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AZ CASE 4 year PhD Studentship (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 29, 2017.

Development of novel mass spectrometry approaches that enable phosphoproteomic analysis in tandem with cellular localisation

Department name: Cambridge Centre for Proteomics (CCP), University of Cambridge (http://proteomics.bio.cam.ac.uk/) Supervisors: Primary: Professor Kathryn Lilley (University of Cambridge) and Derek Barratt (https://www.astrazeneca.co.uk/)

As a key mediator of cellular signalling, phosphorylation remains a principal target for biological question. Identifying and quantifying the phosphorylation state of proteins involved in cell progression, metabolism, growth and disease is critical for the elucidation of cellular function. The initial aim of the project with be to extend recent developments that have demonstrated that the combination of phosphopeptides enrichment using titanium matrices and isobaric chemical labelling (TMT) allows the identification of 10,000 to 15,000 phosphopeptides from total cell lysate (1, 2). This coupled with the hyperLOPIT methodology (Localisation of Organelle proteins by isotope tagging, 3), which combines a biochemical organelle fractionation with a quantitative mass spectrometry analysis, will enable proteomic analysis at the organelle level. Whilst scientifically and experimentally challenging it is realistic to envisage the combination of these methods to deliver a novel approach which will add cellular resolution to phosphoproteomic analysis.

The second goal of the research will be the application of these methods to probe disease relevant cell types and response to compound treatment. This will leverage AstraZeneca's disease expertise and wealth of annotated probe compounds. Hypotheses generated from these analyses with be further tested by, targeted proteomic strategies (Selected Reaction Monitoring) and antibody methods to directly characterise the phosphorylation state of the protein candidates and their localisation within the cell using Western blotting and fluorescence microscopy. Finally, exploiting AstraZeneca's access to disease relevant tissues the expression of targeted protein candidates can be validated on mouse/human samples.

The successful candidate will be jointly supervised by Prof. Kathryn Lilley of the Cambridge Centre for Proteomics which is located in the Department of Biochemistry, University of Cambridge and Discovery Sciences Labs at the Darwin Building on the Cambridge Science Park, working alongside a team delivering Mechanistic Biology support to Oncology Drug Discovery Projects.

Applications

Applications should be sent to Prof. Kathryn Lilley (k.s.lilley@bioc.cam.ac.uk), by midnight on Friday 21st April 2017. enclosing a cover letter, a detailed curriculum vitae (both in PDF format) and the names and contact details of two academic referees.

Funding Notes

This studentship covers 4 years' UK/EU tuition fees (see below for EU eligibility requirements) and a maintenance stipend. BBSRC funding is available for UK nationals and EU students who meet the residency requirements. Further information about eligibility for funding can be found on the BBSRC website: http://www.bbsrc.ac.uk/documents/studentship-eligibility-pdf/

References (1) Evaluating multiplexed quantitative phosphopeptide analysis on a hybrid quadrupole mass filter/linear ion trap/orbitrap mass spectrometer. Erickson BK, Jedrychowski MP, McAlister GC, Everley RA, Kunz R, Gygi SP. Anal Chem. 2015. (2) Comprehensive quantitative comparison of the membrane proteome, phosphoproteome, and sialiome of human embryonic and neural stem cells. Melo-Braga MN, Schulz M, Liu Q, Swistowski A, Palmisano G, Engholm-Keller K, Jakobsen L, Zeng X, Larsen MR. Mol Cell Proteomics. 2014. (3) A draft map of the mouse pluripotent stem cell spatial proteome. Christoforou A, Mulvey CM, Breckels LM, Geladaki A, Hurrell T, Hayward PC, Naake T, Gatto L, Viner R, Martinez Arias A, Lilley KS. Nat Commun. 2016.

Fixed-term: The funds for this post are available for 4 years.

Please quote reference PH11837 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term) KIR polymorphism

From Jobs at the University of Cambridge. Published on Mar 29, 2017.

Applications are invited for an 8 month Research Associate position in the laboratory of Prof John Trowsdale at Department of Pathology based in central Cambridge.

The post is available from 1st May 2017 until 31st December 2017. As the duration of the post is short, prior experience in Next Generation Sequencing in relation to KIR polymorphism is necessary.

The successful candidate will undertake a research project investigating KIR variation in relation to disease.

The ability to work both independently and as part of a team, coupled with excellent communication, organizational and problem solving skills are required. Other duties/responsibilities as outlined in the Further Information document include developing and driving research objectives, writing up work for presentation and publication, assisting in the supervision of student research projects, and delivering seminars and occasional lectures.

Fixed-term: The funds for this post are available until 31 December 2017.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

The deadline for applications is 15th April 2017. Interviews will be held end of April, beginning of May.

General queries should be directed to jobs@path.cam.ac.uk or 01223 333940.

Please quote reference PK11828 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 29, 2017.

Fixed-term: The funds for this post are available for 11 months in the first instance.

Applications are invited for a full-time postdoctoral research associate or research assistant starting as soon as possible. The successful candidate will work on a project called "Creating a toolkit of self-assembling proteins as components for synthetic biology" run jointly by the University of Cambridge (Department of Pharmacology) & Queen Mary, University of London (School of Biological & Chemical Sciences) (QMUL).

The project will investigate the development of novel self-assembly systems using the highly abundant tandem-repeat proteins (also known as solenoid proteins).The work will involve protein design, recombinant protein production, nanoparticle engineering and evaluation of nanostructures produced using a range of biophysical techniques. Applicants should have a first degree or PhD in an area relevant to the project. The key duties and responsibilities will include, but are not limited to: developing research objectives and conducting the research project, writing up research work for presentation and publication, continually updating knowledge and understanding in the research field, translating knowledge of advances in the subject area into research activity, managing own research and administrative activities.

The role holder will be based in Central Cambridge, but it is envisioned that they will make regular visits to QMUL. The successful candidate will be supervised by Dr Laura Itzhaki (see: http://www.phar.cam.ac.uk/research/Itzhaki) and Dr Ewan Main (see: http://www.sbcs.qmul.ac.uk/staff/ewanmain.html).

The funds for this post are available for 11 months. The salary range if appointed as a Research Associate is £29,301 - £38,183 per annum and the salary range if appointed as Research Assistant is £25,298 - £29,301 per annum with promotion to Research Associate on attainment of PhD if applicable.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Applications from agencies will not be considered. If you have any questions about this vacancy or the application process, please contact Dr Laura Itzhaki (lsi10@cam.ac.uk).

The Department holds an Athena SWAN bronze award, demonstrating a commitment to provide equal opportunities and to advance the representation of women in science subjects. We welcome applications from all qualified candidates irrespective of gender but, as women are currently under-represented at this level in our department, we strongly encourage applications from female candidates. Appointment will be based on merit alone.

Applications will be assessed as and when they are submitted and it is anticipated that interviews will take place early-May 2017.

Please quote reference PL11765 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate

From Jobs at the University of Cambridge. Published on Mar 28, 2017.

An ERC-funded postdoctoral research assistant/associate position is available to work in the laboratory of Dr Jenny Gallop on the regulation of actin polymerization at membranes. This exciting project uses biochemical fractionation to isolate novel filopodia elongation factors using an innovative reconstitution assay (Science 329:1341:1341, 2010).

The lab fuses biophysical and biochemical methodologies with cell biological questions, aiming to reconstitute the cell biological processes important for cell shape and movement in vitro and test resulting mechanistic models in vivo within native developmental contexts. The lab employs cell free systems, reconstitution from purified components, single molecule microscopy techniques and quantititative in vivo imaging to elucidate the molecular mechanisms underlying filopodia formation. We are generously funded by the European Research Council and Wellcome Trust with state-of-the art facilities in the centre of Cambridge.

The successful candidate is expected to have, or obtain shortly, a PhD in biochemistry and a first author publication in an international journal. The successful candidate will relish challenging biochemistry and enjoy the precision and rewards of cell-free assays. We are looking for specific experience in protein purification, quantitative biochemical assays and reconstitution approaches. Experience with artificial membranes e.g. liposomes, giant unilamellar vesicles or supported lipid bilayers is an advantage but full training is available. In addition the successful candidate will have the ability to communicate well with colleagues from a range of disciplines.

Limited funding: The funds for this post are available for 2 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries should be directed to Jenny Gallop (j.gallop@gurdon.cam.ac.uk). Please quote reference PR11823 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Benefits include generous maternity/paternity leave, flexible working and funds for returning carers and other family-friendly schemes.

Research Associate - Bayesian statistician and modeller for emerging plant diseases

From Jobs at the University of Cambridge. Published on Mar 28, 2017.

A postdoctoral position is available to work in the Epidemiology and Modelling Group of the Department of Plant Sciences at the University of Cambridge led by Professor Chris Gilligan to work on parameter estimation for epidemiological models to analyse the spread and control of plant diseases across a variety of real-life systems, including crop and natural systems in developed and developing countries.

