design, execute, and interpret your own experiments is essential.

Fixed-term: The funds for this post are available for 12 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The closing date is 29 March 2019, with interviews to be confirmed.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference PS18032 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 14, 2019.

The UK Dementia Research Institute (DRI) in collaboration with the University of Cambridge has an opening for a Research Assistant/Research Associate position in Alzheimer's disease (AD) project. The appointments will be for 2 years with a possibility to extent. A successful candidate will be primarily based at the department of Physiology, Development and Neuroscience supervised by Dr Julija Krupic in collaboration with Prof Bart de Strooper at DRI, University College London. We are interested in developing new behavioural tests and state-of-the-art optical imaging recordings to study the mechanism of Tau and amyloid spread and their effect on glia, neural loss and behavioural impairments in mouse models of AD.

The ideal candidate should be passionate about neuroscience and understanding the brain during disease, have a good experience in in-vivo neural recordings in rodents (including performing surgeries and conducting experiments), experience in performing immuno-staining and good programming skills, preferably Matlab or Python. Preference will be given to candidates with a good experience in managing mice colonies, technical skills such as constructing, building and designing their behavioural setups and experience in performing lesion experiments.

Applicants should have a science degree in a relevant area, and a PhD is required for appointment at Research Associate level.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applications should include a personal statement highlighting suitability to the post, detailed CV, a list of 2-3 key publications and the names and addresses of two academic referees.

Deadline for applications is 16 April 2019.

Please quote reference PM18486 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Human Resources Co-ordinator

From Jobs at the University of Cambridge. Published on Mar 13, 2019.

Applications are invited for a Human Resources Co-ordinator to provide support and guidance to staff within the Department of Biochemistry. This is a front-line role with a balance of face-to-face support and HR administration.

The HR Co-ordinator will provide a full range of dedicated HR support services to the department. This will include providing clear and accurate advice, leading recruitment processes, co-ordinating probation and appraisal procedures, carrying out general administration using the University's HR system and performing payroll related duties. In addition the role advises the department on visa requirements and provides advice to managers and staff on employee relations matters in line with the University policies and procedures.

To perform this role effectively you will join us with experience of working administratively in an HR area and the ability to demonstrate both factual and theoretical knowledge of HR administration, including working with multiple processes and to tight regulations. You will have excellent communication, interpersonal and organizational skills and be educated to HND/HNC level or have an equivalent level of practical experience.

The role additionally requires an individual with excellent communication and organizational skills and a flexible approach to work. The ideal candidates will be self-motivated, reliable, used to dealing with highly confidential information and able to work quickly, methodically and accurately demonstrating good attention to detail. Knowledge of using HR database systems is essential and experience of working in a science or higher education environment would be a distinct advantage albeit, an ability to work independently and to take initiative is more important.

Interviews will take place on 5 April 2019.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Any enquiries can be directed to Steph Favrin - personnel@bioc.cam.ac.uk

Please quote reference PH18349 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Domestic Assistant (Part Time)

From Jobs at the University of Cambridge. Published on Mar 13, 2019.

The Department of Pathology has a vacancy for a part-time early morning or evening Domestic Assistant based at its site in central Cambridge.

Working as part of a team, the post-holder will have responsibility for cleaning, portering and general housekeeping. Duties include cleaning offices, laboratories, meeting rooms, canteen, lavatories and other communal areas. Please see the Further Information document below for more information.

We can offer part time hours up to 25 weekly Monday to Friday. Early morning 6.00am-9.00am or evening 5pm -7.00pm shifts are available

The posts are managed through the Department's Facilities Office with day-to-day supervision coordinated by the Domestic Services Supervisor. The Department of Pathology is split across two sites, and on occasions the post-holder may be required to provide cover at its site in Addenbrooke's Hospital.

Experience of cleaning and an NVQ 1 or 2 in Cleaning Methods would be helpful, although full training will be given. Good communication skills are essential, along with the ability to follow both written and verbal instructions and to understand user and safety instructions regarding the use of chemicals. Due to the nature of the work, candidates are expected to have a good level of physical fitness. A welcoming manner, reliability, professionalism and a high level of attention to detail are also required.

Previous applicants need not apply.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Any queries regarding this position should be directed to hr@path.cam.ac.uk or 01223 333940.

Please quote reference PK18466 on your application and in any correspondence about this vacancy. The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check. This appointment also requires an Honorary Clinical Contract.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Any enquiries relating to the application process please contact Jodi Smith - hr@path.cam.ac.uk

Please quote reference PK18466 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD studentship (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 11, 2019.

RNA methylation is a reversible post-translational modification to RNA that epigenetically numerous biological processes. The biological and molecular functions of RNA methylation are generally very poorly understood, both in normal and pathological biological processes.

Recently we identified the RNA Guanosine trimethylase TGS1 as a factor specifically required for the proliferation of Acute myeloid leukaemia cells (AML). Trimethylation of guanosine has been previously reported on Small nuclear non-coding RNAs and on a specific subset of mRNAs. The aim of the project will be to better understand the role of TGS1 and to characterise it as a potential therapeutic target in AML.

Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject. Additionally, the Department requires that by the time of interview all potential students must have fulfilled the language requirements for admission

Full details of the projects and how to apply are available from the following link: http://www.path.cam.ac.uk/graduate/fully-funded-studentships

The studentships are available to UK nationals and EU students who meet the UK residency requirements. Further information about your fee status can be found at the following website: http://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status . Applications from ineligible candidates will not be considered. Fixed-term: The funds for this post are available for 3 years in the first instance. The closing date for applications is 31 March 2019. Interviews will be held during the week commencing 15th April 2019

General queries regarding these positions should be directed to graduate.studies@path.cam.ac.uk or Izzy Starkey 01223 333872.

Please quote reference PK18433 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Any enquiries relating to the application process please contact Jodi Smith - hr@path.cam.ac.uk

Please quote reference PK18433 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate in Biochemistry/Cell Biology (fixed term)

From Jobs at the University of Cambridge. Published on Mar 11, 2019.

Applications are invited for a Research Associate (fixed term) to join the dynamic multi-disciplinary team of Dr Stephen Graham (http://groups.ds.cam.ac.uk/struvir/) to probe how viruses remodel the intracellular environment of human cells during infection. The successful candidate will join an established team investigating the molecular mechanisms by which viruses modify the architecture and composition of human endomembranes in order to promote virus spread and prevent the host from mounting an effective immune response.

