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Jobs and studentships

University Lecturer (Clinical)

From Jobs at the University of Cambridge. Published on Dec 09, 2016.

Applications are invited for a University Lectureship in Histopathology (Clinical) in the Department of Pathology www.path.cam.ac.uk at the University of Cambridge, to take up the appointment as soon as possible.

The purpose of the role is to strengthen the Department's teaching and training of clinical and undergraduate students, as well as its basic and applied research, and to support and maintain the University's national and international reputation for excellence in teaching and research.

Applicants must be educated to degree level, normally with a PhD in relevant specialist subject area. Applicants for appointment are expected to demonstrate a commitment to teaching at both clinical and undergraduate levels, as well as excellence in research. The successful candidate will have a strong publication record in research in molecular histopathology.

As a University Teaching Officer, the appointee will be expected to conduct lecturing and small group teaching to clinical students and undergraduates and to contribute to directing studies for programmes within their subject area.

The successful candidate will also be expected to pursue academic research at an international level of sufficient quality to be returnable in the Research Excellence Framework, including developing a research group and attaining research funding.

The post is available immediately and is remunerated on the Clinical Academic Scale at Consultant level.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment. This appointment also requires an Honorary Clinical Contract.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please ensure that you upload a covering letter, your curriculum vitae (CV), a list of publications, and a one-page statement of academic interests and future plans, as well as the names and addresses of three referees in the 'Upload' section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Short-listed candidates will be invited to visit the Department, to give a seminar on their work and meet prospective colleagues, prior to a meeting of the Appointments Committee. It is intended to arrange these visits for late January 2017.

For informal enquiries please contact the Head of the Division of Cellular and Molecular Pathology, Professor Nicholas Coleman, by email at nc109@cam.ac.uk

General queries regarding should be directed to jobs@path.cam.ac.uk or 01223 333940.

Please quote reference PK10803 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship (Fixed Term)

From Jobs at the University of Cambridge. Published on Dec 08, 2016.

The Department of Pathology is offering a three-year Microsoft Research funded studentship starting in October 2017 under the supervision of Dr James Ajioka.

Project title: Smart molecular biosensors - Computational design and experimental implementation of biological signal processing.

The project will address fundamental questions regarding the application of biological signal processing in field-use biosensors. Specifically, ongoing research in the Ajioka lab suggests that environmental variability, such as temperature and other chemical contaminants affects the robustness of arsenic biosensor measurements. The development of smart biosensors incorporating biochemical signal processing could address these problems, allowing the fabrication of sensing devices suitable for applications ranging from pathogen detection to cancer diagnostics. The project will build on the expertise of the Ajioka group in developing biosensors for the field (for example as part of the Arsenic Biosensor Collaboration and ongoing research in biological computation at Microsoft Research.

The student will (1) use a model driven approach to systematically investigate the advantages and limitations of combining sensing and signal processing functions within the same biochemical system in the context of biosensors, (2) design, experimentally implement, and characterize biochemical components as sensing and computational primitives. Both in vitro and cellular implementations will be addressed.

Supervision: James Ajioka (Department of Pathology, University of Cambridge). Peter Davenport (Department of Pathology, University of Cambridge). Boyan Yordanov (Biological Computing Group, Microsoft Research Cambridge).

The candidate: UK and EU Students who have, or are expecting to attain at least an upper second class honours degree (or equivalent) in relevant biological subjects, are invited to apply. The interdisciplinary nature of many of the projects available and the training modules means that we also welcome applications from students with physical science and mathematical backgrounds who are interested in using their skills in addressing biological questions. Due to the interdisciplinary nature of the project, a willingness to learn and become engaged with both the experimental and computational aspects of the work will be important. Further information about EU student eligibility can be found at the following website: http://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status

Information on how to apply is available at: http://www.path.cam.ac.uk/graduate/microsoft-phd/

Interviews will be held week commencing 16 January 2017.

Fixed-term: The funds for this post are available for 3 years in the first instance. The funding will be £23.000 pa which includes University and College fees that the student will be responsible for paying.

Any queries regarding this position should be directed to jobs@path.cam.ac.uk or 01223 333940 .

Please quote reference PK10877 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Dec 07, 2016.

We are recruiting a Post-doctoral Research Associate for 6 months in Dr B Sanson's team to develop a research project characterising the dynamics of cell-cell junctions during compartmental boundary formation in Drosophila. Candidates should have a PhD in a biology subject and a solid background in molecular genetics and developmental biology. Prior expertise in live imaging using confocal microscopy and in quantitative image analysis is requested.

Fixed-term: The funds for this post are available for 6 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please ensure that you upload your Curriculum Vitae (CV) and a brief statement (half page) to the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please quote reference PM10933 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Public Engagement Manager

From Jobs at the University of Cambridge. Published on Dec 07, 2016.

Fixed-term: The funds for this post are available until 30 June 2022 in the first instance.

The Cambridge Stem Cell Institute is a world-leading centre of excellence in stem cell biology and regenerative medicine, supported by the Wellcome Trust and the Medical Research Council (www.stemcells.cam.ac.uk). The Institute comprises over 300 scientists whose research spans fundamental science through to clinical applications. Our vision is to develop a deep understanding of stem cell biology for the prevention and treatment of human disease.

Public Engagement (PE) is an essential part of our work. We seek to provide opportunities for the public to explore and question research developments and for researchers to improve their understanding of public views. The purpose of the PE Manager role is to create and support a community of scientists who recognise the importance of dialogue with the public and who have the skills and opportunities to undertake PE activities. Overall, the CSCI aims to have highly visible public engagement that is woven into all aspects of scientific research and the PE Manager is envisioned to develop this ethos across the institute.

The PE Manager is responsible for the implementation and development of the PE Programme, which includes a wide variety of public events for different target communities, as well as digital engagement activities and professional development training for researchers. The post holder will also be responsible for developing a reward and recognition framework for researcher-led public engagement that aligns with institutional public engagement priorities. The role involves both long-term, strategic planning and detailed event management (see further particulars). The PE Manager will manage one part-time (50%) Events Administrator and there may be opportunities to expand the team from 2018 onwards.

We are seeking an innovative and self-motivated public engagement professional to lead the programme through an exciting phase of growth. As we plan for our move to custom-built premises on the Cambridge Biomedical Campus in 2018, you will need to take the lead on multiple large-scale, innovative projects in order to cement PE in the working culture of our institute.

You will be educated to degree level (or equivalent), ideally in a scientific subject. You will have had experience in a similar role, preferably having managed a small team. You must demonstrate a proven track record in relationship building, event organisation, report writing, and data management. You will have outstanding organisational and administrative experience and be comfortable working to tight deadlines with minimal supervision. You should have demonstrable experience in web-based/social media communication and you should have excellent written and verbal communication and negotiation skills.

The post will work in close collaboration with senior roles in the Admin team, with supervision from the PE steering committee and SCI Administrator and will report to the Institute Director.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please upload your current CV and cover letter with your application by Sunday 08 January 2017.

Interviews will be held on the morning of Monday 23 January 2017.

Informal enquiries are also welcome via e-mail to David Kent at dgk23@cam.ac.uk.

Please quote reference PS10876 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Laboratory Technician (Drosophila Neurobiology) (Part Time, Fixed Term)

From Jobs at the University of Cambridge. Published on Dec 06, 2016.

We are seeking to appoint a technician to work 22.5 hours per week in support of a BBSRC-funded project on Drosophila (fruitfly) neurobiology.

The main duties include tracing of single neurons on electron microscopy images using online custom built software, collation and maintenance of computerised image and spreadsheet data. There is also a small amount of bench work that includes genetic crosses and dissections of Drosophila larvae brains, immunolabelling and confocal microscopy of GAL4 lines of traced neurons.

You should have an HNC/HND in a biological subject, and a degree is highly desirable. You should have experience of acquisition and computer analysis of biological microscopy images, and knowledge of Drosophila genetics, particularly in targeted gene expression. Experience in dissection and confocal microscopy is highly desirable.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries may be made to Dr. Liria Masuda-Nakagawa - lm546@cam.ac.uk

Please quote reference PC10917 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Dec 06, 2016.

Applications are invited for a vacancy in bioinformatics at either post-doctoral or pre-doctoral level to join a multi-disciplinary team studying virus comparative genomics, gene expression, evolution, RNA structure and function, and virus discovery. The position will be based in the joint bioinformatic/experimental laboratory of Dr Andrew Firth in the University of Cambridge at the Cambridge Biomedical Campus. Further information about our lab's research may be found at www.firthlab.path.cam.ac.uk.

Applicants should have a good degree in bioinformatics, molecular biology, statistics, mathematics, physics, computer science or a related discipline or equivalent experience. Applicants should have a sound knowledge of at least one programming language, familiarity with the linux operating system, experience in standard bioinformatic techniques and reference resources for RNA/DNA sequence analysis, and an interest in molecular biology. Previous experience of working with high-throughput RNA-Seq sequencing data would be a strong advantage. Experience and knowledge of some of the following are desirable: molecular biology/virology, web development, and software development.

The ability to work both independently as well as part of a team, coupled with excellent communication, organizational and problem solving skills, and an enthusiasm for scientific research, are required. The general duties/responsibilities of this post include developing and driving research objectives, supporting the lab's work, writing up work for presentation and publication, assisting in the supervision of student research projects, and delivering occasional seminars as outlined in the Further Information Documents.