The post: We are seeking a Bayesian statistician and epidemic modeller to build on our work to analyse the spread and control of plant pests and diseases in natural and agricultural settings. The research is intended to inform policy at a national and international level to aid in optimal surveillance to predict the future spread of and management of emerging diseases in developed (UK and US) countries and low and middle income countries, especially in sub-Saharan countries, with which the Epidemiology and Modelling Group has ongoing interactions. The successful individual will work with the current team of modellers to optimise and expand existing statistical inference approaches and will have unique opportunities to inform the implementation of national and international disease management policies, as well as for publication. Initial work will focus on wheat rust, cassava virus diseases and maize lethal necrosis in East Africa.

Qualifications: Applications are invited from candidates with a PhD in Bayesian statistics or a related subject. Practical experience of Makov chain Monte Carlo or Approximate Bayesian Computation is highly desirable and familiarity with statistical inference and mathematical modelling of plant disease epidemics would be an advantage. Knowledge of C++ and R is essential and knowledge of Python or similar language would be an advantage.

The ideal candidate will be able to work closely with epidemiological modellers and with field-based stakeholders involved in the collection of data for national pest and disease surveys and to advise stakeholders on the implementation of disease management strategies. Good communication skills are essential as the post holder will need to work well in a team and collaborate widely including communicating modelling results effectively to specialists and to non-technical clients and policy agencies. The post-holder will be based in the Epidemiology and Modelling Group at Cambridge where there is substantial expertise in modelling and parameter estimation.

Project details: Bayesian statistical inference provides a powerful means of estimating critical epidemiological parameters for the dispersal, transmission and control of plant disease in agricultural and natural environments. The successful applicant will work across multiple research projects supported by a variety of funders including the Bill and Melinda Gates Foundation, BBSRC, DfID and USAID. Initial work will focus on major pest and disease threats to staple crops in Sub-Saharan Africa.

Examples of key challenges that the post-holder will contribute to, include: - Estimation of transmission and dispersal parameters for stochastic epidemiological model, using extensive, patchy and incomplete surveillance data;

  • Allowing for meteorological driving-variables in making inferences from disease spread data;

  • How can we make predictions of the future spread of emerging plant disease epidemics?

  • How can we identify which strategies are most likely to reduce the risk of future spread?

  • How can the results of such simulations be best communicated to key stakeholders?

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please send a copy of your full CV with publications list, a supporting statement and contact information for two referees.

The funding for this post is available for two years in the first instance.

Please quote reference PD11811 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

University Lecturer

From Jobs at the University of Cambridge. Published on Mar 28, 2017.

Applications are invited for the post of University Lecturer in Plant Sciences, with a Fellowship at Pembroke College. Responsibilities include undergraduate teaching, research, supervision of graduate students, and other duties associated with academic life. It is hoped that the appointee will take up the post in October 2017.

We welcome excellent candidates whose expertise would allow them to strengthen our teaching provision in any of the following areas:

Plant and Microbial Metabolism; Cell and Developmental Plant Biology; Biotechnology and Synthetic Biology; Quantitative Biology.

The appointee will teach undergraduates through lectures, practical classes and small group supervisions, and be motivated to further innovate our teaching methods. We expect the successful candidate to develop a research programme that complements and reinforces the existing Departmental research portfolio.

Candidates must have a PhD in a relevant field and an outstanding record of excellence in research that is reflected in their publications. They will have sufficient breadth and/or depth of specialist knowledge in the discipline, and of research methods and techniques, to develop research objectives, projects and proposals. Candidates should be able to teach to a high standard, manage a diverse workload, and lead their own research programme.

The Department of Plant Sciences has an international reputation across the range of plant science. It is one of the few remaining UK University Departments to offer an undergraduate degree in Plant Sciences. The Department has close links with other organisations including the Sainsbury Laboratory (Cambridge University) and the National Institute of Agricultural Botany.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

For further information, please contact Catherine Butler, Department Administrator (cek31@cam.ac.uk)

Please quote reference PD11741 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Junior Clinical Veterinarian Neurology (Service Intern) (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 28, 2017.

UNIVERSITY OF CAMBRIDGE DEPARTMENT OF VETERINARY MEDICINE West Cambridge Site

Limit of Tenure 12 months

The Department seeks to recruit a Junior Clinical Veterinarian in Neurology from 24 April 2017 or as soon as possible after that date, in order to enhance provision of clinical neurology services and undergraduate teaching. The Junior Clinical Neurologist (Service Intern) post will provide support in the provision of clinical neurology services.

This is an opportunity to develop your clinical skills in a well-equipped and supportive academic environment. The successful candidate will be required to participate in the practical instruction of veterinary students and the out-of-hours rota, and to support the training programme for Clinical Training Scholars in Neurology.

The experience and practical skills gained in the twelve months will enable candidates to identify specific fields of Neurology in which to specialise, in preparation for a Senior Clinical Training Scholarship programme.

Candidates must be members of the RCVS or hold a degree qualifying them for membership, and have at least 12 months' experience in companion animal practice.

Closing date for applications: 17 April 2017

Interview date: 9 May 2017

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Further information about the role: click on link below To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not done so already) and log in before completing the online application form.

Please quote reference PP11819 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 28, 2017.

University of Cambridge Department of Veterinary Medicine West Cambridge Site

Salary: Research Assistant - £25,298.00 - £29,301.00

Research Associate - £29,301.00 - £38,183.00

Limit of Tenure: The funds for this position are available until 23 April 2020 in the first instance.

Applications are invited for a Research Assistant/Research Associate position in bacterial genomic epidemiology to start from 1 May 2017 or as soon as possible after this date, funded by the Medical Research Council through a Joint Programming Initiative on Antimicrobial Resistance international consortium project aiming to understand the transmission of antimicrobial resistance (AMR) at the genome, bacterium, national and international levels. This research is highly topical and relevant to both human and animal health. The work will be conducted within a One Health framework, consistent with research recommended by several international policy reviews, including the Food and Agriculture Organization, the World Organisation for Animal Health, and the World Health Organization.

The focus of the research is on extended-spectrum cephalosporin (ESC) resistance in Enterobacteriaceae, comparing bacteria, host populations (humans and domestic animals) and countries. Collaborators providing data are from Canada, France and Germany. A suite of quantitative approaches will be used, including epidemiological, phylodynamic and bioinformatics methods, analysing whole genome sequences. This post will be based in Cambridge led by Dr Alison Mather and Professor James Wood, with opportunities to visit the other consortium partners.

Applicants will have a PhD (or have submitted a PhD) in epidemiology, computational biology or a related quantitative discipline, and experience working with next generation sequencing data. Desirable skills will be experience in mathematical modelling and programming skills in Unix, python and R. The candidate must value teamwork and collaboration, be able to work independently, and have excellent communication and interpersonal skills.

Some of the main duties will include: - Selection of isolates for whole genome sequencing (WGS) from bacterial collections held by collaborators - Epidemiological analysis of bacterial collections - Analysis of WGS data to assess transmission and evolution of bacteria and AMR

A full detailed description of the key responsibilities is available in the further particulars file.

Where a PhD award is pending (e.g, the thesis has been submitted but has not yet been examined), an appointment will be made as a Research Assistant and amended to Research Associate when the PhD is awarded.

For informal enquires please contact: Natalie Wills nw366@cam.ac.uk

Closing date: 17 April 2017

Interviews will be held on 8 May 2017

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

To submit an application for this vacancy, please visit the vacancy pages on the following website: http://www.jobs.cam.ac.uk/ This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) before completing the online application form. Further particulars for the role and information about the Department www.vet.cam.ac.uk.

Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please quote reference PP11624 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Senior Clinical Training Scholarship in Anaesthesia

From Jobs at the University of Cambridge. Published on Mar 28, 2017.

UNIVERSITY OF CAMBRIDGE DEPARTMENT OF VETERINARY MEDICINE THE QUEEN'S VETERINARY SCHOOL HOSPITAL

Start Date 1st September 2017

Scholarship award: £22,059.00 in year one.

The Scholarship is for one year in the first instance, renewable for periods of one year up to a total of three years.

The Scholarship provides an outstanding opportunity to receive specialist training in all aspects of veterinary anaesthesia. You will be required to register for a post-graduate qualification by enrolling onto the European Diploma in Veterinary Anaesthesia and Analgesia.

You will receive core training in all aspects of academic and clinical anaesthesia, pain management and peri-operative medicine (including critical care) in both small and large animals at the Queen's Veterinary School Hospital. You will also be required to undertake and publish a research project, and participate in the small-group teaching of veterinary students. The training programme is approved by the European College of Veterinary Anaesthesia and Analgesia.

You must be a Member of the Royal College of Veterinary Surgeons, or hold a veterinary degree qualifying you for membership. Membership will be required prior to commencing the Scholarship. A minimum of twelve months experience in a rotating internship or at least two years' experience in general practice is essential. Full details of the person specification for the scholarship are supplied in the information pack.

Informal discussion: contact Natalie Wills nw366@cam.ac.uk

Closing date: 20 April 2017

Interview date: 11 May 2017

Application form (SCTS1) and information pack about the Scholarship: download from link below.

Please send a completed application form, curriculum vitae, and covering letter by email to vetmed@hermes.cam.ac.uk or to Melissa Large, Department of Veterinary Medicine, Madingley Road, Cambridge, CB3 OES,

Please quote reference PP11813 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Senior Maintenance Technician

From Jobs at the University of Cambridge. Published on Mar 28, 2017.

