1. Knowles, J.R., Leadlay, P.F. and Maister, S.G. (1971). Triosephosphate isomerase: isotope studies on the mechanistic pathway. Cold Spring Harbor Symp. Quant. Biol., 36, 157-163.
  2. Leadlay, P.F., Albery, W.J. and Knowles, J.R. (1976). Energetics of triosephosphate isomerase: isotope effects in the enzyme-catalysed reaction. Biochemistry, 15, 5617-5620.
  3. Leadlay, P.F., Breathnach, R., Gatehouse, J.A. , Johnson, P. and Knowles, J.R. (1977). Phosphoglycerate mutase from wheat germ: isolation, crystallisation and properties. Biochemistry, 16, 3050-3053.
  4. Leadlay, P.F. (1979). Enzyme Chemistry (a volume in the Chemical Society series of Monographs for Teachers). The Chemical Society, London.
  5. Leadlay, P.F. (1979). (S,S)-diaminopimelate is not an obligatory intermediate in the biosynthesis of lysine in Corynebacterium glutamicum. FEBS Lett., 98, 399-402.
  6. Leadlay, P.F. (1979). Enzyme Chemistry, in Ann. Reports B of the Chemical Society, 472-485.
  7. Armstrong, J., Leadlay, P.F. and Perham, R.N. (1980). Synthesis of methyl [3H]-acetimidate of high specific radioactivity- a protein-labelling reagent. Anal. Biochem., 109, 410-415.
  8. Lambiris, S. and Leadlay, P.F. (1981). Modification of enoyl-CoA hydratase with diethylpyrocarbonate. Biochim. Biophys. Acta, 660, 271-277.
  9. Leadlay, P.F. (1981). Purification and properties of methylmalonyl-CoA epimerase from Propionibacterium shermanii. Biochem. J., 197, 413-419.
  10. Leadlay, P.F. and Greer, S. (1982). Synthesis of chiral acetic acids by a simple enzymatic procedure. Anal. Biochem., 127, 89-92.
  11. Roberts, G. and Leadlay, P.F. (1983). [3H]-tetrahydrocerulenin, a specific reagent for radio-labelling fatty acid synthases and related enzymes. FEBS Lett., 159, 13-16.
  12. Leadlay, P.F. and Fuller, J.Q. (1983). Proton transfer in methylmalonyl-CoA epimerase: studies using specifically-tritiated (2R)-methylmalonyl-CoA as substrate. Biochem. J., 213, 635-642.
  13. Fuller, J.Q. and Leadlay, P.F. (1983). Proton transfer in methylmalonyl-CoA epimerase: the reaction of (2R)-methylmalonyl-CoA in tritiated water. Biochem. J., 213, 643-650.
  14. Roberts, G. and Leadlay, P.F. (1984). The use of [3H]-tetrahydrocerulenin to assay condensing enzyme activity in Streptomyces erythreus. Biochem. Soc. Trans., 11, 642-643.
  15. Leadlay, P.F., Roberts, G, and Walker, J.E. (1984). Isolation of a novel calcium-binding protein from Streptomyces erythreus. FEBS Lett., 178, 157-160.
  16. Hale, R.S. and Leadlay, P.F. (1985). The cloning of structural genes for bacterial acyl carrier proteins. Biochimie, 67, 835-839.
  17. Hoving, H., Chrysell, B. and Leadlay, P.F. (1985). Fluorine NMR studies on stereochemical aspects of the reactions catalysed by transcarboxylase, pyruvate kinase and enzyme I. Biochemistry, 24, 6163-6169.
  18. Francalanci, F., Fuller, J.Q., Davis, N.K., Murfitt, D.M. and Leadlay, P.F. (1986). The subunit structure of methylmalonyl CoA mutase from Propionibacterium shermanii. Biochem. J., 236, 489-494.
  19. Hale, R.S., Jordan, K. and Leadlay, P.F. (1987). A small, discrete acyl carrier protein is involved in de novo fatty acid synthesis in Streptomyces erythreus (Saccharopolyspora erythraea). FEBS Lett., 224, 133-136.
  20. Williams, K., Lowe, P.N. and Leadlay, P.F. (1987). Purification and characterization of pyruvate:ferredoxin oxidoreductase from the anaerobic protozoon Trichomonas vaginalis. Biochem. J., 246, 529-536.
  21. Swan, D.G., Hale, R.S., Dhillon, N. and Leadlay, P.F. (1987). A bacterial calcium-binding protein homologous to calmodulin. Nature, 329, 84-85.
  22. Marsh, E.N., Leadlay, P.F. and Evans, P.R. (1988). Crystallisation and preliminary diffraction data for adenosylcobalamin-dependent methylmalonyl CoA mutase from Propionibacterium shermanii. J. Mol. Biol., 200, 421-422.
  23. Marsh, E.N. and Leadlay, P.F. (1989). Methylmalonyl CoA mutase from Propionibacterium shermanii: evidence for the presence of two masked thiols. Biochem. J., 260, 339-343.
  24. Marsh, E.N., McKie, N., Davis, N.K. and Leadlay, P.F. (1989). Cloning and structural characterisation of the genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase from Propionibacterium shermanii. Biochem. J., 260, 345-352.
  25. Marsh, E.N., Harding, S.E. and Leadlay, P.F. (1989). Subunit interactions in methylmalonyl CoA mutase studied by analytical ultracentrifugation. Biochem. J., 260, 353-358.
  26. Dhillon, N., Hale, R.S., Cortés, J. and Leadlay, P.F. (1989). Cloning, nucleotide sequence, and the effects of disruption of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis. Molec. Microbiol., 3, 1405-1414.