Candidates should have a passion for science and hold a PhD or equivalent in cell biology, biochemistry, virology or a related field. A demonstrated ability to publish high-quality research and experience of protein biochemistry or cell biology techniques is essential. Prior postdoctoral experience with a track record of publication in high-impact journals and prior experience investigating herpesviruses, membrane trafficking and/or lipid biology are highly desirable. The laboratory employs a wide range of techniques, from cell biology and infection studies to biophysics and atomic-resolution structure determination, and support will be available for the successful candidate to expand their skills.

The ability to work both independently and as part of a team, coupled with excellent communication, organizational and problem solving skills are required. The duties/responsibilities of this post include developing and driving research objectives, writing up work for presentation and publication, assisting in the supervision of student research projects, and delivering seminars as outlined on the Further Information Documents. If you have an excellent background in biomedical sciences, have a track record of publishing at an internationally-competitive level, are prepared to face intellectual challenges and wish to develop your scientific skills, we want to hear from you.

The post will be held at the Division of Virology, part of the Department of Pathology within the University of Cambridge. The Division of Virology is located on the Cambridge Biomedical Campus, one of the world's most vibrant centres of biomedical research and home to multiple University of Cambridge departments, two major hospitals, the MRC Laboratory of Molecular Biology, and the world headquarters of Astra Zeneca. This project benefits from strong established collaborations across the Biomedical Campus and beyond.

The closing date for all applications is Monday 15 April 2019 and interviews will be held soon afterwards.

Fixed-term: The funds for this post are available for an immediate start and until 31 January 2021 in the first instance.

For further details or informal enquires please contact Stephen Graham via email (scg34@cam.ac.uk)

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Any enquiries relating to the application process please contact Jodi Smith - hr@path.cam.ac.uk

Please quote reference PK18430 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate in Atmospheric Physics and Meteorology

From Jobs at the University of Cambridge. Published on Mar 11, 2019.

We are seeking a modeller to build on our work in collaboration with the UK Met Office, to analyse how wind-borne, plant pests and diseases spread in natural and agricultural settings.

The post-holder will be primarily responsible for utilising the Numerical Atmospheric Modelling Environment (NAME), developed by the UK Met Office to simulate the large-scale, long distance dispersal of plant pests and pathogens. The modelling is intended to inform policy at national and international levels for developing and developed countries to aid in optimal surveillance to predict the future spread of emerging epidemics and to compare management scenarios.

The successful candidate will work with a team of modellers to optimise and expand current modelling approaches that include the provision of real-time forecasts of disease outbreaks in Ethiopia in collaboration with the UK Met Office, CIMMYT and the Ethiopian Institute of Agricultural Research. There will be opportunities to inform the implementation of national disease management, as well as for scientific publication.

Applications are invited from candidates with a PhD in atmospheric physics, applied mathematics, physics, meteorology or a related subject. Familiarity with, meteorological modelling or atmospheric dispersal models would be an advantage. Knowledge of C++ or Fortran and a generic scripting language (such as Perl, Python or R) is highly desirable.

The ideal candidate will be able to work closely with biologists to incorporate realistic biological processes into the models. Good communication skills are essential as the post holder will need to work well in a team and collaborate widely, including communicating results effectively to non-technical clients and policy agencies.

The post-holder will be based in the Epidemiology and Modelling Group at Cambridge where there is substantial expertise in mathematical modelling and parameter estimation.

Fixed-term: The funds for this post are available for 3 years in the first instance.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

CV and covering letter required. Contact Sally Hames (sah57@cam.ac.uk) if you have any queries.

Please quote reference PD18418 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant x 2 (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 11, 2019.

Two research assistant posts are available in the recently established Drosophila connectomics group headed by Greg Jefferis and Matthias Landgraf. The positions are funded by a £3.25M Wellcome Trust collaborative award to the Department of Zoology. Preferred start date from 13th May 2019 but a later date may also be possible.

The research project is in collaboration with co-applicants from HHMI Janelia Research Campus in the US (Gerry Rubin, Davi Bock), the MRC LMB in Cambridge and the University of Oxford Centre for Neural Circuits and Behaviour (Scott Waddell). The project reconstructs neurons and their connections from a recently completed electron microscopy (EM) volume of a whole adult fly brain. This will enable a comprehensive understanding of the neural circuit basis of memory storage and retrieval.

You will work in a highly collaborative team using web-based software to trace neuronal structures and connections. Sophisticated data analysis tools will be used to identify traced neurons and to analyse their organisational logic. Experienced senior staff will give full training in neuron tracing, data analysis and the required Drosophila neuroanatomy. We are looking for highly motivated individuals with a background in biological or physical/computational sciences and a long-term interest in understanding the circuit basis of brain function and behaviour. In exchange we will work to develop your research skills and scientific independence. You will be expected to contribute directly to scientific publications and to present your work at UK and international conferences. This is an opportunity to join one of the first large scale connectomics efforts that will have a major impact on circuit neuroscience.

Essential Experience/Attributes

  • Relevant BSc, or equivalent, to a good level in an appropriate subject (e.g. neuroscience, biological sciences or computer science/physical sciences).
  • Basic understanding of neuroscience
  • Strong desire to understand circuit basis of brain function and behaviour
  • Good communication skills (written and oral). · Ability to work in a team · Attention to detail

Desirable

  • Formal coursework in neuroscience
  • Prior research experience
  • Experience in analysing neural circuits
  • Experience working with electron microscopy data
  • Experience with Drosophila -Experience with computer programming / scripting / data analysis (e.g. R, Matlab, Python, unix shell)
  • Experience with Image Processing (e.g. Fiji / ImageJ)

Interview dates: Thursday the 18th April to Friday the 3rd May 2019.

Fixed-term: The appointments will be for 1 year, with possibility of extension until 30 Sep 2020.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please quote reference PF18438 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate: Drosophila Phenotype Curator (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 08, 2019.

We are seeking a biocurator to join the FlyBase group at the University of Cambridge, UK. If you are looking for a fulfilling, fly-related career away from the lab, and enjoy the challenge of organizing complex data clearly and concisely, then this is the job for you!