Re-advertisement - previous applicants need not apply.

Applications are invited for the new position of Senior Maintenance Technician to be part of the maintenance team working under the direction of the Deputy Facilities Manager, responsible for the day to day maintenance of this large and busy Department. Duties will include a wide range of planned, preventative and reactive maintenance tasks in addition to minor installations and modifications of building services and equipment.

The successful candidate will work in all areas of the Department including plant rooms, laboratories, controlled environments and support areas with a high degree of autonomy. You will be expected to organise yourself and other available resources in a way that minimises disruption to research activities.

The role holder will supervise two Maintenance Technicians responsible for the allocation of work and ensuring the maintenance team works efficiently to successfully plan and implement a wide variety of infrastructure and maintenance work. You will have a flexible approach to work and be expected to provide support outside of normal working hours in an emergency.

This is a varied role which requires substantial mechanical and electrical engineering knowledge and skills along with excellent communication, problem-solving and team working skills. Previous experience in a similar role is essential and a relevant qualification would be advantageous.

The Department provides a welcoming and collaborative environment with a wide-range of family-friendly benefits and development opportunities.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please complete the online application as fully as possible.

The closing date for applications is midnight on Tuesday 18 April 2017.

Please quote reference PM11461 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Receptionist

From Jobs at the University of Cambridge. Published on Mar 27, 2017.

The Department of Psychology is seeking a friendly and enthusiastic full time Receptionist to provide a professional and welcoming reception for all staff, students and visitors to the Department.

The post holder will be based in the main Psychology building and is responsible for dealing with and directing visitors, answering telephone and email inquiries to the Department. The post holder deals with incoming and outgoing mail and receipt of deliveries. The Receptionist is also assisting with the day-to-day security of the main building of the Department.

Applicants should have good interpersonal and communication skills and a good standard of written and spoken English. The role requires good IT skills and proven customer service experience either in a reception area or other customer facing role. The role holder must be able to multi task and work calmly under pressure to fulfil their duties and present a helpful attitude to visitors or callers.

Further information may be downloaded below.

Informal enquiries about this post may be directed to: Sonia Brignell, spb38@cam.ac.uk

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PJ11787 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate

From Jobs at the University of Cambridge. Published on Mar 23, 2017.

Postdoctoral Research Associate - biotechnological exploitation of photosynthetic microorganisms

The project aims to study the use of photosynthetic microorganisms and macroalgae for the remediation of waste materials.

Applicants should have well-established experience in the biochemistry, growth and genetic manipulation of microorganisms, including photosynthetic species. They should also have well-established experience in routine molecular biological techniques (such as generation of constructs for microbial genetic manipulation). Experience in the biology of macro-algae and/or the bioinformatic analysis of transcriptomic data would also be desirable, but not essential.

The project is a collaborative one between the laboratories of Prof C J Howe in the Department of Biochemistry and Prof J S Dennis in the Department of Chemical Engineering and Biotechnology.

The post is available immediately.

Limited funding: The funds for this post are available for 11 months in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Any enquires regarding the application process can be directed to Adriana Dote (personnel@bioc.cam.ac.uk).

Informal enquiries may be made to Prof C J Howe (c.j.howe@bioc.cam.ac.uk).

Please quote reference PH11775 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 23, 2017.

Applications are invited to recruit an enthusiastic post-doctoral scientist on a BBSRC funded research project, investigating infant lipid metabolism with the aim to identify robust lipidomic markers which reflect healthy growth and development. The project is led by Dr Albert Koulman (director of the NIHR BRC Core Metabolomics and Lipidomics Laboratory and the NIHR BRC Nutritional Biomarker laboratory), in close collaboration with the department of Paediatrics (Prof David Dunger) and King's College London (Dr Sophie Moore).

The overall aim of the project if develop and establish lipid profiling from dried blood spots as biomarkers, which will therefore deliver a robust indicator of metabolic efficacy of infant nutrition and will thus provide a practical tool that can assist the study of feeding strategies and development of new infant formulae for infants that cannot or should not be fully breastfed. The project is part of a larger effort to understand how lipid metabolism is influenced by infant nutrition and contributes to metabolic programming.

Applications are invited from researchers with a PhD, and a proven track record in working with metabolomics or lipidomics data (evidence of one or more high impact publications in a relevant research field). Previous experience with research in paediatrics or infant growth and development is desired. Applicants should have excellent interpersonal and communication skills, and the ability to work as part of a team as well as independently when required.

Fixed-term: The funds for this post are available for 2 and half years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Any enquires regarding the application process can be directed to Adriana Dote (personnel@bioc.cam.ac.uk).

Informal enquiries can be sent to Dr Albert Koulman (ak675@medschl.cam.ac.uk).

Interviews will be taking place towards the end of April 2017.

Please quote reference PH11774 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Postdoctoral Research Associate (Maternity Cover)

From Jobs at the University of Cambridge. Published on Mar 23, 2017.

We are looking for a postdoctoral researcher for maternity cover to work with Prof. William Sutherland on the Conservation Evidence project in the Conservation Science Group. Work will involve overseeing the production of comprehensive reviews of scientific evidence on the effectiveness of interventions for the conservation of biodiversity and ecosystem services. Reviews will be conducted using methods developed by the Conservation Evidence group at Cambridge (www.conservationevidence.com).

You must have excellent writing skills and a strong interest in biodiversity. The successful candidate will work closely with the Conservation Evidence team in Cambridge, and with external synopsis authors and advisory boards. The project is funded by the MAVA Foundation.

Essential required skills

  • A PhD, or equivalent experience, in an area related to biodiversity

  • Detailed knowledge of biodiversity and knowledge of ecosystem services

  • Ability to efficiently understand and extract relevant information from scientific papers

  • Ability to write clear, concise summaries of scientific papers, quickly and accurately, using a standardized style

  • Demonstrable ability to effectively edit work to ensure it includes priority information and follows a specific protocol and style

  • Good general understanding of ecological statistics and experimental design

  • Fluent at writing in English

  • Demonstrable ability to ensure that projects are completed by collaborators to the stage of good quality reports/publications on time

  • Ability to travel to meetings in the UK

Duties and responsibilities

  • Overseeing the production of Conservation Evidence Synopses following our specific protocol. This includes overseeing the formation of international advisory boards, lists of all relevant interventions and literature search methods, and reviewing summaries of the evidence, the draft and final synopses.

  • Helping to seek and secure funding for the project.

  • Overseeing work on collaborative projects that Conservation Evidence is involved with.

Interview date: 26th April 2017

Start date: position available immediately

Fixed-term: This post is for maternity cover for up to 12 months or the return of the post holder, whichever is the earlier.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PF11784 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Visitor Services Assistant (Part Time)

From Jobs at the University of Cambridge. Published on Mar 23, 2017.

We are looking to recruit a Visitor Services Assistant 16 hours per week within the Visitor Services Team of the Botanic Garden, working Saturday and Sunday each week.

Responsible to the Head of Visitor Services, the Visitor Services Assistant team provide excellent front of house service. They welcome visitors, staff the ticket offices, sell publications and membership, patrol the Garden to ensure the safety and security of its collections, buildings and visitors, ensure public areas are clean and fully stocked, and assist in setting up rooms for events and activities. Includes working outside and undertaking practical tasks in a wide variety of weather conditions.

The candidate should be educated to at least GCSE level standard or equivalent and be committed to providing first-class visitor service. Previous experience of cash-handling and cash tills is required and the ability to deal with people at all levels.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

For any questions relating to this recruitment please contact admin@botanic.cam.ac.uk

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 22, 2017.

Structural studies of mosquito vector immunity

A three-year postdoctoral position for a biochemist/structural biologist is available in the Department of Biochemistry, University of Cambridge, England. The Department has state-of-the-art equipment and facilities, including crystallization robots, NMR, cryo-EM, biophysics, metabolomics, and easy access to synchrotron beamlines and confocal microscopy. The postdoctoral position is available immediately with Dr Monique Gangloff following a New Investigator Research Grant award to study mosquito vector innate immunity.

We are looking for a highly motivated postdoctoral Fellow with a strong interest in Structural Biology, Signalling and Vector Biology. The project investigates the structure and function of mosquito immune receptors that have diverged and undergone gene duplication under the influence of selective pressure by pathogenic parasites and viruses, potentially acquiring new functions relating to host-pathogen homeostasis.

You will gain in-depth experience in Structural Biology by determining receptor-ligand complex structures using either X-ray crystallography or complementary techniques such as Small Angle X-ray Scattering (SAXS) and high-resolution cryo-EM. You will establish cell-based assays to verify predicted structure-function relationships. It is expected that you present your results at scientific conferences and write/publish scientific papers in high-quality, peer-reviewed journals.

Essential requirements:

  • PhD in biochemistry, molecular and cellular biology, or related disciplines

  • Strong background in construct design, molecular biology and protein purification

  • Significant experience with biophysical and structural techniques

  • Strong organizational and interpersonal skills

  • A proven record of work published in reputable scientific journals.