  27. Swan, D.G., Hale, R.S., Cortés,J. and Leadlay, P.F. (1989). Expression of an EF hand calcium-binding protein from Saccharopolyspora erythraea in Streptomyces lividans and Escherichia coli. J. Bacteriol., 171, 5614-5619. 
  28. Caffrey, P., Green, B., Packman, L.C., Rawlings, B.J., Staunton, J. and Leadlay, P.F. (1990). An acyl carrier protein-thioesterase domain of the 6-deoxyerythronolide B synthase of Saccharopolyspora erythraea: expression in Escherichia coli, purification and characterisation. Eur. J. Biochem., 195, 823-830.
  29. Dhillon, N. and Leadlay, P.F. (1990). A repeated decapeptide motif in the C-terminal domain of the ribosomal RNA methylase of the erythromycin producer Saccharopolyspora erythraea. FEBS Lett., 262, 189-193.
  30. Cortés, J., Haydock, S.F., Roberts, G.A., Bevitt, D.J. and Leadlay, P.F. (1990). An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea. Nature, 348, 176-178.
  31. Leadlay, P.F. (1990). Structural studies on adenosylcobalamin-dependent methylmalonyl CoA mutase. In Cobalamin 88 (Bhatt, R. and Linnell, J.C., eds.). 321-328.
  32. Leadlay, P.F. and Ledley, F.D. (1990). Sequence homologies between the structural genes for human and bacterial methylmalonyl CoA mutases. In Cobalamin 88 (Bhatt, R. and Linnell, J.C., eds.). 341-352.
  33. Williams, K.P., Leadlay, P.F. and Lowe, P.N. (1990). Inhibition of pyruvate:ferredoxin oxidoreductase from Trichomonas vaginalis by pyruvate and its analogues; comparison with the pyruvate decarboxylase component of the pyruvate dehydrogenase complex. Biochem. J., 268, 69-75.
  34. McKie, N., Patchett, M.L., Keep. N.H. and Leadlay, P.F. (1990). Adenosylcobalamin-dependent methylmalonyl CoA mutase from Propionibacterium shermanii: active holoenzyme produced from Escherichia coli. Biochem. J., 269, 293-298.
  35. Bridges, A.M., Leadlay, P.F., Revill, W.P. and Staunton, J. (1991). Use of electrospray mass spectrometry to assay chemical reactivity of an acyl carrier protein involved in fatty acid biosynthesis in Saccharopolyspora erythraea. J. Chem. Soc., Chem. Commun., 11, 776.
  36. Bridges, A.M., Leadlay, P.F., Revill, W.P. and Staunton. J. (1991). Use of electrospray mass spectrometry in enzymic studies on the acyl carrier protein implicated in fatty acid biosynthesis in Saccharopolyspora erythraea. J. Chem. Soc., Chem. Commun., 11, 778.
  37. Revill, W.P. and Leadlay, P.F. (1991). Cloning, characterization and high-level expression in Escherichia coli of the Saccharopolyspora erythraea gene encoding an acyl carrier protein potentially involved in fatty acid biosynthesis. J. Bacteriol., 173, 4379-4385.
  38. Revill, P., Hale, R.S., Cortés, J. and Leadlay, P.F. (1991). The cloning, nucleotide sequence, and expression in Escherichia coli of an acyl carrier protein gene from the fatty acid synthase gene cluster of Saccharopolyspora erythraea (Streptomyces erythraeus). J. Bacteriol., 173, 4379-4385.
  39. Caffrey, P., Bevitt, D., Staunton, J. and Leadlay, P.F. (1992). Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea. Federation of European Biochemical Societies, 304, 225.
  40. Hellyer, A., Leadlay, P.F. and Slabas, A.R. (1992). Induction, purification and isolation of acyl-ACP thioesterase from developing seeds of oil seed rape (Brassica napus). Plant Mol. Biol., 20, 763-780.
  41. Roy, I. and Leadlay, P.F. (1992). Physical map location of the new Escherichia coli gene sbm. J. Bacteriol., 174, 5763-5764.
  42. Bevitt, D.J., Staunton, J. and Leadlay, P.F. (1993). Mutagenesis of the dehydratase active site in the erythromycin-producing polyketide synthase. Biochem. Soc. Trans., 21, 30S.
  43. Cooper, H.N., Cortés, J., Bevitt, D.J., Leadlay, P.F.and Staunton, J. (1993). Analysis of a gene cluster from Streptomyces longisporoflavus potentially involved in tetronasin biosynthesis. Biochem. Soc. Trans., 21, 31S.
  44. Keep, N.H., Smith, G.A., Evans, M.C., Diahun, G.P. and Leadlay, P.F. (1993). The synthetic substrate succinyl(carbadethia)-CoA generates cob(II)alamin on adenosylcobalamin-dependent methylmalonyl-CoA mutase. Biochem. J., 295, 387-392.
  45. Leadlay, P.F., Staunton, J., Aparicio, J.F., Bevitt, D.J., Caffrey, P., Cortés, J., Marsden, A. and Roberts, G.A. (1993). The erythromycin-producing polyketide synthase. Biochemical Society Transactions, 21, 218.
  46. Morris, S.A., Revill, W.P., Staunton, J. and Leadlay, P.F. (1993). Purification and separation of holo-forms and apro-forms of Saccharopolyspora erythraea acyl-carrier protein released from recombinant Escherichia coli by freezing and thawing. Biochem. J., 294, 521.
  47. Roberts, G.A., Staunton, J. and Leadlay, P.F. (1993). 6-deoxyerythronolide B synthase 3 from Saccharopolyspora erythraea: over-expression in Escherichia coli, purification and characterisation. Biochem. Soc. Trans., 21, 32S.