Appointment at research associate is dependent on having a PhD (or equivalent experience), including those who have submitted but not yet received their PhD (in which case appointment will initially be made at research assistant and amended to research associate when the PhD is awarded). Where the postholder does not hold a PhD (or equivalent experience), appointment will be at the research assistant level. The research assistant salary falls within the range £25,298 - £29,301. The research associate salary falls within the range £29,301 - £38,183.

Applicants should provide a CV, the filename of which should be "CV-followed by your name", including contact details of two or more referees, and a covering letter addressing the selection criteria.

Direct enquiries may be addressed to Dr Andrew Firth (aef24@cam.ac.uk).

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

General queries regarding these positions should be directed to Irene Piper, jobs@path.cam.ac.uk or 01223 333940.

Please quote reference PK10925 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

BBSRC PhD Studentship: Regulation and function of chromatin domains

From Jobs at the University of Cambridge. Published on Dec 05, 2016.

A BBSRC DTP targeted PhD studentship is available to study the regulation and function of chromatin domains in the laboratory of Professor Julie Ahringer.

Eukaryotic genomes are organized into chromatin domains of differing structure. Chromatin domain structure affects gene expression and alterations to structure have been associated with human disease, however, our understanding of how domains form and function is poor. To uncover general principles of genome domain organization, we study this process in the genetically tractable model organism C. elegans. In recent work, we discovered that the genome is organized into extended chromatin domains of either stable or regulated gene activity, enriched for H3K36me3 or H3K27me3 respectively (Evans et al, 2016*). The border regions between domains contain large intergenic regions and a high density of transcription factor binding, suggesting a role for transcription regulation in separating chromatin domains. Despite the differences in cell types, overall domain organization is remarkably similar in across development, indicating that this organization is a fundamental property of the genome. This PhD project aims to investigate the formation and function of chromatin domains. This will involve screens for factors that control domain formation and subsequent study of identified factors. Additionally, CRISPR/Cas9 technology will be used to delete or move border and other sequences to test their functions in controlling domain structure and gene expression. The project will involve techniques such as RNA-seq, ChIP-seq, CRISPR-Cas9 mediated genome engineering, and RNAi screening, phenotypic analyses, and computational analyses.

In addition to the primary PhD research, the student will participate in the Cambridge BBSRC Doctoral Training Programme.

Fixed-term: The funds for this post are available for 4 years. This studentship is available to start on 1 Oct 2017.

Eligibility: Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject. BBSRC studentships are available to UK nationals and EU students who meet the UK residency requirements. Further details can be found at the following link www.bbsrc.ac.uk/documents/studentship-eligibility-pdf

Further enquiries should be made to Professor Julie Ahringer (ja219@cam.ac.uk).

Applications should be made by email to Professor Julie Ahringer (ja219@cam.ac.uk) by sending a covering letter describing your research interests and why you are applying for this PhD position, along with your CV including the names of two or three individuals who can be contacted for a reference.

*Evans, K.J., Huang, N., Stempor, P., Chesney, M.A., Down, T.A., and Ahringer, J. (2016) Stable C. elegans chromatin domains separate broadly expressed and developmentally regulated genes, PNAS, 113, E7020-E7029, doi: 10.1073/pnas.1608162113.

The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Benefits include generous maternity/paternity leave, flexible working and funds for returning carers and other family-friendly schemes.

Research Associate - Global mangrove restoration mapping (Fixed Term)

From Jobs at the University of Cambridge. Published on Dec 02, 2016.

We invite applications for postdoctoral Research Associate position in the Department of Zoology based in the David Attenborough Building in Central Cambridge with Professor William Sutherland's research group and in collaboration with Dr Mark Spalding. It is funded for up to eighteen months, in the first instance, by The Nature Conservancy and should start on 1 February 2017 or thereafter.

Specific goals of this position

This research project will help to inform growing calls for habitat restoration as a means to undo past losses, to restore biodiversity and to re-build ecosystem service benefits. Mangroves are among the most valuable forests in the world in terms of their many important roles for people, but vast areas have been lost. This work will generate the first large scale maps indicating the potential for mangrove restoration world-wide. By linking such maps to models of benefits it will also support the prioritisation of restoration as a means to maximise gains for society. Detailed approaches will be determined as the project progresses, but it is likely that a sequence of methods will be identified. Maps of locations of recent mangrove loss will provide a baseline, these will be enhanced through efforts to map historical losses; to assess "restorability" linked to land-use and socio-economic drivers; and to consider ongoing threats, including sea-level rise and erosion. There may be merit in improving resolution for certain larger countries by connecting with national experts and locating national, high-resolution, datasets. Once developed these base maps of "restorability" will be linked to existing models of the ecosystem service value of mangroves, enabling the outputs to show not only where mangroves can be restored, but also the potential return on restoration investment from enhanced coastal protection, carbon storage and fish production. The work will be linked to, and informed by, policy experts as a means to ensure that it generates rapid and immediate impact in a world where restoration is increasingly being seen as a critical part of development and of climate change resilience and adaptation.

Required skills and desirable experience for the position

Essential:

PhD in an appropriate subject, completed or completion imminent (e.g. environmental-scale modelling and mapping, remote sensing);

Experience with Geographical Information Systems, R statistical software and modelling;

Ambition and drive, strong work ethic and good interpersonal skills and a good publication record;

Enthusiasm to interact with colleagues locally and internationally, and to build partnerships with new partners;

Ability to manage and analyse very large global datasets;

Ability to organise time and work effectively with a considerable degree of independence, but also in a research team setting;

Desirable:

Experience with remote sensing data;

Familiarity with mangrove ecosystems;

Ecosystem modelling;

Global scale data handling

Duties and responsibilities

Designing and carrying out an exercise to map the distribution of areas for the potential restoration of mangrove habitat at a global scale;

Overlay these maps with models of mangrove ecosystem service benefits to help quantify the spatial patterns in the potential value of mangrove restoration;

Analysing and writing up the results for publication.

Interviews in person or by Skype on or after 10 January

Fixed-term: The funds for this post are available for up to 18 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PF10869 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Assistant to the Experimental Section Supervisor

From Jobs at the University of Cambridge. Published on Dec 02, 2016.

We are looking to appoint a full-time horticultural assistant for the Botanic Garden's Experimental Section.

The Experimental Section is one of seven sections that comprise the Garden's horticultural division, each responsible for caring for specific areas of the Garden and associated plant collections within the 40 acre site.

The role-holder supports the Experimental Section Supervisor in the cultivation and provision of plants for research and teaching purposes for University and external researchers. They assist with the maintenance, cultivation and curation of plants in the section which comprises non-public research glasshouses, material in reserve houses, and Experimental plots, and in the public areas eg Understanding Plants, Ecological Mound, Fen Display and elements of the external landscape of the Sainsbury Laboratory. The role-holder assists in the maintenance eg watering and upkeep of the Garden's hardy nursery facility.

The role-holder reports directly to the Experimental Section Supervisor on daily and weekly work plans, progress and developments within the Section. They assist in providing supervision guidance to one trainee horticultural technician and deputise for the Experimental Supervisor as required.

The candidate should be educated to at least GCSE level, hold a National Certificate in Horticulture, or equivalent, and have suitable professional horticultural experience.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

For any enquiries regarding this position, please contact admin@botanic.cam.ac.uk

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Assistant to the Systematics Section Supervisor (Part Time)

From Jobs at the University of Cambridge. Published on Dec 02, 2016.

We are looking to appoint a part-time horticultural assistant, two days per week job-share position, within the Botanic Garden's Systematics Section.

Systematics Section is one of seven sections that comprise the Garden's Horticultural team. Each Section is responsible for caring for specific areas of the Garden and their related plant collections. The Systematics Section comprises approximately 150 individual beds of herbaceous plants, laid out in family order to demonstrate plant classification and relationships between plant families. The beds are laid out in a unique manner and are of great heritage importance. They provide an important resource for research and education purposes within the Garden and University. They are formal in appearance and thus require high standards of plant care, horticultural maintenance and curation.

The role-holder reports directly to the Section Supervisor on daily and weekly work plans, progress and developments within the Section. They assist in providing guidance to one Trainee Horticultural Technician assigned to the Section, along with occasional work experience students/volunteers and deputise for the Section Supervisor as required.

The candidate should be educated to at least GCSE level, hold a National Certificate in Horticulture, or equivalent, and have suitable professional horticultural experience.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

For any enquiries relating to this position please contact admin@botanic.cam.ac.uk

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Trainee Horticultural Technician

From Jobs at the University of Cambridge. Published on Dec 02, 2016.

Each year vacancies under the Trainee Technician scheme are available for people wishing to pursue a career in horticulture by gaining practical experience. The training is for a period of one year starting at the beginning of September. Based within the 40-acre Botanic Garden, the trainees are able to learn and perform the wide range of horticultural skills that are required to maintain a diverse collection of over 8,000 plants, which is of international importance. The scheme is demanding and is intended for those wishing to gain experience in practical horticulture, collection management and plantsmanship. Trainees are part of the staff of the Botanic Garden and receive a salary.

Trainees who successfully complete the scheme will be awarded a Certificate of Higher Education in Practical Horticulture and Plantsmanship by the University of Cambridge Institute of Continuing Education, which works closely with the Botanic Garden. This award attracts 120 credits (Credit Accumulation Transfer [CAT] Points) at FHEQ level 4 (first-year undergraduate level). By the end of the course, students should be able to:

  1. Demonstrate a critical understanding of the roles of botanic gardens
  2. Discuss and review issues relating to plant diversity and conservation
  3. Demonstrate their ability and skill to cultivate and manage plant collections according to scientific principles

The trainees work with experienced Garden staff and rotate between the horticultural sections in the Garden: Trees and Shrubs; Demonstration and Display; Systematic Beds; Alpine and Woodland; Experimental; Glasshouse; Landscape and Machinery. Trainees work on each section, enabling them to experience how the management of each section changes with the seasons. The trainees form a significant proportion of the Garden's workforce and are central to its horticultural operations. The practical training is augmented by a weekly programme including talks, seminars, demonstrations, plant identifications, and visits to other gardens and sites of botanical significance. Trainees must attend all teaching sessions during the year in order to complete the qualification. There is an emphasis on plant diversity, basic taxonomic training and plant identification utilising the plant collections.