Desirable requirements:

  • Experience of protein expression methods using prokaryotic and eukaryotic in particular insect cell expression systems

  • Proficiency in cell-based signaling assays to establish novel luciferase reporter assays in mosquito cell lines

  • Knowledge in ligand fishing experiments using Mass Spectrometry

  • Experience of working with Protein Crystallization, X-ray crystallography, SAXS, cryo-EM, Isothermal Titration Calorimetry and Surface Plasmon Resonance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

The application should include a cover letter describing the candidate's research interests and motivation to apply, the CV and list of publications, and contact details of three referees.

Any enquires regarding the application process can be directed to Adriana Dote (personnel@bioc.cam.ac.uk).

Informal enquiries are welcome and can be made to Dr. Monique Gangloff (mg308@cam.ac.uk).

Please quote reference PH11763 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Museum Volunteer Coordinator (Part Time, Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 21, 2017.

The University Museum of Zoology is undertaking a major re-development project, supported by the Heritage Lottery Fund and it is due to re-open in late 2017. We are inviting applications for a new post of Museum Volunteer Coordinator. The position is a fixed term contract funded by the Heritage Lottery Fund and it is available until 31st December 2018 at the University of Cambridge.

The role is within the Museum of Zoology that contains collections designated as being of national and international importance. This post is crucial in the development and delivery of an exciting new volunteer programme at the Museum. You must be an enthusiastic person that can help the museum to deliver an excellent visitor experience and who loves to communicate and interact with a wide range of people.

Some experience of delivering volunteer training programmes within a museum environment would also be advantageous.

Interviews will take place on Thursday 27th April 2017, if you have not heard by this date please assume you have not been shortlisted.

Fixed-term: The funds for this post are available for up to 31 December 2018.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a Disclosure and Barring Service check (enhanced with children and adults' barred lists) and a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PF11750 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PA to Head of Department (Maternity Cover)

From Jobs at the University of Cambridge. Published on Mar 21, 2017.

University of Cambridge Department of Veterinary Medicine

Limit of Tenure: 12 months maternity cover or the return of the post holder, whichever comes first.

Applications are invited for a PA position from the end of May/beginning of June working with Professor James Wood, Head of Department of Veterinary Medicine and Alborada Professor of Equine and Farm Animal Science. Professor Wood heads up a research group, the Disease Dynamics Unit, an interdisciplinary group, using state-of-the-art methods from epidemiology, mathematics and biological sciences, to study the growth, spread and control of pathogens within and between hosts.

The role holder will provide comprehensive administrative and secretarial support to Professor Wood covering his Departmental and research activities, ensuring the effective management of his diary, making travel arrangements and management of the Professor's research grants, as well as providing general administration to the research group. For more information please refer to the further information document.

The successful candidate must have relevant and extensive secretarial and administrative experience in a busy work environment. They will have excellent communication skills (written and oral) and be highly motivated. They will also have excellent organisational skills with the ability to organise their own workload, working calmly and efficiently under pressure.

It would be desirable to have a knowledge of (or ability to learn quickly) the University Financial System and prior work experience in the higher education sector.

Closing Date: 3 April 2017

Interviews will be held: 21 April 2017

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

For informal enquiries please contact Natalie Wills on nw366@cam.ac.uk To submit an application for this vacancy, please click on the link 'Apply online' or visit the vacancy pages on the following website: www.jobs.cam.ac.uk This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) before completing the online application form. Further particulars for the role and information about the Department www.vet.cam.ac.uk.

Please quote reference PP11427 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Visitor Services Assistant (Part Time 32 hours p/w)

From Jobs at the University of Cambridge. Published on Mar 21, 2017.

We are looking to recruit a Visitor Services Assistant 32 hours per week within the Visitor Services Team of the Botanic Garden, Friday to Monday including all Bank Holidays that fall on those days and weekends.

Responsible to the Head of Visitor Services, the Visitor Services Assistant team provide excellent front of house service. They welcome visitors, staff the ticket offices, sell publications and membership, patrol the Garden to ensure the safety and security of its collections, buildings and visitors, ensure public areas are clean and fully stocked, and assist in setting up rooms for events and activities. Includes working outside and undertaking practical tasks in a wide variety of weather conditions.

The candidate should be educated to at least GCSE level standard or equivalent and be committed to providing first-class visitor service. Previous experience of cash-handling and cash tills is required and the ability to deal with people at all levels.

Interviews: expected week commencing 1 May 2017

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

For any questions relating to this vacancy, please e-mail admin@botanic.cam.ac.uk

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 21, 2017.

Applications are invited for a Post-doctoral Research Associate position in the group of Professor Henrik Jönsson at the Sainsbury Laboratory Cambridge University, to carry out fundamental research in the field of Computational Morphodynamics in plants. The project will focus on theoretical modelling of plant cell wall mechanics and growth at a cellular level. The focus will be on the plant shoot, but the models will also be extended to other plant tissues such as the hypocotyl. The models will be developed in close connection with experimental data, and the successful applicant will have the opportunity to develop skills in advanced live microscopy.

Applicants must have, or be close to obtaining a PhD in computational biology, physics, applied mathematics, computer science, engineering or related field. Proficiency in finite element models of mechanics of materials is required, and experience in working on models of plant cell walls is desirable. Candidates must have advanced knowledge of mechanical modelling and experience in the following areas: finite element modelling, C++ software development. Expertise in systems biology and/or theoretical biophysics would also be advantageous.

The successful candidate will be fully involved in the basic research in these areas whilst also writing up their research work for presentation and publication. The post holder may be required to assist in the supervision of student projects, provide instructions to students and deliver seminars relating to their research area.

Good communication skills are essential as the post holder will need to work well in a team and collaborate with other researchers in the Institute. Candidates should also demonstrate a history of science communication (e.g. presentations, outreach activities, teaching) and have a proven track record of scientific publication.

The Laboratory provides a welcoming and collaborative environment with a wide-range of family-friendly benefits and development opportunities. More about the Sainsbury Laboratory and details of what the University offers to employees, can be found at: http://www.slcu.cam.ac.uk/.

Fixed-term: The funds for this post are available for 2 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please ensure that you upload a copy of your full CV, a covering letter highlighting your suitability for the position and contact information of three referees.

Scientific enquiries apart from the formal application should be directed to Professor Henrik Jönsson at henrik.jonsson@slcu.cam.ac.uk.

The Sainsbury Laboratory receives a high volume of applications. If you have not heard from us within three weeks of the closing date, please consider your application as unsuccessful on this occasion.

Please quote reference PT11751 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 20, 2017.

Applications are invited for a Postdoctoral Research Associate position in Prof. Alison Smith's lab as part of the Cambridge OpenPlant Synthetic Biology Centre. OpenPlant is a joint initiative between the University of Cambridge, John Innes Centre, TSL and the Earlham Institute, funded by BBSRC and EPSRC, which promotes interdisciplinary exchange, open technologies and responsible innovation for sustainable agriculture and conservation.

This position is aimed at generating novel regulatory elements based on riboswitches for plant and algal biotechnology. Riboswitches are sequences within the mRNA that respond to metabolites or other small molecules to alter production of the encoded protein, and offer flexible and tuneable elements to control transgene expression.

You will join the multidisciplinary team in central Cambridge at the Department of Plant Sciences, where the group focuses on a range of algal molecular biology and biotechnology projects. The principal tasks will be:

i) To identify riboswitches from diverse organisms that have already been characterised and shown to regulate transgene expression in their native hosts. These RNA sensors will be used in the generation of new expression platforms that allow metabolite-inducible expression of transgenes. To meet this objective the design, construction and testing of the different elements of these expression platforms will follow synthetic biology principled approaches.

ii) To test the responsiveness of the different riboswitches for the control of transgene expression in different photosynthetic eukaryotic organisms (including microalgae and plants).

Experience in recombinant DNA techniques is essential. Knowledge of systems or synthetic biology is highly desirable, as is familiarity with microbiology, metabolic engineering, and/or metabolism. The successful candidate should have the capacity to communicate effectively, work as part of a team, and take a lead role in the design and execution of the research programme as required. In addition, the PDRA will be expected to be involved in supporting junior scientists in the laboratory. You should hold a PhD in a relevant subject.

Fixed-term: The funds for this post are available for 2 years, in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please upload your CV with publication list, and covering letter to support your application.

The interviews are scheduled to be held in the week beginning 8 May 2017.

Please note if you have not received any news from us 1 month after the closing date you should consider that on this occasion your application has been unsuccessful.

Please quote reference PD11744 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Building Services Technician

From Jobs at the University of Cambridge. Published on Mar 17, 2017.

THIS IS A RE-ADVERTISEMENT. PREVIOUS UNSUCCESSFUL APPLICANTS NEED NOT APPLY.

A Building Service Technician (Plumbing Lead) is required to work in the University of Cambridge, Department of Biochemistry.

The successful applicant will join a small proactive team of three staff under the guidance of the Building Services Manager. The duties of the role include to support both teaching and research within The Department by providing a frontline service. Further duties of the role will be to monitor key plant and equipment, respond to breakdowns, conduct minor plumbing and building repairs / alterations, establish and carry out a range of routine and planned maintenance and minor building works as directed. Since an additional key part of this role will be to act as the Plumbing Lead within The Maintenance Team, the successful candidate will be competent and knowledgeable in the operation of general water, Air Handling Units and heating plant and the setting of control equipment associated with domestic, laboratory, softened and deionised water services.