  48. Roberts, G.A., Staunton, J. and Leadlay, P.F. (1993). Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase. European Journal of Biochemistry, 214, 305.
  49. Aparicio, J.F., Caffrey, P., Marsden, A.F.A., Staunton, J. and Leadlay, P.F. (1994). Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase. Journal of Biological Chemistry, 269, 8524.
  50. Dutton, C.J., Hooper, A.M., Leadlay, P.F. and Staunton, J. (1994). Avermectin biosynthesis - intact incorporation of a diketide chain-assembly intermediate into the polyketide macrocyclic ring. Tetrahedron Lett., 35, 327.
  51. Hailes, H.C., Handa, S., Leadlay, P.F., Lennon, I.C., Ley, S.V. and Staunton, J. (1994). Biosynthesis of tetronasin. Part 2. Identification of the tetraketide intermediate attached to the polyketide synthase. Tetrahedron Lett., 35, 311.
  52. Hailes, H.C., Handa, S., Leadlay, P.F., Lennon, I.C., Ley, S.V. and Staunton, J. (1994). Biosynthesis of tetronasin. Part 3. Preparation of deuterium-labelled triketides and tetraketides as putative biosynthetic precursors of tetronasin. Tetrahedron Lett., 35, 315.
  53. Hailes, H.C., Jackson, C.M., Leadlay, P.F., Ley, S.V. and Staunton, J. (1994). Biosynthesis of tetronasin. Part 1. Introduction and investigation of the diketide and triketide intermediates bound to the polyketide synthase. Tetrahedron Lett., 35, 307.
  54. Linton, K.J., Cooper, H.N., Hunter, I.S. and Leadlay, P.F. (1994). An ABC-transporter from Streptomyces longisporoflavus confers resistance to the polyether-ionophore antibiotic tetronasin. Molec. Miocrobiol., 11, 777-785.
  55. Marsden, A.F.A., Caffrey, P., Aparicio, J.F., Loughran, M.S., Staunton, J. and Leadlay, P.F. (1994). Stereospecific acyl transfers on the erythromycin-producing polyketide synthase. Science, 263, 378.
  56. Aggarwal, R., Caffrey, P., Leadlay, P.F., Smith, C.J. and Staunton, J. (1995). The thioesterase of the erythromycin-producing polyketide synthase: mechanistic studies in vitro to investigate its mode of action and substrate specificity. J. Chem. Soc., Chem. Commun., 15, 1519-1520.
  57. Brown, M.J.B., Cortés, J., Cutter, A.L., Leadlay, P.F. and Staunton, J. (1995). A mutant generated by expression of an engineered DEBS1 protein from the erythromycin-producing polyketide synthase (PKS) in Streptomyces coelicolor produces the triketide as a lactone, but the major product is the nor-analogue derived from acetate as starter acid. J. Chem. Soc., Chem. Commun., 15, 1517-1518.
  58. Cortés, J., Wiesmann, K.E.H., Roberts, G.A., Brown, M.J.B., Staunton, J. and Leadlay, P.F. (1995). Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage. Science, 268, 1487-1489.
  59. Haydock. S.F., Aparicio, J. F., Molnár, I., Schwecke, T., Khaw, L.E., König, A., Marsden, A.F.A., Galloway, I.S., Staunton, J. and Leadlay, P.F. (1995). Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA: ACP transacylase domains in modular polyketide synthases. FEBS Lett., 374, 246-248. 
  60. Schwecke, T., Aparicio, J.F., Molnár, I., König, A., Khaw, L.E., Haydock, S.F., Oliynyk, M., Caffrey, P., Cortés, J., Lester, J.B., Böhm, G.A. Staunton, J. and Leadlay, P.F. (1995). The biosynthetic gene-cluster for the polyketide immunosuppressant rapamycin. Proceedings of the National Academy of Sciences of the United States of America, 92, 7839-7843.
  61. Wiesmann, K.E.H., Cortés, J., Brown, M.J.B., Cutter, A.L., Staunton, J. and Leadlay, P.F. (1995). Polyketide synthesis in vitro on a modular polyketide synthase. Chemistry & Biology, 2, 583-589.
  62. Aparicio, J.F., Molnár, I., Schwecke, T., König, A., Haydock, S.F., Khaw, L. E., Staunton, J. and Leadlay, P.F. (1996). Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus - analysis of the enzymatic domains in the polyketide synthase. Gene, 169, 9-16. 
  63. König, A., Schwecke, T., Molnár, I, Böhm, G.A., Lowden, P.A.S., Staunton, J. and Leadlay, P.F. (1996). The nature of the starter unit for the rapamycin polyketide synthase. Angew. Chemie. Intl. Edn. Engl., 35, 2249-2251. 
  64. Less, S.L., Handa, S. Leadlay, P.F., Dutton, C.J. and Staunton, J. (1996). Biosynthesis of tetronasin 5. Novel fluorinated and non-fluorinated analogues of tetronasin via intact incorporation of diketide, triketide and tetraketide analogue precursors. Tetrahedron Lett., 37, 3511-3514. 
  65. Less, S.L., Handa, S., Millburn, K., Leadlay, P.F., Dutton, C.J. and Staunton, J. (1996). Biosynthesis of tetronasin 6. Preparation of structural analogues of the diketide and triketide biosynthetic precursors to tetronasin. Tetrahedron Lett., 37, 3515-3518. 
  66. Less, S.L., Leadlay, P.F., Dutton, C.J. and Staunton, J. (1996). Biosynthesis of tetronasin 7. Preparation of structural analogues of the tetraketide biosynthetic precursor to tetronasin. Tetrehedron Lett., 37, 3519-3520. 