Fixed-term: 12 months.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

For any enquiries relating to this position, please contact admin@botanic.cam.ac.uk Interviews expected week commencing 10 April 2017

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Temporary Office Administrator (Part Time, Fixed Term)

From Jobs at the University of Cambridge. Published on Dec 02, 2016.

Professor Randall Johnson is looking for someone to take on an administrative role within his research group. The main tasks will include simple database maintenance/data entry, ordering through the University ordering system and picking up orders from stores, processing travel and other reimbursements and managing lab inventory (primarily putting away supplies).

Candidates should be educated to A level (or equivalent) standard. You will have some administrative experience with good computer skills (including databases), good organisational skills and the ability to communicate effectively with a wide range of people. No lab skills are required, but a familiarity with a laboratory environment would be useful.

The post is for 20 hours per week; actual days can be negotiated.

Fixed-term: The funds for this post are available for 6 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please complete the online application as fully as possible and submit your application by midnight on the closing date of Sunday 18 December 2016.

Please quote reference PM10916 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Dec 01, 2016.

A position has arisen in the lab of Professor Gerard Evan, University of Cambridge, Department of Biochemistry, Cambridge (http://www.bioc.cam.ac.uk/uto/evan) to further our ongoing studies on the role of the myc oncogene in haematopoeitic malignancies. The Myc protein is a highly pleiotropic "master" switch that modulates a wide variety of mechanistically diverse processes. Its aberrant expression is implicated in several haematological malignancies, including acute myeloid leukaemia. The lack of pharmacological inhibitors of Myc has hampered the investigation of the role of Myc in the genesis and maintenance of these cancers and the therapeutic efficacy of Myc inhibition. To address this we have established animal models in which we can rapidly and reversibly switch the expression or activity of Myc in haematopoeitic cell lineages. We now seek a postdoctoral researcher to continue our studies investigating the effects of deregulated oncogenic Myc expression (a common finding in many tumours) in these tumours.

Applicants must have a PhD or equivalent, a strong background in tumour biology and previous experience in molecular and cellular biology and in mouse models of tumourigenesis.

A Home Office Personal licence is also required.

Fixed-term: The funds for this post are available for two years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be sent to Trevor Littlewood - tdl2@cam.ac.uk.

Please quote reference PH10892 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate x 2 (Fixed Term)

From Jobs at the University of Cambridge. Published on Dec 01, 2016.

Salary Research Associate: £29,301.00 - £38,183.00

Salary Research Assistant: £25,298.00 - £29,301.00

Fixed-term: The funds for this post are available until 30 November 2018 in the first instance.

Dr Mark Holmes and Dr Andrew Grant are seeking to appoint a postdoctoral Research Associate and a Research Assistant to join a team of scientists to work on an MRC antimicrobial resistance Theme 1 project using chromosome conformation capture metagenomics (3C and HiC) to investigate the transfer of antimicrobial resistance genes within and between species of bacteria in complex microbiomes. The project is a collaboration which includes the Department of Veterinary Medicine, University of Cambridge, The University of Edinburgh and the Roslin Institute.

We are looking for ambitious and hardworking individuals with skills and experience in the relevant fields of molecular microbiology, next-generation sequencing, bioinformatics and metagenomics. The successful candidates would have a strong match in at least one area but with the willingness to extend their expertise and experience. The candidates must value teamwork, collaboration and possess good organisational and communication skills.

Research Associate

The ideal candidate will have a PhD in Molecular Microbiology or a relevant discipline.

Research Assistant

The ideal candidate will have a degree in Molecular Microbiology or a relevant discipline.

Some of the main duties will include:

  • Undertake microbiology, molecular biology, Illumina sequencing, and data analysis work as part of the team.

  • Provide some supervision for PhD students and undergraduate project students.

  • Responsible for sub-projects arising from the main research including the investigation of factors affecting antimicrobial resistance such as novel antimicrobial resistance genes.

A full detailed description of the key responsibilities for both positions are available in the further particulars file.

For informal enquires please contact: Natalie Wills on nw366@cam.ac.uk

To submit an application for this vacancy, please visit the vacancy pages on the following website: http://www.jobs.cam.ac.uk/

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Further particulars for the role and information about the Department www.vet.cam.ac.uk.

Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Closing date: 5 January 2017

Interviews will be held on 18 January 2017

Please quote reference PP10907 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Independent Research Group Leaders in Stem Cell Science

From Jobs at the University of Cambridge. Published on Dec 01, 2016.

The Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute is founded on the concept that deep understanding of stem cell biology will contribute to transforming future healthcare (http://www.stemcells.cam.ac.uk). In 2018 we will move into a new purpose built building adjacent to Addenbrooke's Hospital and multiple research institutes - http://cambridge-biomedical.com/.

The Institute has openings for Group Leaders who will complement and synergise with our existing programmes. Areas of particular interest include:

i. The interface between physical, materials or engineering sciences and stem cell biology

ii. Cell and gene therapy

iii. Ageing of stem cells

Junior group leader candidates will have a minimum of 3 years post-doctoral experience, distinctive research achievements, and an original project proposal. Senior group leader candidates will be internationally recognised for independent high quality science and have an exceptional and well-founded research proposal.

The Institute offers a collegiate environment with excellent core facilities plus extensive opportunities to pursue basic and disease focussed studies. Successful candidates will be supported to obtain external personal fellowship and grant support within 1-2 years. Interim start-up packages may be available. Depending on experience, non-Clinicians can expect remuneration between £39,324 and £66,835.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Applicants should upload a curriculum vitae (max 3 pages, to include date of PhD and details of any career gaps if applicable) with contact details of 3 referees, and a 1-2 page outline of your research proposal, by Sunday 29th January 2017.

Informal enquiries about the post are welcome via email to sci-administrator@stemcells.cam.ac.uk.

Interviews will be held in April 2017.

Please quote reference PS10734 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Accounts Clerk [Temporary Cover] (Maternity Cover)

From Jobs at the University of Cambridge. Published on Nov 30, 2016.

We are seeking to appoint an Accounts Clerk to work as part of a small but busy team in the Department of Biochemistry.

You will be one of the primary points of contact for account enquiries and undertake a full range of support duties including accounts payable, accounts receivable and general ledger activities using the University's financial system, as well as dealing with post, filing and petty cash.

The successful candidate will possess the ability to work effectively in a team and have experience of dealing with customers and colleagues at all levels. Good time management, attention to detail, and ability to use their own initiative is essential.

Candidates should be educated to GCSE level, or equivalent, with at least five grades A* - C including English and Mathematics. Excellent communication skills are essential. Experience using Oracle Financials and iProcurement is desirable. Ideally, the successful candidate will have or be working towards their AAT qualification.

Maternity cover: This post is fixed-term for 1 year or the return of the post holder, whichever is the earlier.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be sent to Personnel - personnel@bioc.cam.ac.uk

Please quote reference PH10884 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Postdoctoral Research Assistant/Associate x 2

From Jobs at the University of Cambridge. Published on Nov 28, 2016.

Applications are invited for up to two postdoctoral research assistants/associates to join the group of Dr Emma Rawlins to work on the regulation of human lung development (http://www.gurdon.cam.ac.uk/research/rawlins). Our recent research has focused on cellular mechanisms of lung development, homeostasis and repair using the mouse as a model system (e.g. Balasooriya et al., Dev Cell 2016; Watson et al., Cell Reports 2015). We have now established novel in vitro systems for studying human lung development which will be the primary focus of our work over the next few years. We aim to recruit outstanding individuals who are interested in lung developmental mechanisms, their contribution to disease development and therapeutic potential. One of the positions will focus on the application of single cell techniques to the human embryonic lung. The other on the development of in vivo models using human cells.

Applicants should have a PhD in a relevant subject, or be close to completion of their degree. Expertise in general areas of developmental/stem cell biology including single cell biology, live cell imaging, image analysis and cell signalling mechanisms would be suitable for these positions. Experience of in vitro models and use of experimental animals would be an advantage.

Limited funding: The funds for this post are available for 1 or 3 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Applications should include a CV and a brief statement outlining key areas of expertise, reasons why you would like to join the group and preferred project. Informal enquiries can be addressed to Dr Emma Rawlins (e.rawlins@gurdon.cam.ac.uk). Please quote reference PR10872 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Benefits include generous maternity/paternity leave, flexible working and funds for returning carers and other family-friendly schemes.

Senior Chief Building Services Technician

From Jobs at the University of Cambridge. Published on Nov 28, 2016.

The Cambridge Stem Cell Institute is a world-leading centre of excellence in stem cell biology and regenerative medicine, supported by the Wellcome Trust and the Medical Research Council (www.stemcells.cam.ac.uk). The Institute comprises over 300 researchers spanning fundamental science through to clinical applications. Our vision is of a deep understanding of stem cell biology for the prevention and treatment of human disease.

We are seeking a self-motivated individual with the skills and experience to lead the building services and maintenance team at our main building located in the Centre of Cambridge.