FlyBase curators extract biological information from scientific articles about the model organism Drosophila melanogaster, recording and organizing these data in template forms and graphical interfaces. Phenotype curators focus on data that illuminate the function of genes based on their mutant phenotypes and genetic interactions. All curated data are subsequently integrated into our central database and made freely available via the FlyBase website (http://flybase.org/).

Additional responsibilities of phenotype curators include: developing strategies/tools to improve curation; enhancing data display/querying on the website; and interacting with the research community through HelpMail and presentations/workshops at research conferences. Curators also have the opportunity to develop programming skills and contribute to FlyBase publications.

Essential skills/experience: - a first degree in a science subject - appointment at Research Associate level requires a PhD. If candidates are working towards their PhD and not yet awarded, they will be initially appointed as a Research Assistant - post-graduate research experience using Drosophila - the ability to identify and organize specified data - good communication skills, including excellent written and spoken English

Useful skills/experience include: · familiarity with databases · familiarity with ontologies · programming · annotation/curation experience

  • The post is available until 31st March 2023 in the first instance. Funding beyond that depends on a successful grant renewal.

Informal enquiries to Dr Steven Marygold (sjm41@cam.ac.uk) or Prof Nick Brown (nb117@cam.ac.uk).

Fixed-term: The funds for this post are available until 31 March 2023 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applications should include: - a covering letter explaining why you are suited to the position - your curriculum vitae

Please quote reference PM18420 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship - Mitochondrial toxicity in Drosophila models of neurodegenerative diseases

From Jobs at the University of Cambridge. Published on Mar 08, 2019.

Project Description

The MRC Toxicology Unit is a leading international research institute within the School of Biological Sciences in the University of Cambridge. The Unit is currently located in Leicester and will be relocating to Cambridge during 2020. Candidates will therefore be undertaking the first part of their PhD at the Unit's current premises in Leicester. The research environment provides state of the art research facilities, with excellent opportunities for collaborative interaction within a vibrant community at the University of Cambridge.

Dr. Miguel Martins is Head of the research group focusing on mitochondria and cell death regulation following toxic injury, with particular interest in toxicity associated with neurodegenerative disease. For further information, please go to (https://www.mrc-tox.cam.ac.uk/staff/dr-l-miguel-martins).

Dr. Martins is seeking a PhD student with a strong interest in cell biology and Drosophila as a model organism to lead a project on the impact of mitochondrial toxicity on cellular and organ dysfunction. The toxic 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aß protofibril formation. A Drosophila model of Aß toxicity has been achieved by creating transgenic flies expressing 'Arctic' mutant (Glu22Gly) Aß peptides (1-42) in neurons (Crowther et al., 2005). Human carriers of this pathogenic amyloid precursor protein mutation, located within the Aß sequence develop AD, involving rapid protofibril formation (Nilsberth et al., 2001).

Mitochondria are involved in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease, and the majority of the metabolic processes in which mitochondria are involved are known to be affected in neurodegeneration (Schon and Przedborski, 2011).

We have characterised the metabolic signature of flies expressing toxic Aß-Arc and detected significant changes in the co-enzyme nicotinamide adenine dinucleotide (NAD+), involved in mitochondrial metabolism. The objective of this project is exploring the neuroprotective potential of enhancing nucleotide metabolism in fly models of AD associated with Aß toxicity.

This studentship is for four years commencing October 2019 with an annual stipend of £15,000 (tax free).

More information about our research can be found at the lab's website:

https://www.mrc-tox.cam.ac.uk/research/l-m-martins-programme

Funding Notes

Candidates must expect to obtain qualifications at the level of a first-class or 2.1 Honours Degree in a biological science or related discipline.

Full funding is available to UK and EU applicants only.

References

The key research papers related to this project are:

  • Lehmann, S., Costa, A.C., Celardo, I., Loh, S.H., and Martins, L.M. (2016). Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease. Cell Death Dis 7, e2166.

  • Lehmann, S., Loh, S.H., and Martins, L.M. (2017a). Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease. Biol Open 6, 141-147

  • Tufi, R., Gandhi, S., de Castro, I.P., Lehmann, S., Angelova, P.R., Dinsdale, D., Deas, E., Plun-Favreau, H., Nicotera, P., Abramov, A.Y., et al. (2014). Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat Cell Biol 16, 157-166.

It is recommended that you contact the supervisor, Dr. Martins, prior to making your formal application - lm795@mrc-tox.cam.ac.uk

Applications must be submitted via the University's online Applicant Portal: https://www.graduate.study.cam.ac.uk/courses/directory/bltopdtox

Please quote reference PU18407 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 07, 2019.

Postdoctoral Research associate position available in the Okkenhaug lab at the University of Cambridge.

Topic: Role of PI3Kδ in immunity and infection

We wish to recruit an enthusiastic postdoctoral scientist to join a highly interactive team investigating the role of PI3Kδ in host resistance to infection. The project will involve both genetic and pharmacological methods designed to explore how the inhibition of PI3Kδ can suppress certain immune response yet enhance others. Determining the balance of these effects will help design strategies to use PI3Kδ inhibitors are immunomodulatory drugs. This work is of relevance both to the recent discovery of a primary immunodeficiency syndrome called Activated PI3Kδ Syndrome (APDS), but possibly also more broadly to individuals who as susceptible to viral and bacterial infections.

The position will be held a newly refurbished lab on Tennis Court Road at the Department of Pathology in Cambridge. The successful applicant will join a dynamic team of about 10 Postdocs and students. The Department is well-resourced and full access to flow cytometry, imaging, sequencing and biological services facilities will be available.

The applicant should have a PhD or equivalent in a relevant biological science. Ideally, the candidate will have experience working with mouse models of immunisation and/or infection. Experience with flow cytometry as well as cytokine and antibody detection methods will also be advantageous, training will be provided as needed.

The position is available for three years in the first instance.

Further Reading:

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

Stark AK, Chandra A, Chakraborty K, Alam R, Carbonaro V, Clark J, Sriskantharajah S, Bradley G, Richter AG, Banham-Hall E, Clatworthy MR, Nejentsev S, Hamblin JN, Hessel EM, Condliffe AM, Okkenhaug K.