One of the largest Department's in The School of Biological Sciences, Biochemistry has varied research activities using complex plant and services to maintain a workable environment for researchers and equipment. The Department occupies two main buildings; both being highly serviced by a large amount of plant equipment supporting a number of high-specification Laboratories. The successful Candidate will be expected to familiarise themselves with the numerous plant rooms in order to guide engineers and contractors when required.

The successful applicant will be able to work in a team, be computer literate and with a good attention to detail. Communication and interpersonal skills are essential as the role holder is required to deal with different personnel both from within The University and outside contractors on a daily basis.

Candidates should hold an industry recognised qualification (eg., BTEC National certificate, City & Guilds, NVQ or equivalent).

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Enquires relating to this role should be directed to Roger Biamonti (rb686@cam.ac.uk).

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Any enquires regarding the application process can be directed to Adriana Dote (personnel@bioc.cam.ac.uk).

Please quote reference PH11380 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 16, 2017.

A position is available for a highly motivated post-doctoral research associate to work on the function of chromatin during plant meiosis. The successful applicant will join Dr. Sebastien Andreuzza in the group of Dr. Ian Henderson in central Cambridge at the Department of Plant Sciences.

Using Arabidopsis as a model, the project will focus on establishing a method to isolate nuclei from meiotic cells specifically. Additional approaches will include chromatin immunoprecipitation and whole RNA isolation, followed by sequencing (ChIP-seq and RNA-seq). This will provide an invaluable tool and resources to understand how epigenetic information impacts meiotic functions such as recombination. Findings in the model system Arabidopsis will provide a useful framework to investigate similar processes in crops, and will have the potential to drive efforts to improve breeding methods.

The position is available for an immediate start. The successful candidate will have a strong background in plant molecular biology, including a PhD in a relevant area (or have submitted a PhD by the time of appointment). Experience with chromatin biology, RNA work, isolation of nuclei, and deep-sequencing technologies will be advantageous. Information on the laboratory is available at http://www.plantsci.cam.ac.uk/research/ianhenderson.

Fixed-term: The funds for this post are available until 31 March 2018 in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please upload your CV with publication list, and covering letter to support your application.

Please note if you have not received any news from us 1 month after the closing date you should consider that on this occasion your application has been unsuccessful.

Please quote reference PD11715 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Administrator, Centre for Trophoblast Research (Part Time, Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 16, 2017.

The Centre for Trophoblast Research (see http://www.trophoblast.cam.ac.uk/) is looking for an experienced and well organised person to work as an Administrator from 1 May 2017, supporting the Director, Professor Graham Burton, and ensuring the smooth running of the Centre.

The successful candidate will effectively run the Centre's administrative and financial processes. You will promote the Centre by maintaining the web site, organising seminars, talks and events, arranging the production of publicity material, monitoring the finances and liaising with the Departmental Communications Co-ordinator. You will support staff, fellows and graduate students funded by the Centre and give advice to academic visitors on visa requirements etc. and arrange accommodation when necessary.

You should have experience of working in a busy administrative role together with excellent written and verbal communication skills, proficiency in the use of Microsoft Office and the capability to learn new computing skills when required. Accuracy and attention to detail are particularly important in this role as well as having the ability to work effectively under pressure and to meet deadlines.

This post is offered at 20 hours a week, spread equally over five days.

Fixed-term: The funds for this post are available for 3 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please complete the online form as fully as possible.

See link to the further particulars for the post below.

Please quote reference PM11713 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Rosetrees Trust PhD: Neonatal Neurogenetic Biomarkers of Dyslexia Risk

From Jobs at the University of Cambridge. Published on Mar 15, 2017.

Applications are invited for a 3-year Rosetrees PhD studentship on neonatal neural and genetic biomarkers of dyslexia risk. The studentship will start in October 2017 at the Department of Psychology, University of Cambridge. The successful candidate will conduct research under the supervision of Dr Victoria Leong (http://www.baby-linc.psychol.cam.ac.uk/) and Prof Zoe Kourtzi, in collaboration with Dr Topun Austin.

Dyslexia is a congenital, lifelong disability in language learning that affects up to 10% of individuals worldwide. Genetic models suggest that the dyslexic brain may be 'mis-wired' during fetal development as a result of faulty axonal guidance mechanisms. Mis-wiring disrupts neuronal oscillatory mechanisms in the auditory cortex that support neural processing of speech, leading to inaccurate speech sound representations that map poorly to letter symbols during reading.

We have previously found that neonates with a high (familial) genetic risk for dyslexia show poorer neural oscillatory processing of speech sounds at birth. We have further identified a single nucleotide polymorphism (SNP) in one dyslexia susceptibility gene, ROBO1, that may significantly predict individual differences in the neonatal neural response to speech. The PhD project builds on these findings to assess the long-term developmental outcomes of neonates with low-risk vs high-risk genetic and neural profiles, in relation to the early home language environment. The specific aims of the research project are to:

(1) Understand how ROBO1 (and other dyslexia susceptibility) genotypes interact with the language environment to affect language outcomes in young infants;

(2) Identify key neural or environmental protective factors that confer resilience to high-risk infants who show normative language development despite their high-risk status;

The PhD candidate will conduct a longitudinal assessment of the development trajectory of 50 high-risk and 50 low-risk neonates over their first 1.5 years of life. Each neonate will be assessed at birth, 6, 12 and 18 months to map their brain development and language development in relation to their risk genotype and the quality of their home language environment.

Eligibility and Funding:

Candidates should have a first or upper second class degree in neuroscience, psychology or molecular biology/genetics and meet the University of Cambridge entrance requirements - see: http://www.graduate.study.cam.ac.uk/entry-requirements

Prior experience of working with infants and/or children in experimental settings, and a good understanding of developmental psychology (in particular, early language development) is essential. Experience and knowledge of EEG acquisition and analysis methods would be highly desirable. The successful candidate should also possess good social and communication skills, in order to interact sensitively with expectant/postpartum mothers and their newborn infants.

The successful candidate will receive a fixed stipend of £17,457 per annum for 3 years. No additional support is available for fees.

Candidates from Overseas will be funded at the same rate, and therefore should only apply if they have sufficient additional personal funding to cover the Overseas rate of fees as well as living expenses.

Informal enquiries about the project may be made to Dr Victoria Leong (vvec2@cam.ac.uk)

Application process:

To apply please e-mail (i) a research statement outlining your suitability, why you are interested in pursuing a PhD in this area, your background and research interests, (ii) your CV stating your citizenship and any relevant research experience (iii) copies of your academic transcripts and (iv) contact details for two academic referees (one of whom should be a project supervisor) to Mrs Dawn Ellis (dle31@cam.ac.uk) by Wednesday 5 April 2017. Please add 'Rosetrees Trust PhD Studentship: Neonatal Neurogenetic Biomarkers of Dyslexia Risk' to the subject line of your e-mail.

Shortlisted candidates will be invited to an interview on Tuesday 18th April.

Once the successful applicant is informed of the outcome, they will be required to complete the University's GRADSAF application form, which will need to be submitted by Thursday 27th April.

Please quote reference PJ11706 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Domestic Assistant (Part Time)

From Jobs at the University of Cambridge. Published on Mar 13, 2017.

The Department of Pathology has a number of vacancies for part-time, early morning or evening Domestic Assistants based at its site in central Cambridge. Working as part of a team, the post-holder will have responsibility for cleaning, portering and general housekeeping. Duties include cleaning offices, laboratories, meeting rooms, canteen, lavatories and other communal areas. Please see the Further Information document below for more information. A range of hours and working patterns across Monday to Friday early morning and late afternoon/evening are available and will be agreed with the successful candidates.

The posts are managed through the Department's Facilities Office with day-to-day supervision coordinated by the Domestic Services Supervisor. The Department of Pathology is split across two sites, and on occasions the post-holder may be required to provide cover at its site in Addenbrooke's Hospital.

Experience of cleaning and an NVQ 1 or 2 in Cleaning Methods would be helpful, although full training will be given. Good communication skills are essential, along with the ability to follow both written and verbal instructions and to understand user and safety instructions regarding the use of chemicals. Due to the nature of the work, candidates are expected to have a good level of physical fitness. A welcoming manner, reliability, professionalism and a high level of attention to detail are also required.

Previous applicants need not apply.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

General enquiries regarding this position should be directed to Irene Piper, jobs@path.cam.ac.uk or 01223333940 .

Please quote reference PK10083 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Teaching and Graduate Administration Assistant (Maternity Cover)

From Jobs at the University of Cambridge. Published on Mar 08, 2017.

Applications are invited for Teaching and Graduate Administration Assistant Maternity Cover position to work in the Teaching and Graduate Office of Department of Zoology.

Zoology is a large, centrally-located Department. The Department has the highest standards in research and teaching, combined with a friendly and supportive work environment. The Teaching and Graduate Office of the Department supports the strategic and operational responsibilities of the Deputy Head of Department and the Chair of the Departmental Graduate Education Committee to assist a very large number of students, lecturers and examiners.