The building hosts approximately 200 researchers from a variety of Institutes/departments and the role holder will assist the Principal Technician with providing front of line building services and maintenance for everyone based in the building. You will be responsible for the complex plant and services on all five floors as well as the associated building services equipment and the coordination of contractors.

The role holder will manage the day to day operation of the mechanical equipment and the steam plant and will organise and control a planned and reactive (24hr) maintenance service for all mechanical and electrical services. The role holder is the first point of contact with the University's Maintenance Unit (MU) as well as other directly employed specialist contractors and will assist in the preventative maintenance and/or repair of our laboratory equipment including electrical testing and fault-finding.

Your expertise in managing plant will be matched with your understanding of a laboratory environment and associated regulations to comply with relevant Health & Safety legislation. You will have a flexible approach to your workload and be able to balance the needs of the research environment as well as work efficiently within a team. You will have excellent communication skills, both verbal and written. You will have good people management skills and the ability to use standard Microsoft software including Word and Outlook. Experience with laboratory equipment is desirable.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

The closing date for all applications is the Monday 02 January 2017.

Informal enquiries are also welcome via email to: jobs@stemcells.cam.ac.uk.

Please quote reference PS10868 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Accounts Clerk

From Jobs at the University of Cambridge. Published on Nov 25, 2016.

The Department of Pharmacology is seeking to appoint an Accounts Assistant to deal with the day-to-day running of our busy accounts office which also acts as the main reception for the Department. The successful candidate will able to work as part of a small team and will be required to fulfil reception duties as well as focusing on accounts payable, accounts receivable and purchasing activities within the Department. The post-holder will be a key member of the team who strive to provide a comprehensive support service to research groups, staff members and students in the Department. The Department aims to provide this support in an efficient yet friendly manner whilst working closely as a team. There will also be times when the post-holder is required to cover the Department stores. Although experience of the University Finance System would be an advantage, full training in the University's financial procedures and processes will be provided. Candidates should be educated to A level or equivalent (including GCSE or equivalent, Mathematics and English), ideally with some formal accountancy training/qualifications, experience of working in an accounting environment and with excellent interpersonal and PC skills. Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Applications from agencies will not be considered. If you have any questions about this vacancy or the application process, please contact Tracey Theobald-Greaves at tlg20@cam.ac.uk, (01223) 334064.

Please quote reference PL10862 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Faculty Administrator (Research and Graduate Matters)

From Jobs at the University of Cambridge. Published on Nov 25, 2016.

Applications are invited for the post of Administrative Officer within the Faculty of Biology responsible for research and graduate matters within the School of the Biological Sciences

This role acts as Secretary to the Graduate School of Life Sciences (GSLS) Strategic Committee, a joint venture between the School of Clinical Medicine and the School of the Biological Sciences whose main activities relate to funding, researcher skills development and the development of joint policy initiatives for the benefit of almost 2000 graduate students within the Life Sciences; Secretary to the Degree Committee for the Faculty of Biology overseeing the work of this Committee which covers ~1200 students across eight Departments, one Research Institute and 8 University Partner Institutes whilst also representing the School on University committees involved with the development of business processes and financing of graduate students, and Secretary to the Joint Faculties Senior Academic Promotion Committee

The ideal candidate will be an experienced administrator with excellent organisational, communication and interpersonal skills. Be educated to degree level or equivalent, as well as experienced in academic affairs and human resources issues within a HEI environment. The candidate should also have the ability to perform under pressure, confidently communicate with staff at all grades, and have the ability to handle complex and difficult situations.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

For specific enquiries about this role, please contact Fiona Russell (fjr22@cam.ac.uk)

Interviews for this post will take place on Monday, 9th January 2017

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Please quote reference PA10860 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate x 2 (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 24, 2016.

Applications are invited for two postdoctoral posts in calcium signalling, one of which will focus on lysosomes, to work in the laboratory of Prof. Colin Taylor at the Department of Pharmacology, University of Cambridge. The lab combines diverse approaches to examine the structural basis of intracellular calcium signalling and it enjoys collaborations with labs in other disciplines. Further information at: http://www.phar.cam.ac.uk/research/taylor. Applicants will have, or be close to obtaining, a PhD. For one post, experience with advanced optical microscopy (TIRFM, STORM) and quantitative image analysis is essential. Applications for both posts are encouraged from applicants familiar with calcium signalling or lysosomal biology, or with experience in other areas (eg, biophysics, cell biology, stem cells) and a willingness to apply their expertise to calcium signalling. The appointees will be enthusiastic, careful and methodical, ready to accept responsibility individually and as part of a team, self-motivated, able to organise, perform and analyse experiments with considerable independence, engaged with the literature, and keen to combine different approaches to explore mechanisms of calcium signalling. Funds for these posts are available for up to 3 years with effect from 1 February 2017 or as soon as possible thereafter. Starting salary will be within the range £29,301 to £38,183 pa. The key duties require the development and execution of a research project, but the appointees will also be involved with our outreach activities, contribute to the activities of others in the lab, and take a share of communal lab responsibilities.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

To apply online for this vacancy, please click on the 'Apply' button below. This will direct you to the University's Web Recruitment System, where you will need to register an account and log in before completing the online application form. For the online application you will need to provide your personal details, names and e-mail addresses of two referees familiar with your recent research, CV, publications and a cover letter (including a description of your experience as it relates to the job specifications). For enquiries about the online application process, please contact Ms Amparo Saez (pharsect@hermes.cam.ac.uk).

The deadline for receipt of applications is 23 December, 2016. Interviews of short-listed candidates will take place in early January.

Please quote reference PL10841 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The Department holds an Athena SWAN bronze award, demonstrating a commitment to provide equal opportunities. The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Events Assistant

From Jobs at the University of Cambridge. Published on Nov 24, 2016.

The Sainsbury Laboratory is a research Institute located within the University Botanic Gardens which focuses on plant developmental biology and computational modelling of plant development. The Institute currently has approximately 150 researchers and 30 support staff.

Applications are invited for the position of Events Assistant, to assist in delivering a full range of events, looking after visitor schedules and supporting outreach projects. This administrative role supports the Events and Outreach Manager and arranges the day to day particulars of a diversified programme of seminars, symposia, workshops, visits, outreach activities and staff events, including occasional evening and week-end occurrences. The role holder is also responsible for publishing an internal weekly newsletter and assisting with the Institute AV systems. The role holder will be working with staff across the Institute, alongside other University departments, external organisations and suppliers.

Candidates must be educated to at least A-level standard or equivalent and have some office experience, particularly in a busy admin or events setting. Previous experience in outreach activities as well as an understanding of an academic environment is desirable. The role holder will have excellent IT skills and be proficient in Microsoft Office software; experience using Microsoft SharePoint would be an advantage.

The successful candidate will have excellent interpersonal, communication and organisational skills, with a positive, service-oriented, can-do attitude. S/he will be able to work both independently and in a team, with a pro-active approach to troubleshooting and problem solving. Attention to detail, a high level of accuracy and effective time management are essential.

The Laboratory provides a welcoming and collaborative environment with a wide-range of family-friendly benefits and development opportunities. More about the Sainsbury Laboratory, further information for the role and details of what the University offers to employees, can be found at http://www.slcu.cam.ac.uk/.

The post is full time and available immediately.

Limited funding: The funds for this post are available until 31 December 2021 in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Interviews are scheduled to be held on Friday 16 December and/or Monday 19 December 2016.

The Sainsbury Laboratory receives a high volume of applications. If you have not heard from us within three weeks of the closing date, please consider your application as unsuccessful on this occasion.

Please quote reference PT10849 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Media Technician

From Jobs at the University of Cambridge. Published on Nov 23, 2016.

The Wellcome Trust/Cancer Research UK Gurdon Institute was founded in 1989 to promote research in the areas of developmental and cancer biology and is located close to the centre of Cambridge.

This is an exciting opportunity for a media technician to join our conscientious, technical support team at the Gurdon Institute. The team prepares media and provides glass washing support for the research groups at the Institute.

The job holder is required to supervise and interact well with others, be helpful and flexible and to work carefully to set standards. An existing understanding of the standards and precision required to produce research media, and familiarity with associated equipment and technologies would be useful, but training will be given.

Limited funding: The funds for this post are available for 5 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

If you have any questions about this vacancy or the application process, please contact Diane Foster at jobs@gurdon.cam.ac.uk. Please quote reference PR10827 on your application and in any correspondence about this vacancy. Interviews will be held during the second and third weeks of January.

The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Benefits include generous maternity/paternity leave, flexible working and funds for returning carers and other family-friendly schemes.

Catalogue Data Assistant - Insects (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 23, 2016.

The University Museum of Zoology has received a Designation Development Fund award from the Arts Council England for an exciting new project called 'The Beetle Voyage' that focuses on the Insect Collections of the Rev Leonard Jenyns (1800-1893) and his entomological notebooks, which record the biodiversity of Cambridgeshire during the early 19th century. We are looking for a Data Catalogue Assistant to work alongside the Museum Curators, Collections Manager and the Chief Technician (Insects) as well as internal and external experts to help identify and catalogue the specimens.

The candidate should have some knowledge of zoological terminology and an ability to transcribe data accurately, as well as being an excellent team player. As neither the specimens nor data from the notebooks are currently incorporated into a collections database, the role will also include uploading relevant information into the Museum's new collections database (EMu). To achieve this, experience of collections databases and particularly with EMu is an advantage.

Interviews will be held on Tuesday 20th December. If you have not heard from us by 20th December, your application will have been unsuccessful.