  67. Lowden, P.A.S., Böhm, G.A., Staunton, J. and Leadlay, P.F. (1996). The nature of the starter unit for the rapamycin polyketide synthase. Angewandte Chemie lntl. Edn. Engl., 35, 2249-2251.
  68. Mancia. F., Keep, N.H., Nakagawa, A., Leadlay, P.F., McSweeney, S., Rasmussen, B., Bösecke, P., Diät, O. and Evans, P. R. (1996). How coenzyme B12 radicals are generated - the crystal structure of methylmalonyl-CoA mutase at 2 angstroms resolution. Structure, 4, 339-350. 
  69. Meier, T., Thomä, N. and Leadlay, P.F. (1996). Tritium isotope effects in adenosylcobalamin-dependent methylmalonyl-CoA mutase. Biochemistry, 35, 11791-11796.
  70. Molnár, I., Aparicio, J.F., Haydock, S.F., Khaw, L.E., Schwecke, T., König, A., Staunton, J. and Leadlay, P.F. (1996). Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus - analysis of genes flanking the polyketide synthase. Gene, 169, 1-7. 
  71. Oliynyk, M., Brown, M.J.B., Cortés, J., Staunton, J. and Leadlay, P.F. (1996). A hybrid modular polyketide synthase obtained by domain swapping.Chemistry & Biology, 3, 833-839. 
  72. Staunton, J., Caffrey, P., Aparicio, J.F., Roberts, G.A., Bethell, S.S. and Leadlay, P.F. (1996). Evidence for a double-helical structure for modular polyketide synthases. Nature Structural Biology, 3, 188-192. 
  73. Thomä, N. and Leadlay, P.F. (1996). Homology modelling of human methylmalonyl-CoA mutase - a structural basis for point mutations causing methylmalonic aciduria. Protein Sci., 5, 1922-1927.
  74. Gaisser, S., Böhm, G.A., Cortés, J. and Leadlay, P.F. (1997). Analysis of seven genes from the eryAl eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea. Molecular & General Genetics, 256, 239-251. 
  75. Galloway, I.S., Rowe, C.J., Cortés, J., Staunton, J. and Leadlay, P.F. (1997). A system for the enhanced expression of genes in Saccharopolyspora erythraea and its use in the production of novel polyketides. Faseb Journal, 11, 1680. 
  76. König, A., Schwecke, T., Molnár, I., Böhm, G.A., Lowden, P.A.S., Staunton, J. and Leadlay, P.F. (1997). The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin - nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus. European Journal of Biochemistry, 247, 526- 534.
  77. Leadlay, P.F. (1997). Combinatorial approaches to polyketide biosynthesis. Current opinion in Chemical Biology, 1, 162-168.
  78. Leadlay, P.F. (1997). Structure and mechanism of modular polyketide synthases. Faseb Journal, 11, 2548. 
  79. Lewis, H.D., Floriano, B., Linton, K.J., White, J., Bibb, M.J., Hunter, I.S. and Leadlay, P.F. (1997). Evidence for a novel mechanism of resistance to the polyether polyketide tetronasin. Faseb Journal, 11, 1022. 
  80. Oliynyk, M., Brown, M.J.B. and Leadlay, P.F. (1997). Engineering of polyketide biosynthesis by domain replacements in a modular polyketide synthase. Faseb Journal, 11, 2644. 
  81. Staunton, J., Leadlay, P.F., Marsden, A.F.A., Wilkinson, B., Dunster, N.J., Cortés, J., Oliynyk, M., Hanefeld U. and Brown M.J.B., (1997). Rational engineering of polyketide biosynthesis: Where do we begin? Developments in Industrial Microbiology - GMBIM, edited by Baltz, R.H., Hegeman, G.D. and Skatrud, P.L., American Society for Microbiology, Washington DC.
  82. Weissman, K.J., Timoney, M., Bycroft, M., Grice, P., Hanefeld, U., Staunton, J. and Leadlay, P.F. (1997). The molecular basis of Celmer's rules: The stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase. Biochemistry, 36, 13849-13855.
  83. Böhm, I., Holzbaur, I.E., Hanefeld, U., Cortés, J., Staunton, J. and Leadlay, P.F. (1998). Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension. Chemistry & Biology, 5, 407-412. 
  84. Celis, R.T., Leadlay, P.F., Roy, I. and Hansen, A. (1998). Phosphorylation of the periplasmic binding protein in two transport systems for arginine incorporation in Escherichia coli K-12 is inrelated to the function of the transport system. J. Bacteriol., 180, 4828-4833.
  85. Cutter, A.L., Hanefeld, U., Wilkinson, B., Leadlay, P.F. and Staunton, J. (1998). Enantiospecific synthesis of tetrasubstituted d-lactones. Tetrahedron Lett., 39, 9827-9830.
  86. Gaisser, S., Böhm, G.A., Doumith, M., Raynal, M.C., Dhillon, N., Cortés, J. and Leadlay, P.F. (1998). Analysis of eryBI eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea. Molecular & General Genetics, 258, 78-88. 
  87. Gaisser, S. and Leadlay, P.F. (1998). Sugaring the pill by design. Nature Biotechnology, 16, 19-20. 
  88. Khaw, L.E., Böhm, G.A., Metcalfe, S., Staunton, J. and Leadlay, P.F. (1998). Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase. Journal of Bacteriology, 180, 809-814. 
  89. Marsden, A.F.A., Wilkinson, B., Cortés, J., Dunster, N.J., Staunton, J. and Leadlay, P.F. (1998). Engineering broader specificity into an antibiotic-producing polyketide synthase. Science, 279, 199-202. 
  90. Pacey, M.S., Dirlam, J.P., Geldart, R.W., Leadlay, P.F., McArthur, H.A.I., McCormick, E.L., Monday, R.A., O'Connell, T.N., Staunton, J. and Winchester, T.J. (1998). Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity. J. Antibiotics, 51, 1029-1034.