In this important role, you will provide support to academics, undergraduate and graduate students and assistant staff, to help ensure that all aspects of undergraduate and graduate administration in the Department run smoothly throughout the year.

We are looking for a well-organized person with great communication skills and previous office/administrative experience who can work with a high degree of accuracy, often to tight deadlines.

Maternity cover: The post is available from 1 May 2017 or soon after for 12 months or the return of the post holder, whichever is the earlier.

Secondment applications from internal candidates are welcomed.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PF11641 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

BBSRC iCase 4 Year PhD Studentship (Lee - Fellows)

From Jobs at the University of Cambridge. Published on Mar 08, 2017.

Collaborative PhD Studentship with Astra Zeneca

Elucidating cellular behaviours and potential oncogenicity utilising in vitro organoid culture system Project Description

Department name: Cambridge Stem Cell Institute, University of Cambridge Supervisors: Primary: Dr Joo-Hyeon Lee (University of Cambridge) and Dr Mick Fellows (AstraZeneca)

Assessment of cell transformation (i.e. the acquisition of malignant characteristics in morphology, growth control or function) has proven problematic to model in vitro. The soft agar cell transformation assay has been validated, but only in a limited number of immortalised or mixed population embryonic cells and the specificity of the assay has been questioned. Furthermore, the genetic basis of cell transformation in this model has not been fully delineated (Harvey et al 2015, Creton et al 2012). The use of genetically and phenotypically stable organoids derived from single human stem cells (Schwank et al 2013) should provide a better model for cell proliferation and transformation.

Organoids have the advantage of 3D morphology, being able to be derived from several major organs and can be engineered to demonstrate proliferative effects by introducing a cell type specific ki67 fluorescent protein to tag. Organoid stability is also dependent on several growth factors and inhibitors e.g. EGF, Wnt, BMP inhibitor, TGFb inhibitor. Growth following withdrawal of these factors, which are known pathways implicated in cancer genesis, will be indicative of cell phenotypic and/or transformative changes. It is also proposed that this model could be used to investigate mechanisms of pro-oncogenicity and also the potential off-target effect of genome editing by CRISPR/Cas9, for which there is currently an unmet need for in vitro assays to assess concerns around inappropriate editing in oncogenes.

The project will develop organoids from a variety of tissue sources, including organoids with the ki67 tag, and assessment of proliferative and morphological changes following withdrawal of growth factors after treatment with reference carcinogens and following transfection with specific and promiscuous guide RNA and associated Cas9 protein. Comparative data will be generated from alternative in vitro methodologies to analyse cell transformation e.g. the soft agar assay. Reference carcinogens will be analysed in this assay along with the potential of CRISPR/Cas9 editing to induce cell transformation (which has not been previously assessed). The student will also use next generation sequencing technologies to identify specific genes involved in morphological changes in both cell and organoid cultures. Success will provide new and more relevant model for understanding and assessment of morphological changes and carcinogenesis.

Eligibility and Funding

This studentship covers 4 years' UK/EU tuition fees (see below for EU eligibility requirements) and a maintenance stipend.

BBSRC funding is available for UK nationals and EU students who meet the residency requirements. Further information about eligibility for funding can be found on the BBSRC website: http://www.bbsrc.ac.uk/documents/studentship-eligibility-pdf/

How to Apply

Please visit our website to find out more, and about the application process itself: http://study.stemcells.cam.ac.uk/study/otheropportunities/#BBSRC-iCASE-ASTRAZENECA.

Deadline for receipt of applications: midnight on Friday 31st March 2017.

References

Harvey, Howe et al. Mutagenesis. 2005 Jan;20(1):51-6. http://mutage.oxfordjournals.org/content/20/1/51.long

Creton, Aardema et al. Mutagenesis. 2012 Jan;27(1):93-101. http://mutage.oxfordjournals.org/content/27/1/93.long

Schwank, Koo et al. Cell Stem Cell . 2013 Dec 5;13(6):653¿58. http://www.sciencedirect.com/science/article/pii/S1934590913004931

Please quote reference PS11650 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 06, 2017.

A short term post-doctoral research position is available within the Department of Plant Sciences to work on the Chlamydomonas photosynthetic carbon concentrating mechanism (CCM) with Professor Howard Griffiths in the Physiological Ecology Group. Induction of the CCM occurs following transfer of cells from high to ambient CO2 concentrations. We hope to identify key components and regulatory processes which facilitate inorganic carbon transport for Rubisco, which also becomes aggregated into a starch-bound microcompartment, known as the pyrenoid.

The project is part of a collaborative programme between Princeton (formerly Stanford), Edinburgh and JIC Norwich, and is part of the Photosynthesis Ideas Lab programme CAPP2 (Combining Algal and Plant Photosynthesis), funded by BBSRC UK and NSF.

Our current interests are focussed on characterising the physiological function of genes found to be associated with induction of the CCM, and associated with either active inorganic carbon transport or chloroplast pyrenoid formation. Some have been identified from an insertional mutagenesis screen undertaken by our US colleagues. Additional elements also involve more detailed analysis of mutants lacking a pyrenoid, or with mis-localised pyrenoids, in order to determine the associated structural elements required for pyrenoid formation and CCM expression.

Expertise is required in microbial molecular biology, gene expression analysis and protein purification, with knowledge of methods for assessing post-translational modification also preferable. This position can be filled by an appropriate candidate at research assistant or research associate level, depending on relevant qualifications and experience. Appointment at research associate level is dependent on having a PhD (or equivalent experience). Where a PhD has yet to be awarded appointment will initially be made as a research assistant and amended to research associate when the PhD is awarded.

Contact: Howard Griffiths hg230@cam.ac.uk; http://www.plantsci.cam.ac.uk/research/howardgriffiths.html Fixed-term: The funds for this post are available until 28 February 2018 in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please upload your CV with publication list, and covering letter to support your application.

Please note if you have not received any news from us 1 month after the closing date you should consider that on this occasion your application has been unsuccessful.

Please quote reference PD11622 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 06, 2017.

Applications are invited for a research assistant post starting from 3 July 2017 until 30 September 2017, to join a research programme with Prof. Trevor Robbins and Dr. Johan Alsiö at the Department of Psychology. The successful applicant will take part in our basic research on the neural basis of reinforcement learning and cognitive flexibility in rodents, with the goal to understand human disorders characterised by inflexible behaviour, e.g. drug addiction and obsessive-compulsive disorder.

The successful candidate will be expected to manage and conduct experiments under supervision by senior researchers. These experiments combine neuropharmacology, chemogenetics, gene silencing, and gene expression profiling with behavioural testing in touchscreen paradigms. Duties include behavioural testing, regulated procedures (to include surgical techniques, systemic injections, microinfusions into the brain, brain stimulation, tissue collection and perfusions), and histological processing of biological material (e.g. cannula placements or expression of transgenes). The post holder will also be expected to contribute to the analysis and interpretation of results and will present their findings at lab meetings.

We are looking for an applicant who has substantial experience with rodent behavioural testing and a keen interest in behavioural neuroscience. A personal licence (PIL) to perform regulated procedures in the UK is required for this position; training in stereotaxic techniques and/or in-vivo microdialysis and electrochemistry would also be valuable. In addition, applicants should have excellent communication skills, be comfortable planning and organising behavioural experiments, and be able to work as part of a team.

If you have a strong background in behavioural neuroscience or neuropharmacology and if you wish to develop your scientific skills further in a collaborative and productive environment, we would like to hear from you.

Informal enquiries can be made to Dr. Johan Alsiö (ja476@cam.ac.uk).

Further information may be downloaded below.

Please note that there is some flexibility with regard to starting date and working hours (e.g. part time) for this post.

Fixed-term: The funds for this post are available for up to 3 months from 3 July 2017 until 30 September 2017.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PJ11604 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 03, 2017.

Applications are invited for a Postgraduate Research Assistant at the Department of Pathology, University of Cambridge, based in central Cambridge. The lab is interested in developing our understanding of the role of immune cells in placenta development and homeostasis, in both health and disease.

The work will involve human placenta processing to isolate and characterize cells of interest, in particular macrophages. The candidate will become familiar with a number of modern technologies including mass cytometry, multi-parameter flow cytometry and immuno-fluorescent microscopy. The candidate will help out with other projects where necessary. Other important responsibilities include ordering and upkeep of lab reagents/equipment and other lab house keeping and administrative tasks.

Candidates should be highly motivated, conscientious, and able to work independently and on own initiative. Good organizational, verbal and interpersonal skills are essential. If you are keen to develop your scientific career, you are highly encouraged to participate in scientific discussions and data analysis.

In addition the candidate must be willing to work with human tissue samples and be able to work flexible hours as human sample availability and experiments require; have an Honors degree in life Sciences, biology, biochemistry or other bio-medical sciences related field; be committed and motivated; have experience with literature research, designing planning and carrying out experiments and data analysis; be able to work with and communicate effectively with others; able to plan tasks independently. Other useful skills include flow cytometry experience. The general duties/responsibilities of this post are outlined in the Further Information Document.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Interviews will be held week commencing 24th April.