For an informal chat please contact Dr Edgar Turner (ect23@cam.ac.uk)

Fixed-term: The funds for this post are available for up to 15 months.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PF10836 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

BBSRC-DTP PhD Studentship (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 22, 2016.

PhD studentship: Rational development of novel small molecule leads against the transcriptional activator protein ExsA of Pseudomonas aeruginosa

A 4-year BBSRC-funded DTP studentship starting in October 2017 is available to work on a collaborative project between the research groups of Dr Taufiq Rahman (Department of Pharmacology) and Dr Martin Welch (Department of Biochemistry). Pseudomonas aeruginosa is a frequent cause of nosocomial infections, including those involving the lungs, the urinary tract, wounds, burns, cornea and the bloodstream. The primary virulence determinant for these acute infections is the type III secretion system (T3SS) which serves effectively as a molecular syringe that directly injects effector proteins into the host cells. This project aims at suppressing T3SS expression by chemically targeting the transcription factor ExsA which is the master regulator of all the genes that encode proteins constituting and regulating the T3SS. It will involve in silico screening of large chemical libraries to find novel chemotypes as preliminary hits against ExsA, the latter will be purified and the top-ranked hits will be characterised through various biophysical and biochemical as well as cell based assays for their ability to a) bind to the ExsA b) to suppress T3SS expression and c) to attenuate virulence of P.aeruginosa. With the most promising molecules, a preliminary structure-activity relationship (SAR) as well as any possible intrinsic toxicity towards eukaryotic cells will also be assessed. Applicants should have (or expect to obtain) the equivalent of a UK first class or upper second-class honours degree in a relevant discipline in the natural sciences (e.g. chemistry, pharmacology, biochemistry, bioinformatics) . We particularly welcome applications from students interested in working at the interface between biology and chemistry. Some background in protein purifications/biochemical techniques with/without in silico screening will be advantageous. We are looking for a highly motivated, enthusiastic individual, capable of thinking and working independently. Eligibility and funding for this studentship are in accordance with the Cambridge BBSRC-DTP scheme, details available here: http://bbsrcdtp.lifesci.cam.ac.uk/dtpprog. Any enquiries should be addressed to Dr Taufiq Rahman (mtur2@cam.ac.uk) or Dr Martin Welch (mw240@cam.ac.uk).

To apply, please e-mail the following to pharsect@hermes.cam.ac.uk: - your CV with full contact details of 2 academic referees (max two A4 pages) - your academic transcript - a cover letter (max two A4 pages) highlighting your background/research interests and how these fit to the proposed project ¿ Deadline for application: December 20, 2016 Interviews will take place between 24th and 31st January 2017.

Please quote reference PL10825 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Decoding the network logic for resetting pluripotency: 4-year PhD Studentship

From Jobs at the University of Cambridge. Published on Nov 21, 2016.

Project Description:

The Smith Group at the Wellcome Trust - Medical Research Council Stem Cell Institute in Cambridge in partnership with the Computational Biology Group at Microsoft Research offers an exciting interdisciplinary 4-year PhD studentship commencing October 2017.

The pluripotent ground state of embryonic stem cells (ESCs) is governed by a self-reinforcing interaction network of transcription factors (Dunn et al, Science 2014). Combinations of factors within this network can induce somatic cells to acquire pluripotency, a process called molecular reprogramming (Takahashi and Yamanaka, Cell, 2006). Experimental and computational efforts have led to circuitry mapping of the key players in maintenance of the ESC state. However, how this molecular circuitry is launched and fully connected during reprogramming remains unclear.

This project is a cross-disciplinary investigation to address systematically how cells transit to the pluripotent ESC state at the molecular network level. The multi-step, heterogeneous and asynchronous nature of the reprogramming process presents technical challenges. This project is designed to overcome these challenges by using a minimal reprogramming system and integrating quantitative single-cell gene expression profiling at defined reprogramming stages with computational network synthesis and modelling. This approach will transform a temporal series of single-cell snapshots of network status into reconfiguring network trajectories. Predictions formulated from the synthesised trajectories will be tested experimentally and the results used for iterative refinement of the model set.

As part of the BBSRC doctoral training programme, this 4-year PhD contains tailored training courses in the first six months of the studentship. In addition, a key element of this project is that the student will spend three months at Microsoft Research Cambridge, under the supervision of our collaborator, Dr Sara-Jane Dunn, to develop wider training and skills.

For further details about our group and the institute, please visit: http://www.stemcells.cam.ac.uk/

Funding Notes:

UK and EEA students who have, or are expecting to attain, at least an upper second class honours degree (or equivalent) in relevant biological subjects are invited to apply. The interdisciplinary nature of the project means that we welcome applications from students with mathematical and computing experience who are interested in using their skills to address biological questions.

Application details are available at http://www.stemcells.cam.ac.uk/study/otheropportunities/#BBSRC. Please ask your referees to submit references directly to the SCI Graduate Administrator: sci-phd@stemcells.cam.ac.uk, using "BBSRCiCASE student reference" in the subject header. The deadline is 20th January 2017 and shortlisted candidates will be interviewed in February.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Four-year PhD Programme, Department of Biochemistry (Three Posts) (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 17, 2016.

Applications are invited for a four-year PhD programme through the generous support of AstraZeneca. The Department of Biochemistry is a member of the School of the Biological Sciences and one of the largest departments in the University of Cambridge. The Department is especially strong in research with investigators of international standing in a wide range of disciplines including structural biology, molecular enzymology, cell signalling and control of gene expression, molecular microbiology, plant molecular biology and bioenergy, cancer and cardiovascular biology.

Purpose and details - The programme aims to educate and train the next-generation doctoral scientists in all aspects of cutting edge biochemistry research which in the department focuses on the fundamental processes of biological systems, with a particular emphasis on understanding at the molecular level.

  1. Students awarded places on the programme will join a specific research group from the outset and undertake a research project agreed with the principal investigator.

  2. All students will have the opportunity to spend some time conducting research at the AstraZeneca Global Research and Development Centre in Cambridge.

  3. All students will receive a tailored career development programme and an AstraZeneca-based project supervisor (in addition to a Biochemistry based supervisor), designed to broaden their research and professional skills.

In addition to her/his direct supervisor, each PhD student will also have an advisor. Each student is also assisted by a graduate thesis panel comprising three members of faculty chosen by the student. Our PhD programmes offer many opportunities for both specialised training and the acquisition of transferable skills.

Applicants should have or shortly expect to obtain a minimum of a UK II.i Honours Degree (or equivalent) in Biochemistry or a related subject. Competition is intense and successful applicants will demonstrate very high academic achievements. We are looking for highly motivated, enthusiastic and industrious individuals who are capable of thinking and working independently.

Application process - You should identify one or more labs in which you might wish to study, then make informal contact with the principal investigator(s) to ensure they are potentially able to supervise you, and to understand the research project you would undertake.

To find PIs' areas of research see Research Group Heads http://www.bioc.cam.ac.uk/people/uto

When making informal contact with the PI, please e-mail the following information to them:

  1. Your CV (max two A4 pages), with full contact details of 2 academic referees.

  2. A covering letter (max two A4 pages) highlighting (a) your research interests, (b) what you hope to achieve from the programme, (c) your career aspirations beyond the programme, and (d) why you wish to undertake this programme in the Department of Biochemistry.

The email addresses of the PIs can be found at http://www.bioc.cam.ac.uk/graduate/apply

If you receive support from the PI you should apply using the Applicant Portal which can be found at: http://www.graduate.study.cam.ac.uk/how-do-i-apply. You can only submit one application with one PI for consideration. Multiple applications with different PIs will not be accepted. Fully completed applications (including references) must be submitted by the deadline.

Funding - Full funding covering the University Composition Fee (at UK/EU rates), Maintenance (currently £17,000 pa), and an allowance for consumables is provided for up to 4 years, with effect from 1 October 2017.

Fixed-term: The funds for this post are available for 4 years in the first instance.

If you have any questions please in the first instance forward your enquiry to our Graduate Admissions Administrator at pg-entry@bioc.cam.ac.uk.

The closing date for applications is 12 noon on 3rd January 2017. Interviews will be held on 18th and or 19th January 2017.

Please quote reference PH10696 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

BBSRC iCASE PhD studentship

From Jobs at the University of Cambridge. Published on Nov 17, 2016.

Epigenetic control of genome function

A four year fully-funded BBSRC PhD studentship is available in the laboratory of Anne Ferguson-Smith (Department of Genetics, University of Cambridge) in partnership with Cambridge Epigenetix (CEGX, Babraham Research Campus). CEGX is a start-up company developing and applying innovative mammalian epigenetics tools for biomedical contexts.

The collaborative project aims to develop robust methodology for the interrogation of locus-specific hydroxymethylation (hmC) and apply this to the functional analysis of this epigenetic modification in vivo.

The studentship will commence during the academic year 2016-17 and students will spend at least 3 months working at CEGX.

Eligibility: Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject. BBSRC studentships are available to UK nationals and EU students who meet the UK residency requirements. BBSRC studentship eligibility conditions apply: EU applicants will receive funding for fees. Home and EU applicants recently resident in the UK will receive fees and maintenance. Further details can be found at the following link www.bbsrc.ac.uk/documents/studentship-eligibility-pdf

Further enquiries should be made to afsmith@gen.cam.ac.uk

Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications consisting of a cover letter, a detailed curriculum vitae and the names and contact details of two academic referees. should be sent to Mrs Deborah Parr dap38@cam.ac.uk, as soon as possible, and at the latest by 16th December 2016.

Please quote reference PC10781 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Junior Clinical Training Scholarship Equine

From Jobs at the University of Cambridge. Published on Nov 17, 2016.