  91. Rowe, C.J., Cortés, J., Gaisser, S., Staunton, J. and Leadlay, P.F. (1998). Construction of new vectors for regulated high-level expression in actinomycetes. Gene, 216, 215-223.
  92. Salah-Bey, K., Doumith, M., Michel, J.M., Haydock, S., Cortés,J., Leadlay, P.F. and Raynal, M.C. (1998). Targeted gene inactivation forthe elucidation of deoxysugar biosynthesis in the erythromycin producerSaccharopolyspora erythraea. Molecular & GeneralGenetics, 257, 542-553.
  93. Thomä, N.H. and Leadlay, P.F. (1998). Mechanistic and structural studies on methylmalonyl-CoA mutase. Biochem. Soc. Trans., 26, 293-298.
  94. Thomä, N.H., Meier, T.W., Evans, P.R. and Leadlay, P.F. (1998). Stabilization of radical intermediates by an active site tyrosine residue in methylmalonyl-CoA mutase. Biochemistry 37, 14386-14393. 
  95. Weissman, K.J., Smith, C.J., Hanefeld, U., Aggarwal, R., Bycroft, M., Staunton, J. and Leadlay, P.F. (1998). The thioesterase of the erythromycin-producing polyketide synthase: Influence of acyl chain structure on the mode of release of substrate analogues from the acyl enzyme intermediates. Angewandte Chemie-International Edition, 37, 1437-1440.
  96. Weissman, K.J., Bycroft, M., Cutter, A.L., Hanefeld, U., Frost, E.J., Timoney, M.C., Harris, R., Handa, S., Roddis, M., Staunton J. and Leadlay, P.F. (1998). Evaluating the efficiency of precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase. Chemistry & Biology, 5, 743-754.
  97. Weissman, K.J., Bycroft, M., Staunton, J. and Leadlay, P.F. (1998). Origin of starter units for erythromycin biosynthesis. Biochemistry, 37, 11012-11017.
  98. Bisang, C., Long, P.F., Cortés, J., Westcott, J., Crosby, J., Matharu, A.L., Cox, R.J., Simpson, T.J., Staunton, J. and Leadlay, P.F. (1999). A chain initiation factor common to both modular and aromatic polyketide synthases. Nature, 401, 502-505.
  99. Gaisser, S., Reather, J., Wirtz, G., Kellengerger, L., Staunton, J. and Leadlay, P.F. (1999). A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. Molec. Microbiol., 36, 391-401.
  100. Gates, P.J., Kearney, G.C., Jones, R., Leadlay, P.F. and Staunton, J. (1999). Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry. Rapid Communication in Mass Spectrometry, 13, 242-246. 
  101. Holzbaur, I.E., Harris, R.C., Bycroft, M., Cortés, J., Bisang, C., Staunton, C., Rudd, B.A.M. and Leadlay, P.F. (1999). Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase. Chemistry & Biology, 6, 189-195. 
  102. Kearney, G.C., Gates, P.J., Leadlay, P.F., Staunton, J. and Jones, R.(1999). Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry II. Rapid Communication in Mass Spectrometry, 13, 242-246. 
  103. Large, K.P., Mirjalili, N., Osborne, M., Peacock, L.M., Zormpaidis, V., Walsh, M., Cavanagh, M.E., Leadlay, P.F. and Ison, A.P. (1999). Lipase activity in Streptomycetes. Enzyme and Microbial Technology, 25, 569-575.
  104. Mirjalili, N., Zormpaidis, V., Leadlay, P.F. and Ison, A.P.(1999). The effect of rapeseed oil uptake on the production of erythromycin and triketide lactone by Saccharopolyspora erythraea. Biotechnology Progress, 15, 911-918.
  105. Ranganathan, A., Timoney, M., Bycroft, B., Cortés, J., Thomas, I.P., Wilkinson, B., Kellenberger, L., Hanefeld, U., Galloway, I.S., Staunton, J. and Leadlay, P.F. (1999). Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues. Chem. Biol., 6, .731-741
  106. Weissman K.J., Kearney G.C., Leadlay P.F., Staunton J. (1999). Structural elucidation studies of polyketide tetrasubstituted delta-lactones by gas chromatography/tandem mass spectrometry and electrospray mass spectrometry. Rapid Communications in Mass Spectrometry, 13, 2103-2108. 
  107. Bycroft, M., Weissman, K. J., Staunton, J. & Leadlay, P. F. (2000). Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase. European Journal of Biochemistry,267, 520-6.
  108. Gaisser, S., Reather, J., Wirtz, G., Kellenberger, L., Staunton, J. & Leadlay, P. F. (2000). A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. Molecular Microbiology, 36, 391-401. 
  109. Thomä, N. H., Evans, P. R. & Leadlay, P. F. (2000). Protection of radical intermediates at the active site of adenosylcobalamin-dependent methylmalonyl-CoA mutase. Biochemistry, 39, 9213-21. 
  110. Wilkinson, B., Foster, G., Rudd, B. A., Taylor, N. L., Blackaby, A. P., Sidebottom, P. J., Cooper, D. J., Dawson, M. J., Buss, A. D., Gaisser, S., Bohm, I. U., Rowe, C. J., Cortés, J., Leadlay, P. F. & Staunton, J. (2000). Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. Chemistry & Biology, 7, 111-7. 
  111. Gaisser, S., Lill, R., Wirtz, G., Grolle, F., Staunton, J. and Leadlay, P. F. (2001). New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster. Molecular Microbiology, 41, 1223-1231. 