Nat Commun. 2018 9(1):3174. doi: 10.1038/s41467-018-05674-8

PI3Kδ and primary immunodeficiencies

Lucas CL, Chandra A, Nejentsev S, Condliffe AM, Okkenhaug K. Nat Rev Immunol. 2016 16(11):702-714. doi: 10.1038/nri.2016.93.

Further information and free links to papers at: https://www.path.cam.ac.uk/directory/klaus-okkenhaug/

Key responsibilities Plan and execute experiments according to the aims of the project Record and analyse data Maintain accurate electronic records or research data Present data at lab meetings Organise the purchase, storage and record of reagents needed for the research Manage mouse colonies and communicate effectively with support staff at the Biological Serviced Unit

Selection criteria: Essential PhD or equivalent in a biological science Working knowledge of Immunology Experience with Flow Cytometry Ability to work with mice

Desirable Research experience evidenced by data published in a peer-reviewed journal, preferably as first-author Home office personal licence (PIL) or FELASA equivalent. Experience with mouse models of immunisation and infection Experience with ELISA and other techniques for measuring antibodies and cytokines

Fixed-term: The funds for this post are available until 31 December 2021 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Any enquiries relating to the application process please contact Jodi Smith - hr@path.cam.ac.uk

Please quote reference PK18401 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Postdoctoral Research Associate: Ancient genomics (fixed term)

From Jobs at the University of Cambridge. Published on Mar 07, 2019.

A post-doctoral Research Associate position in Department of Zoology, located in Central Cambridge, is available from 1 March 2019 for up until 31 December 2019, to work with Professor Eske Willerslev on developing new methodologies in ancient plant genomics.

The PDRA will work on developing novel method for retrieving genomic data from single fossil pollen grains in a high-throughput fashion, and apply this method to generate plant genomic datasets from Quaternary sediment records. Currently, our ability to reconstruct plant population dynamics beyond the last 150 years is limited to only a small number of species. The proposed method is expected to provide information on past population dynamics for thousands of species across the plant kingdom and open up a wide array of exciting new research possibilities in the fields of evolutionary biology, ecology and archaeology.

Duties will include adapting and optimising single-cell and ancient DNA techniques, generating ancient genomic datasets, assisting with data analysis and interpretation, and writing up the results.

Essential skills: - PhD in molecular biology, experimental genetics, ancient genomics, or a related field; - Solid skills in experimental genetic techniques; - Demonstrated experience in generating NGS data; - Demonstrated record in written and oral communication in relevant subjects; - Ambition and drive, strong work ethics, and good communication and interpersonal skills; - Enthusiasm to interact with colleagues; - Ability to organise time and work effectively, independently and responsibly in a research team setting.

Fixed-term: The funds for this post are available until 31 December 2019 in the first instance.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please quote reference PF18399 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Departmental Administrator

From Jobs at the University of Cambridge. Published on Mar 07, 2019.

The Department of Physiology, Development and Neuroscience is seeking a new Departmental Administrator. This is the most senior professional services post in the organisation and provides an exciting opportunity to work in a large, complex and welcoming Department with an exceptional record in teaching and research. As Departmental Administrator, you will directly supervise six heads of section and will have overall responsibility for all professional services staff (c.60) who deliver key services in HR, finance, research and teaching support, buildings and facilities, internal and external communications, compliance and other operational areas. You will advise the joint Heads of Department and other senior academic staff on strategy, planning and policy issues. The role requires close collaboration with other departments in the School of the Biological Sciences and with the University's central administration.

This varied and challenging role requires high-level experience of managing people and budgets as well as the ability to operate at the strategic level, to communicate effectively, to oversee complex projects and to solve problems. Candidates should be qualified to at least first degree level or equivalent.

Further information is available via the link below.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The closing date for this position is 31 March 2019 with interviews likely to be held in April 2019.

Please quote reference PM18390 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Technician (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 07, 2019.

We are looking for someone to provide technical support to Professor Magdalena Zernicka-Goetz's Research Group who are working on early development of the mammalian embryo and stem cells.

The successful applicant will be involved in molecular biology techniques, stem cell and mouse embryo culture, as well as general laboratory duties, record keeping, and making travel arrangements for the Principal Investigator. The successful applicant will also have a chance to assist with research projects. Training will be provided.

You should have four GCSEs or equivalent level qualification to include a science subject and a strong desire to get involved in scientific research.

Limit of tenure: 30 July 2020

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please refer to the Further Particulars for this role, and use this as a guideline for your application.

Please quote reference PM18391 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate x2 (Smith Lab) (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 07, 2019.

The Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

Positions are open in the laboratory of Professor Austin Smith for researchers to join investigations into the biology of pluripotency in human and other mammals. Candidates should have a publication record from their PhD research, but prior experience with pluripotent stem cells is not essential. Homepage: www.stemcells.cam.ac.uk/research/pis/smith

Two post-doctoral research positions are available, each for 2 years:

  • Post 1: Molecular biologist/biochemist with experience in cell culture and analysis of signalling pathways.
  • Post 2: Developmental biologist with expertise in mammalian embryology including pre-implantation embryo isolation and manipulation. Our lab is international in character and this project is collaborative with groups in China and Japan.

Candidates must have good communication skills and the ability to work in a team. Proven capacity to design, execute, and interpret your own experiments is essential.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The closing date is 8 April 2019, with interviews to be confirmed.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference PS18395 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Veterinary Radiographer

From Jobs at the University of Cambridge. Published on Mar 05, 2019.

UNIVERSITY OF CAMBRIDGE DEPARTMENT OF VETERINARY MEDICINE WEST CAMBRDIGE SITE

Queen's Veterinary School Hospital

Are you a qualified Radiographer looking to specialise in veterinary imaging?

Are you a Veterinary Radiographer looking for an exciting change?

Are you a Veterinary Nurse looking for a new challenge?

If you have answered yes to any of the above we want to hear from you!!!

We have an exciting opportunity for a qualified Radiographer to join a team of radiographers in this busy Veterinary Teaching Hospital. Applicants should be qualified Diagnostic Radiographers holding either a BSc (Hons) Diagnostic Radiography or other relevant degree/qualification or qualified Veterinary Nurses. We would also welcome applications from students who will qualify in the near future.