Any general queries regarding this position should be directed to jobs@path.cam.ac.uk or 01223 333940.

Please quote reference PK11593 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Post-Doctoral Research Associate: The Evolutionary Ecology Group (Fixed term)

From Jobs at the University of Cambridge. Published on Mar 02, 2017.

We are looking for a population geneticist to work in Dr Andrea Manica's Research Group in the Department of Zoology on a project investigating localised selection in humans. This ERC funded post is available for up to 40 months, with a start date of 10 April 2017 or soon thereafter. Department of Zoology is located in Cambridge city centre, on Downing Street. Required experience / knowledge for the position Essential: - A PhD in population genetics or closely related subjects; - Experience devising and implementing population genetics models; - Advances programming skills in C++, to develop the spatial population genetics framework used by the project; - Willingness to interact with specialist from other fields, such as archaeology and climatology; - Ability to organise time, plan ahead and to work effectively independently; - Good data handling and data analysis skills; - Good communication skills (written and oral); - Ability to work in a team and strong inter-personal skills. Desirable: - Experience with analysis of whole genome data; - Experience analysing ancient genomes; - Numerical skills and statistical analysis using R or Matlab (or a similar language); - Experience in working with High Performance Computing facilities; - Background knowledge (e.g. from degree courses) of archaeology or anthropology.

Duties will include: - Developing CISGeM, in close collaboration with a climate modeller already employed by the grant; - Using CISGeM to investigate demography and selection during key episodes of the out of Africa expansion and later periods; - Interacting with archaeologists and climate modellers to help result interpretation; - Preparation of manuscripts for publication.

Fixed-term: The funds for this post are available for up to 40 months.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PF11586 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant/Associate (Fixed Term)

From Jobs at the University of Cambridge. Published on Mar 01, 2017.

Applications are invited for a research associate position funded by Bloodwise UK, starting from 10 April 2017.

The successful candidates will join Professor Ming-Qing Du's research group based on the Cambridge Biomedical Campus within Addenbrooke's Hospital and investigate the genetic bases of aggressive B-cell lymphoma using state-of-art of technologies including high throughput targeted resequencing, with the aim to identify genetic markers valuable in disease prognosis and treatment stratification. Applicants should have a PhD or expect to obtain one shortly and a strong background in cancer genetics or related disciplines. Relevant experience in molecular pathology and/or high throughput sequence analyses is an advantage. The post-holder should be highly motivated, and have the ability to plan and conduct high quality experimental work within a multidisciplinary team.

Where the successful applicant does not yet have a PhD, he/she will normally be under-appointed as a Research Assistant in a Research Associate post (on the understanding that he/she will be appointed as a Research Associate upon successful completion of his/her PhD). The higher Research Associate salary should be backdated to the submission date of their thesis.

The general duties/responsibilities of this post include developing and driving research objectives, writing up work for presentation and publication, assisting in the supervision of student research projects, and delivering seminars and occasional lectures are outlined in the Further Information Documents.

Fixed-term: The funds for this post are available until 31 December 2018 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Further information about the research group can be found at the group's website (http://www.path.cam.ac.uk/pages/du/).

Informal enquires may be made to Professor Ming-Qing Du (mailto:mqd20@cam.ac.uk)

Any general queries regarding this position should be directed to jobs@path.cam.ac.uk or 01223 333940.

Please quote reference PK11585 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Core Bioinformatician (Research Associate) x 2

From Jobs at the University of Cambridge. Published on Feb 27, 2017.

The Wellcome Trust/Cancer Research UK Gurdon Institute, a leading cancer and developmental biology research institute with a vibrant computational environment, is seeking two people to join the Core Bioinformatics group, supporting research throughout the Institute.

The persons appointed will have a PhD or equivalent in a scientific, computational or mathematical subject. Applicants with a scientific background are expected to demonstrate a solid understanding of molecular biology and experience of computational techniques used in the analysis of biological data. Applicants from computational or mathematical backgrounds are expected to demonstrate applied computational experience along with demonstrable knowledge and experience of biological research. Applicants from both backgrounds should have a good understanding of statistical methods and their application to large data sets. Expertise in protein sequence and structure, analysis of NGS or other high-throughput data, or bespoke bioinformatics analysis would be beneficial. Knowledge of High Performance Computing would be an asset, though not essential.

The Core Bioinformaticians will work within a small team to: 1) analyse and carry out project requirements from scientists' descriptions; 2) provide clear explanations of computational methods and techniques to bench scientists; 3) liaise with other bioinformaticians within and outside of the Institute. Good oral and written communication skills are essential. The persons appointed will have the ability to multi-task and prioritise work effectively. They are expected to keep up to date with the field, including contributing towards and co-authoring scientific papers.

Limited funding: The funds for this post are available until 30 November 2021 in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be addressed to Alex Sossick (a.sossick@gurdon.cam.ac.uk). Please quote reference PR11542 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Benefits include generous maternity/paternity leave, flexible working and funds for returning carers and other family-friendly schemes.

Post doctoral Research Associate/Assistant x 2 (Fixed Term)

From Jobs at the University of Cambridge. Published on Feb 27, 2017.

Two post doctoral Research Associate/Assistant positions in Learning and Brain Plasticity are available to work at the Adaptive Brain Lab (http://www.abg.psychol.cam.ac.uk).

The first position will focus on behavioural and brain imaging studies that will combine high-field (7T) imaging and MEG for investigating the neural mechanisms that mediate learning and brain plasticity in young and older adults. Further interventional approaches (TMS, neuropharmacology) will be employed to test brain connectivity.

The second position will focus on advanced computational modelling of behavioural and multimodal brain imaging data including Bayesian modelling and machine learning approaches.

Research in the lab aims to understand how humans of all ages translate sensory experience into complex decisions and adaptive behaviours by taking into account previous experience and learning. We address this challenge using an interdisciplinary approach that combines behavioural paradigms, movement recording, multimodal brain imaging (MRI, EEG, MEG, TMS) and state-of-the-art computational methods. We apply these techniques to study the young and ageing brain and understand adaptive behaviours across the lifespan.

Applicants should have or be close to obtaining a PhD, and have a strong academic track record, in a relevant area (e.g., Neuroscience, Psychology, Mathematics, Engineering, Computer Science, Physics). Programming skills are highly desirable and experience with computational modeling and/or brain imaging preferable.

The salary range if appointed as a Post doctoral Research Associate is £29,301 - £38,183 per annum and the salary range if appointed as Research Assistant is £25,298 - £29,301 per annum with promotion to Post doctoral Research Associate on attainment of PhD.

Informal enquiries should be directed to Professor Zoe Kourtzi (zk240@cam.ac.uk)

Further details may be downloaded below.

Fixed-term: The funds for this post are available for 12 months in the first instance with possible extension to 3 years.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PJ11340 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Junior Clinical Training Scholarship Equine

From Jobs at the University of Cambridge. Published on Feb 24, 2017.

UNIVERSITY OF CAMBRIDGE DEPARTMENT OF VETERINARY MEDICINE

One-year Junior Clinical Training Scholarship Scholarship award: £14,800

Start date 1 August 2017

Applications are invited from recently qualified veterinarians for this 12 month post-graduate training programme offering high-quality, post-graduate training in equine studies. The emphasis will be on gaining practical clinical experience in equine medicine and surgery under the supervision of board-certified diplomates, and will allow the intern to identify specific fields in which to specialise, either in preparation for Senior Clinical Scholarship training programmes, or specialist private practice.

Applicants must be a Member of the Royal College of Veterinary Surgeons, or hold a veterinary degree qualifying him or her for membership.

For informal enquiries about the scholarship programme, please contact Natalie Wills nw366@cam.ac.uk

Closing date: 17 April 2017

Interview date: 3 May 2017

An application form (JCTS1) and information pack can be downloaded from the link below or via the following website: http://www.vet.cam.ac.uk/

Please send a completed application form, curriculum vitae, and covering letter by email to vetmed@hermes.cam.ac.uk or to Melissa Large, Department of Veterinary Medicine, Madingley Road, Cambridge, CB3 OES,

Please quote reference PP11548 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Junior Clinical Training Scholarship Farm Animal Health and Production (2 Scholarships available)

From Jobs at the University of Cambridge. Published on Feb 24, 2017.

UNIVERSITY OF CAMBRIDGE DEPARTMENT OF VETERINARY MEDICINE

One-year Junior Clinical Training Scholarship Scholarship award: £14,800

Start date 1 August 2017

Applications are invited for this 12-month Scholarship programme, which provides an opportunity for new graduates or recently qualified veterinarians to receive high-quality postgraduate training in farm animal studies under the supervision of experienced farm animal clinicians in the Cambridge Farm Animal Veterinary Services ambulatory and referral practice at the University of Cambridge. The emphasis of the programme is on gaining practical clinical experience in farm animal medicine and herd health, and will allow the Scholar to identify specific fields of farm animal work in which to specialise, either in preparation for Senior Clinical Training Scholarship programmes, or for specialist private practice.