  112. Heathcote, M.L., Staunton, J. and Leadlay, P.F. (2001). Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units. Chemistry & Biology, 8, 207-20. 
  113. Holzbaur, I.E., Ranganathan, A., Thomas, I.P., Kearney, D.J., Reather, J.A., Rudd, B.A., Staunton, J. and Leadlay, P.F. (2001). Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates. Chemistry & Biology, 8, 329-40. 
  114. Leadlay P.F., Staunton J., Oliynyk M., Bisang C., Cortes J., Frost E., Hughes-Thomas Z.A., Jones M.A., Kendrew S.G., Lester J.B., Long P.F., McArthur H.A., McCormick E.L., Oliynyk Z., Stark C.B., Wilkinson C.J. (2001). Engineering of complex polyketide biosynthesis--insights from sequencing of the monensin biosynthetic gene cluster. J. Ind. Microbiol. Biotechnol., 6, 360-7. Review.
  115. Lowden P.A., Wilkinson B., Bohm G.A., Handa S., Floss H.G., Leadlay P.F., Staunton J. (2001). Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase. Angewandte Chemie International Edition., 40, 777-779.
  116. Rowe, C.J., Böhm, I.U., Thomas, I.P., Wilkinson, B., Rudd, B.A., Foster, G., Blackaby, A.P., Sidebottom, P.J., Roddis, Y., Buss, A.D., Staunton, J. and Leadlay, P.F. (2001). Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase. Chemistry & Biology, 8, 475-85. 
  117. Weissman, K.J., Kearney, G.C., Timoney, M.C., Bycroft, M., Grice, P., Hanefeld, U., Staunton, J. and Leadlay, P.F. (2001). Use of isotopes to investigate the mechanism of stereocontrol in the biosynthesis of erythromycin. In: Synthesis and applications of isotopically labelled compounds, Vol. 7 (eds Pleiss, U. & Voges, R.). John Wiley and Son, New York, pp. 631-635.
  118. Wilkinson C.J., Frost E.J., Staunton J., Leadlay P.F. (2001). Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum. Chem. Biol., 12, 1197-208.
  119. Gaisser S., Martin C.J., Wilkinson B., Sheridan R.M., Lill R.E., Weston A.J., Ready S.J., Waldron C., Crouse G.D., Leadlay P.F., Staunton J. (2002). Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents. Chem. Commun., 6, 618-9.
  120. Gaisser S., Lill R., Staunton J., Mendez C., Salas J., Leadlay P.F. (2002). Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea. Mol. Microbiol., 3, 771-81.
  121. Leadlay, P.F., Staunton, J., Oliynyk, M., Bisang, C., Cortés, J., Frost, E., Hughes-Thomas, Z.A., Jones, M.A., Kendrew, S.G., Long, P.F., McArthur, H.A.I., McCormick, E.L., Oliynyk, Z., Stark, C.B.W. and Wilkinson, C.J. (2002). Engineering of complex polyketide biosynthesis - insights from sequencing of the monensin biosynthetic gene cluster. J. Ind. Molec. Microbiol., 27, 360-367.
  122. Long P.F., Wilkinson C.J., Bisang C.P., Cortes J., Dunster N., Oliynyk M., McCormick E., McArthur H., Mendez C., Salas J.A., Staunton J., Leadlay P.F. (2002). Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. Mol. Microbiol., 5, 1215-25.
  123. Østergaard L.H., Kellenberger L., Cortes J., Roddis M.P., Deacon M., Staunton J., Leadlay P.F. (2002). Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase. Biochemistry, 8, 2719-26.
  124. Thomas I., Martin C.J., Wilkinson C.J., Staunton J., Leadlay P.F. (2002).Skipping in a Hybrid Polyketide Synthase. Evidence for ACP-to-ACP Chain Transfer. Chem. Biol., 7, 781-7.
  125. Weitnauer G., Gaisser S., Kellenberger L., Leadlay P.F., Bechthold A. (2002). Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tu57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1. Microbiology, 148(Pt 2):373-9.
  126. Wilkinson C.J., Hughes-Thomas Z.A., Martin C.J., Bohm I., Mironenko T., Deacon M., Wheatcroft M., Wirtz G., Staunton J., Leadlay P.F. (2002). Increasing the efficiency of heterologous promoters in actinomycetes. J. Mol. Microbiol. Biotechnol., 4, 417-26.
  127. Broadhurst, R.W., Nietlispach, D., Wheatcroft, M.P., Leadlay, P.F. and Weissman, K.J. (2003). The structure of docking domains in modular polyketide synthases. Chem. Biol., 10, 723-731.
  128. Del Vecchio, F., Petkovic, H., Kendrew, S.G., Low, L., Wilkinson, B., Lill, R., Cortés, J., Rudd, B.A., Staunton, J. and Leadlay, P.F. (2003). Active-site residue, domain and module swaps in modular polyketide synthases. J. Ind. Microbiol. Biotechnol., 30, 489-494.
  129. Gaisser, S., Kellenberger, J.L., Kaja, A.L., Weston, A.J., Lill, R.E., Wirtz, G., Kendrew, S.G., Low, L., Sheridan, R.M., Wilkinson, B., Galloway, I.S., Stutzman-Engwall, K., McArthur, H.A.I., Staunton, J. and Leadlay, P.F. (2003). Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. Org. Biomol. Chem., 1, 2840-2847.
  130. Hong, H., Gates, P.J., Staunton, J., Stinear, T.P., Cole, S.T., Leadlay, P.F. and Spencer, J.B. (2003). Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans. J. Chem. Soc. Chem. Commun. (Camb.), 22, 2822-2823.