The role holder will be responsible for producing high quality clinical diagnostic images of small and large animals. This would include a range of modalities such as CT, MRI and Fluoroscopy. This is an excellent opportunity to learn new skills to complement your existing knowledge and experience.

Experience of working in the veterinary profession would be advantageous, but is not essential as full training will be given. There is no out of hour's responsibility attached to this role.

In return we can offer a supportive and engaging environment, generous paid annual leave plus public holidays, CPD is encouraged and has an allowance to support this, along with competitive staff benefits and services.

Candidates who apply for the position are strongly encouraged to spend half a day in the Department to get a good understanding of the role, the Hospital and to meet the Radiography team prior to the interview. To arrange a visit please contact Vicky Hawkins - Head Radiographer email: vo227@cam.ac.uk.

If you have any questions about this role please contact Natalie Wills on nw366@cam.ac.uk

Closing Date: 14 April 2019

Interviews will be held: 1 May 2019

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

To submit an application for this vacancy, please click on the link 'Apply online' or visit the vacancy pages on the following website: www.jobs.cam.ac.uk This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) before completing the online application form. Further particulars for the role and information about the Department www.vet.cam.ac.uk.

Please quote reference PP18359 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 04, 2019.

Cell Fate and Cancer Biology

Applications are invited for a position in the Epithelial Tumour Biology group at the University of Cambridge which focuses on studying and identifying the earliest cellular changes leading to breast and lung cancer (Khaled W.T. 2015 Nat Commun, Bach K. et al. Nat Commun 2017 & Lazarus K. et al. Nat Commun 2018). In this project the successful candidate will utilise various mouse models and genomics to investigate the role of BCL11A in cell fate regulation and pre-cancer.

Applicants should have a strong interest in developmental biology, cancer biology and are expected to hold or obtain shortly, a PhD in the life sciences. They must have demonstrable experience in one or more of the following areas: - Studying genetically engineered mouse models (ideally breast or lung cancer models) - Tumour immunology - CHIPseq, ATACseq or RNAseq - Cell biology The successful applicant will be a careful and methodical worker, accurate and ready to take responsibility as part of a team. They will be self-motivated and able to organise, perform and analyse experiments with minimal instruction. Ideally, they will have relevant laboratory experience and be able to work efficiently and productively without direct supervision. Careful observation and accurate computer-based record-keeping and presentation are essential. Successful candidates who have not been awarded their PhD by the appointment date will be appointed as a Research Assistants at Grade 5 (£26,243-£30,395). Upon the award of the PhD the individual will be promoted to Research Associate, Grade 7 (£32,236-£39,609).

The closing date is 26th April 2019. Interviews will be carried out as applications are received.

Informal enquiries should be made to Dr. Walid Khaled (wtk22@cam.ac.uk).

The position is available for 2 years (subject to a probation period) in the first instance and is available from 1st May 2019 or soon thereafter.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Applications from agencies will not be considered. For the online application, you will need to provide your personal details, names and e-mail addresses of two referees familiar with your recent research, CV, publications and a cover letter (including a description of your experience as it relates to the job specifications). For enquiries about the online application process please contact Ms Saez (pharsect@hermes.cam.ac.uk).

Please quote reference PL18345 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 04, 2019.

Bioinformatics Single Cell Genomics

Applications are invited for a position in the Epithelial Tumour Biology group at the University of Cambridge which focuses on studying and identifying the earliest cellular changes leading to breast and lung cancer (Khaled W.T. 2015 Nat Commun, Bach K. et al. Nat Commun 2017 & Lazarus K. et al. Nat Commun 2018). In this project we will be working in collaboration with Dr. John Marioni (EBI, CRUK, CI) to build a comprehensive breast cell atlas. We will be using scRNAseq, scATACseq and CRISPR-scaring to chart the cellular changes in the breast under different healthy conditions. These tools will allow us to understand the impact of age and parity, known breast cancer risk factors, on cell fate and tissue homeostasis.

Applicants should have a strong interest in developmental biology, cancer biology and are expected to hold or obtain shortly, a PhD in the life sciences. They must have demonstrable experience in one or more of the following areas: - Analysing NGS data (using Unix, R, Python) - Studying genetically engineered mouse models (ideally breast or lung cancer models) - Tumour immunology - Cell biology The successful applicant will be a careful and methodical worker, accurate and ready to take responsibility as part of a team. They will be self-motivated and able to organise, perform and analyse experiments with minimal instruction. Ideally, they will have relevant laboratory experience and be able to work efficiently and productively without direct supervision. Careful observation and accurate computer-based record-keeping and presentation are essential. Successful candidates who have not been awarded their PhD by the appointment date will be appointed as a Research Assistant at Grade 5 (£26,243-£30,395). Upon the award of the PhD the individual will be promoted to Research Associate, Grade 7 (£32,236-£39,609). The closing date is 26th April 2019. Interviews will be carried out as applications are received.

Informal enquiries should be made to Dr. Walid T. Khaled (wtk22@cam.ac.uk).

The position is available for 3 years (subject to a probation period) in the first instance and is available from 1st May 2019 or soon thereafter.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Applications from agencies will not be considered.

For the online application, you will need to provide your personal details, names and e-mail addresses of two referees familiar with your recent research, CV, publications and a cover letter (including a description of your experience as it relates to the job specifications). For enquiries about the online application process please contact Ms. Saez (pharsect@hermes.cam.ac.uk).

Please quote reference PL18346 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate - Centrioles & Centrosomes (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 01, 2019.

A postdoctoral research position is available for 12 months to work with Professor David Glover in the Department of Genetics, funded by CRUK to study the physical organisation of centrioles and centrosomes.

The applicant should hold a PhD in one of the biological sciences, and be familiar with Drosophila as an experimental system for studying cell and developmental biology. They should have experience of recombinant DNA techniques and molecular cell biology; have specific experience with sub-cellular fractionation procedures, (especially in the use of gradient centrifugation techniques to purify centrosomes from Drosophila embryos); in vitro systems to study the nucleation of microtubules; and with approaches to study the roles of protein kinases and phosphatases in such systems.