UNIVERSITY OF CAMBRIDGE DEPARTMENT OF VETERINARY MEDICINE

One-year Junior Clinical Training Scholarship £14,800.00 per annum

Start date 1 April 2017 Fixed-term: 12 months.

Applications are invited from recently qualified veterinarians for this 12 month post-graduate training programme offering high-quality, post-graduate training in equine studies. The emphasis will be on gaining practical clinical experience in equine medicine and surgery under the supervision of board-certified diplomates, and will allow the Scholar to identify specific fields in which to specialise, either in preparation for Senior Clinical Scholarship training programmes, or specialist private practice.

Applicants must be a Member of the Royal College of Veterinary Surgeons, or hold a veterinary degree qualifying him or her for membership.

For informal enquiries about the scholarship programme, please contact Kate Smith, University Equine Surgeon, ks629@cam.ac.uk or 01223 746571.

Closing date: 10 January 2017

Interview date: 24 January 2017

An application form (JCTS1) and information pack can be downloaded from the link below or via the following website: http://www.vet.cam.ac.uk/

Please send a completed application form, curriculum vitae, and covering letter by email to vetmed@hermes.cam.ac.uk or to Melissa Large, Department of Veterinary Medicine, Madingley Road, Cambridge, CB3 OES,

Please quote reference PP10790 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate - Drug Induced Mitochondrial Toxicity in the Context of Hypoxia (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 17, 2016.

We are looking for a post-doctoral Research Associate to join a highly-innovative, collaborative project based in Cambridge at the Department of PDN but also working in association with the Departments of Biochemistry and Medicine, and with industry partners, GSK and AstraZeneca. The academic Principal Investigator for the project is Dr Andrew Murray, whose group work on mitochondrial function with a particular interest in understanding how mitochondria are altered under hypoxic conditions (http://www.pdn.cam.ac.uk/directory/andrew-murray). The academic co-Investigators are Prof Margaret Ashcroft (Medicine), an expert in hypoxia signalling and Prof Julian Griffin (Biochemistry) whose group specialise in metabolomics with a strong interest in metabolic diseases. The Industrial lead investigators are Dr Jon Lyon (GSK), Dr Lindsay Edwards (GSK) and Dr Dominic Williams (AstraZeneca).

The successful applicant will have a PhD in biochemistry, physiology, molecular cellular biology or related field. A background in mitochondrial biology and experience of performing in vivo experiments with rodents and handling large datasets are essential. Experience with either isolated organs, tissue and cell culture or mass spectrometry is desirable; however appropriate training will be provided for the successful candidate.

Prior experience of working within multi-collaborative teams or working within the pharmaceutical industry (eg as an industrial placement student) would be beneficial.

The post is funded by GSK and is available for two years in the first instance with possibility of funding for a further year.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please upload your CV, publication list and research statement in the upload section.

Please quote reference PM10794 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD studentship x 4 (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 16, 2016.

The Department of Pathology has an excellent reputation in pure biological and biomedical research and is offering four fully funded* studentships from October 2017 to work with one of the Research Group Leaders in this large and vibrant Department.

Funding* will cover the student's stipend at the current Research Council rate and University Fees. The studentships will be funded for three years in the first instance subject to eligibility**, with the possibility of additional funding in the fourth year depending on circumstances.

The list of available projects is shown below. Applicants can select up to a maximum of three supervisors/projects, although this is not a requirement. Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject. Additionally, the Department requires that by the time of interview all potential students must have fulfilled the language requirements for admission (http://www.graduate.study.cam.ac.uk/courses/directory/blpapdpth/requirements)

Supervisors and Projects available for October 2017 are:

Dr Brian Ferguson - Anti-viral functions of the DNA repair machinery

Dr Katerina Artavanis-Tsakonas - Harnessing parasitic proteins to modulate skeletal muscle cells

Dr Colin Crump/Dr Rupert Beale - Using CRISPR to identify host factors involved in the replication of viruses.

Dr Ian Brierley - Regulation of RNA virus gene expression through modulation of ribosome function.

**The studentships are available to UK nationals and EU students who meet the UK residency requirements. Further information about your fee status can be found at the following website: http://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status . Applications from ineligible candidates will not be considered.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Full details of the projects and how to apply are available from the following link: http://www.path.cam.ac.uk/graduate/fully-funded-phd

The closing date for applications is 31st December 2016. Interviews will be held week commencing 16th January 2017.

General queries regarding these positions should be directed to graduate.studies@path.cam.ac.uk or 01223 333940.

Please quote reference PK10749 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Research Data Curator) (Part Time, Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 11, 2016.

Virtual Fly Brain is an innovative online resource that integrates diverse types of neurobiological data to allow researchers to explore the neural circuitry of Drosophila and to find reagents for their experiments. We are looking for a postdoctoral researcher to curate neuroanatomical expression data and to annotate figures depicting neural circuitry from the literature.

You will be based in the Virtual Fly Brain (VFB) group that is physically located with the FlyBase group in the Department of Physiology Development and Neuroscience, working as part of a team that is supervised by Dr Cahir O'Kane in the Department of Genetics, and colleagues in the MRC Laboratory of Molecular Biology in Cambridge, the European Bioinformatics Institute near Cambridge, and the University of Edinburgh (See www.virtualflybrain.org for further details).

In this role, you will be responsible for reviewing all peer-reviewed literature that relates to the Drosophila nervous system as it is published. Initially, your remit will be to capture information about the expression of transgenes (such as GAL4 enhancer traps or other molecular tools) in neurons and brain regions and to annotate figures depicting neural circuitry for display on VFB. In due course your role may expand to other aspects of the curation process such as adding newly identified neurons to the Drosophila anatomy ontology, and curating large datasets associated with published papers.

You will interact day to day with expert scientist-curators in the Virtual Fly Brain and FlyBase teams who will provide appropriate training. You will also work with other VFB team members primarily involved in the development of the virtualflybrain.org website to ensure the visibility of curated data. You may also seek input from authors or other expert scientists outside the group.

You should have a PhD in a biological science, and a good general grasp of molecular genetics and neurobiology is essential. The work will suit a researcher with experience in Drosophila genetics and/or neurobiology, particularly with some neuroanatomical expertise, and ideally with an interest in learning scripting, ontology development and other bioinformatics skills. Experience in the following areas would be beneficial - knowledge of ontologies, Drosophila bioinformatic tools and databases, and UNIX and Perl.

The position will be based in the Department of Physiology Development and Neuroscience on the Downing Site in central Cambridge; there may also be possibilities to work in the laboratory of our collaborator at the European Bioinformatics Institute in Hinxton.

Fixed-term: The funds for this post are available until 30 September 2017 in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries should be addressed to Dr Cahir O'Kane cjo1003@cam.ac.uk

Please quote reference PC10725 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 11, 2016.

Applications are invited for a Research Assistant / Research Associate - Bioinformatician position funded by Bloodwise UK, starting as soon as possible.

The successful candidate will develop and implement bioinformatic tools to analyze next generation sequencing (exome, targeted resequencing, CHIP-Seq) and gene expression profiling data from lymphoma in the research laboratory of Professor Ming-Qing Du based on the Cambridge Biomedical Campus within Addenbrooke's Hospital.

Applicants should have a MSc in a relevant subject or PhD, or expect to obtain a PhD shortly, an excellent knowledge of a programming or scripting language, and significant experience in bioinformatic analyses, ideally in next generation sequencing data analyses. The post-holder will work closely with other bioinformaticians in the Biomedical Research Centre, should be highly motivated, and have the ability to plan and conduct high quality bioinformatic analyses within a multidisciplinary team.

Where the successful applicant does not yet have a PhD, he/she will normally be under appointed as a Research Assistant in a Research Associate post (on the understanding that he/she will be appointed as a Research Associate upon successful completion of his/her PhD). The higher Research Associate salary should be backdated to the submission date of their thesis.

Ability to work both as part of a team and independently, coupled with excellent communication, organizational and problem solving skills are required. The duties/responsibilities of this post, as outlined in the further information documents, include developing and driving research objectives, writing up work for presentation and publication, assisting in the supervision of student research projects, and delivering seminars and occasional lectures.

Further information about the research group can be found at the group's website (http://www.path.cam.ac.uk/pages/du/).

Informal enquires may be made to Professor Ming-Qing Du (mailto:mqd20@cam.ac.uk)

Fixed-term: The funds for this post are available until 31 August 2018 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Any queries regarding this position should be directed to Irene Piper, jobs@path.cam.ac.uk or 01223 333940 .

Please quote reference PK09838 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

University Lecturer

From Jobs at the University of Cambridge. Published on Nov 11, 2016.

Applications are invited for a University Lectureship in the Department of Pharmacology, University of Cambridge with effect from 1 June 2017 or as soon as possible thereafter. The Department offers excellent facilities for teaching and research, and has particular interests in cell signalling, cancer, macromolecular structure, neuropharmacology and vascular pharmacology. We are seeking to recruit within the broad field of cellular and molecular neuropharmacology.

The role holder will be based in Central Cambridge. The key duties and responsibilities will include but not be limited to: mentoring and giving lectures and seminars to undergraduate / graduate students (including marking their work), taking an active part in examinations, carrying out active research and writing papers on topics relevant to the specialist subject area (this will include journals, books and other material), actively investigating funding opportunities within the area of research and submitting research grant applications. A full description of the teaching and research activities in the Department can be found at http://www.phar.cam.ac.uk.