  131. Hughes-Thomas, Z.A., Stark, C.B., Böhm, I.U., Staunton, J. and Leadlay, P.F. (2003). Intermediates released from a polyether-producing polyketide synthase provide insight into the mechanism of oxidative cyclisation. Angew. Chem. Int. Ed. Engl., 42, 4475-4478.
  132. Leadlay, P.F. and Baerga-Ortiz, A. (2003). Mammalian fatty acid synthase: closure on a textbook mechanism? Chem. Biol., 10, 101-103.
  133. Martin, C.J., Timoney, M.C., Sheridan, R.M., Kendrew, S.G., Wilkinson, B., Staunton, J. and Leadlay, P.F. (2003). Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase. Org. Biomol. Chem., 1, 4144-4147.
  134. Olano, C., Wilkinson, B., Moss, S.J., Brana, A.F., Mendez, C., Leadlay, P.F. and Salas. J.A. (2003). Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. J. Chem. Soc. Chem. Commun. (Camb.), 22, 2780-2782.
  135. Oliynyk, M., Stark, C.B.W., Bhatt, A., Jones, M.A., Hughes-Thomas, Z.A., Oliynyk, Z., Demydchuk, Y., Staunton, J. and Leadlay, P.F. (2003). Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclisation. Molec. Microbiol., 49, 1179-1190.
  136. Petkovic, H., Lill, R.E., Sheridan, R.M., Wilkinson, B., McCormick, E.L., McArthur, H.A.I., Staunton, J., Leadlay, P.F. and Kendrew, S.J. (2003). A novel erythromycin, 6-desmethylerythromycin D, made by substituting an acyltransferase domain of the erythromycin polyketide synthase. J. Antibiot., 56, 543-551.
  137. Squire, C.M., Goss, R.J., Hong, H., Leadlay, P.F. and Staunton, J. (2003). Catalytically active tetramodular 6-deoxyerythronolide B synthase fusion proteins. ChemBiochem., 4, 1225-1228.
  138. Wilkinson, B., Kendrew, S.G., Sheridan, R.M. and Leadlay, P.F. (2003). Biosynthetic engineering of polyketide synthases. Expert Opin. Ther. Patents, 13, 1579-1606.
  139. Garcia-Bernardo, J., Xiang, L., Hong, H., Moore, B.S. and Leadlay, P.F. (2004). Engineered biosynthesis of phenyl-substituted polyketides. ChemBiochem., 5, 1129-1131.
  140. Gregory, M.A., Gaisser, S., Lill, R.E., Hong, H., Sheridan, R,M., Wilkinson, B., Petkovic, H., Weston, A.J., Carletti, I., Lee, H.L., Staunton, J. and Leadlay, P.F. (2004). Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by Streptomyces hygroscopicus. Angew. Chem. Int. Ed. Engl., 43, 2551-2553.
  141. Haydock, S.F., Mironenko, T., Ghoorahoo, H.I. and Leadlay, P.F. (2004). The putative elaiophylin biosynthetic gene cluster in Streptomyces sp. DSM4137 is adjacent to genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase and to genes for synthesis of cobalamin. J. Biotechnol., 113, 55-68.
  142. Li, T.L., Huang, F., Haydock, S.F., Mironenko, T., Leadlay, P.F. and Spencer, J.B. (2004). Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase. Chem. Biol., 11, 107-119.
  143. Lowden, P.A., Böhm, G.A., Metcalfe, S., Staunton, J. and Leadlay, P.F. (2004). New rapamycin derivatives by precursor-directed biosynthesis. ChemBiochem., 6, 535-538.
  144. Olano, C., Moss, S.J., Brana, A.F. Sheridan, R.M., Math, V., Weston, A.J., Mendez, C., Leadlay, P.F., Wilkinson, B. and Salas, J.A. (2004). Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation. Molec. Microbiol., 52, 1745-1756.
  145. Olano, C., Wilkinson, B., Sanchez, C., Moss, S.j., Sheridan, R.M., Math, V., Weston, A.J., Braña, A.F., Martin, C.J., Oliynyk, M., Mendez, C., Leadlay. P.F. and Salas, J.A. (2004). Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assingment of functions. Chem. Biol., 11, 87.97.
  146. Stinear, T.P., Mve-Obiang, A., Small, P.L., Frigui, W., Pryor, M.J., Brosch, R., Jenkin, G.A., Johnson, P.D., Davies, J.K., Lee, R.E., Adusumilli, S., Garnier, T., Haydock, S.F., Leadlay, P.F. and Cole, S.T. (2004). Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proc. Natl. Acad. Sci. USA, 101, 1345-1349.
  147. Weissman, K.J., Hong, H., Oliynyk, M., Siskos, A.P. and Leadlay, P.F. (2004). Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea. ChemBiochem., 5, 116-125.
  148. Bhatt, A., Stark, C.B., Harvey, B.M., Gallimore, A.R., Demydchuk, Y., Spencer, J.B., Staunton, J. and Leadlay, P.F. (2005). Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked. Angew. Chem. Int. Ed. Engl., 44, 7075-7078.
  149. Boakes, S., Oliynyk, M., Cortés, J., Böhm, I., Rudd, B.A., Revill, W.P., Staunton, J. and Leadlay, P.F. (2005). A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea. J. Mol. Microbiol. Biotechnol., 8, 73-80.
  150. Gregory, M.A., Petkovic, H., Lill, R.E., Moss, S.J., Wilkinson, B., Gaisser, S., Leadlay, P.F. and Sheridan, R.M. (2005). Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis. Angew. Chem. Int. Ed. Engl., 44, 4757-4760.
  151. Haydock, S.F., Appleyard, A.N., Mironenko, T., Lester, J., Scott, N. and Leadlay, P.F. (2005). Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC27449. Microbiology, 151, 3161-3169.