Fixed-term: The funds for this post are available for 12 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Please quote reference PC18337 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Junior Clinical Training Scholarship Farm Animal Health and Production

From Jobs at the University of Cambridge. Published on Mar 01, 2019.

Scholarship award: £15,000 (Tax Free)

Start date 1 August 2019

Applications are invited for this 12-month Scholarship programme, which provides an opportunity for new graduates or recently qualified veterinarians to receive high-quality postgraduate training in farm animal studies under the supervision of experienced farm animal clinicians in the Cambridge Farm Animal Veterinary Services ambulatory and referral practice at the University of Cambridge. The emphasis of the programme is on gaining practical clinical experience in farm animal medicine and herd health, and will allow the Scholar to identify specific fields of farm animal work in which to specialise, either in preparation for Senior Clinical Training Scholarship programmes, or for specialist private practice.

The internship will cover:

  • Case management of individual production animals, including emergency and critical care, surgery, anaesthesia, diagnostics, internal medicine and obstetrics

  • Involvement in a busy and expanding first opinion farm animal practice

  • Training and practice in population medicine and herd health management, with an emphasis on evidence-based medicine

  • Experience in teaching and communication

  • Basic tuition in research methods and scientific writing

  • Opportunity to design and undertake research projects

An applicant must be a Member of the Royal College of Veterinary Surgeons, or hold a veterinary degree qualifying them for membership.

Informal enquiries about scholarship programme: contact Natalie Wills on nw366@cam.ac.uk

Closing date: 31 March 2019

Interview date: 16 April 2019

An application form (JCTS1) and information pack can be downloaded from the link below or via the following website: http://www.vet.cam.ac.uk/

Completed application form, curriculum vitae, covering letter: send to Melissa Large, Department of Veterinary Medicine, Madingley Road, Cambridge, CB3 OES, or via email to vetmed@hermes.cam.ac.uk

Please quote reference PP18328 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate x 2 (Fixed Term): Collation of scientific evidence for the effective management of biodiversity

From Jobs at the University of Cambridge. Published on Feb 28, 2019.

We are looking for two postdoctoral researchers to work with Prof. William Sutherland and Dr Rebecca Smith on the Conservation Evidence project in the Conservation Science Group. Work will involve producing comprehensive reviews of scientific evidence on the effectiveness of interventions for the conservation of biodiversity. Reviews will be conducted using methods developed by the Conservation Evidence group at Cambridge (www.conservationevidence.com).

You must have excellent writing skills and a strong interest in biodiversity. The successful candidate will work closely with the Conservation Evidence team in Cambridge, and with external synopsis authors and advisory boards. The project is funded by Arcadia.

Essential required skills

  • A PhD, or equivalent experience, in an area related to biodiversity;

  • Ability to efficiently understand and extract relevant information from scientific papers;

  • Ability to write clear, concise summaries of scientific papers, quickly and accurately , using a standardized style;

  • Detailed knowledge of biodiversity and knowledge of ecosystem services;

  • Good general understanding of ecological statistics and experimental design;

  • Fluent at writing in English;

  • Demonstrable ability to complete projects to the stage of good quality reports/publications on time;

  • Ability to travel to meetings in the UK;

Duties and responsibilities

  • Planning development of Conservation Evidence synopses, including forming international advisory boards, developing agreed lists of interventions and agreeing literature search methods;

  • Compiling databases of relevant references;

  • Summarising key results in plain English and producing synopses using standardized methods and formats developed by Conservation Evidence (http://conservationevidence.com/site/page?view=methods);

  • Completing the online synopses.

Interview dates: Wednesday 17th and Thursday 18th April 2019

Fixed-term: The funds for this post are available for up to 15 months.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PF18317 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

EU Marie-Curie PhD Studentship (Fixed Term)

From Jobs at the University of Cambridge. Published on Feb 27, 2019.

PhD Studentship in Directed Protein Evolution

Mechanism-based Ultrahigh Throughput Enzyme Evolution in Droplets

A graduate studentship leading to the award of a PhD is available from 1 March 2019 to work at Cambridge University in the Biochemistry Department, Central Cambridge, with Dr. F. Hollfelder (http://www.bioc.cam.ac.uk/hollfelder). The studentship is in the context of the EU Marie-Curie network EvoDrops) on Directed Protein Evolution for Synthetic Biology and Biocatalysis.

Efficient exploration of sequence space requires new technologies that connect genotype and phenotype. Using droplet compartmentalization we have developed systems in which evolution of binders or catalysts is possible completely in vitro. These powerful technologies will be further developed, to select functional proteins from large libraries, so that they have programmed binding and recognition properties. We hope to develop strategies for evolution that are inspired by insight into enzyme mechanism that will enhance our understanding of how enzyme accelerate reactions.

Candidates will be mainly based in the Biochemistry Department in central Cambridge, but also work for extended secondments in the labs of the academic and industrial network partners in Glasgow, Zürich, Paris, Bordeaux, Vilnius and Warsaw. All students take part in a training programme that includes workshops, meetings and courses given by all network partners.

Applicants should have a first (or upper second) class degree in biochemistry, biotechnology, chemistry or a related, relevant subject. Specific skills in protein engineering, directed evolution, chemical and kinetic analysis of enzyme mechanisms, organic synthesis and familiarity with molecular biology techniques (e.g. phage or ribosome display, cloning, DNA manipulation, preparation and handling of DNA libraries) are advantages.

The full stipend will be paid at rates of the EU Marie-Curie programme for the 3 year duration of the award.

Fixed-term: The funds for this post are available for 36 months in the first instance.

Applications should contain a description of your research interests (e.g. as part of the cover letter) and your detailed CV (with exam marks and all relevant practical experience). Please also include the names and email addresses of at least two referees, who know you from your courses or laboratory research work. Send your application by email to studentships@bioc.cam.ac.uk.

Enquiries about the application process can be sent to the departmental HR team at personnel@bioc.cam.ac.uk.

Please quote reference PH17443 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate

From Jobs at the University of Cambridge. Published on Feb 25, 2019.

We are looking to recruit a motivated postdoctoral researcher to work on the biochemical characterisation of a highly conserved non-canonical KRAB Zinc Finger Protein (KZFP) regulating mammalian epigenetic states within the research group of Anne Ferguson-Smith in the Department of Genetics.