The successful applicant should have a PhD in a relevant specialist subject area and be developing a bibliography of research publications. They will keep up-to-date with the latest thinking in their specialist subject area by reading other academic material, attending conferences and active discussions with other academics in the field. The successful candidate will also have a strong track record in teaching at a higher education institution.

Appointments will be made at University Lecturer level with a probationary period of five years, with appointment to the retiring age thereafter. The starting salary, depending upon experience, will be in the range of £39,324 - £49,772 pa. Once an offer of employment has been accepted, the successful candidates will be required to undergo a basic disclosure, a security check and a health assessment. Whether the outcome is satisfactory will be determined by the University.

The Department holds an Athena SWAN bronze award, demonstrating a commitment to provide equal opportunities and to advance the representation of women in science subjects. We welcome applications from all qualified candidates irrespective of gender but, as women are currently under-represented at this level in our department, we strongly encourage applications from female candidates. Appointment will be based on merit alone.

Interviews will be held week commencing 6th February 2017.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Prospective candidates are invited to contact the Head of Department, Prof. Mike Edwardson, for informal enquires (Tel: +44 (0) 1223 334014, e-mail: jme1000@cam.ac.uk).

Please ensure that in the Upload section of the online application you upload your Curriculum Vitae (CV), research publications list and a covering letter (max 2 pages outlining your professional, teaching and research experience and describing your future research plans). If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. For enquiries about the online application process contact Ms. Amparo Saez at acs99@cam.ac.uk.

Please quote reference PL09696 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Physical Biology of Stem Cells MRC 4-Year PhD Programme in Stem Cell Biology & Medicine

From Jobs at the University of Cambridge. Published on Nov 11, 2016.

Is this you?:

  • Physical Sciences, Mathematical Sciences or Computational Sciences background?

  • Interested in applying your training to aspects of Stem Cell Biology?

  • Passion for scientific research & hold (or expect to) a relevant 1st degree at the highest level?

If so, the Cambridge Stem Cell Institute would like to hear from you.

To find out more and apply, please visit: http://www.stemcells.cam.ac.uk/study/physical-biology

Application Deadline: 6 February 2017

Please quote reference PS10729 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant in Human Germ Cell Biology

From Jobs at the University of Cambridge. Published on Nov 10, 2016.

We are seeking to recruit a Research Assistant to work on Human Primordial Germ Cell Specification and Development in the laboratory of Professor Azim Surani. The applicant will contribute to the ongoing recently established methods for in vitro derivation of human Primordial Germ Cells, in conjunction with human fetal germ cells. The project will focus on the role of transcription factors and signaling molecules that regulate progression of human germ cells with the view to extending their development in vitro. This is a part of comprehensive studies in the group on the establishment and epigenetic programming of mammalian germ line towards totipotency. We seek candidates with general experience of tissue culture methods and/or expertise in human embryonic stem cells/induced pluripotent stem cells, but training will be provided if necessary. Familiarity with molecular techniques, including gene expression analysis will be an advantage. The post holder will also contribute to day-to-day management of the tissue culture infrastructure and other house keeping duties within the group. Candidates with a degree in a relevant subject or equivalent experience are invited to apply for the post.

Limited funding: The funds for this post are available for 3 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Applications should include a brief statement outlining key areas of expertise and reasons why you would like to join the group. If you have any questions about this vacancy or the application process, please contact Lynn Froggett at l.froggett@gurdon.cam.ac.uk, or Azim Surani at a.surani@gurdon.cam.ac.uk for informal enquiries about the post. Please quote reference PR10712 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Benefits include generous maternity/paternity leave, flexible working and funds for returning carers and other family-friendly schemes.

BBSRC-DTP CASE Studentship

From Jobs at the University of Cambridge. Published on Nov 09, 2016.

Optimization and development of functionally active anti-Cdc42/Ras peptides

A fully funded 4-year BBSRC-DTP Industrial CASE PhD studentship is available, commencing in October 2017, to develop peptide-based therapeutics designed to target Ras-driven cancers. The project builds on a considerable body of data generated in the academic research group led by Drs Darerca Owen and Helen Mott investigating the structure, thermodynamics and functions of small G protein-effector complexes, which has led to the development of candidate peptide therapeutics. The aim of the BBSRC-DTP Industry CASE awards is to provide PhD students with a first class, challenging training experience within the context of a mutually beneficial collaboration between academic and non-academic partner organizations. This project is partnered by MedImmune, a world-leading company specializing in antibody and peptide therapeutics, based just outside Cambridge. The work will use MedImmune's considerable experience to optimize peptides for use as cellular probes and as lead therapeutic molecules. Candidate peptides will be tested in the Owen/Mott laboratory using a range of biophysical and biochemical assays. Those peptides with desired properties will be taken into cell-based assays to test their effects on Ras signalling. The project will provide a thorough training in a wide range of state-of-the-art techniques: advanced peptide chemistry and high-throughput screening techniques; molecular biology, protein biochemistry, biophysics and NMR for protein-protein interaction analysis; cell culture assays e.g. cell proliferation, anchorage-independent growth and focus formation assays.

The successful candidate will join the group led by Drs Darerca Owen and Helen Mott (http://www.bio.cam.ac.uk/~hrm28/) in the Department of Biochemistry, University of Cambridge and will be part of the Antibody Discovery and Protein Engineering (ADPE) department at MedImmune, working alongside a skilled team of scientists in a dynamic biotech environment, supervised by Dr Jeff Revell (https://www.medimmune.com/).

Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject. BBSRC studentships are available to UK nationals and EU students who meet the UK residency requirements. Further information about eligibility for Research Council UK funding can be found on the BBSRC website: http://www.bbsrc.ac.uk/documents/studentship-eligibility-pdf/ The successful candidate will receive a stipend paid at RCUK rates for the 4 year duration of the award (£14,296 per annum for 2016-17) and in addition will benefit from a £2,500 per annum stipend enhancement; fees will be met in full for EU nationals.

Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications should be sent to Dr Darerca Owen (do@bioc.cam.ac.uk), as soon as possible, and at the latest by 16th December 2016, enclosing a cover letter, a detailed curriculum vitae and the names and contact details of two academic referees. Interviews will be held in January 2017.

Please quote reference PH10700 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Group Leader (Cancer Biology)

From Jobs at the University of Cambridge. Published on Nov 07, 2016.

Senior Research Associate (£48,327 - £49,772) or Principal Research Associate (£57,674 - £66,835)

The Gurdon Institute brings together world-class researchers in the fields of cancer and developmental biology to exploit synergies at the interface between these two fields. We are now searching for one or more new group leaders at junior or mid-career level in any area of cancer biology whose research complements our existing strengths in human organoid systems, mouse genetics, in vivo imaging, epigenetics and DNA replication and repair.

The Institute is located in the heart of the historic city of Cambridge, and part of the University's School of Biological Sciences. Founded in 1991, its purpose is to provide the best possible environment for research, and to foster interactions and collaborations between scientists with diverse but complementary interests. It is generously supported by core funding from the Wellcome Trust and Cancer Research UK, and benefits from state-of-the art facilities in a friendly, modern environment (see www.gurdon.cam.ac.uk).

Applicants are expected to conduct their own research and to lead a group of researchers, including postdocs and PhD students, as well as managing support staff. They should have demonstrable and significant postdoctoral expertise in the relevant field of cancer biology and an excellent publication record.

Limited funding: The funds for this post are available for 5 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please ensure that you upload your CV, covering letter, publications list and research statement in the upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. The names and contact details of three referees are a necessary part of the submission. Referees will be contacted automatically following an application but applicants are strongly advised to prepare nominated referees for the need to provide references within two weeks of the closing date.

Please submit your application by midnight (GMT) on the closing date of 09 January 2017. If you wish to discuss your application before applying, please contact glsearch@gurdon.cam.ac.uk. Please quote reference PR10677 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Benefits include generous maternity/paternity leave, flexible working and funds for returning carers and other family-friendly schemes.

Postdoctoral Research Associate - Insect Ecology Group

From Jobs at the University of Cambridge. Published on Nov 07, 2016.

We invite applications for a Postdoctoral Research Associate position in Dr Edgar Turner's Insect Ecology research group in the Department of Zoology, University of Cambridge. This position is funded for up to 9.94 months, up to 29 October 2017 (in the first instance) by the Natural Environment Research Council (NERC) and should start on 1 January 2017 or thereafter. The position will be mostly based in central Cambridge, but will also involve fieldwork trips to Riau, Indonesia.

Specific goals of this position

The successful candidate will investigate the effects of the recent El Niño drought event in Southeast Asia on ecosystem processes. In particular, the project will consider the potential of different plantation management treatments to promote resistance and recovery of biodiversity and ecosystem processes. This will be done using existing and newly collected data from an ongoing experiment, the Biodiversity and Ecosystem Function in Tropical Agriculture (BEFTA) Project. The BEFTA Project is a long term, large scale, ecological experiment based in oil palm plantations in Riau, Indonesia (see Kurz et al 2016, Biotropica 48, pp. 483-490 and the project website www.oilpalmbiodiversity.com). The BEFTA Project involves a close collaboration between the oil palm industry (Sinar Mas Agro Resources and Technology Corporation Research Institute (SMARTRI)), the University of Southampton, Centre for Biological Sciences and the University of Cambridge, Department of Zoology, ensuring that results are disseminated to both the academic community and the oil palm industry.