  152. Hong, H., Appleyard, A.N., Siskos, A.P., Garcia-Bernardo, J., Staunton, J. and Leadlay, P.F. (2005). Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry. FEBS J., 272, 2373-2387.
  153. Hong, H., Spencer, J.B., Porter, J.L., Leadlay, P.F. and Stinear, T.P. (2005). A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase. ChemBiochem., 6, 643-648.
  154. Hong, H., Stinear, T.P., Skelton, P., Spencer, J.B. and Leadlay, P.F. (2005). Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry. J. Chem. Soc. Chem. Cummun. (Camb.), 34, 4306-4308.
  155. Siskos, A.P., Baerga-Ortiz, A., Bali, S., Stein, V., Mamdani, H., Spiteller, D., Popovic, B., Spencer, J.B., Staunton, J., Weissman, K.J. and Leadlay, P.F. (2005). Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chem. Biol., 12, 1145-1153.
  156. Stinear, T.P., Frigui, W., Pryor, M.J., Brosch, R., Garnier, T., Leadlay, P.F. and Cole, S.T. (2005). Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans. J. Bacteriol., 187, 1668-1676.
  157. Weissman, K.J. and Leadlay, P.F. (2005). Combinatorial biosynthesis of reduced polyketides. Nature Reviews Microbiol., 3, 925-936.
  158. Baerga-Ortiz, A., Popovic, B., Siskos, A.P., O'Hare, H., Spiteller, D., Williams, M.G., Campillo, N., Spencer, J.B. and Leadlay, P.F. (2006). Site-directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin-producing polyketide synthase. Chem. Biol., 13, 277-285.
  159. Gallimore, A.R., Stark, C.B.W., Bhatt, A., Harvey, B.M., Demydchuk, Y., Bolanos-Garcia, V., Fowler, D.J., Staunton, J., Leadlay, P.F. and Spencer, J.B. (2006). Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis. Chem. Biol., 13, 453-460.
  160. Gregory, M.A., Hong, H., Lill, R.E., Gaisser, S., Petkovic, H., Low, L., Sheehan, L.S., Carletti, I., Ready, S.J., Ward, M.J., Kaja, A.L., Weston, A.J., Challis, I.R., Leadlay, P.F., Martin, C.J., Wilkinson, B. and Sheridan, R.M. (2006). Rapamycin biosynthesis: elucidation of gene product formation. Org. Biomol. Chem., 7, 3565-3568.
  161. Harvey, B.M., Hong, H., Jones, M.A., Hughes-Thomas, Z.A., Goss, R.M., Heathcote, M.L., Bolanos-Garcia, V.M., Kroutil, W., Staunton, J. and Leadlay, P.F. (2006). Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin. ChemBiochem., 7, 1435-1442.
  162. Harvey, B.M., Jones, M.A., Hughes-Thomas, Z.A., Goss, R.M., Bolanos-Garcia, M., Kroutil, W., Staunton, J., Leadlay, P.F. and Spencer, J.B. (2006). Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin. ChemBiochem., In revision.
  163. Harvey, B.M., Mironenko, T., Sun, Y., Deng, Z., Leadlay, P.F., Weissman, K.J. and Haydock, S.F. (2006). Insights into polyether antibiotic biosynthesis from analysis of the gene cluster for the biosynthesis of the closely-related polyethers abierixin and nigericin in Streptomyces sp. DSM4137. Chem. Biol., In revision.
  164. Huang, F., Haydock, S.F., Spiteller, D., Mironenko, T., Li, T.L., O'Hahan, D., Leadlay, P.F. and Spencer, J.B. (2006). The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-CoA. Chem. Biol., 13, 475-484.
  165. Moss, S.J., Carletti, I., Olano, C., Sheridan. R.M., Ward, M., Math, V., Nur-E-Alam, M., Braña, A.F., Zhang, M.Q., Leadlay, P.F., Méndez, C., Salas, J.A. and Wilkinson, B. (2006). Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues. J. Chem. Soc. Chem. Commun., , 2341-2343.
  166. O'Hare, H.M., Baerga-Ortiz, A., Popovic, B., Spencer, J.B. and Leadlay, P.F. (2006). High throughput mutagenesis of active site residues to evaluate models of stereochemical control in ketoreductase domains from the erythromycin-producing polyketide synthase. Chem. Biol., 13, 287-296.
  167. Sheehan, L.S., Lill, R.E., Wilkinson, B., Sheridan, R.M., Vousden, W.A., Kaja, A.L., Crouse, G.D., Gifford, J., Graupner, P.R., Karr, L., Lewer, P., Sparks, T.C., Leadlay, P.F., Waldron, C. and Martin, C.J. (2006). Engineering of the spinosyn PKS: directing starter unit incorporation. J. Nat. Prod., 69, 1702-1710.
  168. Sun, Y., Hong, H., Samborskyy, M., Mironenko, T., Leadlay, P.F. and Haydock, S.F. (2006). Organization of the biosynthetic gene cluster in Streptomyces sp. DSM4137 for the novel neuroprotectant polyketide meridamycin. Microbiology, 152, 3507-3515.
  169. Wilkinson, B., Gregory, M.A., Moss, S.J., Carletti, I., Sheridan, R.M., Kaja, A., Ward, M., Olano, C., Mendez, C., Sala, J.A., Leadlay, P.F., van Ginckel, R. and Zhang, M.Q. (2006). Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain. Bioorg. Med. Chem. Lett., 16, 5814-5817.
  170. Oliynyk, M., Samborskyy, M., Lester, J.B., Mironenko, T., Scott, N., Dickens, S., Haydock, S.F. and Leadlay, P.F. (2007). Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nature Biotechnology, 24, 447-453.
  
     
 
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