The project involves the identification of protein partners and the role of protein subdomains in the targeted regulation of chromatin states by KZFPs. Mouse mutants and mutant ES cell models have been generated to underpin this project which will integrate in vivo functional analyses with proteomics and protein biochemistry.

Candidates should hold a PhD in biochemistry or molecular biology and should have experience in proteomics and bioinformatics, as well as mammalian cell culture.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Enquiries should be addressed to Professor Anne Ferguson-Smith (afsmith@gen.cam.ac.uk)

Please quote reference PC18270 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Feb 22, 2019.

We wish to recruit a highly driven, enthusiastic postdoctoral research scientist to join the Edgar lab to investigate the role exosomes play in MHC-II presentation. The project will combine functional immunological assays, biochemistry and molecular biology to determine what role exosomes play in MHC-II presentation, and define which molecules are found on exosomes from antigen presenting cells. The labs focuses on the physiological and pathological roles of surface-tethered exosomes, following our recent findings that exosomes may be proteinaceously tethered to the cell surface in addition to being released into the extracellular milieu.

Further reading; Tetherin is an exosomal tether. Edgar JR, Manna PT, Nishimura S, Banting G, Robinson MS. Elife. 2016 Sep 22;5. pii: e17180. doi: 10.7554/eLife.17180.

The position is funded by the Isaac Newton Trust / Wellcome Trust ISSF / University of Cambridge Joint Research Grants Scheme. This post is for 18 months, starting from 1st May 2019 in the first instance. The position will be held at a newly refurbished laboratory on Tennis Court Road at the Department of Pathology in the centre of Cambridge. The Department is well-resourced and full access to flow cytometry, imaging (fluorescence and electron microscopy) and biological services facilities are available. https://www.path.cam.ac.uk/directory/james-edgar

The applicant should have a PhD or equivalent in a relevant biological science.

The applicant should have the following skills:

Essential Proven track record in immunology and/or cell biology. Proven ability to deliver research at an internationally competitive level.

Desirable Candidates would have experience working with mouse models of antigen presentation, flow cytometry and biochemistry.

Key responsibilities Plan and execute experiments according to the aims of the project. Will include; record and analyse data, maintain accurate electronic records or research data, present data at lab meetings, organise the purchase, storage and record of reagents needed for the research. The successful candidate will also be expected to help supervise PhD and rotation students.

Start date: 1st May 2019

Fixed-term: The funds for this post are available for 18 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Any enquiries relating to the application process please contact Jodi Smith - hr@path.cam.ac.uk

Please quote reference PK18229 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

University Lecturer

From Jobs at the University of Cambridge. Published on Feb 21, 2019.

Tenure-track University Lectureship in Neuroscience

Applications are invited for a research-oriented, tenure-track University Lectureship in Neuroscience, available from 1 October 2019. Based in central Cambridge, we are keen to recruit a pioneering researcher working in this major theme in our Department (http://www.pdn.cam.ac.uk/research/). We are therefore searching for an outstanding scientist, with an excellent publication record, undertaking cutting edge and fundable work in any aspect of Neuroscience.

The successful applicant will have a PhD in a relevant subject area, will have an aptitude and enthusiasm for teaching, and be willing to contribute effectively to our undergraduate programmes in preclinical medicine, preclinical veterinary science, and natural sciences (http://www.pdn.cam.ac.uk/teaching). He/she will be expected to contribute to the design and delivery of undergraduate and graduate lecture courses and to perform other academic duties including administration, examining and assessment.

We particularly welcome applications from women and black and minority ethnic candidates. Appointment will be based on merit alone. The Department strongly supports DORA (https://sfdora.org/) and will assess research on its own merits rather than on the basis of the journal in which it is published. Informal enquiries may be made to the joint Heads of Department, Professors Sarah Bray and Bill Colledge (pdnhod@hermes.cam.ac.uk; +44 (0) 1223 333772).

The appointment will be made at University Lecturer level with a probationary period of five years, with appointment to the retirement age thereafter subject to satisfactory progress. The pensionable salary scale starts at £39,992 to £50,618 per annum. Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment, with a satisfactory outcome determined by the University.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please ensure that, in the Upload section of the online application, you upload your Curriculum Vitae (CV), a research publication list which highlights your three most important published outputs, an outline of your current and future research plans (no more than two pages) and a covering letter that includes an indication of the fit within the research profile of the Department and how you might contribute to our teaching.

If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Deadline for applications is Sunday 31 March 2019.

Please quote reference PM18244 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Teaching Associate (Part Time, Fixed Term)

From Jobs at the University of Cambridge. Published on Feb 20, 2019.

We are seeking a Teaching Associate to join Professor Nicola Clayton's Comparative Cognition Lab (see: http://www.psychol.cam.ac.uk/people/nicola-clayton) in the Department of Psychology. The roleholder will join a project investigating causal reasoning in corvids and humans, funded by the European Research Council (ERC).

The person appointed will contribute to supporting and maintaining the University's national and international reputation for excellence in teaching. Alongside Professor Clayton, as the PI, they will also lead in lab management responsibilities, and in the administration of the ERC grant.

The teaching will involve planning, preparing and delivering lectures and practical classes, as well as providing guidance to students and marking exam papers. The lab management role will involve liaising with other members of the lab and technicians, and reporting to the Principal Investigator. It will also involve training and supervising graduate and undergraduate students and internship visitors involved in any related research projects, and working closely with other members of the ERC team (Postdocs and Research Assistant).

Consequently, it is essential that the post-holder has a PhD in Experimental Psychology or related discipline, and experience of teaching at university level. It is also essential that the post holder is self-motivated and able to work independently, as well as part of a team. They must have excellent organisational, leadership and communication skills.

This is a part-time position, 50% fte/ 18.5 hours per week. Some flexibility is required due to the variable nature of teaching hours and lab manager duties, including the potential of some weekend work.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries about the position can be made to Professor N S Clayton(nsc22@cam.ac.uk)

Please note the closing date for applications is 24 March 2019. Applications received after this time will not be considered.

Please quote reference PJ18222 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate: Image Processing (Fixed Term)

From Jobs at the University of Cambridge. Published on Feb 19, 2019.

Applications are invited for a two year Research Associate position to work on a project on light sheet microscopy image analysis.