The internship will cover:

  • Case management of individual production animals, including emergency and critical care, surgery, anaesthesia, diagnostics, internal medicine and obstetrics

  • Involvement in a busy and expanding first opinion farm animal practice

  • Training and practice in population medicine and herd health management, with an emphasis on evidence-based medicine

  • Experience in teaching and communication

  • Basic tuition in research methods and scientific writing

  • Opportunity to design and undertake research projects

An applicant must be a Member of the Royal College of Veterinary Surgeons, or hold a veterinary degree qualifying them for membership.

Informal enquiries about scholarship programme: contact Natalie Wills on nw366@cam.ac.uk

Closing date: 5 April 2017

Interview date: 20 April 2017

An application form (JCTS1) and information pack can be downloaded from the link below or via the following website: http://www.vet.cam.ac.uk/

Completed application form, curriculum vitae, covering letter: send to Melissa Large, Department of Veterinary Medicine, Madingley Road, Cambridge, CB3 OES, or via email to vetmed@hermes.cam.ac.uk

Please quote reference PP11547 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate - Comparative Neurobiology (Fixed Term)

From Jobs at the University of Cambridge. Published on Feb 23, 2017.

We invite applications for postdoctoral Research Associate position in the Department of Zoology in Central Cambridge on Downing Street with Dr Stephen Montgomery's research group. It is funded for up to 12 months, by the Isaac Newton Trust/Wellcome Trust ISSF/University of Cambridge Joint Research Grants Scheme and should start on 1 June 2017 or as soon as possible thereafter.

The PDRA will study the cellular basis of mushroom body expansion in Heliconius butterflies. We have recently confirmed previous reports that Heliconius have massively expanded mushroom bodies (see Montgomery et al. 2016 J. Comp. Neurol. 524 (9):1747-1769), providing a novel case study for investigating the causes and consequences of volumetric expansion of 'higher order' brain regions. We are interested in understanding the cellular basis of mushroom body expansion by investigating how the number of neurons and synaptic complexes vary with size, and by testing the hypothesis that mushroom body expansion co-occurs with changes in input to the mushroom bodies from other brain regions.

Duties will include designing and carrying out experiments to investigate the cellular changes that accompany increases in mushroom body size using multiple species of Heliconiini butterflies, and analysing and writing up the results.

The successful applicant should have a Ph.D., completed or completion imminent, in comparative neurobiology, evolutionary biology, cell/developmental biology or a related field, and a strong interest in brain and behavioural evolution. Candidates should have a good collaborative spirit, and can expect a high degree of support and assistance from the PI. Enthusiasm, determination and the capacity to work independently are also essential.

Fixed-term: The funds for this post are available for up to 12 months.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PF11538 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD studentship in Molecular Microbiology

From Jobs at the University of Cambridge. Published on Feb 10, 2017.

A BBSRC-funded Targeted PhD studentship (for uptake in October 2017) is available in the laboratory of Dr Martin Welch (Department of Biochemistry, Tennis Court Road, Cambridge). The project will investigate the role of an acetate-inducible denitrification pathway in the opportunistic human pathogen, Pseudomonas aeruginosa. Recent RNA-Seq analyses carried out in the lab have revealed that when grown on acetate as a sole carbon source, gene products comprising the Nar/Nir/Nos/Nor denitrification pathways are among the most highly up-regulated transcripts in the cell. This was a surprising observation because transcripts encoding the known regulators of denitrification in P. aeruginosa (Anr and Dnr) were not modulated at all, suggesting that in these conditions, denitrification is controlled by some other mechanism(s). The practical relevance of this is that (i) fatty acids and other acetate-producing substrates are now known to be the preferred energy source for P. aeruginosa during many infection scenarios, and (ii) denitrification is critically-important in industry for microaerobic bacterial growth. Therefore, the key question and the main aim of this project, is to understand why P. aeruginosa turns on the denitrification pathways during growth on acetate, and what regulates this. The successful candidate will investigate this problem using a combined biochemical, genetic and systems-based approach which should provide a rich and varied training opportunity.

The successful applicant will join our Departmental PhD programme and must complete their studies within 4 years. Full funding (covering maintenance, fees and laboratory consumables) is available for UK citizens or EEA students who meet UK residency requirements. In addition to a programme of work in the MW lab, the appointed student will participate in DTP training courses, two 10-week rotation projects (one of which will be based in the MW lab) and a three month internship (PIPS), as well as other DTP-related events.

In the first instance, interested candidates should contact Dr Martin Welch (mw240@cam.ac.uk) with a CV, list of academic referees and a cover letter. Shortlisted candidates will be invited for interview in Cambridge.

Please quote reference PH11425 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship (Fixed Term)

From Jobs at the University of Cambridge. Published on Feb 10, 2017.

Applications are invited for a three-year PhD studentship position funded by the Pathological Society of Great Britain & Ireland, starting from 1 October 2017. Funding will cover the student's stipend at the current Research Council rate and University Fees. **The studentship is available to UK nationals and EU students who meet the UK residency requirements.

The successful candidate will join Professor Ming-Qing Du's research group and investigate the molecular function of KLF2, a transcriptional factor, which is frequently inactivated by somatic mutations in splenic marginal zone B-cell lymphoma (Clipson et al Leukemia 2015:29:1177-85). Applicants should have or expect to have an upper second honours BSc or MSc degree in biomedical science or a related subject. Experience in biomedical research is an advantage. The post-holder should be highly motivated, and keen to work within a multidisciplinary team. Additionally, the Department requires that by the time of interview all potential students must have fulfilled the language requirements for admission (http://www.graduate.study.cam.ac.uk/courses/directory/blpapdpth/requirements)

** Further information about the UK residency requirements and your fee status can be found at the following website: http://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status. Applications from ineligible candidates will not be considered.

Further information about the research group can be found at the group's website (http://www.path.cam.ac.uk/pages/du/).

Informal enquires may be made to Professor Ming-Qing Du (mailto:mqd20@cam.ac.uk). General queries regarding this position should be directed to graduate.studies@path.cam.ac.uk or 01223 333940

The closing date for applications is 6 April 2017.

Fixed-term: The funds for this post are available for 3 years in the first instance.

The application form and how to apply is available from the following link: http://www.path.cam.ac.uk/graduate/fully-funded-phd/path-soc-studentship

Please quote reference PK11417 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

BBSRC iCase 4 Year PhD Studentship

From Jobs at the University of Cambridge. Published on Feb 10, 2017.

Decoding the network logic for resetting pluripotency ¿ Collaborative Stem Cell Research PhD Studentship with Microsoft Research - re-advertised, revised closing date 31st March 2017.

Outline Project Description:

  • Interdisciplinary project at the interface of stem cell research and computational modelling

  • Delineation of network trajectories for cellular reprogramming at single cell resolution

  • Combination of wet lab research with logical modelling

  • Collaboration between the laboratory of Prof. Austin Smith and Microsoft Research Cambridge

The Smith Group at the Medical Research Council Wellcome Trust Stem Cell Institute in Cambridge in partnership with the Computational Biology Group at Microsoft Research offers an exciting interdisciplinary 4-year PhD studentship commencing October 2017.

The pluripotent ground state of embryonic stem cells (ESCs) is governed by a self-reinforcing interaction network of transcription factors (Dunn et al, Science 2014). Combinations of factors within this network can induce somatic cells to acquire pluripotency, a process called molecular reprogramming (Takahashi and Yamanaka, Cell, 2006). Experimental and computational efforts have led to circuitry mapping of the key players in maintenance of the ESC state. However, how this molecular circuitry is launched and fully connected during reprogramming remains unclear.

This project is a cross-disciplinary investigation to address systematically how cells transit to the pluripotent ESC state at the molecular network level. The multi-step, heterogeneous and asynchronous nature of the reprogramming process presents technical challenges. This project is designed to overcome these challenges by using a minimal reprogramming system and integrating quantitative single-cell gene expression profiling at defined reprogramming stages with computational network synthesis and modelling. This approach will transform a temporal series of single-cell snapshots of network status into reconfiguring network trajectories. Predictions formulated from the synthesised trajectories will be tested experimentally and the results used for iterative refinement of the model set.

As part of the BBSRC doctoral training programme, this 4-year PhD contains tailored training courses in the first six months of the studentship. In addition, a key element of this project is that the student will spend three months at Microsoft Research Cambridge, under the supervision of our collaborator, Dr Sara-Jane Dunn, to develop wider training and skills.

For further details about our group and the institute, please visit:http://www.stemcells.cam.ac.uk/

Funding Notes

UK and EEA students who have, or are expecting to attain, at least an upper second class honours degree (or equivalent) in relevant biological subjects are invited to apply. The interdisciplinary nature of the project means that we welcome applications from students with mathematical and computing experience who are interested in using their skills to address biological questions.

Application details are available at http://www.stemcells.cam.ac.uk/study/otheropportunities/#BBSRC. Please ask your referees to submit references directly to the SCI Graduate Administrator: sci-phd@stemcells.cam.ac.uk, using "BBSRCiCASE student reference" in the subject header. The deadline is 31st March 2017 and shortlisted candidates will be interviewed in April. Please note: this studentship is being re-advertised. Previous applicants need not apply.

Please quote reference PS10826 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.