Required skills and desirable experience for the position

Essential:

Completed (or imminently completed) PhD in an appropriate subject (e.g. tropical ecology, agricultural or environmental sciences);

Experience of analysing large datasets to answer ecological questions;

Knowledge of a programming language, such as R;

Experience of working in complex tropical ecosystems, preferably tropical agriculture;

Ambition and drive, strong work ethic and good interpersonal skills and a strong publication record;

Enthusiasm to interact with both academic and industry colleagues;

Ability to organise time and work effectively, independently and responsibly in a research team setting;

Willingness to conduct extended periods of fieldwork in Indonesia (several weeks, or months)

Desirable:

Experience of working within oil palm landscapes;

Experience of working with the agronomic industry;

Experience of insect identification.

Duties and responsibilities

Managing data collection at the field-site and liaising closely with project partner staff allocated to this project

Identifying and curating insect specimens collected as part of this project

Analysing and writing up the results

Contributing to planned knowledge-exchange activities

Fixed-term: The funds for this post are available for up to 9.94 months (until 29 October 2017) in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PF10670 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

AstraZeneca/Pharmacology 4-year PhD studentships x 4 (Fixed Term)

From Jobs at the University of Cambridge. Published on Nov 04, 2016.

AstraZeneca/Pharmacology 4-year PhD studentships

Applications are invited for 4-year PhD studentships funded by AstraZeneca and the Department of Pharmacology. The students will be working on collaborative projects co-led by departmental supervisors and AstraZeneca scientists. Apart from carrying out their research, in their first year, the students will have compulsory training in: 1) Statistics, 2) Analysis of Biological Data and 3) Systems Training in Maths, Informatics, Statistics and Computation Biology (SysMIC). The students will join a vibrant research community of PhD students and scientists working on various research themes such as; Cell Signalling, Cancer and Infectious Diseases, Macromolecular Structure, Neuropharmacology and Vascular Pharmacology.

Candidates We are looking for highly motivated, enthusiastic individuals, capable of thinking and working independently. Applicants should have or shortly expect to obtain a minimum of a UK II.i Honours Degree (or equivalent) in Pharmacology or a related subject including Cellular or Molecular Biology and Biochemistry. Competition is intense and successful applicants are expected to demonstrate high academic achievements. These positions are open to UK/EU candidates only.

Funding Full funding covering the University Composition Fee and Maintenance (currently £17,000 pa), is provided for up to 4 years, with effect from 1 October 2017. A maximum of four studentships will be awarded in this application round.

A summary of the projects available can be found at https://www.phar.cam.ac.uk/postgraduate/studentships

Application process Please send the following to (pharsect@hermes.cam.ac.uk) 1. Your CV (max two A4 pages), with full contact details of 2 academic referees. 2. A covering letter (max two A4 pages) highlighting (a) your research interests and relevant experience and (b) what you hope to achieve from the programme. You should also state in order of preference which two projects you would like to be considered for. Informal inquires about individual projects should be directed to the supervisors listed above. Applications need to be submitted by 5pm (GMT) on 12th Dec 2016. Applications will be assessed as and when they are submitted. Interviews will take place between 16th and 27th, January 2017.

Please quote reference PL10631 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship in Evolutionary Microbiology of a Human Pathogen

From Jobs at the University of Cambridge. Published on Nov 01, 2016.

A fully-funded PhD studentship from the National Centre for Replacement, Refinement and Reduction (NC3R) is available for uptake in October 2017 in the laboratories of Dr Martin Welch (Department of Biochemistry, Tennis Court Road, Cambridge) and Prof Andres Floto (Laboratory of Molecular Biology and Papworth Hospital, Cambridge). Most of the hands-on work will be done in the MW laboratory.

The project is entitled "In vitro reconstitution of the polymicrobial community associated with cystic fibrosis (CF) airway infections". The airway infections associated with many (if not most) chronic respiratory diseases are predominantly polymicrobial, yet there are currently no models mimicking polymicrobial respiratory infection in vitro and the developing animal models are still very rudimentary. We therefore have an unparalleled window of opportunity in which to develop a robust, experimentally-tuneable in vitro model of polymicrobial respiratory infection. This will be the main aim of the project. The ability to work with stable polymicrobial communities will allow us to address some important ecological and evolutionary questions. For example, what happens to the community structure and dynamics when it is perturbed following antibiotic addition? What happens when a new species is introduced? Does co-culturing of different species affect their phenotypes, cell-cell communication or virulence profiles? These are fascinating fundamental questions that can be directly addressed using an in vitro setup. This PhD project would be suitable for a candidate with a background in Biology, Biochemistry, Microbiology or Genetics and a desire to apply the very latest modern molecular biological techniques to address a variety of unanswered ecological and evolutionary questions.

The successful applicant will join our Departmental PhD programme and must complete their studies within 4 years. Full funding (covering maintenance, fees and laboratory consumables) is available for UK citizens or EEA students who meet UK residency requirements. NC3Rs-specific training will be supplied, and is an integral part of the training programme.

Fixed-term: The funds for this post are available for 3 years in the first instance.

In the first instance, interested candidates should contact Dr Martin Welch (mw240@cam.ac.uk) with a CV, list of academic referees and a cover letter. Shortlisted candidates will be invited for interview in Cambridge.

Please quote reference PH10614 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Wellcome Trust Four Year (1+3) PhD Programme in Stem Cell Biology & Medicine

From Jobs at the University of Cambridge. Published on Oct 26, 2016.

Studentships starting October 2017

http://www.stemcells.cam.ac.uk/study/wtprogramme/

Stem Cell Biology

Stem cells are defined by the dual capacity to self-renew and to differentiate. These properties sustain homeostatic cell turnover in adult tissues and enable repair and regeneration throughout the lifetime of the organism. In contrast, pluripotent stem cells are generated in the laboratory from early embryos or by molecular reprogramming. They have the capacity to make any somatic cell type, including tissue stem cells.

Stem cell biology aims to identify and characterise which cells are true stem cells, and to elucidate the physiological, cellular and molecular mechanisms that govern self-renewal, fate specification and differentiation. This research should provide new foundations for biomedical discovery, biotechnological and biopharmaceutical exploitation, and clinical applications in regenerative medicine.

Cambridge Stem Cell Community

The University of Cambridge is exceptional in the depth and diversity of its research in Stem Cell Biology, and has a dynamic and interactive research community that is ranked amongst the foremost in the world. By bringing together members of both the Schools of Biology and Medicine, this four year PhD programme will enable you to take advantage of the strength and breadth of stem cell research available in Cambridge. Choose from over 50 participating host laboratories using a range of experimental approaches and organisms.

Programme Outline

During the first year students will:

  • Perform laboratory rotations in three different participating groups working on both basic and translational stem cell biology.

  • Study fundamental aspects of Stem Cell Biology through a series of teaching modules led by leaders in the field.

  • Learn a variety of techniques, such as advanced imaging, flow cytometry, and management of complex data sets.

Students are expected to choose a laboratory for their thesis research by June 2018, and will then write a research proposal to be assessed for the MRes Degree in Stem Cell Biology. This assessment will also be used to determine whether students continue on to a 3-year PhD.

Application Process

Visit http://www.stemcells.cam.ac.uk/study/wtprogramme/ for further details including how to apply. Please note: you will be required to complete and submit a departmental application form, provide two references and upload copies of your transcripts as part of the application process.

We invite applications from both EU and Non-EU applicants*.

Application Deadline: Thursday 5th January 2017 Interviews will be held on: 23rd, 24th and 25th January 2017

*Non-EU applicants, who need to apply for additional funding (which covers tuition fees at the 'overseas' rate), must also apply through the University Graduate Student Application Form 'Applicant Portal' by Wednesday 7th December 2016.

Informal enquiries are also welcome via email to sci-phd@stemcells.cam.ac.uk.

Please quote reference PS10545 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship in Molecular Microbiology

From Jobs at the University of Cambridge. Published on Oct 18, 2016.

A BBSRC-funded Targeted PhD studentship (for uptake in October 2017) is available in the laboratory of Dr Martin Welch (Department of Biochemistry, Tennis Court Road, Cambridge). The project will investigate the role of an acetate-inducible denitrification pathway in the opportunistic human pathogen, Pseudomonas aeruginosa. Recent RNA-Seq analyses carried out in the lab have revealed that when grown on acetate as a sole carbon source, gene products comprising the Nar/Nir/Nos/Nor denitrification pathways are among the most highly up-regulated transcripts in the cell. This was a surprising observation because transcripts encoding the known regulators of denitrification in P. aeruginosa (Anr and Dnr) were not modulated at all, suggesting that in these conditions, denitrification is controlled by some other mechanism(s). The practical relevance of this is that (i) fatty acids and other acetate-producing substrates are now known to be the preferred energy source for P. aeruginosa during many infection scenarios, and (ii) denitrification is critically-important in industry for microaerobic bacterial growth.

Therefore, the key question and the main aim of this project, is to understand why P. aeruginosa turns on the denitrification pathways during growth on acetate, and what regulates this. The successful candidate will investigate this problem using a combined biochemical, genetic and systems-based approach which should provide a rich and varied training opportunity.

The successful applicant will join our Departmental PhD programme and must complete their studies within 4 years. Full funding (covering maintenance, fees and laboratory consumables) is available for UK citizens or EEA students who meet UK residency requirements. In addition to a programme of work in the MW lab, the appointed student will participate in DTP training courses, two 10-week rotation projects (one of which will be based in the MW lab) and a three month internship (PIPS), as well as other DTP-related events.

Fixed-term: The funds for this post are available for 4 years in the first instance.

In the first instance, interested candidates should contact Dr Martin Welch (mw240@cam.ac.uk) with a CV, list of academic referees and a cover letter. Shortlisted candidates will be invited for interview in Cambridge.

Please quote reference PH10464 on your application and in any correspondence about this vacancy.

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