The project is entitled "Scalable image enhancement for light-sheet microscopy: space varying deconvolution and image fusion". The project is funded by the Isaac Newton Trust/Wellcome Trust/University of Cambridge Joint Research Grant awarded to Dr Leila Muresan, an RSE EPSRC fellow hosted by the Cambridge Advanced Imaging Centre. Key collaborators include Cambridge Image Analysis - DAMTP, MRC-LMB and Sainsbury Laboratories Cambridge University (SLCU).

With the advent of light sheet microscopy, imaging of large volumes (e.g. entire embryos) over several days became a reality. However the analysis of acquired datasets (on the order of terabytes) remains a challenge. The goal of the project is to develop the computational tools that will allow to unlock the potential of this technique. The image quality will be enhanced via space varying deconvolution and information fusion. The downstream analysis of the datasets will be explored. The developed algorithms will be tested and refined based on the data acquired by several light-sheet systems in CAIC, LMB and SLCU.

The successful candidate should have, or be about to receive, a PhD in computer science, applied mathematics or a related area. Experience in image processing in an interdisciplinary research environment is required. Experience in optimisation, inverse problems, data science, microscopy and high performance computing would be advantageous.

Given the interdisciplinary nature of the project, you will communicate and liaise with biologists, mathematicians, engineers and physicists forming collaborative relationships.

Fixed-term: The funds for this post are available for 2 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquires regarding the position should be made to Dr Leila Muresan email: lam94@cam.ac.uk

Please quote reference PM18217 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Programme Leader Track: Epigenetics

From Jobs at the University of Cambridge. Published on Feb 18, 2019.

The MRC Toxicology Unit in the University of Cambridge is seeking to appoint a Programme Leader Track at the grade of Senior Research Associate within the area of epigenetics. The successful candidate will lead a small research team and be free to pursue their own research agenda within the theme of gene-environment interactions following toxic exposure.

We are particularly interested in those with a strong research record in this area for example, research directed towards determining how the DNA or RNA epigenome changes following exposure to pharmaceuticals/environmental agents. Proposed future studies should be directed at obtaining mechanistic information about the mode of action and physiological consequence of these epigenetic changes.

The appointment will be made at Programme Leader Track/Senior Research Associate level and will provide you with the opportunity to develop a full range of skills necessary to progress your research programme. It is expected that within 5-6 years you will prove yourself fully able to be an internationally competitive group leader and equally merit promotion to Programme Leader/Principle Research Associate within the same time frame. Duties will include developing research objectives, projects and proposals for the delivery of your own research programme; leading a small team of researchers and PhD students; managing research budgets and resources; developing collaborations; identifying and securing funding; disseminating research findings in peer-reviewed literature and at international conferences.

The successful candidate will have made significant contributions to the subject area with important research papers in high quality journals; a PhD in a related discipline; relevant postdoctoral experience including leading others and outstanding potential for independent research. A background in toxicology is desirable but not essential.

The MRC Toxicology Unit is a leading international research institute within the School of Biological Sciences. The Unit delivers high impact mechanistic toxicology research, pursuing hypothesis-driven toxicological questions with a particular focus on the study of the causal links between exposure to endogenous and exogenous toxicants, molecular initiating events and adverse outcome pathways. The Unit's overall aims are to carry out pioneering research which leads to improved health and to train and mentor the next generation of toxicologists.

The research environment provides state-of-the-art research facilities including microscopy, Cryo-EM, flow cytometry; proteomics; bioinformatics and imaging. In addition, excellent opportunities exist for collaborative interactions within a vibrant community at the University of Cambridge.

To apply for this position please provide your CV and a research proposal (using the guidance document provided below) outlining the research questions you would like to address and why these are important to the study and advancement of toxicology, including the approaches you will take and resources required.

Interviews are expected to take place on 30th May 2019. The selection process will include a research presentation and panel interview.

We offer a generous support package, including intramural MRC funding, core-funded posts and PhD studentships.

This is an open-ended position funded by the Medical Research Council.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries are welcomed and should be directed to: Professor Anne Willis aew80@cam.ac.uk

If you have any queries regarding the application process please contact Rebecca Heatherley rsh49@mrc-tox.cam.ac.uk

Please quote reference PU18201 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate: Computational Science (Fixed Term)

From Jobs at the University of Cambridge. Published on Feb 07, 2019.

The newly established Boroviak lab is looking to recruit a highly enthusiastic individual to carry out ground-breaking research on primate embryogenesis. Recent advances in the field have shown that early human and non-human primate development substantially differs from the rodent paradigm. This divergence has dramatic implications for our understanding of germ cell specification, placental development and pluripotency in the embryo and embryonic stem cells.

Working closely with our international collaborators, your principal research focus will be on embryonic lineage segregation in the implanting primate embryo using the very latest single-cell RNA-seq methods for combined transcriptome and methylome analysis.

Our approach entails the generation of a TRANSCRIPTIONAL and EPIGENETIC BLUEPRINT of primate development, from the fertilised egg up until gastrulation.

Based on these insights, we will generate synthetic embryos and develop an in vitro model of primate implantation. You will be responsible for integrating multi-omics single-cell data, statistical analysis, innovative data visualisation and cross-species comparisons. A particular focus will be on signalling pathway analysis and target prediction for functional validation in close collaboration with wet-lab colleagues.

The successful applicant will be based within a vibrant working environment at the interface of computational science, embryology and molecular biology. We are looking for a team player with excellent communication skills and you will liaise with colleagues and fellow computational scientists.

You should have a PhD (or about to complete a PhD) or equivalent experience in bioinformatics, mathematics, statistical analysis or genomics. The ideal candidate will have experience in a scientific programming language e.g. R, Python, C or Java; bioinformatics, mathematics, statistical analysis or genomics. Previous exposure to single-cell transcriptomics is a plus. Most importantly, you will have a can-do attitude with a genuine drive to push boundaries.

Fixed-term: The funds for this post are available for 3 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be directed to Dr Thorsten Boroviak (teb45@cam.ac.uk).

https://boroviaklab.pdn.cam.ac.uk/

https://www.pdn.cam.ac.uk/directory/thorsten-boroviak

Please quote reference PM18061 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.